Blunt-ended telomeres: An alternative ending to the replication and end protection stories

Genes and Development

Volumn 26, Issue 15, 2012, Pages 1648-1652

  Nelson, Andrew D L ^a   Shippen, Dorothy E ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Arabidopsis; Ku; Recombination; T circle; Telomerase; Telomere

Indexed keywords

BINDING PROTEIN; GUANINE; KU ANTIGEN; PLANT DNA;

ANGIOSPERM; ARABIDOPSIS; ARTICLE; BLUNT ENDED TELOMERE; GENE REPLICATION; NONHUMAN; NUCLEOTIDE REPEAT; PLANT CHROMOSOME; PLANT GENOME; PRIORITY JOURNAL; PROTEIN FUNCTION; TELOMERE;

ARABIDOPSIS; CHROMOSOMES, PLANT; TELOMERE;

ARABIDOPSIS; MAGNOLIOPHYTA;

EID: 84864780658     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.199059.112     Document Type: Article

References (42)

1. Aichinger E, Kornet N, Friedrich T, Laux T. 2012. Plant stem cell niches. Annu Rev Plant Biol 63: 615-636.
2. Bailey SM, Cornforth MN, Kurimasa A, Chen DJ, Goodwin EH. 2001. Strand-specific postreplicative processing of mammalian telomeres. Science 293: 2462-2465.
3. Bertuch AA, Lundblad V. 2004. Exo1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae. Genetics 166: 1651-1659.
4. Bonetti D, Clerici M, Anbalagan S, Martina M, Lucchini G, Longhese MP. 2010a. Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telo-meres. PLoS Genet 27: e1000966. doi: 10.1371/journal.pgen. 1000966.
5. Bonetti D, Clerici M, Manfrini N, Lucchini G, Longhese MP. 2010b. The MRX complex plays multiple functions in resection of Yku- and Rif2-protected DNA ends. PLoS ONE 5: e14142. doi: 10.1371/journal.pone.0014142.
6. Boulton SJ, Jackson SP. 1996. Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double strand break rejoining and in telomere maintenance. Nucleic Acids Res 24: 4639-4648.
7. Casteel DE, Zhuang S, Zeng Y, Perrino FW, Boss GR, Goulian M, Pilz RB. 2009. A DNA polymerase-a/primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. J Biol Chem 284: 5807-5818.
8. Chow TT, Zhao Y, Mak SS, Shay JW, Wright WE. 2012. Early and late steps in telomere overhang processing in normal human cells: The position of the final RNA primer drives telomere shortening. Genes Dev 26: 1167-1178.
9. de Lange T. 2005. Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev 19: 2100-2110.
10. Gallego ME, Jalut N, White CI. 2003. Telomerase dependence of telomere lengthening in Ku80 mutant Arabidopsis. Plant Cell 15: 782-789.
11. Gu P, Min JN, Wang Y, Huang C, Peng T, Chai W, Chang S. 2012. CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J 31: 2309-2321.
12. Henderson ER, Blackburn EH. 1989. An overhanging 39 terminus is a conserved feature of telomeres. Mol Cell Biol 9: 345-348.
13. Karamysheva ZN, Surovtseva YV, Vespa L, Shakirov EV, Shippen DE. 2004. A C-terminal Myb extension domain defines a novel family of double-strand telomeric DNA-binding proteins in Arabidopsis. J Biol Chem 279: 47799-47807.
14. Kazda A, Zellinger B, Rössler M, Derboven E, Kusenda B, Riha K. 2012. Chromosome end protection by blunt-ended telo-meres. Genes Dev (this issue). doi: 10.1101/gad.194944.112.
15. Lingner J, Cech TR. 1996. Purification of telomerase from Euplotes aediculatus: Requirement of a primer 39 overhang. Proc Natl Acad Sci 93: 10712-10717.
16. Lopez CR, Ribes-Zamora A, Indiviglio SM, Williams CL, Haricharan S, Bertuch AA. 2011. Ku must load directly onto the chromosome end in order to mediate its telomeric functions. PLoS Genet 7: e1002233. doi: 10.1371/journal.pgen. 1002233.
17. Makarov VL, Hirose Y, Langmore JP. 1997. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88: 657-666.
18. Mari PO, Florea BI, Persengiev SP, Verkaik NS, Bruggenwirth HT, Modesti M, Giglia-Mari G, Bezstarosti K, Demmers JA, Luider TM, et al. 2006. Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc Natl Acad Sci 103: 18597-18602.
19. Maringele L, Lydall D. 2002. EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70D mutants. Genes Dev 16: 1919-1933.
20. Miyake Y, Nakamura M, Nabetani A, Shimamura S, Tamura M, Yonehara S, Saito M, Ishikawa F. 2009. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Mol Cell 36: 193-206.
21. Nakaoka H, Nishiyama A, Saito M, Ishikawa F. 2012. Xenopus laevis Ctc1-Stn1-Ten1 (xCST) protein complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract. J Biol Chem 287: 619-627.
22. Nugent CI, Bosco G, Ross LO, Evans SK, Salinger AP, Moore JK, Haber JE, Lundblad V. 1998. Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr Biol 8: 657-660.
23. Oganesian L, Karlseder J. 2011. Mammalian 59 C-rich telomeric overhangs are a mark of recombination-dependent telomere maintenance. Mol Cell 42: 224-236.
24. Olovnikov AM. 1973. A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 41: 181-190.
25. Price CM, Boltz KA, Chaiken MF, Stewart JA, Beilstein MA, Shippen DE. 2010. Evolution of CST function in telomere maintenance. Cell Cycle 9: 3157-3165.
26. Raices M, Verdun RE, Compton SA, Haggblom CI, Griffith JD, Dillin A, Karlseder J. 2008. C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. Cell 132: 745-757.
27. Raffa GD, Raimondo D, Sorino C, Cugusi S, Cenci G, Cacchione S, Gatti M, Ciapponi L. 2010. Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex. Genes Dev 24: 1596-1601.
28. Riha K, Shippen DE. 2003. Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis. Proc Natl Acad Sci 100: 611-615.
29. Riha K, McKnight TD, Fajkus J, Vyskot B, Shippen DE. 2000. Analysis of the G-overhang structures on plant telomeres: Evidence for two distinct telomere architectures. Plant J 23: 633-641.
30. Riha K, McKnight TD, Griffing LR, Shippen DE. 2001. Living with genome instability: Plant responses to telomere dysfunction. Science 291: 1797-1800.
31. Riha K, Watson JM, Parkey J, Shippen DE. 2002. Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70. EMBO J 21: 2819-2826.
32. Riha K, Heacock ML, Shippen DE. 2006. The role of the nonhomologous end-joining DNA double-strand break repair pathway in telomere biology. Annu Rev Genet 40: 237-277.
33. Sfeir AJ, Chai W, Shay JW, Wright WE. 2005. Telomere-end processing the terminal nucleotides of human chromosomes. Mol Cell 18: 131-138.
34. Song X, Leehy K, Warrington RT, Lamb JC, Surovtseva YV, Shippen DE. 2008. STN1 protects chromosome ends in Arabidopsis thaliana. Proc Natl Acad Sci 105: 19815-19820.
35. Surovtseva YV, Churikov D, Boltz KA, Song X, Lamb JC, Warrington R, Leehy K, Heacock M, Price CM, Shippen DE. 2009. Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes. Mol Cell 36: 207-218.
36. van Overbeek M, de Lange T. 2006. Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase. Curr Biol 16: 1295-1302.
37. Wang Y, Ghosh G, Hendrickson EA. 2009. Ku86 represses lethal telomere deletion events in human somatic cells. Proc Natl Acad Sci 106: 12430-12435.
38. Watson JD. 1972. Origin of concatemeric T7 DNA. Nat New Biol 239: 197-201.
39. Wellinger RJ, Wolf AJ, Zakian VA. 1993. Saccharomyces telo-meres acquire single-strand TG1-3 tails late in S phase. Cell 72: 51-60.
40. Wu TJ, Chiang YH, Lin YC, Tsai CR, Yu TY, Sung MT, Lee YH, Lin JJ. 2009. Sequential loading of Saccharomyces cerevisiae Ku and Cdc13p to telomeres. J Biol Chem 284: 12801-12808.
41. Wu P, van Overbeek M, Rooney S, de Lange T. 2010. Apollo contributes to G overhang maintenance and protects leading-end telomeres. Mol Cell 39: 606-617.
42. Zellinger B, Akimcheva S, Puizina J, Schirato M, Riha K. 2007. Ku suppresses formation of telomeric circles and alternative telomere lengthening in Arabidopsis. Mol Cell 27: 163-169.