Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex

Genes and Development

Volumn 24, Issue 15, 2010, Pages 1596-1601

  Raffa, Grazia D ^a,b   Raimondo, Domenico ^a   Sorino, Cristina ^a,b   Cugusi, Simona ^a,b   Cenci, Giovanni ^c   Cacchione, Stefano ^a,b   Gatti, Maurizio ^a,b   Ciapponi, Laura ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Istituto Di Biologia E Patologia Molecolari Rome   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Drosophila; Rpa2 Stn1; Telomeres; Terminin; Verrocchio

Indexed keywords

BINDING PROTEIN; HETEROCHROMATIN PROTEIN 1; TELOMERASE; UNCLASSIFIED DRUG; VERROCCHIO PROTEIN; DROSOPHILA PROTEIN; HP1 ORC ASSOCIATED PROTEIN, DROSOPHILA; HP1 ORC-ASSOCIATED PROTEIN, DROSOPHILA; MODIGLIANI PROTEIN, DROSOPHILA; NONHISTONE PROTEIN; NUCLEAR PROTEIN; TELOMERE BINDING PROTEIN; TERMININ; VERROCCHIO PROTEIN, DROSOPHILA;

ANIMAL CELL; ARTICLE; BIOINFORMATICS; CHROMOSOME; CONTROLLED STUDY; DNA SEQUENCE; DROSOPHILA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; TELOMERE; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MUTATION; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANIMALS; CHROMOSOMAL PROTEINS, NON-HISTONE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; MODELS, MOLECULAR; MUTATION; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; TELOMERE; TELOMERE-BINDING PROTEINS;

EID: 77955904676     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.574810     Document Type: Article

References (29)

1. Biegert A, Soding J. 2009. Sequence context-specific profiles for homology searching. Proc Natl Acad Sci 106: 3770-3775.
2. Bochkarev A, Pfuetzner RA, Edwards AM, Frappier L. 1997. Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA. Nature 385: 176-181. (Pubitemid 27034221)
3. Carré C, Szymczak D, Pidoux J, Antoniewski C. 2005. The histone H3 acetylase dGcn5 is a key player in Drosophila melanogaster metamorphosis. Mol Cell Biol 25: 8228-8238. (Pubitemid 41263013)
4. Cenci G, Siriaco G, Raffa GD, Kellum R, Gatti M. 2003. The Drosophila HOAP protein is required for telomere capping. Nat Cell Biol 5: 82-84. (Pubitemid 36054334)
5. Cenci G, Ciapponi L, Gatti M. 2005. The mechanism of telomere protection: A comparison between Drosophila and humans. Chromosoma 114: 135-145. (Pubitemid 41349172)
6. Ciapponi L, Cenci G. 2008. Telomere capping and cellular checkpoints: Clues from fruit flies. Cytogenet Genome Res 122: 365-373.
7. Clark AG, Eisen MB, Smith DR, Bergman CM, Oliver B, Markow TA, Kaufman TC, Kellis M, Gelbart W, Iyer VN, et al. 2007. Evolution of genes and genomes on the Drosophila phylogeny. Nature 450: 203-218. (Pubitemid 351972300)
8. Fanti L, Giovinazzo G, Berloco M, Pimpinelli S. 1998. The heterochromatin protein 1 prevents telomere fusions in Drosophila. Mol Cell 2: 527-538. (Pubitemid 128379079)
9. Gao H, Cervantes RB, Mandell EK, Otero JH, Lundblad V. 2007. RPA-like proteins mediate yeast telomere function. Nat Struct Mol Biol 14: 208-214.
10. Gelinas AD, Paschini M, Reyes FE, Heroux A, Batey RT, Lundblad V, Wuttke DS. 2009. Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain. Proc Natl Acad Sci 106: 19298-19303.
11. Holm L, Kaariainen S, Rosenstrom P, Schenkel A. 2008. Searching protein structure databases with DaliLite v.3. Bioinformatics 24: 2780-2781.
12. Kosinski J, Cymerman IA, Feder M, Kurowski MA, Sasin JM, Bujnicki JM. 2003. A 'FRankenstein's monster' approach to comparative modeling: Merging the finest fragments of fold-recognition models and iterative model refinement aided by 3D structure evaluation. Proteins 53: 369-379.
13. Linger BR, Price CM. 2009. Conservation of telomere protein complexes: Shuffling through evolution. Crit Rev Biochem Mol Biol 44: 434-446.
14. Lue NF. 2009. Plasticity of telomere maintenance mechanisms in yeast. Trends Biochem Sci 35: 8-17.
15. Martin V, Du LL, Rozenzhak S, Russell P. 2007. Protection of telomeres by a conserved Stn1-Ten1 complex. Proc Natl Acad Sci 104: 14038-14043. (Pubitemid 350003331)
16. Mason JM, Frydrychova RC, Biessmann H. 2008. Drosophila telomeres: An exception providing new insights. Bioessays 30: 25-37.
17. Mitton-Fry RM, Anderson EM, Hughes TR, Lundblad V, Wuttke DS. 2002. Conserved structure for single-stranded telomeric DNA recognition. Science 296: 145-147. (Pubitemid 34280074)
18. Miyake Y, Nakamura M, Nabetani A, Shimamura S, Tamura M, Yonehara S, Saito M, Ishikawa F. 2009. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Mol Cell 36: 193-206.
19. Musarò M, Ciapponi L, Fasulo B, Gatti M, Cenci G. 2008. Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint. Nat Genet 40: 362-366. (Pubitemid 351311761)
20. Palm W, de Lange T. 2008. How shelterin protects mammalian telomeres. Annu Rev Genet 42: 301-334.
21. Raffa GD, Cenci G, Siriaco G, Goldberg ML, Gatti M. 2005. The putative Drosophila transcription factor woc is required to prevent telomeric fusions. Mol Cell 20: 821-831. (Pubitemid 41814872)
22. Raffa GD, Siriaco G, Cugusi S, Ciapponi L, Cenci G, Wojcik E, Gatti M. 2009. The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection. Proc Natl Acad Sci 106: 2271-2276.
23. Rong YS. 2008. Telomere capping in Drosophila: Dealing with chromosome ends that most resemble DNA breaks. Chromosoma 117: 235-242.
24. Schmid KJ, Tautz D. 1997. A screen for fast evolving genes from Drosophila. Proc Natl Acad Sci 94: 9746-9750. (Pubitemid 27408134)
25. Shareef MM, King C, Damaj M, Badagu R, Huang DW, Kellum R. 2001. Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing. Mol Biol Cell 12: 1671-1685. (Pubitemid 33049721)
26. Song X, Leehy K, Warrington RT, Lamb JC, Surovtseva YV, Shippen DE. 2008. STN1 protects chromosome ends in Arabidopsis thaliana. Proc Natl Acad Sci 105: 19815-19820.
27. Sun J, Yu EY, Yang Y, Confer LA, Sun SH, Wan K, Lue NF, Lei M. 2009. Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev 23: 2900-2914.
28. Surovtseva YV, Churikov D, Boltz KA, Song X, Lamb JC, Warrington R, Leehy K, Heacock M, Price CM, Shippen DE. 2009. Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes. Mol Cell 36: 207-218.
29. Zhang J, Rosenberg HF, Nei M. 1998. Positive Darwinian selection after gene duplication in primate ribonuclease genes. Proc Natl Acad Sci 95: 3708-3713. (Pubitemid 28173193)