Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation

International Journal of Oncology

Volumn 41, Issue 3, 2012, Pages 910-918

  Shin, Dong Yeok ^a,b   Park, You Soo ^b   Yang, Kwangmo ^b   Kim, Gi Young ^c   Kim, Wun Jae ^d   Han, Min Ho ^e   Kang, Ho Sung ^a,b   Choi, Yung Hyun ^e,f  

^a Pusan National University   (South Korea)

^b Dongnam Institute of Radiological and Medical Science   (South Korea)

^c Jeju National University   (South Korea)

^d Chungbuk National University College of Medicine   (South Korea)

^e Dong Eui University   (South Korea)

^f Dong Eui University   (South Korea)

Author keywords

Apoptosis; Caspase; Decitabine; Leukemia; Reactive oxygen species

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ACETYLCYSTEINE; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; PROTEIN BCL 2; PROTEIN BID; REACTIVE OXYGEN METABOLITE; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL GROWTH; CELL STRAIN HL 60; CELL STRAIN U937; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE;

ACETYLCYSTEINE; APOPTOSIS; AZACITIDINE; CASPASES; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; ENZYME INHIBITORS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; LEUKEMIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84864970709     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1546     Document Type: Article

References (44)

1. Chang H, Lin H, Yi L, Zhu J, Zhou Y, Mi M and Zhang Q: 3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cells via reactive oxygen species-mediated p38 MAPK/JNK pathway. Eur J Pharmacol 648: 31-38, 2010.
2. Abramson N and Melton B: Leukocytosis: basics of clinical assessment. Am Fam Physician 62: 2053-2060, 2000.
3. Gilliland DG, Jordan CT and Felix CA: The molecular basis of leukemia. Hematology Am Soc Hematol Educ Program: 80-97, 2004.
4. Green DR and Reed JC: Mitochondria and apoptosis. Science 281: 1309-1312, 1998. (Pubitemid 28406816)
5. Siegelin MD, Habel A and Gaiser T: 17-AAG sensitized malignant glioma cells to death-receptor mediated apoptosis. Neurobiol Dis 33: 243-249, 2009.
6. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG and Earnshaw WC: Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371: 346-347, 1994. (Pubitemid 24300618)
7. Jin Z and El-Deiry WS: Overview of cell death signaling pathways. Cancer Biol Ther 4: 139-163, 2005. (Pubitemid 41351311)
8. Li H, Zhu H, Xu CJ and Yuan J: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491-501, 1998. (Pubitemid 28391865)
9. Luo X, Budihardjo I, Zou H, Slaughter C and Wang X: Bid, a bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94: 481-490, 1998. (Pubitemid 28391864)
10. Dlugosz PJ, Billen LP, Annis MG, Zhu W, Zhang Z, Lin J, Leber B and Andrews DW: Bcl-2 changes conformation to inhibit Bax oligomerization. EMBO J 25: 2287-2296, 2006. (Pubitemid 44012212)
11. Park C, Jin CY, Kwon HJ, Hwang HJ, Kim GY, Choi IW, Kwon TK, Kim BW, Kim WJ and Choi YH: Induction of apoptosis by esculetin in human leukemia U937 cells: roles of Bcl-2 and extracellular-regulated kinase signaling. Toxicol In Vitro 24: 486-494, 2010.
12. De Laurenzi V and Melino G: Apoptosis. The little devil of death. Nature 406: 135-136, 2000.
13. Gao Z, Tian Y, Wang J, Yin Q, Wu H, Li YM and Jiang X: A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo. J Biol Chem 282: 30718-30727, 2007. (Pubitemid 350035215)
14. Crack PJ and Taylor JM: Reactive oxygen species and the modulation of stroke. Free Radic Boil Med 38: 1433-1444, 2005. (Pubitemid 40693828)
15. Fiers W, Beyaert R, Declercq W and Vandenabeele P: More than one way to die: apoptosis, necrosis and reactive oxygen damage. Oncogene 18: 7719-7730, 1999. (Pubitemid 30052757)
16. Skulachev VP: Bioenergetic aspects of apoptosis, necrosis and mitoptosis. Apoptosis 11: 473-485, 2006.
17. Chakraborti T, Das S, Mondal M, Roychoudhury S and Chakraborti S: Oxidant, mitochondria and calcium: an overview. Cell Signal 11: 77-85, 1999. (Pubitemid 29056164)
18. Choi WY, Kim GY, Lee WH and Choi YH: Sanguinarine, a benzophenanthridine alkaloid, induces apoptosis in MDA-MB-231 human breast carcinoma cells through a reactive oxygen species-mediated mitochondrial pathway. Chemotherapy 54: 279-287, 2008.
19. Robertson KD: DNA methylation and human disease. Nat Rev Genet 6: 597-610, 2005.
20. Watanabe Y and Maekawa M: Methylation of DNA in cancer. Adv Clin Chem 52: 145-167, 2010.
21. Jones PA and Taylor SM: Cellular differentiation, cytidine analogs and DNA methylation. Cell 20: 85-93, 1980. (Pubitemid 10117303)
22. Bender CM, Pao MM and Jones PA: Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res 58: 95-101, 1998. (Pubitemid 28027723)
23. Karpf AR and Jones DA: Reactivating the expression of methylation silenced genes in human cancer. Oncogene 21: 5496-5503, 2002. (Pubitemid 34983484)
24. Kihslinger JE and Godley LA: The use of hypomethylating agents in the treatment of hematologic malignancies. Leuk Lymphoma 48: 1676-1695, 2007. (Pubitemid 47386703)
25. Santos FP, Kantarjian H, Garcia-Manero G, Issa JP and Ravandi F: Decitabine in the treatment of myelodysplastic syndromes. Expert Rev Anticancer Ther 10: 9-22, 2010.
26. Robak T: New nucleoside analogs for patients with hematological malignancies. Expert Opin Investig Drugs 20: 343-359, 2011.
27. Issa JP and Kantarjian HM: Targeting DNA methylation. Clin Cancer Res 15: 3938-3946, 2009.
28. Boumber Y and Issa JP: Epigenetics in cancer: what's the future? Oncology 25: 220-206, 2011.
29. Hurtubise A and Momparler RL: Effect of histone deacetylase inhibitor LAQ824 on antineoplastic action of 5-Aza-2'-deoxycytidine (decitabine) on human breast carcinoma cells. Cancer Chemother Pharmacol 58: 618-625, 2006. (Pubitemid 44167387)
30. Valdez BC, Li Y, Murray D, Corn P, Champlin RE and Andersson BS: 5-Aza-2'-deoxycytidine sensitizes busulfan-resistant myeloid leukemia cells by regulating expression of genes involved in cell cycle checkpoint and apoptosis. Leuk Res 34: 364-372, 2010.
31. Ng KP, Ebrahem Q, Negrotto S, Mahfouz RZ, Link KA, Hu Z, Gu X, Advani A, Kalaycio M, Sobecks R, et al: p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia. Leukemia 25: 1739-1750, 2011.
32. Festuccia C, Gravina GL, D'Alessandro AM, Millimaggi D, Di Rocco C, Dolo V, Ricevuto E, Vicentini C and Bologna M: Downmodulation of dimethyl transferase activity enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in prostate cancer cells. Int J Oncol 33: 381-388, 2008.
33. Deng T and Zhang Y: 5-Aza-2'-deoxycytidine reactivates expression of RUNX3 by deletion of DNA methyltransferases leading to caspase independent apoptosis in colorectal cancer Lovo cells. Biomed Pharmacother 63: 492-500, 2009.
34. Capper D, Gaiser T, Hartmann C, Habel A, Mueller W, Herold-Mende C, von Deimling A and Siegelin MD: Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation. Acta Neuropathol 117: 445-456, 2009.
35. Ruiz-Magaña MJ, Rodríguez-Vargas JM, Morales JC, Saldivia MA, Schulze-Osthoff K and Ruiz-Ruiz C: The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells. Int J Cancer 130: 1195-1207, 2012
36. Kim SY, Kang HT, Choi HR and Park SC: Biliverdin reductase A in the prevention of cellular senescence against oxidative stress. Exp Mol Med 43: 15-23, 2011.
37. Choi JH, Choi AY, Yoon H, Choe W, Yoon KS, Ha J, Yeo EJ and Kang I: Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction. Exp Mol Med 42: 811-822, 2010.
38. Jeong JH, Ryu DS, Suk DH and Lee DS: Anti-inflammatory effects of ethanol extract from Orostachys japonicus on modulation of signal pathways in LPS-stimulated RAW 264.7 cells. BMB Rep 44: 399-404, 2011.
39. Hengartner MO: The biochemistry of apoptosis. Nature 407: 770-776, 2000.
40. Lin CT, Lin WH, Lee KD and Tzeng PY: DNA mismatch repair as an effector for promoting phorbol ester-induced apoptotic DNA damage and cell killing: implications in tumor promotion. Int J Cancer 119: 1776-1784, 2006.
41. Brodská B and Holoubek A: Generation of reactive oxygen species during apoptosis induced by DNA-damaging agents and/ or histone deacetylase inhibitors. Oxid Med Cell Longev 2011: 253529, 2011.
42. Hell K, Saleh M, Crescenzo GD, O'Connor-McCourt MD and Nicholson DW: Substrate cleavage by caspases generates protein fragments with Smac/Diablo-like activities. Cell Death Differ 10: 1234-1239, 2003. (Pubitemid 37407125)
43. Choi YE, Butterworth M, Malladi S, Duckett CS, Cohen GM and Bratton SB: The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. J Biol Chem 284: 12772-12782, 2009.
44. Fleury C, Mignotte B and Vayssière JL: Mitochondrial reactive oxygen species in cell death signaling. Biochimie 84: 131-141, 2002. (Pubitemid 34946949)