Possible direct cytoxicity effects of cyclophosphamide on cultured human follicles: An electron microscopy study

Journal of Assisted Reproduction and Genetics

Volumn 19, Issue 10, 2002, Pages 500-506

  Raz, Ahud ^a   Fisch, Benjamin ^a   Okon, Elimelech ^b   Feldberg, Dov ^a   Nitke, Shmuel ^a   Raanani, Hila ^a   Abir, Ronit ^a  

^a RABIN MEDICAL CENTER   (Israel)

^b Rabin Medical Center Beilinson Campus ^*  (Israel)

Author keywords

Cyclophosphamide; Granulosa cells; Oocytes; Ovarian failure; Primordial follicles

Indexed keywords

CYCLOPHOSPHAMIDE; FOLLITROPIN; UROFOLLITROPIN;

ADOLESCENT; ADULT; BASEMENT MEMBRANE; CELL CULTURE; CELL NUCLEUS; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DRUG EFFECT; FEMALE; GRANULOSA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; OVARY FOLLICLE DEVELOPMENT; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

ALKYLATION; CELL NUCLEUS; CELLS, CULTURED; CYCLOPHOSPHAMIDE; FEMALE; GRANULOSA CELLS; HUMANS; MICROSCOPY, ELECTRON; OVARIAN FOLLICLE;

EID: 0036773594     PISSN: 10580468     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020318704960     Document Type: Conference Paper

References (11)

1. Meirow D: Reproduction post-chemotherapy in young cancer patients. Mol Cell Endocrinol 2000;169:123-131
2. Tilly J: Apoptosis and ovarian function. Rev Reprod 1996;1:162-172
3. Moore MJ: Clinical pharmacokinetics of cyclophosphamide. Clin Pharmacokinet 1991;20:194-208
4. Abir R, Fisch B, Nitke S, Okon E, Raz Ah, Ben-Rafael Z: Morphological study of fully and partially isolated early human follicles. Fertil Steril 2001;75:141-146
5. Familiari G, Caggiati A, Nottola SA, Ermini M, Di Benedetto MR, Motta PM: Ultrastructure of human ovarian primordial follicles after combination chemotherapy for Hodgkin's disease. Hum Reprod 1993;8:2080-2087
6. Lee CJ, Park HH, Do BR, Yoon Y, Kim JK: Natural and radiation-induced degeneration of primordial and primary follicles in mouse ovary. Anim Reprod Sci 2000;59:109-117
7. Chen WY, Yang JG, Huang SH, Li PS: Effects of cyclophosphamide on maturation and subsequent fertilizing capacity of pig oocytes in vitro. Chin J Physiol 1998;30:75-83
8. Fein A, Ben-Nun O, Wengier N, Torchinsky A, Toder V: The effect of cyclophosphamide on rat blastocysts in vitro and their subsequent development following transfer to psuedopregnant rats. Isr J Med Sci 1996;32:129-134
9. Tannock IF, Lee C: Evidence against apoptosis as a major mechanism for reproductive cell death following treatment of cell lines with anti-cancer drugs. Br J Cancer 2001;84:100-105
10. Gougeon A: Regulations of ovarian follicular development in primates: Facts and hypotheses. Endocr Rev 1996;17:121-154
11. Marcello MF, Nuciforo G, Romeo R, Di Dinno G, Russo I, Russo A, Palumbo G, Schiliro G: Structural and ultrastructural study of the ovary in childhood leukemia after successful treatment. Cancer 1990;66:2099-2104