Neuroprotection of neurotrophin-3 against focal cerebral ischemia/reperfusion injury is regulated by hypoxia-responsive element in rats

Neuroscience

Volumn 222, Issue , 2012, Pages 1-9

  Zhang, J ^a   Shi, Q ^a,b   Yang, P ^a   Xu, X ^a,c   Chen, X ^a   Qi, C ^a   Lu, H ^a   Zhao, B ^d   Zheng, P ^d   Zhang, P ^a,e   Liu, Y ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^c XI'AN MEDICAL UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

^e THE SECOND AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Gene therapy; Hypoxia inducible gene expression; Ischemic stroke; Neuroprotection

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; FIVE COPIES OF HYPOXIA RESPONSIVE ELEMENT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NEUROTROPHIN 3; RETROVIRUS VECTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; GENE REGULATORY NETWORK; GENETIC TRANSDUCTION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REPERFUSION; RNA VECTOR; UPREGULATION; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; DNA; GENETIC VECTORS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFARCTION, MIDDLE CEREBRAL ARTERY; NEUROLOGIC EXAMINATION; NEUROPROTECTIVE AGENTS; NEUROTROPHIN 3; POLYMERASE CHAIN REACTION; RATS; REPERFUSION INJURY; RESPONSE ELEMENTS; RETROVIRIDAE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84864933037     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.07.023     Document Type: Article

References (43)

1. Ashwal S., Tone B., Tian H.R., Cole D.J., Pearce W.J. Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion. Stroke 1998, 29:1037-1046. discussion 1047.
2. Barnabe-Heider F., Miller F.D. Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways. J Neurosci 2003, 23:5149-5160.
3. Beenken A., Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov 2009, 8:235-253.
4. Cheng M.Y., Lee I.P., Jin M., Sun G., Zhao H., Steinberg G.K., Sapolsky R.M. An insult-inducible vector system activated by hypoxia and oxidative stress for neuronal gene therapy. Transl Stroke Res 2011, 2:92-100.
5. Cristofaro B., Stone O.A., Caporali A., Dawbarn D., Ieronimakis N., Reyes M., Madeddu P., Bates D.O., Emanueli C. Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia. Arterioscler Thromb Vasc Biol 2010, 30:1143-1150.
6. Hu H.W., Li X.K., Zheng R.Y., Xiao J., Zeng J.Q., Hou S.T. BFGF expression mediated by a hypoxia-regulated adenoviral vector protects PC12 cell death induced by serum deprivation. Biochem Biophys Res Commun 2009, 390:115-120.
7. Huang D., Desbois A., Hou S.T. A novel adenoviral vector which mediates hypoxia-inducible gene expression selectively in neurons. Gene Ther 2005, 12:1369-1376.
8. Huang E.J., Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001, 24:677-736.
9. Ito M., Sonokawa T., Mishina H., Sato K. Penetrating injury of the brain by the burr of a high-speed air drill during craniotomy: case report. J Clin Neurosci 2001, 8:261-263.
10. 2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 1998, 12:149-162.
11. Johnson P.J., Tatara A., Shiu A., Sakiyama-Elbert S.E. Controlled release of neurotrophin-3 and platelet-derived growth factor from fibrin scaffolds containing neural progenitor cells enhances survival and differentiation into neurons in a subacute model of SCI. Cell Transpl 2010, 19:89-101.
12. Kaplan D.R., Miller F.D. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 2000, 10:381-391.
13. Ke Q., Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol 2006, 70:1469-1480.
14. Kilic E., Hermann D.M., Kugler S., Kilic U., Holzmuller H., Schmeer C., Bahr M. Adenovirus-mediated Bcl-X(L) expression using a neuron-specific synapsin-1 promoter protects against disseminated neuronal injury and brain infarction following focal cerebral ischemia in mice. Neurobiol Dis 2002, 11:275-284.
15. Kim D., Chung J. Akt: versatile mediator of cell survival and beyond. J Biochem Mol Biol 2002, 35:106-115.
16. Kim H.A., Mahato R.I., Lee M. Hypoxia-specific gene expression for ischemic disease gene therapy. Adv Drug Deliv Rev 2009, 61:614-622.
17. Lee R.J., Springer M.L., Blanco-Bose W.E., Shaw R., Ursell P.C., Blau H.M. VEGF gene delivery to myocardium: deleterious effects of unregulated expression. Circulation 2000, 102:898-901.
18. Li X., Yang Z., Zhang A. The effect of neurotrophin-3/chitosan carriers on the proliferation and differentiation of neural stem cells. Biomaterials 2009, 30:4978-4985.
19. Liot G., Gabriel C., Cacquevel M., Ali C., MacKenzie E.T., Buisson A., Vivien D. Neurotrophin-3-induced PI-3 kinase/Akt signaling rescues cortical neurons from apoptosis. Exp Neurol 2004, 187:38-46.
20. Lloyd-Jones D., Adams R.J., Brown T.M., Carnethon M., Dai S., De Simone G., Ferguson T.B., Ford E., Furie K., Gillespie C., Go A., Greenlund K., Haase N., Hailpern S., Ho P.M., Howard V., Kissela B., Kittner S., Lackland D., Lisabeth L., Marelli A., McDermott M.M., Meigs J., Mozaffarian D., Mussolino M., Nichol G., Roger V.L., Rosamond W., Sacco R., Sorlie P., Thom T., Wasserthiel-Smoller S., Wong N.D., Wylie-Rosett J. Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 2010, 121. e46-e215.
21. Lu H., Li M., Song T., Qian Y., Xiao X., Chen X., Zhang P., Feng X., Parker T., Liu Y. Retrovirus delivered neurotrophin-3 promotes survival, proliferation and neuronal differentiation of human fetal neural stem cells in vitro. Brain Res Bull 2008, 77:158-164.
22. Lu H.X., Hao Z.M., Jiao Q., Xie W.L., Zhang J.F., Lu Y.F., Cai M., Wang Y.Y., Yang Z.Q., Parker T., Liu Y. Neurotrophin-3 gene transduction of mouse neural stem cells promotes proliferation and neuronal differentiation in organotypic hippocampal slice cultures. Med Sci Monit 2011, 17:305-311.
23. Mori N., Stein R., Sigmund O., Anderson D.J. A cell type-preferred silencer element that controls the neural-specific expression of the SCG10 gene. Neuron 1990, 4:583-594.
24. Ohtsuka M., Fukumitsu H., Furukawa S. Neurotrophin-3 stimulates neurogenetic proliferation via the extracellular signal-regulated kinase pathway. J Neurosci Res 2009, 87:301-306.
25. Patapoutian A., Reichardt L.F. Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 2001, 11:272-280.
26. Poo M.M. Neurotrophins as synaptic modulators. Nat Rev Neurosci 2001, 2:24-32.
27. Reglodi D., Tamas A., Lengvari I. Examination of sensorimotor performance following middle cerebral artery occlusion in rats. Brain Res Bull 2003, 59:459-466.
28. Ruan H., Su H., Hu L., Lamborn K.R., Kan Y.W., Deen D.F. A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapy. Neoplasia 2001, 3:255-263.
29. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000, 103:211-225.
30. Semenza G.L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003, 3:721-732.
31. Shen F., Fan Y., Su H., Zhu Y., Chen Y., Liu W., Young W.L., Yang G.Y. Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice. Gene Ther 2008, 15:30-39.
32. Shen F., Su H., Fan Y., Chen Y., Zhu Y., Liu W., Young W.L., Yang G.Y. Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice. Stroke 2006, 37:2601-2606.
33. Shi Q., Zhang P., Zhang J., Chen X., Lu H., Tian Y., Parker T.L., Liu Y. Adenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in mice. Neurosci Lett 2009, 465:220-225.
34. Shibata T., Giaccia A.J., Brown J.M. Development of a hypoxia-responsive vector for tumor-specific gene therapy. Gene Ther 2000, 7:493-498.
35. Shibata T., Giaccia A.J., Brown J.M. Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Neoplasia 2002, 4:40-48.
36. Shimazu K., Zhao M., Sakata K., Akbarian S., Bates B., Jaenisch R., Lu B. NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis. Learn Mem 2006, 13:307-315.
37. Springer M.L., Chen A.S., Kraft P.E., Bednarski M., Blau H.M. VEGF gene delivery to muscle: potential role for vasculogenesis in adults. Mol Cell 1998, 2:549-558.
38. Su H., Arakawa-Hoyt J., Kan Y.W. Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model. Proc Natl Acad Sci USA 2002, 99:9480-9485.
39. Su H., Joho S., Huang Y., Barcena A., Arakawa-Hoyt J., Grossman W., Kan Y.W. Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts. Proc Natl Acad Sci USA 2004, 101:16280-16285.
40. Su H., Kan Y.W. Adeno-associated viral vector-delivered hypoxia-inducible gene expression in ischemic hearts. Methods Mol Biol 2007, 366:331-342.
41. Takada J., Ooboshi H., Yao H., Kitazono T., Ibayashi S., Iida M. Adenovirus-mediated gene transfer to ischemic brain is augmented in aged rats. Exp Gerontol 2003, 38:423-429.
42. Wang Y.Q., Guo X., Qiu M.H., Feng X.Y., Sun F.Y. VEGF overexpression enhances striatal neurogenesis in brain of adult rat after a transient middle cerebral artery occlusion. J Neurosci Res 2007, 85:73-82.
43. Zhang Z.H., Wang R.Z., Li G.L., Wei J.J., Li Z.J., Feng M., Kang J., Du W.C., Ma W.B., Li Y.N., Yang Y., Kong Y.G. Transplantation of neural stem cells modified by human neurotrophin-3 promotes functional recovery after transient focal cerebral ischemia in rats. Neurosci Lett 2008, 444:227-230.