What have we learned from brucellosis in the mouse model?

Veterinary Research

Volumn 43, Issue 1, 2012, Pages

  Grillá, María Jesús ^a   Blasco, José María ^b   Gorvel, Jean Pierre ^c,d,e   Moriyán, Ignacio ^f   Moreno, Edgardo ^g,h  

^a PUBLIC UNIVERSITY OF NAVARRE   (Spain)

^b Agrifood Institute of Aragón IA2   (Spain)

^c CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^d INSERM   (France)

^e CNRS   (France)

^f UNIVERSITY OF NAVARRA   (Spain)

^g UNIVERSIDAD NACIONAL   (Costa Rica)

^h UNIVERSIDAD DE COSTA RICA   (Costa Rica)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; BACTERIA (MICROORGANISMS); BRUCELLA; MURINAE; MUS; NEGIBACTERIA;

ANIMAL; BRUCELLA; BRUCELLOSIS; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; MICROBIOLOGY; MOUSE; PATHOGENICITY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; VIRULENCE;

ANIMALS; BRUCELLA; BRUCELLOSIS; DISEASE MODELS, ANIMAL; HUMANS; MICE; VIRULENCE;

EID: 84864780098     PISSN: 09284249     EISSN: 12979716     Source Type: Journal    
DOI: 10.1186/1297-9716-43-29     Document Type: Review

References (204)

1. The genus Brucella. Moreno E, Moriyán I, The Prokaryotes, Volume 5. Part 1, section 31 Springer, Ne York, Dworkin M, Falkow S, Rosenberg E, Schleifer KH, Stackebrant E, 2006 315 456
2. The pathogenesis and pathobiology of Brucella infection in domestic animals. Enright FM, Animal Brucellosis CRC Press, Boca Raton, Nielsen KH, Duncan JR, 1990 301 320
3. Spink WW, The Nature of Brucellosis The University of Minnesota Press, Minnesota 1956
4. An evolutionary strategy for a stealthy intracellular Brucella pathogen. Martirosyan A, Moreno E, Gorvel JP, Immunol Rev 2011 240 211 234
5. Brucella melitensis: a nasty bug with hidden credentials for virulence. Moreno E, Moriyán I, Proc Nat Acad Sci USA 2002 99 1 3 (Pubitemid 34060303)
6. Efficacy and safety of abortion vaccines prepared from Brucella abortus strains of different degrees of virulence. Cotton WE, Buck JM, Smith HE, J Agricul Res 1933 46 291 314
7. Experimental infection of Brucella abortus in man: Preliminary report, Puerto Rico. Morales-Otero P, J Pub Health Trop Med 1929 5 144 157
8. Studies of experimental brucellosis in cows in France. Plommet M, Bovine Brucellosis Texas A&M University Press, College Station, Texas, Crawford RM, Hidalgo RJ, 1977 116 1134
9. Ruiz-Castãeda M, Brucelosis Ediciones Científicas, Prensa Médica Mexicana, S A, Copilco-Universidad, México, DF 3 1986
10. Observations on the infections of chick embryos with Bacterium tularense, Brucella and Pasteurella pestis. Buddingh GJ, Womack FC, J Exp Med 1941 74 213 222
11. Studies of some biological activities of Brucella endotoxin in normal and infected animals and the role of the hypersensitivity factor. Díaz R, Oyeledun A, Ann Sclavo 1977 19 117 130 (Pubitemid 8157164)
12. Alton GG, Jones LM, Angus RD, Verger JM, Techniques for the brucellosis laboratory Institut National de la Recherche Agronomique (INRA), Paris 1988
13. Laboratory animal models for brucellosis studies. García-Carrillo C, Animal Brucellosis CRC Press, Boca Raton, FL, Nielsen K, Duncan JR, 1990 423 442
14. Studies in the pathology and pathogenesis of experimental brucellosis II The formation of the hepatic granuloma and its evolution. Braude AI, J Infect Dis 1951 89 87 102
15. Studies in the pathology and pathogenesis of experimental brucellosis III Investigations pertaining to the function of the spleen. Braude AI, Spink WW, J Infect Dis 1951 89 272 297
16. Office International des pizooties Bovine brucellosis, Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. Volume 2 Paris 2008
17. Recombinant Brucella abortus proteins that induce proliferation and gamma-interferon secretion by CD4+ T cells from Brucella-vaccinated mice and delayed-type hypersensitivity in sensitized guinea pigs. Oliveira SC, Harms JS, Banai M, Splitter GA, Cell Immunol 1996 172 262 268 (Pubitemid 26319784)
18. The pathogenecity of Brucella abortus for white mice. Feldman WH, Olson C, J Infect Dis 1935 57 212 222
19. Brucella infection in white mice. Singer-Brooks CH, J Infect Dis 1937 60 265 275
20. Green EL, Biology of the Laboratory Mouse Dover publication Inc, New York 2 1966
21. Of mice and not men:differences between mouse and human immunology. Mestas J, Hughes CC, J Immunol 2004 172 2731 2738 (Pubitemid 38263654)
22. Brucellosis vaccines: assessment of Brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and export. González D, Grillá MJ, De Miguel MJ, Ali T, Arce-Gorvel V, Delrue RM, Conde-Alvarez R, Mũoz P, Lápez-Gõi I, Iriarte M, Marín CM, Weintraub A, Widmalm G, Zygmunt M, Letesson JJ, Gorvel JP, Blasco JM, Moriyán I, PLoS One 2008 3 2760
23. Reactivation of a residual Brucella abortus 19 vaccine infection in mice by a virulent challenge or by injection of brucellin or of Brucella lipopolysaccharide. Plommet M, Plommet AM, Ann Rech Vet 1988 19 245 251
24. Virulence of Brucella: bacterial growth and decline in mice. Plommet M, Plommet AM, Ann Rech Vet 1988 19 65 67
25. Evolution de l'infection de la souris par Brucella abortus, Brucella melitensis et Brucella suis vers l'état chronique et la guérison. Bosseray N, Plommet M, De Rycke J, Ann Rech Vet 1982 13 153 161 in French
26. Development of spleenic infection in the mouse following intravenous inoculation of various species of Brucella in smooth (S) or rough (R) phases. Pardon P, C R Acad Sci Hebd Seances Acad Sci D 1975 281 81 84
27. Effect of polyadenine: polyuridine on brucellosis in conventional and congenitally athymic mice. Cheers C, Cone RE, J Immunol 1974 112 1535 1539
28. Prophylaxis or treatment of experimental brucellosis with interleukin-1. Zhan YF, Stanley ER, Cheers C, Infect Immun 1991 59 1790 1794
29. Resistance of Brucella abortus infected mice to intravenous or intraperitoneal Brucella reinfection. Pardon P, Marly J, Ann Immunol Inst Pasteur 1976 127C 57 70
30. Outcome and immune responses after Brucella abortus infection in young adult and aged mice. High KP, Prasad R, Marion CR, Schurig GG, Boyle SM, Sriranganathan N, Biogerontology 2007 8 583 593 (Pubitemid 47365346)
31. Jiménez De Bagüés MP, González-Carrerá MI, García-Lobo JM, Blasco JM, Agüero J: The defect in the metabolism of erythritol of the Brucella abortus B19 vaccine strain is unrelated with its attenuated virulence in mice. Sangari FJ, Grillá MJ, Vaccine 1988 16 1640 1645
32. Brucella melitensis Rev 1 living attenuated vaccine: stability of markers, residual virulence and immunogenicity in mice. Bosseray N, Biologicals 1991 19 355 363
33. In vitro markers and biological activity in mice of seed lot strains and commercial Brucella melitensis Rev1 and Brucella abortus B19 vaccines. Grillá MJ, Bosseray N, Blasco JM, Biologicals 2000 28 119 127
34. Evaluation of Brucella abortus S19 vaccine strains by bacteriological tests, molecular analysis of ery loci and virulence in BALB/c mice. Mukherjee F, Jain J, Grillá MJ, Blasco JM, Nair M, Biologicals 2005 33 153 160 (Pubitemid 41208094)
35. Comparison of living and nonliving vaccines for Brucella abortus in BALB/c mice. Montaraz JA, Winter AJ, Infect Immun 1986 53 245 251 (Pubitemid 16073848)
36. Evaluation of protection afforded by Brucella abortus and Brucella melitensis unmarked deletion mutants exhibiting different rates of clearance in BALB/c mice. Kahl-McDonagh MM, Ficht TA, Infect Immun 2006 74 4048 4057 (Pubitemid 43993337)
37. BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence. Manterola L, Guzmán-Verri C, Chaves-Olarte E, Barquero-Calvo E, de Miguel MJ, Moriyán I, Grillá MJ, Lápez-Gõi I, Moreno E, Infect Immun 2007 75 4867 4874 (Pubitemid 47502157)
38. Brucella abortus nicotinamidase (PncA) contributes to its intracellular replication and infectivity in mice. Kim S, Kurokawa D, Watanabe K, Makino S, Shirahata T, Watarai M, FEMS Microbiol Lett 2004 234 289 295 (Pubitemid 38595645)
39. Resistance and susceptibility of mice to bacterial infection IV Genetic and cellular basis of resistance to chronic infection with Brucella abortus. Ho M, Cheers C, J Infect Dis 1982 146 381 387 (Pubitemid 12031215)
40. Immunologic, histopathologic, and bacteriologic responses of five strains of mice to Brucella abortus strain 2308. Pugh GW, Zehr ES, Meador VP, Phillips M, McDonald TJ, Deyoe BL, Am J Vet Res 1989 50 323 328
41. Genetic factors involved in murine resistance to experimental brucellosis. Cannat A, Serre A, Dev Biol Stand 1984 56 307 313
42. Genetic factors involved in murine susceptibility to experimental brucellosis. Cannat A, Serre A, Ann Immunol 1981 132D 15 24 (Pubitemid 12207769)
43. Nramp1 is not a major determinant in the control of Brucella melitensis infection in mice. Guilloteau LA, Dornand J, Gross A, Olivier M, Cortade F, Vern YL, Kerboeuf D, Infect Immun 2003 71 621 628 (Pubitemid 36150753)
44. MyD88-dependent activation of B220-CD11b+LY-6C+dendritic cells during Brucella melitensis infection. Copin R, De Baetselier P, Carlier Y, Letesson JJ, Muraille E, J Immunol 2007 178 5182 5191 (Pubitemid 46595302)
45. Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection. Macedo GC, Magnani DM, Carvalho NB, Bruna-Romero O, Gazzinelli RT, Oliveira SC, J Immunol 2008 180 1080 1087
46. Role of TLRs in Brucella mediated murine DC activation in vitro and clearance of pulmonary infection in vivo. Surendran N, Hiltbold EM, Heid B, Akira S, Standiford TJ, Sriranganathan N, Boyle SM, Zimmerman KL, Makris MR, Witonsky SG, Vaccine 2012 30 1502 1512
47. Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice. Campos MA, Rosinha GM, Almeida IC, Salgueiro XS, Jarvis BW, Splitter GA, Qureshi N, Bruna-Romero O, Gazzinelli RT, Oliveira SC, Infect Immun 2004 72 176 186 (Pubitemid 38018175)
48. Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection. Barquero-Calvo E, Chaves-Olarte E, Weiss DS, Guzmán-Verri C, Chacán-Díaz C, Rucavado A, Moriyán I, Moreno E, PLoS One 2007 2 631
49. Duration of strain 2308 infection and immunogenicity of Brucella abortus lipopolysaccharide in five strains of mice. Phillips M, Pugh GW, Deyoe BL, Am J Vet Res 1989 50 318 322 50
50. MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus. Weiss DS, Takeda K, Akira S, Zychlinsky A, Moreno E, Infect Immun 2005 73 5137 5143 (Pubitemid 41105672)
51. Nucleotide-binding oligomerization domain-1 and 2 play no role in controlling Brucella abortus infection in mice. Oliveira FS, Carvalho NB, Zamboni DS, Oliveira SC, Clin Dev Immunol 2012 2012 861426
52. Interleukin-1 receptor-associated kinase 4 is essential for initial host control of Brucella abortus infection. Oliveira FS, Carvalho NB, Brandão AP, Gomes MT, de Almeida LA, Oliveira SC, Infect Immun 2011 79 4688 4695
53. Virulence criteria for Brucella abortus strains as determined by interferon regulatory factor 1-deficient mice. Ko J, Gendron-Fitzpatrick A, Ficht TA, Splitter GA, Infect Immun 2002 70 7004 7012 (Pubitemid 35387936)
54. Mice lacking components of adaptive immunity show increased Brucella abortus virB mutant colonization. Rolán HG, Tsolis RM, Infect Immun 2007 75 2965 2973 (Pubitemid 46870179)
55. B cell-deficient mice display markedly enhanced resistance to the intracellular bacterium Brucella abortus. Goenka R, Parent MA, Elzer PH, Baldwin CL, J Infect Dis 2011 203 1136 1146
56. A Splitter G: CD8+ type 1 CD44hi CD45 RBlo T lymphocytes control intracellular Brucella abortus infection as demonstrated in major histocompatibility complex class I- and class II-deficient mice. Oliveira SC, Eur J Immunol 1995 25 2551 2557
57. Interferon-gamma is crucial for surviving a Brucella abortus infection in both resistant C57BL/6 and susceptible BALB/c mice. Murphy EA, Sathiyaseelan J, Parent MA, Zou B, Baldwin CL, Immunology 2001 103 511 518 (Pubitemid 32744399)
58. Host susceptibility to Brucella abortus infection is more pronounced in IFN- knockout than IL-12/2-microglobulin double-deficient mice. Brandão AP, Oliveira FS, Carvalho NB, Vieira LQ, Azevedo V, Macedo GC, Oliveira SC, Clin Dev Immunol 2012 2012 589494
59. Persistence of Brucella abortus in the livers of T cell-deficient nude mice. Cheville NF, Kunkle RA, Jensen AE, Palmer MV, Lab Invest 1995 73 96 102
60. Murine and bovine T cells enhance innate immunity against Brucella abortus infections. Skyberg JA, Thornburg T, Rollins M, Huarte E, Jutila MA, Pascual DW, PLoS One 2011 6 21978
61. Brucella requires a functional Type IV secretion system to elicit innate immune responses in mice. Roux CM, Rolán HG, Santos RL, Beremand PD, Thomas TL, Adams LG, Tsolis RM, Cell Microbiol 2007 9 1851 1869 (Pubitemid 46958808)
62. MyD88 and STING signaling pathways are required for IRF3-mediated IFN- induction in response to Brucella abortus infection. de Almeida LA, Carvalho NB, Oliveira FS, Lacerda TL, Vasconcelos AC, Nogueira L, Bafica A, Silva AM, Oliveira SC, PLoS One 2011 6 23135
63. Control of IL-12 and IFN-gamma production in response to live or dead bacteria by TNF and other factors. Zhan Y, Cheers C, J Immunol 1998 161 1447 1453 (Pubitemid 28380576)
64. Comparative histopathology in BALB/c mice infected with virulent and attenuated strains of Brucella abortus. Enright FM, Araya LN, Elzer PH, Rowe GE, Winter AJ, Vet Immunol Immunopathol 1990 26 171 182 (Pubitemid 20328089)
65. Delayed type hypersensitivity-associated disruption of splenic periarteriolar lymphatic sheaths coincides with temporary loss of IFN-gamma production and impaired eradication of bacteria in Brucella abortus-infected mice. Hort GM, Weisenburger J, Borsdorf B, Peters C, Banai M, Hahn H, Jacob J, Mielke ME, Microbes Infect 2003 5 95 106 (Pubitemid 36316051)
66. Host immune responses to the intracellular bacteria Brucella: does the bacteria instruct the host to facilitate chronic infection? Baldwin CL, Goenka R, Crit Rev Immunol 2006 26 407 442 (Pubitemid 44785489)
67. Comparison of immune responses and resistance to brucellosis in mice vaccinated with Brucella abortus 19 or RB51. Stevens MG, Olsen SC, Pugh GW, Brees D, Infect Immun 1995 63 264 270
68. Increases of efficacy as vaccine against Brucella abortus infection in mice by simultaneous inoculation with avirulent smooth bvrS/bvrR and rough wbkA mutants. Grillá MJ, Manterola L, de Miguel MJ, Mũoz PM, Blasco JM, Moriyán I, Lápez-Gõi I, Vaccine 2006 24 2910 2916
69. Charting A New Course in Tissue Analysis http://www.flagshipbio.com/ uncategorized/the-spleen-the-whole-spleen-and-nothing-but-the-spleen/
70. Genomic island 2 is an unstable genetic element contributing to Brucella lipopolysaccharide spontaneous smooth-to-rough dissociation. Mancilla M, Lápez-Gõi I, Moriyán I, Zárraga AM, J Bacteriol 2010 192 6346 6351
71. DeltaznuADeltapurE Brucella abortus 2308 mutant as a live vaccine candidate. Yang X, Thornburg T, Walters N, Pascual DW, Vaccine 2010 28 1069 1074
72. Protection of BALB/c mice against homologous and heterologous species of Brucella by rough strain vaccines derived from Brucella melitensis and Brucella suis biovar 4. Winter AJ, Schurig GG, Boyle SM, Sriranganathan N, Bevins JS, Enright FM, Elzer PH, Kopec JD, Am J Vet Res 1996 57 677 683 (Pubitemid 26173285)
73. Lipopolysaccharide-deficient Brucella variants arise spontaneously during infection. Turse JE, Pei J, Ficht TA, Front Microbiol 2011 2 54
74. Colonization of mouse placentas by Brucella abortus inoculated during pregnancy. Bosseray N, Br J Exp Pathol 1980 61 361 368 (Pubitemid 10024397)
75. Brucella suis S2, Brucella melitensis Rev 1 and Brucella abortus S19 living vaccines: residual virulence and immunity induced against three Brucella species challenge strains in mice. Bosseray N, Plommet M, Vaccine 1990 8 462 468 (Pubitemid 20332855)
76. Temporal analysis of pathogenic events in virulent and avirulent Brucella melitensis infections. Rajashekara G, Glover DA, Krepps M, Splitter GA, Cell Microbiol 2005 7 1459 1473 (Pubitemid 41335249)
77. Pathology of striped dolphins (Stenella coeruleoalba) infected with Brucella ceti. González-Barrientos R, Morales JA, Hernández-Mora G, Barquero-Calvo E, Guzmán-Verri C, Chaves-Olarte E, Moreno E, J Comp Pathol 2010 142 347 352
78. Brucella abortus-associated meningitis in aborted bovine fetuses. Hong CB, Donahue JM, Giles RC, Poonacha KB, Tuttle PA, Cheville NF, Vet Pathol 1991 28 492 496
79. Clinical categories of neurobrucellosis a report on 19 cases. Shakir RA, Al-Din AS, Araj GF, Lulu AR, Mousa AR, Saadah MA, Brain 1987 110 213 223 (Pubitemid 17011345)
80. Immunization against Brucella infections: immune response of mice, guinea pigs, and Cynomolgus philipinensis to live and killed Brucella melitensis strain Rev I administered by various methods. Chen TH, Elberg SS, J Infect Dis 1970 122 489 500
81. Evaluation of vaccines and of antigen therapy in a mouse model for Brucella ovis. Jiménez-de-Bagüés MP, Marín CM, Barberán M, Blasco JM, Vaccine 1993 11 61 66 (Pubitemid 23080730)
82. Resistance against a subcutaneous Brucella challenge of mice immunized with living or dead Brucella or by transfer of immune serum. Pardon P, Ann Immunol Inst Pasteur 1977 128C 1025 1037 (Pubitemid 8221956)
83. Levolution de la brucellose chronique de la souris nest pas améliorée par Iadministration dun antigène vaccinal. Plommet M, Plommet AM, Bosseray N, Ann Rech Vet 1982 13 127 132 (Pubitemid 13156723)
84. Immune serum-mediated effects on brucellosis evolution in mice Infect Immun. Plommet M, Plommet AM, Infect Immun 1983 41 97 105 (Pubitemid 13063024)
85. Rough mutants defective in core and O-polysaccharide synthesis and export induce antibodies reacting in an indirect ELISA with smooth lipopolysaccharide and are less effective than Rev1 vaccine against Brucella melitensis infection of sheep. Barrio MB, Grillá MJ, Mũoz PM, Jacques I, González D, de Miguel MJ, Marín CM, Barberán M, Letesson JJ, Gorvel JP, Moriyán I, Blasco JM, Zygmunt MS, Vaccine 2009 27 1741 1749
86. Aerosol infection of BALB/c mice with Brucella melitensis and Brucella abortus and protective efficacy against aerosol challenge. Kahl-McDonagh MM, Arenas-Gamboa AM, Ficht TA, Infect Immun 2007 75 4923 4932 (Pubitemid 47502164)
87. Development and characterization of mouse models of infection with aerosolized Brucella melitensis and Brucella suis. Smither SJ, Perkins SD, Davies C, Stagg AJ, Nelson M, Atkins HS, Clin Vaccine Immunol 2009 16 779 783
88. Bacteriologic and histologic features in mice after intranasal inoculation of Brucella melitensis. Mense MG, Van De Verg LL, Bhattacharjee AK, Garrett JL, Hart JA, Lindler LE, Hadfield TL, Hoover DL, Am J Vet Res 2001 62 398 405 (Pubitemid 33605599)
89. Pathogenesis of placentitis in the goat inoculated with Brucella abortus I Gross and histologic lesions. Anderson TD, Meador VP, Cheville NF, Vet Pathol 1986 23 219 226
90. A bile salt hydrolase of Brucella abortus contributes to the establishment of a successful infection through the oral route in mice. Delpino MV, Marchesini MI, Estein SM, Comerci DJ, Cassataro J, Fossati CA, Baldi PC, Infect Immun 2007 75 299 305 (Pubitemid 46047905)
91. Establishment of systemic Brucella melitensis infection through the digestive tract requires urease, the type IV secretion system, and lipopolysaccharide O antigen. Paixão TA, Roux CM, den Hartigh AB, Sankaran-Walters S, Dandekar S, Santos RL, Tsolis RM, Infect Immun 2009 77 4197 4208
92. Brucella abortus RB51 induces protection in mice orally infected with the virulent strain B abortus 2308. Pasquali P, Rosanna A, Pistoia C, Petrucci P, Ciuchini F, Infect Immun 2003 71 2326 2330 (Pubitemid 36519842)
93. Brucella abortus in Puerto Rico. Morales-Otero P, J Pub Health Trop Med 1930 6 3 22
94. Is Brucella an enteric pathogen? Gorvel JP, Moreno E, Moriyán I, Nat Rev Microbiol 2009 7 250
95. Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1. Salcedo SP, Marchesini MI, Lelouard H, Fugier E, Jolly G, Balor S, Muller A, Lapaque N, Demaria O, Alexopoulou L, Comerci DJ, Ugalde RA, Pierre P, Gorvel JP, PLoS Pathog 2008 4 21
96. T cell regulation of the thymus-independent antibody response to trinitrophenylated-Brucella abortus (TNP-BA). Tanay A, Strober S, J Immunol 1985 134 3669 3674 (Pubitemid 15034371)
97. Proposed general method of controlling the activity of Brucella vaccines. Plommet M, Bosseray N, Dev Biol Stand 1984 56 247 255 (Pubitemid 14041378)
98. Vaccination with Brucella abortus rough mutant RB51 protects BALB/c mice against virulent strains of Brucella abortus, Brucella melitensis, and Brucella ovis. Jiménez-de-Bagüés MP, Elzer PH, Jones SM, Blasco JM, Enright FM, Schurig GG, Winter AJ, Infect Immun 1994 62 4990 4996 (Pubitemid 24332806)
99. Experimental studies with four species of Brucella in selected wildlife, laboratory, and domestic animals Am. Thorpe BD, Sidwell RW, Lundgren DL, J Trop Med Hyg 1967 16 665 674
100. Resistance and susceptibility of mice to bacterial infection. IV. Functional specificity in natural resistance to facultative intacellular bacteria. Cheers C, Ho M, J Reticuloendothel Soc 1983 34 299 309 (Pubitemid 14249468)
101. Fundamentals of host immune response against Brucella abortus: what the mouse model has revealed about control of infection. Baldwin CL, Parent M, Vet Microbiol 2002 90 367 382 (Pubitemid 35279890)
102. Growth of Brucella abortus in macrophages from resistant and susceptible mouse strains. Sathiyaseelan J, Jiang X, Baldwin CL, Clin Exp Immunol 2000 121 289 294 (Pubitemid 30659767)
103. Host cellular immune responses against Brucella spp evaluated using the mouse model. Baldwin CL, Goenka R, Brucella: Molecular and Cellular Biology Horizon Scientific Press, United Kindom, Lápez-Gõi I, Moriyán I, 2004 287 312
104. The Ity/Lsh/Bcglocus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. Vidal S, Tremblay ML, Govoni G, Gauthier S, Sebastiani G, Malo D, Skamene E, Olivier M, Jothy S, Gros P, J Exp Med 1995 182 655 666
105. Induction of immune and adjuvant immunoglobulin G responses in mice by Brucella lipopolysaccharide. Moreno E, Kurtz RS, Berman DT, Infect Immun 1984 46 74 80 (Pubitemid 14047198)
106. Protective action of monospecific anti-Brucella sera in mice. Sulitzeanu D, Jones L, Stableforth AW, Nature 1955 175 1040 1041
107. Temporal development of protective cell-mediated and humoral immunity in BALB/c mice infected with Brucella abortus. Araya LN, Elzer PH, Rowe GE, Enright FM, Winter AJ, J Immunol 1989 143 3330 3337 (Pubitemid 20010164)
108. Humoral immunity in mice mediated by monoclonal antibodies against the A and M antigens of Brucella. Limet JN, Bosseray N, Garin-Bastuji B, Dubray G, Plommet M, J Med Microbiol 1989 30 37 43 (Pubitemid 19233548)
109. Protection conferred on mice by monoclonal antibodies directed against outer-membrane-protein antigens of Brucella. Cloeckaert A, Jacques I, Bosseray N, Limet JN, Bowden R, Dubray G, Plommet M, J Med Microbiol 1991 34 175 180
110. Protection against Brucella melitensis or Brucella abortus in mice with immunoglobulin G (IgG), IgA, and IgM monoclonal antibodies specific for a common epitope shared by the Brucella A and M smooth lipopolysaccharides. Cloeckaert A, Jacques I, de Wergifosse P, Dubray G, Limet JN, Infect Immun 1992 60 312 315
111. In vivo and in vitro effects of monoclonal antibody to Ly antigens on immunity to infection. Pavlov H, Hogarth M, McKenzie IF, Cheers C, Cell Immunol 1982 71 127 138 (Pubitemid 12032752)
112. Cheers C Endogenous gamma interferon mediates resistance to Brucella abortus infection. Zhan Y, Infect Immun 1993 61 4899 4901 (Pubitemid 23320553)
113. Tabatabai LB: Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice. Stevens MG, Pugh GW, Infect Immun 1992 60 4407 4409
114. Treatment of Brucella-susceptible mice with IL-12 increases primary and secondary immunity. Sathiyaseelan J, Goenka R, Parent M, Benson RM, Murphy EA, Fernandes DM, Foulkes AS, Baldwin CL, Cell Immunol 2006 243 1 9 (Pubitemid 46275613)
115. Effect of Brucella abortus transfer factor in preventing murine brucellosis. Stevens MG, G Pugh W, FEMS Immunol Med Microbiol 1995 11 279 284
116. Lack of a role for natural killer cells in early control of Brucella abortus 2308 infections in mice. Fernandes DM, Benson R, Baldwin CL, Infect Immun 1995 63 4029 4033
117. Polyadenylic acid-polyuridylic acid (poly A:U) and experimental murine brucellosis I Effect of single and double-stranded polynucleotides on Brucella abortus in vivo and in vitro. Madraso ED, Cheers C, Immunology 1978 35 69 76 (Pubitemid 8377704)
118. Immune control of Brucella abortus 2308 infections in BALB/c mice. Murphy EA, Parent M, Sathiyaseelan J, Jiang X, Baldwin CL, FEMS Immunol Med Microbiol 2001 32 85 88 (Pubitemid 34025079)
119. T cell subsets in granulomatous inflammation and immunity to L monocytogenes and B abortus. Mielke ME, Behring Inst Mitt 1991 88 99 111
120. CD4+CD25+ T regulatory cells limit effector T cells and favor the progression of brucellosis in BALB/c mice. Pasquali P, Thornton AM, Vendetti S, Pistoia C, Petrucci P, Tarantino M, Pesciaroli M, Ruggeri F, Battistoni A, Shevach EM, J Clin Microbiol 2010 48 3806 3809
121. Interleukin-10 downregulates protective immunity to Brucella abortus. Fernandes DM, Baldwin CL, Infect Immun 1995 63 1130 1133
122. Comparison of T cell cytokines in resistant and susceptible mice infected with virulent Brucella abortus strain 2308 FEMS. Fernandes DM, Jiangn X, Jung JH, Baldwin CL, Immunol Med Microbiol 1996 16 193 203 (Pubitemid 27041955)
123. Endogenous interleukin-12 is involved in resistance to Brucella abortus infection. Zhan Y, Cheers C, Infect Immun 1995 63 1387 1390
124. Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms. Zhan Y, Liu Z, Cheers C, Infect Immun 1996 64 2782 2786 (Pubitemid 26226846)
125. The differential interaction of Brucella and Ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens. Barquero-Calvo E, Conde-Alvarez R, Chacán-Díaz C, Quesada-Lobo L, Martirosyan A, Guzmán-Verri C, Iriarte M, Mancek-Keber M, Jerala R, Gorvel JP, Moriyán I, Moreno E, Chaves-Olarte E, Plos One 2009 4 5893
126. Natural antibody contributes to host defense against an attenuated Brucella abortus virB mutant. Rolán HG, Xavier MN, Santos RL, Tsolis RM, Infect Immun 2009 77 3004 3013
127. Kinetics of placental colonization of mice inoculated intravenously with Brucella abortus at day 15 of pregnancy. Bosseray N, Br J Exp Pathol 1983 64 612 616 (Pubitemid 14176435)
128. A study on the use of male animal models for developing a live vaccine for brucellosis. Izadjoo MJ, Mense MG, Bhattacharjee AK, Hadfield TL, Crawford RM, Hoover DL, Transbound Emerg Dis 2008 55 145 151 (Pubitemid 351530884)
129. Brucellosis in 418 patients from the Balkan Peninsula: exposure-related differences in clinical manifestations, laboratory test results, and therapy outcome. Bosilkovski M, Krteva L, Dimzova M, Kondova I, Int J Infect Dis 2007 11 342 347 (Pubitemid 46994762)
130. Pathogenesis of bovine brucellosis. Carvalho-Neta AV, Mol P, Xavier MN, Paixão A, Lage AP, Santos RL, Vet J 2010 184 146 155
131. Brucellose bovine experimentale 3 Excretion vaginale de Brucella abortus. Philippon A, Renoux G, Plommet M, Ann Rech Vet 1970 1 215 224
132. Mother to young transmission of Brucella abortus infection in mouse model. Bosseray N, Ann Rech Vet 1982 13 341 349
133. Serum- and cell-mediated immune protection of mouse placenta and fetus against a Brucella abortus challenge: expression of barrier effect of placenta. Bosseray N, Plommet M, Placenta 1988 9 65 79 (Pubitemid 18066115)
134. Evaluation of the Sprague-Dawley rat as a model for vertical transmission of Brucella abortus. Baek BK, Lee BO, Hur J, Rahman MS, Lee SI, Kakoma I, Can J Vet Res 2005 69 305 308 (Pubitemid 41723358)
135. Interferon-gamma promotes abortion due to Brucella infection in pregnant mice. Kim S, Lee DS, Watanabe K, Furuoka H, Suzuki H, Watarai M, BMC Microbiol 2005 5 22
136. Some aspects of experimental bovine brucellosis. Fensterbank R, Ann Rech Vet 1987 18 421 428
137. Regulated upon activation normal T-cell expressed and secreted (RANTES) contributes to abortion caused by Brucella abortus infection in pregnant mice. Watanabe K, Iwai N, Tachibana M, Furuoka H, Suzuki H, Watarai M, J Vet Med Sci 2008 70 681 686
138. Endogenous gamma interferon and interleukin-10 in Brucella abortus 2308 infection in mice. Fernández-Lago L, Monte M, Chordi A, FEMS Immunol Med Microbiol 1996 15 109 114 (Pubitemid 26292706)
139. Immunization with attenuated Salmonella typhimurium producing catalase in protection against gastric. Chen M, Chen J, Liao W, Zhu S, Yu J, Leung WK, Hu P, Sung JJ, Helicobacter 2003 8 613 625 (Pubitemid 37553436)
140. Evaluation of the role of LcrV-Toll-like receptor 2-mediated immunomodulation in the virulence of Yersinia pestis. Pouliot K, Pan N, Wang S, Lu S, Lien E, Goguen JD, Infect Immun 2007 75 3571 3580 (Pubitemid 47040960)
141. Comparative study of gamma interferon production in mice immunized with outer membrane proteins and whole bacteria of Brucella abortus. Cha SB, Rayamajhi N, Kang ML, Lee WJ, Shin MK, Yoo HS, Jpn J Infect Dis 2010 63 49 51
142. Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium. Koebernick H, Grode L, David JR, Rohde W, Rolph MS, Mittrücker HW, Kaufmann SH, Proc Natl Acad Sci U SA 2002 99 13681 13686 (Pubitemid 35215441)
143. BALB/c mice infected with Brucella abortus express protrected polyclonal responses of both IgG2a and IgG3 isotypes. Elzer PH, Jacobson RH, Nielsen KH, Douglas JT, Winter AJ, Immunol Lett 1994 42 145 150 (Pubitemid 24378124)
144. Reduced interleukin-18 secretion in Brucella abortus 2308-infected murine peritoneal macrophages and in spleen cells obtained from B abortus 2308- infected mice. Fernández-Lago L, Ordũa A, Vizcaíno N, J Med Microbiol 2005 54 527 531 (Pubitemid 40791848)
145. Placental pathology of the pregnant mouse inoculated with Brucella abortus strain 2308. Tobias L, Cordes DO, Schurig GG, Vet Pathol 1993 30 119 129
146. Recruitment of dendritic cells to pathological niches in inflamed liver. Yoneyama H, Ichida T, Med Mol Morphol 2005 38 136 141 (Pubitemid 351543870)
147. Morphometric and histopathologic analysis of lymphoid depletion in murine spleens following infection with Brucella abortus strains 2308 or RB51 or an htrA deletion mutant. Palmer V, Cheville F, Tatum M, Vet Pathol 1996 33 282 289
148. Differential secretion of interleukin-12 (IL-12) subunits and heterodimeric IL-12p70 protein by CD-1 mice and murine macrophages in response to intracellular infection by Brucella abortus. Fernández-Lago L, Rodríguez-Tarazona E, Vizcaíno N, J Med Microbiol 1999 48 1065 1073
149. Interleukin-6 production during chronic experimental infection Immunol. Saunders BM, Liu Z, Zhan Y, Cheers C, Cell Biol 1993 71 275 280 (Pubitemid 23253518)
150. Mouse cytokine profiles associated with Brucella abortus RB51 vaccination or B. abortus 2308 infection. Pasquali P, Adone R, Gasbarre LC, Pistoia C, Ciuchini F, Infect Immun 2001 69 6541 6544 (Pubitemid 32885224)
151. Differential activation of Brucella-reactive CD4+ T cells by Brucella infection or immunization with antigenic extracts. Zhan Y, Kelso A, Cheers C, Infect Immun 1995 63 969 975
152. Lymphocyte proliferation in response to Brucella abortus 2308 or RB51 antigens in mice infected with strain 2308, RB51, or 19. Stevens MG, Olsen SC, Pugh GW, Infect Immun 1994 62 4659 4663 (Pubitemid 24302008)
153. The immunological basis of acquired cellular resistance. Mackaness GB, J Exp Med 1964 120 105 120
154. Expression of heme oxygenase-1 is associated with abortion caused by Brucella abortus infection in pregnant mice. Tachibana M, Watanabe K, Yamasaki Y, Suzuki H, Watarai M, Microb Pathog 2008 45 105 109
155. Frequent exposure of mice to crude Brucella abortus proteins down-regulates immune response. Õate A, Andrews E, Beltran A, Eller G, Schurig G, Folch H, J Vet Med B Infect Dis Vet Public Health 2000 47 677 682
156. IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses. Finkelman FD, Katona IM, Mosmann TR, Coffman RL, J Immunol 1988 140 1022 1027 (Pubitemid 18088561)
157. Influence of endotoxin-protein in immunoglobulin G isotype responses of mice to Brucella abortus lipopolysaccharide. Kurtz S, Berman DT, Infect Immun 1986 54 728 734 (Pubitemid 17186443)
158. Therapeutic effects of rifampin and erythromycin in experimental murine brucellosis. Felek S, Demirdag K, Kalkan A, Akbulut A, Clin Microbiol Infect 2000 6 111 114 (Pubitemid 36267453)
159. Antibiotic treatment induces an increase of the specific antibody levels in Brucella melitensis infected mice. Domingo S, Díaz R, Gamazo C, FEMS Immunol Med Microbiol 1995 12 91 95
160. Nondividing but metabolically active gamma-irradiated Brucella melitensis is protective against virulent B melitensis challenge in mice. Magnani DM, Harms JS, Durward MA, Splitter GA, Infect Immun 2009 77 5181 5189
161. Comparison of protective efficacy of subcutaneous versus intranasal immunization of mice with a Brucella melitensis lipopolysaccharide subunit vaccine. Bhattacharjee AK, Izadjoo MJ, Zollinger WD, Nikolich MP, Hoover DL, Infect Immun 2006 74 5820 5825 (Pubitemid 44484568)
162. Evaluation of particulate acellular vaccines against Brucella ovis infection in rams. Da Costa Martins R, Irache JM, Blasco JM, Mũoz MP, Marín CM, Jesús Grillá M, Jesús De Miguel M, Barberán M, Gamazo C, Vaccine 2010 28 3038 3046
163. Partial protection against Brucella infection in mice by immunization with nonpathogenic alphaproteobacteria. Delpino MV, Estein SM, Fossati CA, Baldi PC, Clin Vaccine Immunol 2007 14 1296 1301 (Pubitemid 350012971)
164. Protection of mice against Brucella abortus 544 challenge by vaccination with recombinant OMP28 adjuvanted with CpG oligonucleotides. Kaushik P, Singh DK, Kumar SV, Tiwari AK, Shukla G, Dayal S, Chaudhuri P, Vet Res Commun 2010 34 119 132
165. Tabatabai LB, Bricker BJ, Mayfield JE, Phillips M, Zehr ES, Belzer CA: Immunogenicity of Brucella-extracted and recombinant protein vaccines in CD-1 and BALB/c mice. Pugh GW, Am J Vet Res 1990 51 1413 1420
166. Comparative protection of mice against virulent and attenuated strains of Brucella abortus by passive transfer of immune T cells or serum. Araya LN, Winter AJ, Infect Immun 1990 58 254 256 (Pubitemid 20064893)
167. Control methods and thresholds of acceptability for anti-Brucella vaccines. Bosseray N, Dev Biol Stand 1992 79 121 128
168. Theoretical, practical and statistical basis for a general control method of activity for anti-Brucella vaccines. Bosseray N, Plommet AM, Plommet M, Dev Biol Stand 1984 56 257 270 (Pubitemid 14041379)
169. The Mouse Phenome Database http://phenome.jax.org/
170. REV-2: Calculation of the RT 50 for vaccines http://www.afssa.fr/interne/ rev2.html
171. The Brucella abortus S19vjbR live vaccine candidate is safer than S19 and confers protection against wild-type challenge in BALB/c mice when delivered in a sustained-release vehicle. Arenas-Gamboa AM, Ficht TA, Kahl-McDonagh MM, Gomez G, Rice-Ficht AC, Infect Immun 2009 77 877 884
172. Development and evaluation as vaccines in mice of Brucella melitensis Rev1 single and double deletion mutants of the bp26 and omp31 genes coding for antigens of diagnostic significance in ovine brucellosis. Cloeckaert A, Jacques I, Grillá MJ, Marín CM, Grayon M, Blasco JM, Verger JM, Vaccine 2004 22 2827 2835 (Pubitemid 38900661)
173. Transformation normalisant la distribution du nombre de Brucella dans la rate de souris inoculées par voie intrapéritonéale. Bosseray N, Plommet M, J Biol Stand 1976 4 341 351 in French
174. Brucellosis in Venezuela. Vargas-O FJ, Vet Microbiol 2002 90 39 44
175. Epidemiological study of Brucellosis in cattle, immunized with Brucella abortus RB51 vaccine in endemic zones. Herrera-Lápez E, Suárez-Güemes F, Hernández-Andrade L, Cárdova- Lápez D, Díaz-Aparicio E, Vaccine 2010 5 Suppl 59 F63
176. Expressions cliniques et biologiques de la Brucellose humaine. Place actuelle de l'immunotherapie. Bertrand A, Bull Soc SciVét Méd Comp 1981 83 53 57 in French
177. Macrophage activation during experimental murine brucellosis: a basis for chronic infection. Cheers C, Pagram F, Infect Immun 1979 23 197 205 (Pubitemid 9119814)
178. Recall of acquired cellular resistance in mice by antigens from killed Brucella. Halliburton BL, Hinsdill RD, Infect Immun 1972 5 42 47
179. The behavior of Brucella neotomae and Brucella suis in reciprocal superinfection experiments in mice and guinea pigs. Stoenner HG, Am J Vet Res 1963 24 376 380
180. Efficacy of ciprofloxacin versus doxycycline as prophylaxis against experimental murine Brucella melitensis infection. Atkins HS, Spencer S, Brew SD, Jenner DC, Russell P, MacMillan AP, Eley SM, Simpson AJ, Int J Antimicrob Agents 2009 34 474 476
181. Efficacy of moxifloxacin or gatifloxacin as prophylaxis against experimental murine Brucella melitensis infection. Atkins HS, Spencer S, Brew SD, Laws TR, Thirlwall RE, MacMillan AP, Brooks TJ, Simpson AJ, Int J Antimicrob Agents 2009 34 471 473
182. International Society of Chemotherapy; Institute of Continuing Medical Education of Ioannina: Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations. Ariza J, Bosilkovski M, Cascio A, Colmenero JD, Corbel MJ, Falagas ME, Memish ZA, Roushan MR, Rubinstein E, Sipsas NV, Solera J, Young EJ, Pappas G, PLoS Med 2007 4 317
183. Penetration of antibiotics into human leukocytes and dermal suction blisters. Solberg CO, Halstensen A, Digranes A, Hellum KB, Rev Infect Dis 1983 3 468 S473
184. Brucella melitensis Rev1 vaccine as a cause of human brucellosis. Blasco JM, Díaz R, Lancet 1993 342 805 (Pubitemid 23279816)
185. Efficacy of several antibiotic combinations against Brucella melitensis Rev1 experimental infection in BALB/c mice. Grillá MJ, De Miguel MJ, Mũoz PM, Marín CM, Ariza J, Blasco JM, J Antimicrob Chemother 2006 58 622 626 (Pubitemid 44288128)
186. Efficacy of oral levofloxacin and dirithromycin alone and in combination with rifampicin in the treatment of experimental murine Brucella abortus. Arda B, Tunçel M, Yaimazhan T, Gökengin D, Gürel O, Int J Antimicrob Agents 2004 23 204 207 (Pubitemid 38175404)
187. Inadequate azithromycin activity against Brucella melitensis in mice with acute or chronic infections. Doming S, Gamazo C, J Chemother 1996 8 55 58 (Pubitemid 26067069)
188. Gentamicin-loaded microspheres for treatment of experimental Brucella abortus infection in mice. Prior S, Gander B, Irache JM, Gamazo C, J Antimicrob Chemother 2005 55 1032 1036 (Pubitemid 40883195)
189. Poly(D, L-lactide-coglycolide) particles containing gentamicin: pharmacokinetics and pharmacodynamics in Brucella melitensis-infected mice. Lecaroz MC, Blanco-Prieto MJ, Campanero MA, Salman H, Gamazo C, Antimicrob Agents Chemother 2007 51 1185 1190 (Pubitemid 46586792)
190. Targeting Brucella melitensis with polymeric nanoparticles containing streptomycin and doxycycline. Seleem MN, Jain N, Pothayee N, Ranjan A, Riffle JS, Sriranganathan N, FEMS Microbiol Lett 2009 294 24 31
191. Effect of early antibiotic treatment on the antibody response to cytoplasmic proteins of Brucella melitensis in mice. Bowden RA, Racaro GC, Baldi PC, Clin Diag Lab Immunol 1999 16 440 443 (Pubitemid 29226822)
192. Serological follow-up of human brucellosis by measuring IgG antibodies directed to S-LPS and cytoplasmic proteins of Brucella. Baldi PC, Miguel SE, Fossati CA, Wallach JC, Clin Infect Dis 1996 22 446 455 (Pubitemid 26259173)
193. Brucella species synchronize their life cycle to the gestation cycle of their ruminant hosts. Bardenstein S, Banai M, The Challenge of Highly Pathogenic Microorganisms Springer Verlag, New York, Baruch Velan B, Shafferman A, Ordentlich A, 2010 135 146
194. Development of structures and transport functions in the mouse placenta. Watson ED, Cross JC, Physiology (Bethesda) 2005 20 180 193 (Pubitemid 40807056)
195. Integrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks. Huang SS, Fraenkel E, Sci Signal 2009 2 a40
196. Tizard IR, Veterinary Immunology Saunders Elsevier, Philadelphia 8 2008
197. The intramacrophagic environment of Brucella spp and their replicative niche. Jubier-Maurin V, Loisel S, Liautard JP, Köhler S, Brucella: Molecular and Cellular Biology Horizon Scientific Press, United Kindom, Lápez-Gõi I, Moriyán I, 2004 313 340
198. Rough vaccines in animal brucellosis: structural and genetic basis and present status. Moriyán I, Grillá MJ, Monreal D, González D, Marín C, Lápez-Gõi I, Mainar-Jaime RC, Moreno E, Blasco JM, Vet Res 2004 35 1 38 (Pubitemid 38380146)
199. Comparison of the efficacy of Brucella suis strain 2 and Brucella melitensis Rev. 1 live vaccines against a Brucella melitensis experimental infection in pregnant ewes. Verger JM, Grayon M, Zundel E, Lechopier P, Olivier-Bernardin V, Vaccine 1995 13 191 196
200. Using genomic data to unravel the root of the placental mammal phylogeny. Murphy WJ, Pringle TH, Crider TA, Springer MS, Miller W, Genome Res 2007 17 413 421 (Pubitemid 46556445)
201. Brucella evolution. Moreno E, Prevention of Brucellosis in Mediterranean Countries International Center for Advanced Mediterranean Agronomic Studies, Pudoc Scientific Publishers, Wageningen, Plommet M, 1992 198 218
202. Evolution and taxonomy of the genus Brucella: brucellosis of rodents. Meyer ME, Theriogenology 1976 6 263 273
203. Brucella microti sp nov, isolated from the common vole Microtus arvalis. Scholz HC, Hubalek Z, Sedlácek I, Vergnaud G, Tomaso H, Al Dahouk S, Melzer F, Kämpfer P, Neubauer H, Cloeckaert A, Maquart M, Zygmunt MS, Whatmore AM, Falsen E, Bahn P, Göllner C, Pfeffer M, Huber B, Busse HJ, Nöckler K, Int J Syst Evol Microbiol 2008 58 375 382 (Pubitemid 351298409)
204. The evolution of house mice. Boursot P, Auffray JC, Britton-Davidian J, Bonhomme F, Ann Rev Ecol Syst 1993 24 119 152