The "two faces" of tumor suppressor p53-revisited

Molecular and Cellular Pharmacology

Volumn 2, Issue 3, 2010, Pages 117-119

  Smith, Martin L ^a   Kumar, M Suresh ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA damage protection; DNA repair

Indexed keywords

CARBOPLATIN; CISPLATIN; DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PROTEIN P53; RECOMBINANT GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; RECOMBINANT PROTEIN; RECOMBINANT PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; XERODERMA PIGMENTOSUM GROUP C PROTEIN;

APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELL LINE; CELL SURVIVAL; DNA DAMAGE; DNA REPAIR; DRUG MECHANISM; EXCISION REPAIR; GENE ACTIVATION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROCESSING; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION; WILD TYPE;

EID: 77954295382     PISSN: None     EISSN: 19381247     Source Type: Journal    
DOI: 10.4255/mcpharmacol.10.16     Document Type: Article

References (14)

1. Seo YR, Kelley MR, Smith ML. Selenomethionine regulation of p53 by a Ref 1 dependent redox mechanism. Proc Natl Acad Sci USA 2002;99:14548-53.
2. She QB, Ma WY, Dong Z. Role of MAP kinases in UVB-induced phosphorylation of p53 at serine 20. Oncogene 2002;21:1580-9.
3. Smith ML, Fornace AJ Jr. The two faces of tumor suppressor p53. Am J Path 1996;148:1019-22.
4. Smith ML, Fornace AJ Jr. p53-mediated protective responses to UV irradiation. Proc Natl Acad Sci USA.1997;94:12255-7.
5. Adimoolam S, Ford JM. p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene. Proc Natl Acad Sci USA. 2002;99:12985-90.
6. Smith ML, Chen IT, Zhan Q, O'Connor PM, Fornace AJ Jr. Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage. Oncogene 1995;10:1053-9.
7. Smith ML, Ford JM, Hollander MC, et al. p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol Cell Biol. 2000;20:3705-14.
8. Fischer JL, Kumar MA, Day TW, et al. The Xpc gene markedly affects cell survival in mouse bone marrow. Mutagenesis 2009;24:309-16.
9. Carrier F, Georgel PT, Pourquier P, et al. Gadd 45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol Cell Biol 1999;19:1673-85.
10. Hollander MC, Kovalsky O, Salvador JM et al. Dimethylbenzanthracene carcinogenesis in Gadd 45a-null mice is associated with decreased DNA repair and increased mutation frequency. Cancer Res. 2001;61:2487-91.
11. Fan S, Smith ML, Rivet DJ et al. Disruption of p53 sensitizes breast cancer MCF7 cells to cisplatin and pentoxifylline. Cancer Res. 1995;55:1649-54.
12. Seo YR, Chen EI, Smith ML. Sensitivity of p53 - deficient cells to oxaliplatin and thio-TEPA (N,N',N" triethylenethiophosphoramide). Breast Cancer Res Treat 2002;72:255-63.
13. Gudkov A, Komarova EA. Dangerous habits of a security guard: the two faces of p53 as a drug target. Human Mol Genet 2007;16:67-72.
14. Seo YR, Fishel ML, Amundson SA, Kelley MR, Smith ML. Implication of p53 in base excision DNA repair: in vivo evidence. Oncogene. 2002;21:731-7.