CD4 + T cells disarm or delete cytotoxic T lymphocytes under IL-17-polarizing conditions

Journal of Immunology

Volumn 189, Issue 4, 2012, Pages 1671-1679

  Tsai, Jy Ping ^a   Lee, Meng Hua ^b   Hsu, Shu Ching ^a,c,d   Chen, Mei Yu ^a   Liu, Shih Jen ^a,e   Chang, Joseph T ^f   Liao, Chun Ta ^f   Cheng, Ann Joy ^b   Chong, Pele ^a,e   Chu, Ching Liang ^a   Shen, Chia Rui ^b   Chen, Hsin Wei ^a,e  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; INTERLEUKIN 17; INTERLEUKIN 2 ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CD4+ CD25+ REGULATORY T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ IL 17+ T LYMPHOCYTE; CELL SPECIFICITY; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; T LYMPHOCYTE; TUMOR ESCAPE; TUMOR MICROENVIRONMENT;

ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELL POLARITY; COCULTURE TECHNIQUES; FEMALE; FLOW CYTOMETRY; HEAD AND NECK NEOPLASMS; HUMANS; INTERLEUKIN-17; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REAL-TIME POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, CYTOTOXIC; TUMOR MICROENVIRONMENT;

EID: 84864813859     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1103447     Document Type: Article

References (46)

1. Husmann, L. A., and M. J. Bevan. 1988. Cooperation between helper T cells and cytotoxic T lymphocyte precursors. Ann. N. Y. Acad. Sci. 532: 158-169. (Pubitemid 19017636)
2. Keene, J. A., and J. Forman. 1982. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J. Exp. Med. 155: 768-782. (Pubitemid 12187851)
3. + T-cell response. Nat. Rev. Immunol. 4: 595-602.
4. +T cells: when, where, and how. Annu. Rev. Immunol. 24: 519-540.
5. Williams, M. A., and M. J. Bevan. 2007. Effector and memory CTL differentiation. Annu. Rev. Immunol. 25: 171-192. (Pubitemid 46697906)
6. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164.
7. + regulatory T cells. Nat. Immunol. 4: 330-336.
8. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061. (Pubitemid 36222930)
9. + T cell responses. J. Exp. Med. 198: 889-901.
10. Onizuka, S., I. Tawara, J. Shimizu, S. Sakaguchi, T. Fujita, and E. Nakayama. 1999. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor a) monoclonal antibody. Cancer Res. 59: 3128-3133. (Pubitemid 29316012)
11. + T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163: 5211-5218.
12. Chen, M. L., M. J. Pittet, L. Gorelik, R. A. Flavell, R. Weissleder, H. von Boehmer, and K. Khazaie. 2005. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-b signals in vivo. Proc. Natl. Acad. Sci. USA 102: 419-424. (Pubitemid 40116782)
13. Mempel, T. R., M. J. Pittet, K. Khazaie, W. Weninger, R. Weissleder, H. von Boehmer, and U. H. von Andrian. 2006. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 25: 129-141. (Pubitemid 44066829)
14. + T-cell priming by blocking early T-cell expansion. Eur. J. Immunol. 40: 339-350.
15. + T cell activity during cross-priming strongly enhances T cell-mediated immunity. Eur. J. Immunol. 38: 1585-1597.
16. + T-cell effector differentiation by modulating IL-2 homeostasis. Proc. Natl. Acad. Sci. USA 108: 7529-7534.
17. Liu, S.-J., J.-P. Tsai, C.-R. Shen, Y.-P. Sher, C.-L. Hsieh, Y.-C. Yeh, A.-H. Chou, S.-R. Chang, K.-N. Hsiao, F.-W. Yu, and H.-W. Chen. 2007. Induction of a distinct CD8 Tnc17 subset by transforming growth factor-β and interleukin-6. J. Leukoc. Biol. 82: 354-360. (Pubitemid 47230647)
18. + Tc17 cells with reduced cytotoxic activity. Eur. J. Immunol. 39: 1716-1725.
19. Yen, H. R., T. J. Harris, S. Wada, J. F. Grosso, D. Getnet, M. V. Goldberg, K. L. Liang, T. C. Bruno, K. J. Pyle, S. L. Chan, et al. 2009. Tc17 CD8 T cells: functional plasticity and subset diversity. J. Immunol. 183: 7161-7168.
20. Hamada, H., Mde. L. Garcia-Hernandez, J. B. Reome, S. K. Misra, T. M. Strutt, K. K. McKinstry, A. M. Cooper, S. L. Swain, and R. W. Dutton. 2009. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J. Immunol. 182: 3469-3481.
21. Curtis, M. M., S. S. Way, and C. B. Wilson. 2009. IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons. J. Immunol. 183: 381-387.
22. Tsai, J.-P., H.-W. Chen, M.-L. Cheng, H.-K. Liu, Y.-P. Lee, C. L. Hsieh, K.-T. Luh, C.-W. Wu, L.-H. Hsu, T.-Y. Chao, et al. 2005. Analysis of host versus tumor interaction in cancer patients: opposing role of transforming growth factor-b1 and interleukin-6 in the development of in situ tumor immunity. Immunobiology 210: 661-671. (Pubitemid 41600507)
23. Bettelli, E., Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner, and V. K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
24. Mangan, P. R., L. E. Harrington, D. B. O'Quinn, W. S. Helms, D. C. Bullard, C. O. Elson, R. D. Hatton, S. M. Wahl, T. R. Schoeb, and C. T. Weaver. 2006. Transforming growth factor-b induces development of the T(H)17 lineage. Nature 441: 231-234.
25. Veldhoen, M., R. J. Hocking, C. J. Atkins, R. M. Locksley, and B. Stockinger. 2006. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24: 179-189. (Pubitemid 43214587)
26. 2 exacerbates collagen-induced arthritis in mice through the inflammatory interleukin-23/interleukin-17 axis. Arthritis Rheum. 56: 2608-2619.
27. 2 induces IL-23 production in bone marrow-derived dendritic cells. FASEB J. 18: 1318-1320.
28. Kryczek, I., S. Wei, L. Zou, S. Altuwaijri, W. Szeliga, J. Kolls, A. Chang, and W. Zou. 2007. Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J. Immunol. 178: 6730-6733. (Pubitemid 46847396)
29. Murugaiyan, G., and B. Saha. 2009. Protumor vs antitumor functions of IL-17. J. Immunol. 183: 4169-4175.
30. Maniati, E., R. Soper, and T. Hagemann. 2010. Up for mischief? IL-17/Th17 in the tumour microenvironment. Oncogene 29: 5653-5662.
31. Wilke, C. M., I. Kryczek, S. Wei, E. Zhao, K. Wu, G. Wang, and W. Zou. 2011. Th17 cells in cancer: help or hindrance? Carcinogenesis 32: 643-649.
32. Ji, Y., and W. Zhang. 2010. Th17 cells: positive or negative role in tumor? Cancer Immunol. Immunother. 59: 979-987.
33. Laurence, A., C. M. Tato, T. S. Davidson, Y. Kanno, Z. Chen, Z. Yao, R. B. Blank, F. Meylan, R. Siegel, L. Hennighausen, et al. 2007. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26: 371-381. (Pubitemid 46413906)
34. Amadi-Obi, A., C. R. Yu, X. Liu, R. M. Mahdi, G. L. Clarke, R. B. Nussenblatt, I. Gery, Y. S. Lee, and C. E. Egwuagu. 2007. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat. Med. 13: 711-718. (Pubitemid 46889754)
35. Neufert, C., C. Becker, S. Wirtz, M. C. Fantini, B. Weigmann, P. R. Galle, and M. F. Neurath. 2007. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur. J. Immunol. 37: 1809-1816. (Pubitemid 47065120)
36. Brucklacher-Waldert, V., K. Steinbach, M. Lioznov, M. Kolster, C. Hölscher, and E. Tolosa. 2009. Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression. J. Immunol. 183: 5494-5501.
37. + T cells: a population of T cells with immune regulatory activities in vitro. Eur. J. Immunol. 28: 3435-3447.
38. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
39. + T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines. J. Leukoc. Biol. 86: 435-443.
40. Krammer, P. H., R. Arnold, and I. N. Lavrik. 2007. Life and death in peripheral T cells. Nat. Rev. Immunol. 7: 532-542. (Pubitemid 46987784)
41. + T cells for IL-2 and exploit it for the induction of IL-10 production. Int. Immunol. 17: 279-288.
42. + T cells. Nat. Immunol. 8: 1353-1362.
43. + T cells in hepatocellular carcinoma patients. J. Immunol. 185: 1544-1549.
44. Garcia-Hernandez, Mde. L., H. Hamada, J. B. Reome, S. K. Misra, M. P. Tighe, and R.W. Dutton. 2010. Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in mice. J. Immunol. 184: 4215-4227.
45. Chen, X., J. Wan, J. Liu, W. Xie, X. Diao, J. Xu, B. Zhu, and Z. Chen. 2010. Increased IL-17-producing cells correlate with poor survival and lymphangio-genesis in NSCLC patients. Lung Cancer 69: 348-354.
46. Wu, C., S.Wang, F. Wang, Q. Chen, S. Peng, Y. Zhang, J. Qian, J. Jin, and H. Xu. 2009. Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia. Clin. Exp. Immunol. 158: 199-204.