3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK/JNK pathway

European Journal of Pharmacology

Volumn 648, Issue 1-3, 2010, Pages 31-38

  Chang, Hui ^a   Lin, Hui ^a   Yi, Long ^a   Zhu, Jundong ^a   Zhou, Yong ^a   Mi, Mantian ^a   Zhang, Qianyong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

3,6 Dihydroxyflavone; Glutathione redox balance; Leukemia HL 60 cell; Mitogen activated protein kinase; Reactive oxygen species

Indexed keywords

3,6 DIHYDROXYFLAVONE; ACETYLCYSTEINE; CASPASE; CYTOCHROME C; FLAVONE DERIVATIVE; GLUTATHIONE; GLUTATHIONE DISULFIDE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL MEMBRANE FLUIDITY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL LINE; LIPID PEROXIDATION; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

APOPTOSIS; CASPASES; FLAVONOIDS; GLUTATHIONE; HL-60 CELLS; HUMANS; INTRACELLULAR SPACE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKEMIA; LIPID PEROXIDATION; MAP KINASE SIGNALING SYSTEM; MEMBRANE FLUIDITY; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES;

EID: 77957750458     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.08.020     Document Type: Article

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