Second generation benzofuranone ring substituted noscapine analogs: Synthesis and biological evaluation

Biochemical Pharmacology

Volumn 82, Issue 2, 2011, Pages 110-121

  Mishra, Ram Chandra ^a   Karna, Prasanthi ^a   Gundala, Sushma Reddy ^a   Pannu, Vaishali ^a   Stanton, Richard A ^a   Gupta, Kamlesh Kumar ^b   Robinson, M Hope ^a   Lopus, Manu ^c   Wilson, Leslie ^c   Henary, Maged ^a   Aneja, Ritu ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anticancer activity; Cell cycle; Noscapine; Tubulin binding

Indexed keywords

5 METHOXY 1 [4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO 1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL] 3 OXO 1,3 DIHYDROISOBENZOFURAN 4 YL BENZYLCARBAMATE; 5 METHOXY 1 [4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL] 3 OXO 1,3 DIHYDROISOBENZOFURAN 4 YL ETHYLCARBAMATE; 5 METHOXY 1 [4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL] 3 OXO 1,3 DIHYDROISOBENZOFURAN 4 YL PHENYLCARBAMATE; 5 METHOXY 1 [4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO[1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL] 3 OXO 1,3 DIHYDROISOBENZOFURAN 4 YL ACETATE; 5 METHOXY 1 [4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO[1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL] 3 OXO 1,3 DIHYDROISOBENZOFURAN 4 YL BENZOATE; 7 HYDROXY 6 METHOXY 3 [4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO[1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL]ISOBENZOFURAN 1(3H) ONE; BENZOFURANONE; CARBAMIC ACID DERIVATIVE; COLCHICINE; FURANONE DERIVATIVE; NOSCAPINE; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LUNG CANCER; LYMPHOMA; MICROTUBULE ASSEMBLY; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PURIFICATION; RING OPENING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOFURANS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; HUMANS; MODELS, MOLECULAR; NOSCAPINE; PROTEIN STRUCTURE, QUATERNARY; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 79958092061     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.03.029     Document Type: Article

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