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Volumn 8, Issue 10, 2008, Pages 1980-1986

Identification of novel substrates for Cdk5 and new targets for Cdk5 inhibitors using high-density protein microarrays

Author keywords

Kinase; Protein array; Selectivity screen; Substrate screen

Indexed keywords

CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE INHIBITOR; HIGH DENSITY LIPOPROTEIN; INDOLINONE A; PHOSPHOPROTEIN PHOSPHATASE 1;

EID: 44649091314     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.200701063     Document Type: Article
Times cited : (30)

References (43)
  • 1
    • 2342634487 scopus 로고    scopus 로고
    • Cdk5: Mediator of neuronal death and survival
    • Cheung, Z. H., Ip, N. Y., Cdk5: Mediator of neuronal death and survival. Neurosci. Lett. 2004, 361, 47-51.
    • (2004) Neurosci. Lett , vol.361 , pp. 47-51
    • Cheung, Z.H.1    Ip, N.Y.2
  • 2
    • 1642452714 scopus 로고    scopus 로고
    • Cdk5 phosphorylation of doublecortin Ser297 regulates its effect on neuronal migration
    • Tanaka, T., Serneo, F. F., Tseng, H.-C., Kulkarni, A. B. et al., Cdk5 phosphorylation of doublecortin Ser297 regulates its effect on neuronal migration. Neuron 2004, 41, 215-227.
    • (2004) Neuron , vol.41 , pp. 215-227
    • Tanaka, T.1    Serneo, F.F.2    Tseng, H.-C.3    Kulkarni, A.B.4
  • 3
    • 0026680802 scopus 로고
    • Purification and characterization of a novel proline-directed protein kinase from bovine brain
    • Lew, J., Beaudette, K., Litwin, C. M. E., Wang, J. H., Purification and characterization of a novel proline-directed protein kinase from bovine brain. J. Biol. Chem. 1992, 276, 13383-13390.
    • (1992) J. Biol. Chem , vol.276 , pp. 13383-13390
    • Lew, J.1    Beaudette, K.2    Litwin, C.M.E.3    Wang, J.H.4
  • 4
    • 0035448915 scopus 로고    scopus 로고
    • p35 and p39 are essential for cyclin-dependent kinase 5 function during development
    • Ko, J., Humbert, S., Bronson, R. T., Takahashi, S. et al., p35 and p39 are essential for cyclin-dependent kinase 5 function during development. J. Neurosci. 2001, 21, 6758-6771.
    • (2001) J. Neurosci , vol.21 , pp. 6758-6771
    • Ko, J.1    Humbert, S.2    Bronson, R.T.3    Takahashi, S.4
  • 6
    • 1642269125 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 in neurodegeneration
    • Shelton, S. B., Johnson, G. V. W., Cyclin-dependent kinase-5 in neurodegeneration. J. Neurochem. 2004, 88, 1313-1326.
    • (2004) J. Neurochem , vol.88 , pp. 1313-1326
    • Shelton, S.B.1    Johnson, G.V.W.2
  • 7
    • 0033540060 scopus 로고    scopus 로고
    • Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    • Patrick, G. N., Zuckerberg, L., Nikolic, M., de la Monte, S. et al., Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 1999, 402, 615-622.
    • (1999) Nature , vol.402 , pp. 615-622
    • Patrick, G.N.1    Zuckerberg, L.2    Nikolic, M.3    de la Monte, S.4
  • 8
    • 0027425599 scopus 로고
    • Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system
    • Tsai, L.-H., Takahashi, T., Caviness, V. S., Jr., Harlow, E., Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 1993, 119, 1029-1040.
    • (1993) Development , vol.119 , pp. 1029-1040
    • Tsai, L.-H.1    Takahashi, T.2    Caviness Jr., V.S.3    Harlow, E.4
  • 9
    • 0034832115 scopus 로고    scopus 로고
    • Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism
    • Grant, P., Sharma, P., Pant, H. C., Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism. FEBS J. 2001, 268, 1534-1546.
    • (2001) FEBS J , vol.268 , pp. 1534-1546
    • Grant, P.1    Sharma, P.2    Pant, H.C.3
  • 10
    • 0037431130 scopus 로고    scopus 로고
    • Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis
    • Gong, X., Tang, X., Wiedmann, M., Wang, X. et al., Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron 2003, 38, 33-46.
    • (2003) Neuron , vol.38 , pp. 33-46
    • Gong, X.1    Tang, X.2    Wiedmann, M.3    Wang, X.4
  • 11
    • 0036312755 scopus 로고    scopus 로고
    • Cdk5 phosphorylates p53 and regulates its activity
    • Zhang, J., Krishnamurthy, P. K., Johnson, G. V., Cdk5 phosphorylates p53 and regulates its activity. J. Neurochem. 2002, 81, 307-313.
    • (2002) J. Neurochem , vol.81 , pp. 307-313
    • Zhang, J.1    Krishnamurthy, P.K.2    Johnson, G.V.3
  • 13
    • 0036527429 scopus 로고    scopus 로고
    • Protein kinases - the major drug targets of the twenty-first century?
    • Cohen, P., Protein kinases - the major drug targets of the twenty-first century? Nat. Rev. Drug Discov. 2002, 1, 309-315.
    • (2002) Nat. Rev. Drug Discov , vol.1 , pp. 309-315
    • Cohen, P.1
  • 14
    • 0037392444 scopus 로고    scopus 로고
    • Issues and progress with protein kinase inhibitors for cancer treatment
    • Dancey, J., Sausville, E. A., Issues and progress with protein kinase inhibitors for cancer treatment. Nature 2003, 2, 296-313.
    • (2003) Nature , vol.2 , pp. 296-313
    • Dancey, J.1    Sausville, E.A.2
  • 15
    • 0035990906 scopus 로고    scopus 로고
    • Cyclin-dependent kinases as potential targets to improve stroke outcome
    • O'Hare, M., Wang, F., Pakr, D. S., Cyclin-dependent kinases as potential targets to improve stroke outcome. Pharmacol. Ther. 2002, 93, 135-143.
    • (2002) Pharmacol. Ther , vol.93 , pp. 135-143
    • O'Hare, M.1    Wang, F.2    Pakr, D.S.3
  • 16
    • 0142250831 scopus 로고    scopus 로고
    • Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction
    • Weishaupt, J. H., Kussmaul, L., Grötsch, P., Heckel, A. et al., Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction. Mol. Cell. Neurosci. 2003, 24, 489-502.
    • (2003) Mol. Cell. Neurosci , vol.24 , pp. 489-502
    • Weishaupt, J.H.1    Kussmaul, L.2    Grötsch, P.3    Heckel, A.4
  • 17
    • 3142689920 scopus 로고    scopus 로고
    • Involvment of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis
    • Lin, H., Juang, J.-L., Wang, P. S., Involvment of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis. J. Biol. Chem. 2004, 79, 29302-29307.
    • (2004) J. Biol. Chem , vol.79 , pp. 29302-29307
    • Lin, H.1    Juang, J.-L.2    Wang, P.S.3
  • 19
    • 0037137711 scopus 로고    scopus 로고
    • Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor
    • Eto, M., Bock, R., Brautigan, D. L., Linden, D. J., Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor. Neuron 2002, 36, 1145-1158.
    • (2002) Neuron , vol.36 , pp. 1145-1158
    • Eto, M.1    Bock, R.2    Brautigan, D.L.3    Linden, D.J.4
  • 20
    • 0032475973 scopus 로고    scopus 로고
    • Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinase, a novel family of dual specificity protein kinases
    • Becker, W., Weber, Y., Wetzel, K., Eirmbter, K. et al., Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinase, a novel family of dual specificity protein kinases. J. Biol. Chem. 1998, 273, 25893-25902.
    • (1998) J. Biol. Chem , vol.273 , pp. 25893-25902
    • Becker, W.1    Weber, Y.2    Wetzel, K.3    Eirmbter, K.4
  • 21
    • 0742270492 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the post-synaptic density protein PSD-95 in neurons
    • Morabito, M. A., Sheng, M., Tsai, L.-H., Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the post-synaptic density protein PSD-95 in neurons. J. Neurosci. 2004, 24, 865-876.
    • (2004) J. Neurosci , vol.24 , pp. 865-876
    • Morabito, M.A.1    Sheng, M.2    Tsai, L.-H.3
  • 22
    • 11144247943 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 phoshorylates serine 31 of tyrosine hydroxylase and regulates its stability
    • Moy, L. Y., Tsai, L.-H., Cyclin-dependent kinase 5 phoshorylates serine 31 of tyrosine hydroxylase and regulates its stability. J. Biol. Chem. 2004, 297, 54487-54493.
    • (2004) J. Biol. Chem , vol.297 , pp. 54487-54493
    • Moy, L.Y.1    Tsai, L.-H.2
  • 23
    • 0032504964 scopus 로고    scopus 로고
    • The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity
    • Nikolic, M., Chou, M. M., Lu, W., Mayer, B. J., Tsai, L.-H., The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nature 1998, 395, 194-198.
    • (1998) Nature , vol.395 , pp. 194-198
    • Nikolic, M.1    Chou, M.M.2    Lu, W.3    Mayer, B.J.4    Tsai, L.-H.5
  • 24
    • 0037096334 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of reelin signaling
    • Keshvara, L., Magdaleno, S., Benhayon, D., Curran, T., Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of reelin signaling. J. Neurosci. 2002, 22, 4869-4877.
    • (2002) J. Neurosci , vol.22 , pp. 4869-4877
    • Keshvara, L.1    Magdaleno, S.2    Benhayon, D.3    Curran, T.4
  • 25
    • 0034520636 scopus 로고    scopus 로고
    • NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein
    • Niethammer, M., Smith, D. S., Ayala, R., Peng, J. et al., NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron 2000, 28, 697-711.
    • (2000) Neuron , vol.28 , pp. 697-711
    • Niethammer, M.1    Smith, D.S.2    Ayala, R.3    Peng, J.4
  • 26
    • 0034520597 scopus 로고    scopus 로고
    • A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system
    • Sasaki, S., Shionoya, A., Ishida, M., Gambello, M. J. et al., A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron 2000, 28, 681-696.
    • (2000) Neuron , vol.28 , pp. 681-696
    • Sasaki, S.1    Shionoya, A.2    Ishida, M.3    Gambello, M.J.4
  • 27
    • 33748694505 scopus 로고    scopus 로고
    • Phoshorylation of the tubulin-binding protein, stathmin, by Cdk5 and MAP kinases in the brain
    • Hayashi, K., Pan, Y., Oshima, T., Kansy, J. W. et al., Phoshorylation of the tubulin-binding protein, stathmin, by Cdk5 and MAP kinases in the brain. J. Neurochem. 2006, 99, 237-250.
    • (2006) J. Neurochem , vol.99 , pp. 237-250
    • Hayashi, K.1    Pan, Y.2    Oshima, T.3    Kansy, J.W.4
  • 28
    • 0029583638 scopus 로고
    • A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization
    • Eto, M., Ohmori, T., Suzuki, M., Furuya, K., Morita, F., A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization. J. Biochem. 1995, 118, 1104-1107.
    • (1995) J. Biochem , vol.118 , pp. 1104-1107
    • Eto, M.1    Ohmori, T.2    Suzuki, M.3    Furuya, K.4    Morita, F.5
  • 30
    • 34548515717 scopus 로고    scopus 로고
    • Alternative roles for Cdk5 in learning and synaptic plasticity
    • Hawasaki, A. H., Bibb, J. A., Alternative roles for Cdk5 in learning and synaptic plasticity. Biotechnol. J. 2007, 2, 941-948.
    • (2007) Biotechnol. J , vol.2 , pp. 941-948
    • Hawasaki, A.H.1    Bibb, J.A.2
  • 31
    • 34548496016 scopus 로고    scopus 로고
    • The role of cyclin-dependent kinase 5 in dendrite and synapse development
    • Zelda, H. C., Ip, N. Y., The role of cyclin-dependent kinase 5 in dendrite and synapse development. Biotechnol. J. 2007, 2, 949-957.
    • (2007) Biotechnol. J , vol.2 , pp. 949-957
    • Zelda, H.C.1    Ip, N.Y.2
  • 32
    • 0024397415 scopus 로고
    • The structure and regulation of protein phosphatase
    • Cohen, P., The structure and regulation of protein phosphatase. Annu. Rev. Biochem. 1989, 58, 453-508.
    • (1989) Annu. Rev. Biochem , vol.58 , pp. 453-508
    • Cohen, P.1
  • 33
    • 0033558440 scopus 로고    scopus 로고
    • Phosphorylase phosphatase: New horizons for an old enzyme
    • Lee, E. Y. C., Zhao, L. Z. S., Wei, Q., Zhang, J. et al., Phosphorylase phosphatase: New horizons for an old enzyme. Front. Biosci. 1999, 4, 270-285.
    • (1999) Front. Biosci , vol.4 , pp. 270-285
    • Lee, E.Y.C.1    Zhao, L.Z.S.2    Wei, Q.3    Zhang, J.4
  • 34
    • 34250312098 scopus 로고    scopus 로고
    • Phosphorylation of protein phosphatase 1 by cyclin- dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation
    • Li, T., Chalifour, L. E., Paudel, H. K., Phosphorylation of protein phosphatase 1 by cyclin- dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. J. Biol. Chem. 2006, 282, 6619-6628.
    • (2006) J. Biol. Chem , vol.282 , pp. 6619-6628
    • Li, T.1    Chalifour, L.E.2    Paudel, H.K.3
  • 35
    • 3042634127 scopus 로고    scopus 로고
    • A novel Cdk5-dependent pathway for regulating GSK3 activity and kinesin driven motility in neurons
    • Morfini, G., Szebenyi, G., Brown, H., Pant, H. et al., A novel Cdk5-dependent pathway for regulating GSK3 activity and kinesin driven motility in neurons. EMBO J. 2004, 2, 2235-2245.
    • (2004) EMBO J , vol.2 , pp. 2235-2245
    • Morfini, G.1    Szebenyi, G.2    Brown, H.3    Pant, H.4
  • 36
    • 34250344611 scopus 로고    scopus 로고
    • Phosphorylation of parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation
    • Avraham, E., Rott, R., Liani, E., Szargel, R., Engelender, S., Phosphorylation of parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation. J. Biol. Chem. 2007, 282, 12842-12850.
    • (2007) J. Biol. Chem , vol.282 , pp. 12842-12850
    • Avraham, E.1    Rott, R.2    Liani, E.3    Szargel, R.4    Engelender, S.5
  • 37
    • 0034730122 scopus 로고    scopus 로고
    • Cyclin-dependent kinases as a therapeutic target for stroke
    • Osuga, H., Osuga, S., Wang, F., Fetni, R. et al., Cyclin-dependent kinases as a therapeutic target for stroke. Proc. Natl. Acad. Sci. USA 2000, 97, 10254-10259.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10254-10259
    • Osuga, H.1    Osuga, S.2    Wang, F.3    Fetni, R.4
  • 38
    • 17044391895 scopus 로고    scopus 로고
    • Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor
    • Gillardon, F., Steinlein, P., Bürger, E., Hildebrandt, T., Gerner, C., Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor. Proteomics 2005, 5, 1299-1307.
    • (2005) Proteomics , vol.5 , pp. 1299-1307
    • Gillardon, F.1    Steinlein, P.2    Bürger, E.3    Hildebrandt, T.4    Gerner, C.5
  • 39
    • 22744441684 scopus 로고    scopus 로고
    • Therapeutic potential of Cdk5 inhibitors to promote corneal epithelial wound healing
    • Zelenka, P. S., Smith, J., Therapeutic potential of Cdk5 inhibitors to promote corneal epithelial wound healing. Expert Opin. Ther. Pat. 2005, 15, 875-887.
    • (2005) Expert Opin. Ther. Pat , vol.15 , pp. 875-887
    • Zelenka, P.S.1    Smith, J.2
  • 40
    • 33645468473 scopus 로고    scopus 로고
    • Selectivity and potency of cyclin-dependent kinase inhibitors
    • Sridhar, J., Akula, N., Pattabiraman, N., Selectivity and potency of cyclin-dependent kinase inhibitors. AAPS J. 2006, 8, E204-E221.
    • (2006) AAPS J , vol.8
    • Sridhar, J.1    Akula, N.2    Pattabiraman, N.3
  • 41
    • 1642412825 scopus 로고    scopus 로고
    • Inhibitors of protein kinase signaling pathway
    • Force, T., Kuida, K., Namchuk, M., Inhibitors of protein kinase signaling pathway. Circulation 2004, 109, 1196-1205.
    • (2004) Circulation , vol.109 , pp. 1196-1205
    • Force, T.1    Kuida, K.2    Namchuk, M.3
  • 42
    • 33644792454 scopus 로고    scopus 로고
    • Fabrication of protein function microarrays for systems-orientated proteomic analysis
    • Blackburn, J. M., Hart, D. J., Fabrication of protein function microarrays for systems-orientated proteomic analysis. Methods Mol. Biol. 2005, 310, 197-216.
    • (2005) Methods Mol. Biol , vol.310 , pp. 197-216
    • Blackburn, J.M.1    Hart, D.J.2
  • 43
    • 3042857301 scopus 로고    scopus 로고
    • Functional protein microarrays for parallel characterisation of p53 mutants
    • Boutell, J. M., Hart, D. J., Godber, B. L. J., Kozlowski, R. Z., Blackburn, J. M., Functional protein microarrays for parallel characterisation of p53 mutants. Proteomics 2004, 4, 1950-1958.
    • (2004) Proteomics , vol.4 , pp. 1950-1958
    • Boutell, J.M.1    Hart, D.J.2    Godber, B.L.J.3    Kozlowski, R.Z.4    Blackburn, J.M.5


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