Sigma receptor research: Progress towards diagnostic and therapeutic uses of sigma ligands

Current Pharmaceutical Design

Volumn 18, Issue 7, 2012, Pages 861-862

  Abate, Carmen ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; N ALLYLNORMETAZOCINE; N,N DIMETHYLTRYPTAMINE; NALOXONE; NALTREXONE; PHENCYCLIDINE; PROGESTERONE RECEPTOR; SIGMA OPIATE RECEPTOR;

AFFINITY CHROMATOGRAPHY; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANXIETY DISORDER; BINDING AFFINITY; BRAIN FUNCTION; CELL COMPARTMENTALIZATION; CELL PROLIFERATION; DEPRESSION; DRUG DEPENDENCE; DRUG RECEPTOR BINDING; EDITORIAL; ENDOPLASMIC RETICULUM; GENE MUTATION; HUMAN; NEOPLASM; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SCHIZOPHRENIA; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; CENTRAL NERVOUS SYSTEM AGENTS; HUMANS; LIGANDS; NEOPLASMS; RECEPTORS, SIGMA;

EID: 84857133965     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212799436502     Document Type: Editorial

References (17)

1. Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE. The effects of morphine-and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 1976; 197: 517-32.
2. Su TP. Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain. J Pharmacol Exp Ther 1982; 223: 284-90.
3. Quirion R, Bowen WD, Itzhak Y, et al. A proposal for the classification of sigma binding sites. Trends Pharmacol Sci 1992; 13: 85-6.
4. Hanner M, Moebius FF, Flandorfer A, et al. Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci U S A 1996; 93: 8072-7.
5. Glennon RA, Ablordeppey SY, Ismaiel AM, el-Ashmawy MB, Fischer JB, Howie KB. Structural features important for s1 receptor binding. J Med Chem 1994; 37: 1214-9.
6. Ramachandran S, Chu UB, Mavlyutov TA, Pal A, Pyne S, Ruoho AE. The sigma-1 receptor interacts with N-alkyl amines and endogenous sphingolipids. Eur J Pharmacol 2009; 609: 19-26.
7. Fontanilla D, Johannessen M, Hajipour AR, Cozzi NV, Jackson MB, Ruoho AE. The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science 2009; 323: 934-7.
8. Keiser MJ, Setola V, Irwin JJ, et al. Predicting new molecular targets for known drugs. Nature 2009; 462:175-81.
9. Hayashi T, Su TP. Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca2+ signaling and cell survival. Cell 2007; 131: 596-610.
10. Al-Saif A, Al-Mohanna F, Bohlega S. A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis. Ann Neurol 2011; 70: 913-9.
11. Schetz JA, Perez E, Liu R, Chen S, Lee I, Simpkins JW. A prototypical Sigma-1 receptor antagonist protects against brain ischemia. Brain Res 2007; 1181:1-9.
12. Tsai SY, Hayashi T, Harvey BK, et al. Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanisminvolving Rac1·GTP pathway. Proc Natl Acad Sci U S A 2009; 106: 22468-73.
13. Sabino V, Cottone P, Parylak SL, Steardo L, Zorrilla EP. Sigma-1 receptor knockout mice display a depressive-like phenotype. Behav Brain Res 2009; 198: 472-6.
14. van Waarde A, Rybczynska AA, Ramakrishnan N, Ishiwata K, Elsinga PH, Dierckx RA. Sigma receptors in oncology: therapeutic and diagnostic applications of sigma ligands. Curr Pharm Des 2010; 16: 3519-37.
15. Mach RH, Wheeler KT. Development of molecular probes for imaging sigma-2 receptors in vitro and in vivo. Cent Nerv Syst Agents Med Chem 2009; 9: 230-45.
16. Colabufo NA, Berardi F, Abate C, Contino M, Niso M, Perrone R. Is the σ2 receptor a histone binding protein? J Med Chem 2006, 49: 4153-8.
17. Xu J, Zeng C, Chu W, et al. Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun. 2011; 2:380.