Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons

Experimental Neurology

Volumn 221, Issue 1, 2010, Pages 166-174

  Yang, Zeng Jin ^a   Carter, Erin L ^a   Torbey, Michel T ^a   Martin, Lee J ^a   Koehler, Raymond C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac arrest; Global cerebral ischemia; Hypoxia ischemia; Neonate; NMDA receptor; PSD 95

Indexed keywords

4 PHENYL 1 (4 PHENYLBUTYL) PIPERIDINE; LIGAND; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NUCLEIC ACID; PIPERIDINE DERIVATIVE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN; RECEPTOR SUBUNIT; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPHYXIA; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN NERVE CELL; CONTINUOUS INFUSION; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVITY; HEART ARREST; HYPOTHESIS; IMMUNOBLOTTING; MALE; NERVE CELL DEGENERATION; NEUROPROTECTION; NITRATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PIGLET; PRIORITY JOURNAL; PUTAMEN; RESUSCITATION; STROKE;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BRAIN ISCHEMIA; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOPERIDOL; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; NERVE DEGENERATION; NEURONS; NITRIC OXIDE SYNTHASE TYPE I; OXIDATIVE STRESS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SIGMA; SWINE;

EID: 72749115893     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2009.10.019     Document Type: Article

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