메뉴 건너뛰기




Volumn 11, Issue 8, 2012, Pages 1713-1723

REST is a novel prognostic factor and therapeutic target for medulloblastoma

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; ENTINOSTAT; HISTONE DEACETYLASE; PROTEASOME; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR REST; TRICHOSTATIN A; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT;

EID: 84864880240     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-11-0990     Document Type: Article
Times cited : (48)

References (50)
  • 1
    • 70449089596 scopus 로고    scopus 로고
    • Introduction to a special issue on pediatric neurooncology
    • Fangusaro J, Chi S. Introduction to a special issue on pediatric neurooncology. J Child Neurol 2009;24:1341-2.
    • (2009) J Child Neurol , vol.24 , pp. 1341-1342
    • Fangusaro, J.1    Chi, S.2
  • 4
    • 36149000214 scopus 로고    scopus 로고
    • Medulloblastoma in childhood: new biological advances
    • DOI 10.1016/S1474-4422(07)70289-2, PII S1474442207702892
    • Crawford JR, MacDonald TJ, Packer RJ. Medulloblastoma in childhood: new biological advances. Lancet Neurol 2007;6:1073-85. (Pubitemid 350116703)
    • (2007) Lancet Neurology , vol.6 , Issue.12 , pp. 1073-1085
    • Crawford, J.R.1    MacDonald, T.J.2    Packer, R.J.3
  • 6
    • 84855464229 scopus 로고    scopus 로고
    • HDACi: Molecular mechanisms and therapeutic implications in the innate immune system
    • Suliman BA, Xu D, Williams BR. HDACi: molecular mechanisms and therapeutic implications in the innate immune system. Immunol Cell Biol 2012;90:23-32.
    • (2012) Immunol Cell Biol , vol.90 , pp. 23-32
    • Suliman, B.A.1    Xu, D.2    Williams, B.R.3
  • 7
    • 26944447574 scopus 로고    scopus 로고
    • Treatment strategies for high-risk medulloblastoma and supratentorial primitive neuroectodermal tumors: Review of the literature
    • Jakacki RI. Treatment strategies for high-risk medulloblastoma and supratentorial primitive neuroectodermal tumors. Review of the literature. J Neurosurg 2005;102:44-52. (Pubitemid 44955009)
    • (2005) Journal of Neurosurgery , vol.102 PEDIATRICS , Issue.SUPPL. 1 , pp. 44-52
    • Jakacki, R.I.1
  • 10
    • 77649093393 scopus 로고    scopus 로고
    • Role of high-dose chemotherapy for recurrent medulloblastoma and other CNS primitive neuroectodermal tumors
    • Gajjar A, Pizer B. Role of high-dose chemotherapy for recurrent medulloblastoma and other CNS primitive neuroectodermal tumors. Pediatr Blood Cancer 2010;54:649-51.
    • (2010) Pediatr Blood Cancer , vol.54 , pp. 649-651
    • Gajjar, A.1    Pizer, B.2
  • 11
    • 80053947386 scopus 로고    scopus 로고
    • Finding the perfect partner for medulloblastoma prognostication
    • Gilbertson RJ. Finding the perfect partner for medulloblastoma prognostication. J Clin Oncol 2011;29:3841 -2.
    • (2011) J Clin Oncol , vol.29 , pp. 3841-3842
    • Gilbertson, R.J.1
  • 12
    • 52449119078 scopus 로고    scopus 로고
    • Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
    • Kool M, Koster J, Bunt J, Hasselt NE, Lakeman A, van Sluis P, et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One 2008;3:e3088.
    • (2008) PLoS One , vol.3
    • Kool, M.1    Koster, J.2    Bunt, J.3    Hasselt, N.E.4    Lakeman, A.5    Van Sluis, P.6
  • 14
    • 63749118521 scopus 로고    scopus 로고
    • Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci
    • Pfister S, Remke M, Benner A, Mendrzyk F, Toedt G, Felsberg J, et al. Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci. J Clin Oncol 2009;27:1627-36.
    • (2009) J Clin Oncol , vol.27 , pp. 1627-1636
    • Pfister, S.1    Remke, M.2    Benner, A.3    Mendrzyk, F.4    Toedt, G.5    Felsberg, J.6
  • 16
    • 51349102950 scopus 로고    scopus 로고
    • The molecular genetics of medulloblastoma: An assessment of new therapeutic targets
    • discussion 368-9
    • Carlotti CG Jr, Smith C, Rutka JT. The molecular genetics of medulloblastoma: an assessment of new therapeutic targets. Neurosurg Rev 2008;31:359- 68; discussion 368-9.
    • (2008) Neurosurg Rev , vol.31 , pp. 359-368
    • Carlotti Jr., C.G.1    Smith, C.2    Rutka, J.T.3
  • 17
    • 60549111837 scopus 로고    scopus 로고
    • Biological background of pediatric medulloblastoma and ependymoma: A review from a translational research perspective
    • de Bont JM, Packer RJ, Michiels EM, den Boer ML, Pieters R. Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective. Neuro Oncol 2008;10:1040- 60.
    • (2008) Neuro Oncol , vol.10 , pp. 1040-1060
    • De Bont, J.M.1    Packer, R.J.2    Michiels, E.M.3    Den Boer, M.L.4    Pieters, R.5
  • 18
    • 54049131773 scopus 로고    scopus 로고
    • Signaling pathways in medulloblastoma
    • Guessous F, Li Y, Abounader R. Signaling pathways in medulloblastoma. J Cell Physiol 2008;217:577-83.
    • (2008) J Cell Physiol , vol.217 , pp. 577-583
    • Guessous, F.1    Li, Y.2    Abounader, R.3
  • 19
    • 0028934541 scopus 로고
    • REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
    • Chong JA, Tapia-Ramirez J, Kim S, Toledo-Aral JJ, Zheng Y, Boutros MC, et al. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 1995;80:949-57.
    • (1995) Cell , vol.80 , pp. 949-957
    • Chong, J.A.1    Tapia-Ramirez, J.2    Kim, S.3    Toledo-Aral, J.J.4    Zheng, Y.5    Boutros, M.C.6
  • 20
    • 0030451494 scopus 로고    scopus 로고
    • Cell type-specific regulation of choline acetyltransferase gene expression. Role of the neuron-restrictive silencer element and cholinergic-specific enhancer sequences
    • Lonnerberg P, Schoenherr CJ, Anderson DJ, Ibanez CF. Cell type-specific regulation of choline acetyltransferase gene expression. Role of the neuron-restrictive silencer element and cholinergic-specific enhancer sequences. J Biol Chem 1996;271: 33358 -65.
    • (1996) J Biol Chem , vol.271 , pp. 33358-33365
    • Lonnerberg, P.1    Schoenherr, C.J.2    Anderson, D.J.3    Ibanez, C.F.4
  • 21
    • 0028968802 scopus 로고
    • The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes
    • Schoenherr CJ, Anderson DJ. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 1995;267:1360-3.
    • (1995) Science , vol.267 , pp. 1360-1363
    • Schoenherr, C.J.1    Anderson, D.J.2
  • 23
    • 0033942317 scopus 로고    scopus 로고
    • The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells
    • Lawinger P, Venugopal R, Guo ZS, Immaneni A, Sengupta D, Lu W, et al. The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells. Nat Med 2000;6:826 -31.
    • (2000) Nat Med , vol.6 , pp. 826-831
    • Lawinger, P.1    Venugopal, R.2    Guo, Z.S.3    Immaneni, A.4    Sengupta, D.5    Lu, W.6
  • 24
    • 33644518372 scopus 로고    scopus 로고
    • Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation
    • Su X, Gopalakrishnan V, Stearns D, Aldape K, Lang FF, Fuller G, et al. Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol 2006;26:1666-78.
    • (2006) Mol Cell Biol , vol.26 , pp. 1666-1678
    • Su, X.1    Gopalakrishnan, V.2    Stearns, D.3    Aldape, K.4    Lang, F.F.5    Fuller, G.6
  • 26
    • 0036237621 scopus 로고    scopus 로고
    • The synapsins: Beyond the regulation of neurotransmitter release
    • DOI 10.1007/s00018-002-8451-5
    • Ferreira A, Rapoport M. The synapsins: beyond the regulation of neurotransmitter release. Cell Mol Life Sci 2002;59:589-95. (Pubitemid 34457537)
    • (2002) Cellular and Molecular Life Sciences , vol.59 , Issue.4 , pp. 589-595
    • Ferreira, A.1    Rapoport, M.2
  • 27
    • 7444228699 scopus 로고    scopus 로고
    • The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas
    • Hallahan AR, Pritchard JI, Hansen S, Benson M, Stoeck J, Hatton BA, et al. The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res 2004;64:7794- 800.
    • (2004) Cancer Res , vol.64 , pp. 7794-7800
    • Hallahan, A.R.1    Pritchard, J.I.2    Hansen, S.3    Benson, M.4    Stoeck, J.5    Hatton, B.A.6
  • 28
    • 84856521159 scopus 로고    scopus 로고
    • cited 2012 Mar 5 . Available from: http://pubchem.ncbi. nlm.nih.gov/summary/summary.cgicid444732; http://pubchem.ncbi. nlm.nih.gov/summary/summary.cgicid3221; http://pubchem.ncbi. nlm.nih.gov/summary/summary.cgicid5311
    • National Center for Biotechnology Information. PubChem Compound Database. [cited 2012 Mar 5 ]. Available from: http://pubchem.ncbi. nlm.nih.gov/summary/ summary.cgicid4261; http://pubchem.ncbi. nlm.nih.gov/summary/summary. cgicid444732; http://pubchem.ncbi. nlm.nih.gov/summary/summary.cgicid3221; http://pubchem.ncbi. nlm.nih.gov/summary/summary.cgicid5311.
    • PubChem Compound Database
  • 30
    • 33846122993 scopus 로고    scopus 로고
    • Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug
    • DOI 10.1038/nbt1272, PII NBT1272
    • Marks PA, Breslow R. Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotechnol 2007;25:84-90. (Pubitemid 46087907)
    • (2007) Nature Biotechnology , vol.25 , Issue.1 , pp. 84-90
    • Marks, P.A.1    Breslow, R.2
  • 31
    • 79959344464 scopus 로고    scopus 로고
    • Autophagic and apoptotic effects of HDAC inhibitors on cancer cells
    • Rikiishi H. Autophagic and apoptotic effects of HDAC inhibitors on cancer cells. J Biomed Biotechnol 2011;2011:830260.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 830260
    • Rikiishi, H.1
  • 32
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action
    • DOI 10.1038/sj.onc.1210620, PII 1210620
    • Xu WS, Parmigiani RB, Marks PA. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 2007;26:5541-52. (Pubitemid 47255934)
    • (2007) Oncogene , vol.26 , Issue.37 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 33
    • 77957196094 scopus 로고    scopus 로고
    • Chromatin remodelling at the topoisomerase II-beta promoter is associated with enhanced sensitivity to etoposide in human neuroblastoma cell lines
    • Das CM, Zage PE, Taylor P, Aguilera D, Wolff JE, Lee D, et al. Chromatin remodelling at the topoisomerase II-beta promoter is associated with enhanced sensitivity to etoposide in human neuroblastoma cell lines. Eur J Cancer 2010;46:2771-80.
    • (2010) Eur J Cancer , vol.46 , pp. 2771-2780
    • Das, C.M.1    Zage, P.E.2    Taylor, P.3    Aguilera, D.4    Wolff, J.E.5    Lee, D.6
  • 34
    • 80555155590 scopus 로고    scopus 로고
    • Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCF(beta-TRCP) in neuroblastoma cells
    • Singh A, Rokes C, Gireud M, Fletcher S, Baumgartner J, Fuller G, et al. Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCF(beta-TRCP) in neuroblastoma cells. Cancer. 2011;117:5189-202.
    • (2011) Cancer , vol.117 , pp. 5189-5202
    • Singh, A.1    Rokes, C.2    Gireud, M.3    Fletcher, S.4    Baumgartner, J.5    Fuller, G.6
  • 35
    • 67349128584 scopus 로고    scopus 로고
    • Reactivation of death receptor 4 (DR4) expression sensitizes medulloblastoma cell lines to TRAIL
    • Aguilera DG, Das CM, Sinnappah-Kang ND, Joyce C, Taylor PH, Wen S, et al. Reactivation of death receptor 4 (DR4) expression sensitizes medulloblastoma cell lines to TRAIL. J Neurooncol 2009; 93:303- 18.
    • (2009) J Neurooncol , vol.93 , pp. 303-318
    • Aguilera, D.G.1    Das, C.M.2    Sinnappah-Kang, N.D.3    Joyce, C.4    Taylor, P.H.5    Wen, S.6
  • 36
    • 67149121885 scopus 로고    scopus 로고
    • REST and the RESTless: In stem cells and beyond
    • Gopalakrishnan V. REST and the RESTless: in stem cells and beyond. Future Neurol 2009;4:317-29.
    • (2009) Future Neurol , vol.4 , pp. 317-329
    • Gopalakrishnan, V.1
  • 37
    • 34250767817 scopus 로고    scopus 로고
    • Chromatin crosstalk in development and disease: Lessons from REST
    • DOI 10.1038/nrg2100, PII NRG2100
    • Ooi L, Wood IC. Chromatin crosstalk in development and disease: lessons from REST. Nat Rev Genet 2007;8:544-54. (Pubitemid 46955208)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.7 , pp. 544-554
    • Ooi, L.1    Wood, I.C.2
  • 38
    • 33947153003 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood
    • DOI 10.1002/ijc.22401
    • Furchert SE, Lanvers-Kaminsky C, Juurgens H, Jung M, Loidl A, Fruhwald MC. Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. Int J Cancer 2007;120:1787-94. (Pubitemid 46399367)
    • (2007) International Journal of Cancer , vol.120 , Issue.8 , pp. 1787-1794
    • Furchert, S.E.1    Lanvers-Kaminsky, C.2    Jurgens, H.3    Jung, M.4    Loidl, A.5    Fruhwald, M.C.6
  • 39
    • 79551600613 scopus 로고    scopus 로고
    • Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells
    • Huang Z, Wu Q, Guryanova OA, Cheng L, Shou W, Rich JN, et al. Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Nat Cell Biol 2011;13:142-52.
    • (2011) Nat Cell Biol , vol.13 , pp. 142-152
    • Huang, Z.1    Wu, Q.2    Guryanova, O.A.3    Cheng, L.4    Shou, W.5    Rich, J.N.6
  • 40
    • 41149119961 scopus 로고    scopus 로고
    • SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation
    • Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, et al. SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 2008;452: 370 -4.
    • (2008) Nature , vol.452 , pp. 370-374
    • Westbrook, T.F.1    Hu, G.2    Ang, X.L.3    Mulligan, P.4    Pavlova, N.N.5    Liang, A.6
  • 41
    • 55949119785 scopus 로고    scopus 로고
    • Data mining PubChem using a support vector machine with the Signature molecular descriptor: Classification of factor XIa inhibitors
    • Weis DC, Visco DP Jr, Faulon JL. Data mining PubChem using a support vector machine with the Signature molecular descriptor: classification of factor XIa inhibitors. J Mol Graph Model 2008;27: 466-75.
    • (2008) J Mol Graph Model , vol.27 , pp. 466-475
    • Weis, D.C.1    Visco Jr., D.P.2    Faulon, J.L.3
  • 42
    • 67651243724 scopus 로고    scopus 로고
    • Classic and desmoplastic medulloblastoma: Complete case reports and characterizations of two new cell lines
    • Holthouse DJ, Dallas PB, Ford J, Fabian V, Murch AR, Watson M, et al. Classic and desmoplastic medulloblastoma: complete case reports and characterizations of two new cell lines. Neuropathology 2009;29: 398-409.
    • (2009) Neuropathology , vol.29 , pp. 398-409
    • Holthouse, D.J.1    Dallas, P.B.2    Ford, J.3    Fabian, V.4    Murch, A.R.5    Watson, M.6
  • 43
    • 79960028740 scopus 로고    scopus 로고
    • Histology predicts a favorable outcome in young children with desmoplastic medulloblastoma: A report from the children's oncology group
    • Leary SE, Zhou T, Holmes E, Geyer JR, Miller DC. Histology predicts a favorable outcome in young children with desmoplastic medulloblastoma: a report from the children's oncology group. Cancer 2011;117: 3262- 7.
    • (2011) Cancer , vol.117 , pp. 3262-3267
    • Leary, S.E.1    Zhou, T.2    Holmes, E.3    Geyer, J.R.4    Miller, D.C.5
  • 44
    • 84862776537 scopus 로고    scopus 로고
    • Clonal selection drives genetic divergence of metastatic medulloblastoma
    • Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, Witt H, et al. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature 2012;482:529-33.
    • (2012) Nature , vol.482 , pp. 529-533
    • Wu, X.1    Northcott, P.A.2    Dubuc, A.3    Dupuy, A.J.4    Shih, D.J.5    Witt, H.6
  • 45
    • 33748581975 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma
    • DOI 10.1007/s11060-006-9142-0
    • Spiller SE, Ravanpay AC, Hahn AW, Olson JM. Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma. J Neurooncol 2006;79:259-70. (Pubitemid 44363729)
    • (2006) Journal of Neuro-Oncology , vol.79 , Issue.3 , pp. 259-270
    • Spiller, S.E.1    Ravanpay, A.C.2    Hahn, A.W.3    Olson, J.M.4
  • 46
    • 69849094949 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8
    • Hacker S, Dittrich A, Mohr A, Schweitzer T, Rutkowski S, Krauss J, et al. Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8. Oncogene 2009;28: 3097 - 110.
    • (2009) Oncogene , vol.28 , pp. 3097-3110
    • Hacker, S.1    Dittrich, A.2    Mohr, A.3    Schweitzer, T.4    Rutkowski, S.5    Krauss, J.6
  • 47
    • 33645226815 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells
    • Sonnemann J, Kumar KS, Heesch S, Muller C, Hartwig C, Maass M, et al. Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. Int J Oncol 2006;28:755 -66.
    • (2006) Int J Oncol , vol.28 , pp. 755-766
    • Sonnemann, J.1    Kumar, K.S.2    Heesch, S.3    Muller, C.4    Hartwig, C.5    Maass, M.6
  • 48
    • 19344378337 scopus 로고    scopus 로고
    • REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis
    • DOI 10.1016/j.cell.2005.03.013, PII S0092867405002850
    • Ballas N, Grunseich C, Lu DD, Speh JC, Mandel G. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 2005;121:645-57. (Pubitemid 40720016)
    • (2005) Cell , vol.121 , Issue.4 , pp. 645-657
    • Ballas, N.1    Grunseich, C.2    Lu, D.D.3    Speh, J.C.4    Mandel, G.5
  • 49
    • 44349122993 scopus 로고    scopus 로고
    • Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: Tipping the scales of cancer
    • DOI 10.1038/nrc2396, PII NRC2396
    • Frescas D, Pagano M. Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer 2008;8:438-49. (Pubitemid 351744963)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.6 , pp. 438-449
    • Frescas, D.1    Pagano, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.