Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats

Current Neurovascular Research

Volumn 3, Issue 2, 2006, Pages 89-98

  Ajmo Jr , Craig T ^a   Vernon, Dionne O L ^a   Collier, Lisa ^a   Pennypacker, Keith R ^a   Cuevas, Javier ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Anti inflammation; Fluoro jade; Infarction; Ischemia; Middle cerebral artery occlusion; Neuroprotection; Sigma receptors; Stroke

Indexed keywords

1,3 DI 2 TOLYGUANIDINE; GLIAL FIBRILLARY ACIDIC PROTEIN; GUANIDINE DERIVATIVE; MONOCLONAL ANTIBODY; NEURONAL NUCLEUS MONOCLONAL ANTIBODY; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN INFARCTION SIZE; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LECTIN BINDING; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRIATE CORTEX;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTICONVULSANTS; BIOLOGICAL MARKERS; BRAIN; BRAIN ISCHEMIA; CELL SURVIVAL; DISEASE MODELS, ANIMAL; ENCEPHALITIS; GLIOSIS; GUANIDINES; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROGLIA; NEUROPROTECTIVE AGENTS; NUCLEAR PROTEINS; ORGANIC CHEMICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SIGMA; TIME FACTORS; TREATMENT OUTCOME;

EID: 33646876375     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720206776875849     Document Type: Article

References (57)

1. National Institute of Neurological Disorders and Stroke (NINDS): (1995) Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 333 (24): 1581-7.
2. Albers, GW, Amarenco, P, Easton, JD, Sacco, RL. and Teal, P. (2004) Antithrombotic and thrombolytic therapy for ischemic stroke: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126 (3 Suppl): 483S-512S.
3. Aydar, E, Palmer, CP, Klyachko, VA. and Jackson, MB. (2002) The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron 34 (3): 399-410.
4. Bal-Price, A. and Brown, GC. (2001) Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J Neurosci 21 (17): 6480-91.
5. Bonde, C, Noraberg, J, Noer, H. and Zimmer, J. (2005) Ionotropic glutamate receptors and glutamate transporters are involved in necrotic neuronal cell death induced by oxygen-glucose deprivation of hippocampal slice cultures. Neuroscience 136 (3): 779-94.
6. Bourrie, B, Benoit, JM, Derocq, JM, Esclangon, M, Thomas, C, Le Fur, G. and Casellas, P. (1996) A sigma ligand, SR 31747A, potently modulates Staphylococcal enterotoxin B-induced cytokine production in mice. Immunology 88 (3): 389-93.
7. Bourrie, B, Bouaboula, M, Benoit, JM, Derocq, JM, Esclangon, M, Le Fur, G. and Casellas, P. (1995) Enhancement of endotoxin-induced interleukin-10 production by SR 31747A, a sigma ligand. Eur J Immunol 25 (10): 2882-7.
8. Bourrie, B, Bribes, E, De Nys, N, Esclangon, M, Garcia, L, Galiegue, S, Lair, P, Paul, R, Thomas, C, Vernieres, JC. and Casellas, P. (2002) SSR125329A, a high affinity sigma receptor ligand with potent anti-inflammatory properties. Eur J Pharmacol 456 (1-3): 123-31.
9. Bowen, WD, Hellewell, SB. and McGarry, KA. (1989) Evidence for a multi-site model of the rat brain sigma receptor. Eur J Pharmacol 163 (2-3): 309-18.
10. Butler, TL, Kassed, CA, Sanberg, PR, Willing, AE. and Pennypacker, KR. (2002) Neurodegeneration in the rat hippocampus and striatum after middle cerebral artery occlusion. Brain Res 929 (2): 252-60.
11. Crawford, KW. and Bowen, WD. (2002) Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines. Cancer Res 62 (1): 313-22.
12. DeCoster, MA, Klette, KL, Knight, ES. and Tortella, FC. (1995) Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures. Brain Res 671 (1): 45-53.
13. Derocq, JM, Bourrie, B, Segui, M, Le Fur, G. and Casellas, P. (1995) In vivo inhibition of endotoxin-induced pro-inflammatory cytokines production by the sigma ligand SR 31747. J Pharmacol Exp Ther 272 (1): 224-30.
14. Duckworth, EA, Butler, TL, De Mesquita, D, Collier, SN, Collier, L. and Pennypacker, KR. (2005) Temporary focal ischemia in the mouse: technical aspects and patterns of Fluoro-Jade evident neurodegeneration. Brain Res 1042 (1): 29-36.
15. Gido, G, Kristian, T. and Siesjo, BK. (1997) Extracellular potassium in a neocortical core area after transient focal ischemia. Stroke 28 (1): 206-10.
16. Ginsberg, MD. (2003) Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture. Stroke 34 (1): 214-23.
17. Goldstein, IJ. and Winter, HG. (1999) The Griffonia simplicifolia I-B4 isolectin. A probe for alpha-D-galactosyl end groups. Subcell Biochem 32: 127-41.
18. Goyagi, T, Goto, S, Bhardwaj, A, Dawson, VL, Hurn, PD. and Kirsch, JR. (2001) Neuroprotective effect of sigma (1)-receptor ligand 4-phenyl-1-(4- phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production. Stroke 32 (7): 1613-20.
19. Hacke, W, Brott, T, Caplan, L, Meier, D, Fieschi, C, von Kummer, R, Donnan, G, Heiss, WD, Wahlgren, NG, Spranger, M, Boysen, G. and Marler, JR. (1999) Thrombolysis in acute ischemic stroke: controlled trials and clinical experience. Neurology 53 (7 Suppl 4): S3-14.
20. Hall, A, Y, C, C, K, J, C. and KR, P. (2005) The Sigma Receptor Agonist 1,3-Di-O-Tolylguanidine suppresses the Activation of Primary Microglia and the Subsequent Release of TNF-alpha and Nitric Oxide. SEPS.
21. Hanner, M, Moebius, FF, Flandorfer, A, Knaus, HG, Striessnig, J, Kempner, E. and Glossmann, H. (1996) Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci USA 93 (15): 8072-7.
22. Harukuni, I, Bhardwaj, A, Shaivitz, AB, DeVries, AC, London, ED, Hurn, PD, Traystman, RJ, Kirsch, JR. and Faraci, FM. (2000) Sigma (1)-receptor ligand 4-phenyl-1- (4-phenylbutyl)-piperidine affords neuroprotection from focal ischemia with prolonged reperfusion. Stroke 31 (4): 976-82.
23. Hayashi, T. and Su, TP. (2005) The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: implication for drug abuse. Life Sci 77 (14): 1612-24.
24. Heales, SJ, Bolanos, JP, Stewart, VC, Brookes, PS, Land, JM. and Clark, JB. (1999) Nitric oxide, mitochondria and neurological disease. Biochim Biophys Acta 1410 (2): 215-28.
25. Hertz, L, Hansson, E. and Ronnback, L. (2001) Signaling and gene expression in the neuron-glia unit during brain function and dysfunction: Holger Hyden in memoriam. Neurochem Int 39 (3): 227-52.
26. Hill, M, Parizek, A, Bicikova, M, Havlikova, H, Klak, J, Fait, T, Cibula, D, Hampl, R, Cegan, A, Sulcova, J. and Starka, L. (2000) Neuroactive steroids, their precursors, and polar conjugates during parturition and postpartum in maternal and umbilical blood: 1. Identification and simultaneous determination of pregnanolone isomers. J Steroid Biochem Mol Biol 75 (4-5): 237-44.
27. Kest, B, Mogil, JS, Sternberg, WF, Pechnick, RN. and Liebeskind, JC. (1995) Antinociception following 1,3,-di-o-tolylguanidine, a selective sigma receptor ligand. Pharmacol Biochem Behav 50 (4): 587-92.
28. Klingelhofer, J. and Sander, D. (1997) Cardiovascular consequences of clinical stroke. Baillieres Clin Neurol 6 (2): 309-35.
29. Kristian, T. and Siesjo, BK. (1997) Changes in ionic fluxes during cerebral ischaemia. Int Rev Neurobiol 40: 27-45.
30. Kume, T, Nishikawa, H, Taguchi, R, Hashino, A, Katsuki, H, Kaneko, S, Minami, M, Satoh, M. and Akaike, A. (2002) Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro. Eur J Pharmacol 455 (2-3): 91-100.
31. Kumura, E, Yoshimine, T, Iwatsuki, KI, Yamanaka, K, Tanaka, S, Hayakawa, T, Shiga, T. and Kosaka, H. (1996) Generation of nitric oxide and superoxide during reperfusion after focal cerebral ischemia in rats. Am J Physiol 270 (3 Pt 1): C748-52.
32. Langa, F, Codony, X, Tovar, V, Lavado, A, Gimenez, E, Cozar, P, Cantero, M, Dordal, A, Hernandez, E, Perez, R, Monroy, X, Zamanillo, D, Guitart, X. and Montoliu, L. (2003) Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice. Eur J Neurosci 18 (8): 2188-96.
33. Lesage, AS, De Loore, KL, Peeters, L. and Leysen, JE. (1995) Neuroprotective sigma ligands interfere with the glutamate-activated NOS pathway in hippocampal cell culture. Synapse 20 (2): 156-64.
34. Lockhart, BP, Soulard, P, Benicourt, C, Privat, A. and Junien, JL. (1995) Distinct neuroprotective profiles for sigma ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studies. Brain Res 675 (1-2): 110-20.
35. Longa, EZ, Weinstein, PR, Carlson, S. and Cummins, R. (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 (1): 84-91.
36. Mattson, MP, Culmsee, C. and Yu, ZF. (2000) Apoptotic and antiapoptotic mechanisms in stroke. Cell Tissue Res 301 (1): 173-87.
37. Maurice, T. (2004) Neurosteroids and sigma1 receptors, biochemical and behavioral relevance. Pharmacopsychiatry 37 Suppl 3: S171-82.
38. Newcomb, J, Ajmo, C, Sanberg, C, Sanberg, P, Pennypacker, K. and Willing, A. (2005) Cord blood treatment leads to full recovery in rats with experimental stroke. Cell Transplantation (in press).
39. Novakova, M, Ela, C, Bowen, WD, Hasin, Y. and Eilam, Y. (1998) Highly selective sigma receptor ligands elevate inositol 1,4,5-trisphosphate production in rat cardiac myocytes. Eur J Pharmacol 353 (2-3): 315-27.
40. Nuwayhid, SJ. and Werling, LL. (2003) Sigma1 receptor agonist-mediated regulation of N-methyl-D-aspartate-stimulated [3H]dopamine release is dependent upon protein kinase C. J Pharmacol Exp Ther 304 (1): 364-9.
41. O'Callaghan, JP. (1994) Biochemical analysis of glial fibrillary acidic protein as a quantitative approach to neurotoxicity assessment: advantages, disadvantages and application to the assessment of NMDA receptor antagonist-induced neurotoxicity. Psychopharmacol Bull 30 (4): 549-54.
42. O'Neill, M, Caldwell, M, Earley, B, Canney, M, O'Halloran, A, Kelly, J, Leonard, BE. and Junien, JL. (1995) The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia. Eur J Pharmacol 283 (1-3): 217-25.
43. Peters, O, Back, T, Lindauer, U, Busch, C, Megow, D, Dreier, J. and Dirnagl, U. (1998) Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 18 (2): 196-205.
44. Quirion, R, Bowen, WD, Itzhak, Y, Junien, JL, Musacchio, JM, Rothman, RB, Su, TP, Tam, SW. and Taylor, DP. (1992) A proposal for the classification of sigma binding sites. Trends Pharmacol Sci 13 (3): 85-6.
45. Rawls, SM, Baron, DA, Geller, EB. and Adler, MW. (2002) Sigma sites mediate DTG-evoked hypothermia in rats. Pharmacol Biochem Behav 73 (4): 779-86.
46. Schmued, LC, Albertson, C. and Slikker, W, Jr. (1997) Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res 751 (1): 37-46.
47. Schroeter, M, Jander, S, Huitinga, I, Witte, OW. and Stoll, G. (1997) Phagocytic response in photochemically induced infarction of rat cerebral cortex. The role of resident microglia. Stroke 28 (2): 382-6.
48. Spruce, BA, Campbell, LA, McTavish, N, Cooper, MA, Appleyard, MV, O'Neill, M, Howie, J, Samson, J, Watt, S, Murray, K, McLean, D, Leslie, NR, Safrany, ST, Ferguson, MJ, Peters, JA, Prescott, AR, Box, G, Hayes, A, Nutley, B, Raynaud, F, Downes, CP, Lambert, JJ, Thompson, AM. and Eccles, S. (2004) Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res 64 (14): 4875-86.
49. Stoll, G, Jander, S. and Schroeter, M. (1998) Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56 (2): 149-71.
50. Swanson, RA, Ying, W. and Kauppinen, TM. (2004) Astrocyte influences on ischemic neuronal death. Curr Mol Med 4 (2): 193-205.
51. Takahashi, H, Kirsch, JR, Hashimoto, K, London, ED, Koehler, RC. and Traystman, RJ. (1996) PPBP [4-phenyl-1- (4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke 27 (11): 2120-3.
52. Tanaka, K, Ito, D, Suzuki, S, Dembo, T, Kosakai, A. and Fukuuchi, Y. (2002) A novel voltage-sensitive Na (+) and Ca (2+) channel blocker, NS-7, prevents suppression of cyclic AMP-dependent protein kinase and reduces infarct area in the acute phase of cerebral ischemia in rat. Brain Res 924 (1): 98-108.
53. Trendelenburg, G. and Dirnagl, U. (2005) Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning. Glia 50 (4): 307-20.
54. Vendrame M, Gemma C, de Mesquita D, Collier L, Bickford PC, Sanberg CD, Sanberg PR, Pennypacker KR, and Willing, AE. (2005) Anti-inflammatory effects of human cord blood cells in a rat model of stroke. Stem Cells and Development (in press).
55. Vendrame, M, Cassady, J, Newcomb, J, Butler, T, Pennypacker, KR, Zigova, T, Sanberg, CD, Sanberg, PR. and Willing, AE. (2004) Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke 35 (10): 2390-5.
56. Zhang, H. and Cuevas, J. (2002) Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons. J Neurophysiol 87 (6): 2867-79.
57. Zhang, H. and Cuevas, J. (2005) Sigma Receptor activation blocks potassium channels and depresses neuroexcitability in rat intracardiac neurons. J Pharmacol Exp Ther 313 (3): 1387-96.