N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents

Cell Research

Volumn 22, Issue 8, 2012, Pages 1285-1303

  Song, Shanshan ^a,b,c   Xing, Guichun ^b,c   Yuan, Lin ^b,c   Wang, Jian ^b,c   Wang, Shan ^b,c   Yin, Yuxin ^d   Tian, Chunyan ^b,c   He, Fuchu ^a,b,c   Zhang, Lingqiang ^b,c  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^c National Engineering Research Center for Protein Drugs   (China)

^d PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

alkylating agents; base excision repair; cell cycle arrest; MPG; p53

Indexed keywords

ALKYLATING AGENT; CELL CYCLE PROTEIN; DACARBAZINE; DNA 3 METHYLADENINE GLYCOSIDASE II; DNA GLYCOSYLTRANSFERASE; DNA-3-METHYLADENINE GLYCOSIDASE II; DRUG DERIVATIVE; FLUOROURACIL; GADD45A PROTEIN, HUMAN; MESYLIC ACID METHYL ESTER; NUCLEAR PROTEIN; PROTEIN P53; TEMOZOLOMIDE; TP53 PROTEIN, HUMAN;

ARTICLE; CELL CYCLE CHECKPOINT; CELL STRAIN HCT116; CELL STRAIN MCF 7; CELL SURVIVAL; COMET ASSAY; DNA REPAIR; DNA STRAND BREAKAGE; DRUG SCREENING; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; POINT MUTATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; TRANSCRIPTION INITIATION;

ANTINEOPLASTIC AGENTS, ALKYLATING; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL SURVIVAL; COMET ASSAY; DACARBAZINE; DNA BREAKS; DNA GLYCOSYLASES; DNA REPAIR; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROURACIL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; MCF-7 CELLS; METHYL METHANESULFONATE; NUCLEAR PROTEINS; POINT MUTATION; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84864978769     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2012.107     Document Type: Article

References (44)

1. Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002; 2:594-604. (Pubitemid 37328926)
2. Kern SE, Kinzler KW, Bruskin A, et al. Identifcation of p53 as a sequence-specifc DNA-binding protein. Science 1991; 252:1708-1711. (Pubitemid 21917093)
3. Harris SL, Levine AJ. The p53 pathway: positive and nega-tive feedback loops. Oncogene 2005; 24:2899-2908. (Pubitemid 40638098)
4. Dumaz N, Meek DW. Serine15 phosphorylation stimulates p53 transactivation but does not directly infuence interaction with HDM2. EMBO J 1999; 18:7002-7010. (Pubitemid 30000453)
5. Tian C, Xing G, Xie P, et al. KRAB-type zinc-fnger protein Apak specifcally regulates p53-dependent apoptosis. Nat Cell Biol 2009; 11:580-591.
6. Sullivan A, Lu X. ASPP: a new family of oncogenes and tu-mour suppressor genes. Br J Cancer 2007; 96:196-200. (Pubitemid 46160620)
7. Tanaka T, Ohkubo S, Tatsuno I, Prives C. hCAS/CSE1L asso-ciates with chromatin and regulates expression of select p53 target genes. Cell 2007; 130:638-650. (Pubitemid 47268061)
8. Das S, Raj L, Zhao B, et al. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell 2007; 130:624-637. (Pubitemid 47277418)
9. Schnack C, Hengerer B, Gillardon F. Identifcation of novel substrates for Cdk5 and new targets for Cdk5 inhibitors using high-density protein microarrays. Proteomics 2008; 8:1980-1986. (Pubitemid 351775778)
10. Samson L, Derfer B, Boosalis M, Call K. Cloning and char-acterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16. Proc Natl Acad Sci USA 1991; 88:9127-9131. (Pubitemid 21915582)
11. Trivedi RN, Almeida KH, Fornsaglio JL, Schamus S, Sobol RW. The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death. Cancer Res 2005; 65:6394-6400. (Pubitemid 40994427)
12. Fishel ML, He Y, Smith ML, Kelley MR. Manipulation of base excision repair to sensitize ovarian cancer cells to alky-lating agent temozolomide. Clin Cancer Res 2007; 13:260-267. (Pubitemid 46121878)
13. Klapacz J, Lingaraju GM, Guo HH, et al. Frameshift muta-genesis and microsatellite instability induced by human alky-ladenine DNA glycosylase. Mol Cell 2010; 37:843-853.
14. Coquerelle T, Dosch J, Kaina B. Overexpression of N-meth-ylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosom-al aberrations by methylating agents-a case of imbalanced DNA repair. Mutat Res 1995; 336:9-17.
15. Posnick LM, Samson LD. Imbalanced base excision repair increases spontaneous mutation and alkylation sensitivity in Escherichia coli. J Bacteriol 1999; 181:6763-6771. (Pubitemid 29517992)
16. Gillen CD, Walmsley RS, Prior P, Andrews HA, Allan RN. Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis. Gut 1994; 35:1590-1592. (Pubitemid 24339258)
17. Hofseth LJ, Saito S, Hussain SP, et al. Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc Natl Acad Sci USA 2003; 100:143-148. (Pubitemid 36078042)
18. Paik J, Duncan T, Lindahl T, Sedgwick B. Sensitization of hu-man carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase. Can-cer Res 2005; 65:10472-10477. (Pubitemid 41743742)
19. Lau AY, Scharer OD, Samson L, Verdine GL, Ellenberger T. Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide fipping and base excision. Cell 1998; 95:249-258. (Pubitemid 28473785)
20. Lau AY, Wyatt MD, Glassner BJ, Samson LD, Ellenberger T. Molecular basis for discriminating between normal and dam-aged bases by the human alkyladenine glycosylase, AAG. Proc Natl Acad Sci USA 2000; 97:13573-13578.
21. Berglind H, Pawitan Y, Kato S, Ishioka C, Soussi T. Analysis of p53 mutation status in human cancer cell lines: a paradigm for cell line cross-contamination. Cancer Biol Ther 2008; 7:699-708.
22. Hollstein M, Sidransky D, Vogelstein, B, Harris CC. p53 mu-tations in human cancers. Science 1991; 253:49-53.
23. Weisz L, Oren M, Rotter V. Transcription regulation by mu-tant p53. Oncogene 2007; 26:2202-2211
24. Watanabe S, Ichimura T, Fujita N, et al. Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin. Proc Natl Acad Sci USA 2003; 100:12859-12864. (Pubitemid 37339990)
25. Lee CY, Delaney JC, Kartalou M, et al. Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG). Biochemistry 2009; 48:1850-1861.
26. Adhikari S, Toretsky JA, Yuan L, Roy R. Magnesium, essen-tial for base excision repair enzymes, inhibits substrate bind-ing of N-methylpurine-DNA glycosylase. J Biol Chem 2006; 281:29525-29532. (Pubitemid 44536960)
27. Wood RD, Mitchell M, Sgouros J, Lindahl T. Human DNA repair genes. Science 2001; 291:1284-1289. (Pubitemid 32173086)
28. Tentori L, Graziani G. Pharmacological strategies to increase the antitumor activity of methylating agents. Curr Med Chem 2002; 9:1285-1301. (Pubitemid 34693069)
29. Rinne M, Caldwell D, Kelley MR. Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts che-motherapeutic sensitivity to human breast cancer cells. Mol Cancer Ther 2004; 3:955-967. (Pubitemid 39199590)
30. Chou WC, Wang HC, Wong FH, et al. Chk2-dependent phos-phorylation of XRCC1 in the DNA damage response pro-motes base excision repair. EMBO J 2008; 27:3140-3150.
31. Nakamura J, Asakura S, Hester SD, de Murcia G, Caldecott KW, Swenberg JA. Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair defcient cells in real time. Nucleic Ac-ids Res 2003; 31:e104.
32. Swain U, Subba Rao K. Study of DNA damage via the comet assay and base excision repair activities in rat brain neurons and astrocytes during aging. Mech Ageing Dev 2011; 132:374-381.
33. Olive PL, Banath JP. The comet assay: a method to measure DNA damage in individual cells. Nat Protoc 2006; 1:23-29.
34. Kow YW, Dare A. Detection of abasic sites and oxidative DNA base damage using an ELISA-like assay. Methods 2000; 22:164-169. (Pubitemid 32896721)
35. Bapat A, Glass LS, Luo M, et al. Novel small-molecule inhib-itor of apurinic/apyrimidinic endonuclease 1 blocks prolifera-tion and reduces viability of glioblastoma cells. J Pharmacol Exp Ther 2010; 334:988-998.
36. Drablos F, Feyzi E, Aas PA, et al. Alkylation damage in DNA and RNA-repair mechanisms and medical signifcance. DNA Repair (Amst) 2004; 3:1389-1407. (Pubitemid 39221738)
37. Labahn J, Scharer OD, Long A, et al. Structural basis for the excision repair of alkylation-damaged DNA. Cell 1996; 86:321-329. (Pubitemid 26286114)
38. Dittmer D, Pati S, Zambetti G, et al. Gain of function muta-tions in p53. Nat Genet 1993; 4:42-46.
39. Hofseth LJ, Khan MA, Ambrose M, et al. The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. J Clin Invest 2003; 112:1887-1894. (Pubitemid 38063712)
40. Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 2003; 3:330-338. (Pubitemid 37328853)
41. Miao F, Bouziane M, Dammann R, et al. 3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins. J Biol Chem 2000; 275:28433-28438.
42. Rui Y Xu Z, Lin S, et al. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex for-mation. EMBO J 2004; 23:4583-4594. (Pubitemid 39657858)
43. Mi B, Wang X, Bai Y, et al. Beta-catenin expression is altered in dysplastic and nondysplastic aberrant crypt foci of human colon. Appl Immunohistochem Mol Morphol 2009; 17:294-300.
44. Abner CW, Lau AY, Ellenberger T, Bloom LB Base excision and DNA binding activities of human alkyladenine DNA gly-cosylase are sensitive to the base paired with a lesion. J Biol Chem 2001; 276:13379-13387.