Pathogenesis of bovine brucellosis

Veterinary Journal

Volumn 184, Issue 2, 2010, Pages 146-155

  Neta, Alcina V Carvalho ^a,b   Mol, Juliana P S ^a   Xavier, Mariana N ^a   Paixão, Tatiane A ^a   Lage, Andrey P ^a   Santos, Renato L ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSIDADE ESTADUAL DO MARANHÃO   (Brazil)

Author keywords

Brucella abortus; Brucellosis; Cattle; Pathogenesis

Indexed keywords

ADAPTIVE IMMUNITY; ANTIBIOTIC RESISTANCE; BACTERIAL SURVIVAL; BRUCELLA ABORTUS; BRUCELLOSIS; CATTLE DISEASE; CELL INVASION; DIAGNOSTIC TEST; EPIDEMIC; HOST CELL; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; LABORATORY TEST; MOLECULAR DYNAMICS; NONHUMAN; PATHOGENESIS; PHAGOCYTE; PHAGOLYSOSOME; REVIEW; SEROLOGY;

ABORTION, VETERINARY; ANIMALS; BRUCELLA ABORTUS; BRUCELLOSIS, BOVINE; CATTLE; FEMALE; FETUS; IMMUNOHISTOCHEMISTRY; MALE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS;

BOS; BOVINAE; BRUCELLA; BRUCELLA MELITENSIS BIOVAR ABORTUS; NEGIBACTERIA;

EID: 77549086586     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2009.04.010     Document Type: Review

References (162)

1. Ackermann M.R., Cheville N.F., and Deyeoe B.L. Bovine ileal dome lymphoepithelial cell: endocytosis and transport of Brucella abortus strain 19. Veterinary Pathology 25 (1988) 28-35
2. Adams L.G. The pathology of brucellosis reflects the outcome of the battle between the host genome and the Brucella genome. Veterinary Microbiology 90 (2002) 553-561
3. Adams L.G., and Templeton J.W. Genetic resistance to bacterial diseases of animals. Revue Scientifique et Technique de l'Office International des Epizooties 17 (1998) 200-219
4. Allan G., Chappel R., Williamson P., and McNaught D. A quantitative comparison of the sensitivity of serological tests for bovine brucellosis to different antibody classes. Journal of Hygiene 76 (1976) 287-298
5. Allen C.A., Adams L.G., and Ficht T.A. Transposon-derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival. Infection and Immunity 66 (1998) 1008-1016
6. Anderson T.D., Meador V.P., and Cheville N.F. Pathogenesis of placentitis in the goat inoculated with Brucella abortus. I. Gross and histologic lesions. Veterinary Pathology 23 (1986) 219-226
7. Anderson T.D., Meador V.P., and Cheville N.F. Pathogenesis of placentitis in the goat inoculated with Brucella abortus. II. Ultrastructural studies. Veterinary Pathology 23 (1986) 227-239
8. Arellano-Reynoso B., Lapaque N., Salcedo S., Briones G., Ciocchini A.E., Ugalde R., Moreno E., Moriyón I., and Gorvel J.P. Cyclic beta-1, 2-glucan is a Brucella virulence factor required for intracellular survival. Nature Immunology 6 (2005) 618-625
9. Barquero-Calvo E., Chaves-Olarte E., Weiss D.S., Guzmán-Verri C., Chacón-Díaz C., Rucavado A., Moriyón I., and Moreno E. Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection. PLoS ONE 18 (2007) e.7
10. Barthel R., Feng J., Piedrahita J.A., McMurray D.N., Templeton J.W., and Adams L.G. Stable transfection of the bovine Nramp1 gene into murine RAW264.7 cells: effect on Brucella abortus survival. Infection and Immunity 69 (2001) 3110-3119
11. Beh K.J. Quantitative distribution of Brucella antibody amongst immunoglobulin classes in vaccinated and infected cattle. Research in Veterinary Science 17 (1974) 1-4
12. Billard E., Dornand J., and Gross A. Interaction of Brucella suis and Brucella abortus rough strains with human dendritic cells. Infection and Immunity 75 (2007) 5916-5923
13. Boschiroli M.L., Foulongne V., and O'Callaghan D. Brucellosis: a worldwide zoonosis. Current Opinion in Microbiology 4 (2001) 58-64
14. Boschiroli M.L., Ouahrani-Bettache S., Foulongne V., Michaux-Charachon S., Bourg G., Allardet-Servent A., Cazevieille C., Lavigne J.P., Liautard J.P., Ramuz M., and O'Callaghan D. Type IV secretion and Brucella virulence. Veterinary Microbiology 90 (2002) 341-348
15. Brew S.D., Perrett L.L., Stack J.A., Macmillan A.P., and Staunton N.J. Human exposure to Brucella recovered from a sea mammal. Veterinary Record 144 (1999) 483
16. Bricker B.J. PCR as a diagnostic tool for brucellosis. Veterinary Microbiology 90 (2002) 435-446
17. Bricker B.J., Ewalt D.R., and Halling S.M. Brucella 'HOOF-Prints': strain typing by multi-locus analysis of variable number tandem repeats (VNTRs). BMC Microbiology 3 (2003) 15
18. Briones G., Iñón de Iannino N., Roset M., Vigliocco A., Paulo P.S., and Ugalde R.A. Brucella abortus cyclic beta-1, 2-glucan mutants have reduced virulence in mice and are defective in intracellular replication in HeLa cells. Infection and Immunity 69 (2001) 4528-4535
19. Butler J., Seawright G., McGivern P., and Gilsdorf M. Preliminary evidence for a diagnostic immunoglobulin G1 antibody response among culture-positive cows vaccinated with Brucella abortus strain 19 and challenge exposed with strain 2308. American Journal of Veterinary Research 47 (1986) 1258-1264
20. Campbell G.A., Adams L.G., and Sowa B.A. Mechanism of binding of Brucella abortus to mononuclear phagocytes from cows naturally resistant or susceptible to brucellosis. Veterinary Immunology and Immunopathology 41 (1994) 295-306
21. Campbell G.A., and Adams L.G. The long-term culture of bovine monocyte-derived macrophages and their use in the study of intracellular proliferation of Brucella abortus. Veterinary Immunology and Immunopathology 34 (1992) 291-305
22. Campero C.M., Ladds P.W., Hoffmann D., Duffield B., Watson D., and Fordyce G. Immunopathology of experimental Brucella abortus strain 19 infection of the genitalia of bulls. Veterinary Immunology and Immunopathology 24 (1990) 235-246
23. Campos M.A., Rosinha G.M., Almeida I.C., Salgueiro X.S., Jarvis B.W., Splitter G.A., Qureshi N., Bruna-Romero O., Gazzinelli R.T., and Oliveira S.C. Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice. Infection and Immunity 72 (2004) 176-186
24. Carvalho Neta A.V., Steynen A.P.R., Paixão T.A., Miranda K.L., Silva F.L., Roux C.M., Tsolis R.M., Everts R.E., Lewin H.A., Adams L.G., Carvalho O.A.F., Lage A.P., and Santos R.L. Modulation of bovine trophoblastic innate immune response by Brucella abortus. Infection and Immunity 76 (2008) 1897-1907
25. Castañeda-Roldán O.U., Ahrani-Bettache S., Saldaña Z., Avelino F., Rendón M.A., Dornand J., and Girón J.A. Characterization of SP41, a surface protein of Brucella associated with adherence and invasion of host epithelial cells. Cell Microbiology 8 (2006) 1877-1887
26. Celli J. Surviving inside a macrophage: the many ways of Brucella. Research in Microbiology 157 (2006) 93-98
27. Chain P.S.G., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., and Garcia E. Whole-genome analyses of speciation events in pathogenic Brucella. Infection and Immunity 73 (2005) 8353-8361
28. Chaves-Olarte E., Guzmán-Verri C., Méresse S., Desjardins M., Pizarro-Cerdá J., Gorvel J.P., and Moreno E. Activation of Rho and Rab GTPases dissociate Brucella abortus internalization from intracellular trafficking. Cell Microbiology 4 (2002) 663-676
29. Cheville N.F., Stevens M.G., Jensen A.E., Tatum F.M., and Halling S.M. Immune responses and protection against infection and abortion in cattle experimentally vaccinated with mutant strains of Brucella abortus. American Journal of Veterinary Research 54 (1993) 1591-1597
30. Cirl C., Wieser A., Yadav M., Duerr S., Schubert S., Fischer H., Stappert D., Wantia N., Rodriguez N., Wagner H., Svanborg C., and Miethke T. Subversion of Toll-like receptor signalling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins. Nature Medicine 14 (2008) 399-406
31. Comerci D.J., Martinez-Lorenzo M.J., Sieira R., Gorvel J.P., and Ugalde R.A. Essential role of the VirB machinery in the maturation of the Brucella abortus-containing vacuole. Cell Microbiology 3 (2001) 159-168
32. Copin R., De Baetselier P., Carlier Y., Letesson J.J., and Muraille E. MyD88-dependent activation of B220-CD11b+LY-6C+ dendritic cells during Brucella melitensis infection. Journal of Immunology 178 (2007) 5182-5191
33. Corbeil L.B., Blau K., Inzana T.J., Nielsen K.H., Jacobson R.H., Corbeil R.R., and Winter A.J. Killing of Brucella abortus by bovine serum. Infection and Immunity 56 (1988) 3251-3261
34. Corbel M.J. Brucellosis: an overview. Emerging Infectious Diseases 3 (1997) 213-221
35. Crawford R.P., Huber J.D., and Adams B.S. Epidemiology and surveillance. In: Nielsen K., and Duncan J.R. (Eds). Animal Brucellosis (1990), CRC Press, Boca Raton, USA 131-151
36. Delrue R.M., Martinez-Lorenzo M., Lestrate P., Danese I., Bielarz V., Mertens P., De Bolle X., Tibor A., Gorvel J.P., and Letesson J.J. Identification of Brucella spp. genes involved in intracellular trafficking. Cell Microbiology 3 (2001) 487-497
37. Delvecchio V.G., Kapatral V., Elzer P., Patra G., and Mujer C.V. The genome of Brucella melitensis. Veterinary Microbiology 90 (2002) 587-592
38. Delvecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.J., Haselkorn R., Kyrpides N., and Overbeek R. The genome sequence of the facultative intracellular pathogen Brucella melitensis. Proceedings of the National Academy of Science of the United States of America 99 (2002) 443-448
39. Den Hartigh A.B., Sun Y.H., Van Sonder D., Heuvelmans N., Reinders M.O., Ficht T.A., and Tsolis R.M. Differential requirements for VirB1 and VirB2 during Brucella abortus infection. Infection and Immunity 72 (2004) 5143-5149
40. Den Hartigh A.B., Rolán H.G., De Jong M.F., and Tsolis R.M. VirB3 to VirB6 and VirB8 to VirB11, but not VirB7, are essential for mediating persistence of Brucella in the reticuloendothelial system. Journal of Bacteriology 190 (2008) 4427-4436
41. Detilleux P.G., Deyoe B.L., and Cheville N.F. Penetration and intracellular growth of Brucella abortus in non phagocytic cells in vitro. Infection and Immunity 58 (1990) 2320-2328
42. Detilleux P.G., Deyoe B.L., and Cheville N.F. Entry and intracellular localization of Brucella spp. in Vero cells: fluorescence and electron microscopy. Veterinary Pathology 27 (1990) 317-328
43. Dueñas A.I., Orduna A., Crespo M.S., and Garcia-Rodriguez C. Interaction of endotoxins with Toll-like receptor 4 correlates with their endotoxic potential and may explain the proinflammatory effect of Brucella spp. LPS. International Immunology 16 (2004) 1467-1475
44. Emminger A.C., and Schalm O.W. The effect of Brucella abortus on the bovine udder and its secretion. American Journal of Veterinary Research 4 (1943) 100-109
45. Enright F.M., Walker J.V., Jeffers G., and Deyoe B.L. Cellular and humoral responses of Brucella abortus-infected bovine fetuses. American. Journal of Veterinary Research 45 (1984) 424-430
46. Ewalt D.R., Payeur J.B., Rhyan J.C., and Geer P.L. Brucella suis biovar 1 in naturally infected cattle: a bacteriological, serological and histological study. Journal of Veterinary Diagnostic Investigation 9 (1997) 417-420
47. Foster G., Osterman B.S., Godfroid J., Jacques I., and Cloeckaert A. Brucella ceti sp. Nov. and Brucella pinnipedialis sp. nov. for Brucella strains with cetaceans and seals as their preferred hosts. International Journal of Systematic and Evolutionary Microbiology 57 (2007) 2688-2693
48. Garrity G.M. Bergey's Manual of Systematic Bacteriology. second ed. (2001), Springer, New York 721 pp
49. Godfroid J., and Käsbohrer A. Brucellosis in the European Union and Norway at the turn of the twenty-first century. Veterinary Microbiology 90 (2002) 135-145
50. Golding B., Scott D.E., Scharf O., Huang L.Y., Zaitseva M., Laphan C., Eller N., and Golding H. Immunity and protection against Brucella abortus. Microbes and Infection 3 (2001) 43-48
51. Gorham S.L., Enright F.M., Snider III T.G., and Roberts E.D. Morphologic lesions in Brucella abortus infected ovine fetuses. Veterinary Pathology 23 (1986) 331-332
52. Gorvel J.P., and Moreno E. Brucella intracellular life: from invasion to intracellular replication. Veterinary Microbiology 90 (2002) 281-297
53. Guzmán-Verri C., Chaves-Olarte E., Von Eichel-Streiber C., López-Goñi L., Thelestam M., Arvidson S., Gorvel J.P., and Moreno E. GTPases of the Rho subfamily are required for Brucella abortus internalization in non professional phagocytes: direct activation of CDC42. Journal of Biological Chemistry 276 (2001) 44435-44443
54. Guzmán-Verri C., Manterola L., Sola-Landa A., Parra A., Cloekaert A., Garin J., Gorvel J.P., Moriyón I., Moreno E., and Lopéz-Goñi L. The two-component system BvrR-BvrS essential for Brucella abortus virulence regulates the expression of the outer membrane proteins with counterparts in members of the Rizhobiaceae. Proceedings of the National Academy of Science of the United States of America 99 (2002) 12375-12380
55. Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.L., Kapur V., Alt D.P., and Olsen S.C. Completions of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis. Journal of Bacteriology 187 (2005) 2715-2726
56. Hartigan P. Human brucellosis: epidemiology and clinical manifestations. Irish Veterinary Journal 50 (1997) 179-180
57. Hernández-Mora G., González-Barrientos R., Morales J.A., Chaves-Olarte E., Guzmán-Verri C., Baquero-Calvo E., De-Miguel M.J., Marín C.M., Blasco J.M., and Moreno E. Neurobrucellosis in stranded dolphins, Costa Rica. Emerging Infectious Diseases 14 (2008) 1430-1433
58. Hoffmann E.M., and Houle J.J. Contradictory holes for antibody and complement in the interaction of Brucella abortus with its host. Critical Reviews in Microbiology. 21 (1995) 153-163
59. Hong C.B., Donahue J.M., Giles R.C.J.R., Poonacha K.B., Tuttle P.A., and Cheville N.F. Brucella abortus-associated meningitis in aborted bovine fetuses. Veterinary Pathology 28 (1991) 492-496
60. Hong P.C., Tsolis R.M., and Ficht T.A. Identification of genes required for chronic persistence of Brucella abortus in mice. Infection and Immunity 68 (2000) 4102-4107
61. Huang L.Y., Aliberti J., Leifer C.A., Segal D.M., Sher A., Golenbock D.T., and Golding B. Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent. Journal of Immunology 171 (2003) 1441-1446
62. Huang L.Y., Ishii K.J., Akira S., Aliberti J., and Golding B. Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering TLR9. Journal of Immunology 175 (2005) 3964-3970
63. Janeway C.A. The T-cell receptor as multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T-cell activation. Annual Review of Immunology 10 (1992) 645-674
64. Jiang X., and Baldwin C.L. Effects of cytokines on intracellular growth of Brucella abortus. Infection and Immunity 61 (1993) 124-134
65. Jiang X., Leonard B., Benson R., and Baldwin C.L. Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxide. Cellular Immunology 151 (1993) 309-319
66. Jimenez de Bagues M.P., Terraza A., Gross A., and Dornand J. Different responses of macrophages to smooth and rough Brucella spp.: relationship to virulence. Infection and Immunity 72 (2004) 2429-2433
67. Jones S.M., and Winter A.J. Survival of virulent and attenuated strains of Brucella abortus in normal and gamma interferon-activated murine peritoneal macrophages. Infection and Immunity 60 (1992) 3011-3014
68. Keleti G., Feingold D.S., and Youngner J.S. Interferon inducing in mice by lipopolysaccharide from Brucella abortus. Infection and Immunity 10 (1974) 282-283
69. Kim Y.J., Kwak C.I., Gu Y.Y., Hwang I.T., and Chun J.Y. Annealing control primer system for identification of differentially expressed genes on agarose gels. Biotechniques 36 (2004) 1-5
70. Ko J., and Splitter G.A. Molecular host-pathogen interaction in brucellosis: current understanding and future approaches to vaccine development for mice and humans. Clinical Microbiology Reviews 6 (2003) 65-78
71. Ko J., Gendron-Fitzpatrick A., Ficht T.A., and Splitter G.A. Virulence criteria for Brucella abortus strains as determined by interferon regulatory factor 1-deficient mice. Infection and Immunity 70 (2002) 7004-7012
72. Kopp E.B., and Medzhitov R. The Toll-receptor family and control of innate immunity. Current Opinion in Immunology 11 (1999) 13-18
73. Lamb V., Jones L., Shurig G., and Berman D. Enzyme linked immunosorbent assay for bovine immunoglobulin subclass-specific response to Brucella abortus lipopolysaccharides. Infection and Immunity 26 (1979) 240-247
74. Lambert G., Manthei C.A., and Deyoe B.L. Studies on Brucella abortus infection in bulls. American Journal of Veterinary Research 24 (1963) 1153-1157
75. Lapaque N., Moriyon I., Moreno E., and Gorvel J.P. Brucella lipopolysaccharide acts as a virulence factor. Current Opinion in Microbiology 8 (2005) 60-66
76. Leal-Klevezas D.S., Lopez-Merino A., and Martinez-Soriano J.P. Molecular detection of Brucella spp: rapid identification of B. abortus biovar 1 using PCR. Archives of Medical Research 26 (1995) 263-267
77. López A., Hitos F., Perez A., and Navarro-Fierro R.R. Lung lesions in bovine fetuses aborted by Brucella abortus. Canadian Journal of Comparative Medicine 48 (1984) 275-277
78. López-Goñi I., Guzmán-Verri C., Manterola L., Sola Landa A., Moriyón I., and Moreno E. Regulation of Brucella virulence by the two-component system BvrR/BvrS. Veterinary Microbiology 90 (2002) 329-339
79. Lucero N.E., Ayala S.M., Escobar G.I., and Jacob N.R. Brucella isolated in humans and animals in Latin America from 1968 to 2006. Epidemiology and Infection 136 (2008) 496-503
80. Macedo G.C., Magnani D.M., Carvalho N.B., Bruna-Romero O., Gazzinelli R.T., and Oliveira S.C. Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection. Journal of Immunology 180 (2008) 1080-1087
81. Martínez R., Dunner S., Barrera G., and Cañon J. Novel variants within the coding regions of the Slc11A1 gene identified in Bos taurus and Bos indicus breeds. Journal of Animal Breeding and Genetics 125 (2008) 57-62
82. McCaughey W.J., and Purcell D.A. Brucellosis in bull. Veterinary Record 93 (1973) 336-337
83. McDonald W.L., Jamaludin R., Mackereth G., Hansen M., Humphrey S., and Short P. Characterization of a Brucella sp. strain as a marine-mammal type despite isolation from a patient with spinal osteomyelitis in New Zealand. Journal of Clinical Microbiology 44 (2006) 4363-4367
84. Meador V.P., and Deyoe B.L. Intracellular localization of Brucella abortus in bovine placenta. Veterinary Pathology 26 (1989) 513-515
85. Meador V.P., Tabatabai L.B., Hagemoser W.A., and Deyoe B.L. Identification of Brucella abortus in formalin-fixed, paraffin-embedded tissues of cows, goats, and mice with an avidin-biotin-peroxidase complex immunoenzymatic staining technique. American Journal of Veterinary Research 47 (1986) 2147-2150
86. Meador V.P., Hagemoser W.A., and Deyoe B.L. Histopathologic findings in Brucella abortus-infected, pregnant goats. American Journal of Veterinary Research 49 (1988) 274-280
87. Meador V.P., Deyoe B.L., and Cheville N.F. Pathogenesis of Brucella abortus infection of the mammary gland and supramammary lymph node of the goat. Veterinary Pathology 26 (1989) 357-368
88. Moreno E., and Moriyón I. The genus Brucella. In: Dworking M., Falkow S., Rosemberg E., Schleifer K.H., and Stackebrandt E. (Eds). The Prokaryotes (2001), Springer, New York, USA (Electronic version)
89. Nicoletti P. The epidemiology of bovine brucellosis. Advances in Veterinary Science and Comparative Medicine 24 (1980) 69-95
90. Nielsen K. Diagnosis of brucellosis by serology. Veterinary Microbiology 90 (2002) 447-459
91. Nielsen K.H., and Ewalt D.R. Bovine Brucellosis. Office International des Epizooties. Manual of Standards for Diagnostic Tests and Vaccines (2004), Office International des Epizooties, Paris, FR pp. 328-345
92. Nielsen K., Heck F., Wagner G., Stiller J., Rosenbaum B., Pugh R., and Flores E. Comparative assessment of antibody isotypes to Brucella by primary and secondary binding assays. Preventive Veterinary Medicine 2 (1984) 197-204
93. O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L., Bourg G., Foulongne V., Frutos P., Kulakov Y., and Ramuz M. A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis. Molecular Microbiology 33 (1999) 1210-1220
94. Oliveira S.C., and Splitter G.A. CD8+ type 1 CD44hi CD45Rblo T lymphocytes control intracellular Brucella abortus infection as demonstrated in major histocompatibility complex class I and class II deficient mice. European Journal of Immunology 25 (1995) 2551-2557
95. Oliveira S.C., Harms J.S., Rech E.L., Rodarte R.S., Bocca A.L., Goes A.M., and Splitter G.A. The role of T-cell subsets and cytokines in the regulation of intracellular bacterial infection. Brazilian Journal of Medical and Biological Research 31 (1998) 77-84
96. Oliveira S.C., Soeurt N., and Splitter G.A. Molecular and cellular interactions between Brucella abortus antigens and host immune responses. Veterinary Microbiology 90 (2002) 417-424
97. Osterman B., and Moriyon I. International Committee on Systematics of Prokaryotes Subcommittee on the taxonomy of Brucella. International Journal of Systematic and Evolutionary Microbiology 56 (2006) 1173-1175
98. Ottones F., Liautard J., Gross A., Rabenoelina F., Liautard J.P., and Favero J. Activation of human Vγ9Vδ2 T-cells by a Brucella suis non-peptidic fraction impairs bacterial intracellular multiplication in monocytic infected cells. Immunology 100 (2000) 252-258
99. Paixão T.A., Ferreira C., Borges A.M., Oliveira D.A.A., Lage A.P., and Sanros R.L. Frequency of bovine Nramp1 (Slc11a1) alleles in Holstein and Zebu breeds. Veterinary Immunology and Immunopathology 109 (2006) 37-42
100. Paixão T.A., Poester F.P., Carvalho Neta A.V., Borges A.M., Lage A.P., and Santos R.L. NRAMP1 3'UTR polymorphisms are not associated with natural resistance to Brucella abortus in cattle. Infection and Immunity 75 (2007) 2493-2499
101. Pappas G., Papadimitriou P., Akritidis N., Christou L., and Tsianos E.V. The new global map of human brucellosis. Lancet Infectious Diseases 6 (2006) 91-99
102. Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayan L., Brinkac L.M., Beanan M.J., Daugherty S.C., Deboy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J., Aken S.E.V., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., and Fraser C.M. The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts. Proceedings of the National Academy of Science of the United States of America 99 (2002) 13148-13153
103. Payne J.M. The pathogenesis of experimental brucellosis in the pregnant cow. Journal of Pathology and Bacteriology 78 (1959) 447-463
104. Pei J., and Ficht T.A. Brucella abortus rough mutants are cytopathic for macrophages in culture. Infection and Immunity 72 (2004) 440-450
105. Pei J., Turse J.E., Wu Q., and Ficht T.A. Brucella abortus rough mutants induce macrophage oncosis that requires bacterial protein synthesis and direct interaction with the macrophage. Infection and Immunity 74 (2006) 2667-2675
106. Phillips M., Deyoe B.L., and Canning P.C. Protection of mice against Brucella abortus infection by inoculation with monoclonal antibodies recognizing Brucella O-antigen. American Journal of Veterinary Research 50 (1989) 2158-2161
107. Pizarro-Cerdá J., Moreno E., Sanguedolce V., Mege J.L., and Gorvel J.P. Virulent Brucella abortus prevents lysosome fusion and is distributed within autophagosome-like compartments. Infection and Immunity 66 (1998) 2387-2392
108. Pizarro-Cerdá J., Méresse S., Parton R.G., Van Der Goot G., Sola-Landa A., Lopez-Goni I., Moreno E., and Gorvel J.P. Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes. Infection and Immunity 66 (1998) 5711-5724
109. Pizarro-Cerdá J., Desjardins M., Moreno E., Akira S., and Gorvel J.P. Modulation of endocytosis in nuclear factor IL6 (-/-) macrophages is responsible for high susceptibility to intracellular bacterial infection. Journal of Immunology 162 (1999) 3519-3526
110. Pizarro-Cerdá J., Moreno E., and Gorvel J.P. Invasion and intracellular trafficking of Brucella abortus in non phagocytic cells. Review Microbes and Infection 2 (2000) 829-835
111. Poester F.P., Gonçalves V.S., and Lage A.P. Brucellosis in Brazil. Veterinary Microbiology 90 (2002) 55-62
112. Poester F.P., Samartino L.E., and Lage A.P. Diagnóstico da Brucelose Bovina. Cadernos Técnicos de Veterinária e Zootecnia 47 (2005) 13-29
113. Poester F.P., Gonçalves V.S.P., Paixão T.A., Santos R.L., Olsen S.O., Schuring G.G., and Lage A.P. Efficacy of strain RB51 vaccine in heifers against experimental brucellosis. Vaccine 24 (2006) 5327-5334
114. Porte F., Liautard J.P., and Kohler S. Early acidification of phagosomes containing Brucella suis is essential for intracellular survival in murine macrophages. Infection and Immunity 67 (1999) 4041-4047
115. Porte F., Naroeni A., Ouahrani-Bettache S., and Liautard J.P. Role of the Brucella suis lipopolysaccharide O antigen in phagosomal genesis and in inhibition of phagosome-lysosome fusion in murine macrophages. Infection and Immunity 71 (2003) 1481-1490
116. Qureshi T., Templeton J.W., and Adams L.G. Intracellular survival of Brucella abortus, Mycobacterium bovis BCG, Salmonella Dublin and Salmonella typhimurium in macrophages from cattle genetically resistant to Brucella abortus. Veterinary Immunology and Immunopathology 50 (1996) 55-65
117. Rajashekara G., Glasner J.D., Glover D.A., and Splitter G.A. Comparative whole-genome hybridization reveals genomic islands in Brucella species. Journal of Bacteriology 186 (2004) 5040-5051
118. Rankin J.E.F. Brucella abortus in bull: a study of twelve naturally-infected cases. Veterinary Record 77 (1965) 132-135
119. Ray W.C., Brown R.R., Stringfellow D.A., Schnurrenberger P.R., Scanlan C.M., and Swann A.I. Bovine brucellosis: an investigation of latency in progeny of culture-positive cows. Journal of American Veterinary Medical Association 192 (1988) 182-186
120. Renukaradhya G.J., Isloor S., and Rajasekhar M. Epidemiology, zoonotic aspects, vaccination and control/eradication of brucellosis in India. Veterinary Microbiology 90 (2002) 183-195
121. Ritting M.G., Kaufmann A., Robins A., Shaw B., Sprenger H., Gemsa D., Foulongne V., Rouot B., and Dornand J. Smooth and rough lipopolysaccharide phenotypes of Brucella induce different intracellular trafficking and cytokine/chemokine release in human monocytes. Journal of Leukocyte Biology 74 (2003) 1045-1055
122. Rock F.L., Hardiman G., Timans J.C., Kastelein R.A., and Bazan J.F. A family of human receptors structurally related to Drosophila Toll. Proceedings of the National Academy of Sciences of the United States of America 95 (1998) 588-593
123. Rogers R.J., Cook D.R., Kettlerer P.J., Baldock F.C., Blachall P.J., and Stewart S.W. An Evaluation of three serological tests for antibody to Brucella suis in pigs. Australian Veterinary Journal 66 (1989) 77-80
124. Rolán H.G., and Tsolis R.M. Mice lacking components of adaptive immunity show increased Brucella abortus virB mutant colonization. Infection and Immunity 75 (2007) 2965-2973
125. Rolán H.G., and Tsolis R.M. Inactivation of the type IV secretion system reduces the Th1 polarization of the immune response to Brucella abortus infection. Infection and Immunity 76 (2008) 3207-3213
126. Roux C.M., Rolán H.G., Santos R.L., Beremand P.D., Thomas T.L., Adams L.G., and Tsolis R.M. Brucella requires a functional Type IV secretion system to elicit innate immune responses in mice. Cell Microbiology 9 (2007) 1851-1869
127. Salcedo, S.P., Maechesini, M.I., Lelouard, H., Fugier, E., Jolly, G., Balor, S., Muller, A., Lapaque, N., Demaria, O., Alexopoulou, L., Comerci, D.J., Ugalde. R.A., Pierre, P., Gorvel, J.P., 2008. Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1. PLoS Pathogens 4 e21.
128. Salmeron I., Rodrigue-Zapata M., Salmeron O., Manzano L., Vaquer S., and Alvarez-Mon M. Impaired activity of natural killer cells in patients with acute brucellosis. Clinical Infectious Diseases 15 (1992) 764-770
129. Samartino L.E., and Enright F.M. Pathogenesis of abortion of bovine brucellosis. Comparative Immunology Microbiology and Infectious Diseases 16 (1993) 95-101
130. Samartino L.E., and Enright F.M. Brucella abortus differs in the multiplication within bovine chorioallantoic membrane explants from early and late gestation. Comparative Immunology Microbiology and Infectious Diseases 19 (1996) 55-63
131. Samartino L.E., Traux R.E., and Enright F. Invasion and replication of Brucella abortus in three different trophoblastic cell lines. Zentralblatt fur Veterinarmedizin B 41 (1994) 229-236
132. Sangari F.J., and Aguero J. Molecular basis of Brucella pathogenicity an update. Microbiology 12 (1996) 207-218
133. Santos R.L., and Baumler A.J. Cell tropism of Salmonella enterica. International Journal of Medical Microbiology 294 (2004) 225-233
134. Santos R.L., Barreto Filho J.B., Marques Júnior A.P., and Andrade J.S. Erythrophagocytosis in caprine trophoblast. Theriogenology 46 (1996) 1077-1083
135. Santos R.L., Peixoto M.T.D., Serakides R., Costa G.M., and Martins N.E. Detección de Brucella abortus (muestra B19) por el complejo inmunoenzimático avidina-biotina-peroxidasa en el testículo y en el epidídimo de bovinos inoculados experimentalmente. Archivos de Reproduccion Animal 6 (1998) 34-41
136. Santos R.L., Tsolis R.M., Bäumler A.J., and Adams L.G. Pathogenesis of Salmonella-induced enteritis: a review. Brazilian Journal of Medical and Biological Research 36 (2003) 3-12
137. Sauret J.M., and Vilissova N. Human brucellosis review. The Journal of the American Board of Family Practice 15 (2002) 401-406
138. Schlafer D.H., and Miller R.B. Female genital system. In: Maxie M.G. (Ed). Jubb, Kennedy, and Palmer's Pathology of Domestic Animals Vol.3 (2007), Elsevier, Saunders, Philadelphia, USA 429-564
139. Scholz H.C., Hubalek Z., Sedlácek I., Vergnaud G., Tomaso H., Al Dahouk S., Melzer F., Kämpfer P., Neubauer H., Cloeckaert A., Maquart M., Zygmunt M.S., Whatmore A.M., Falsen E., Bahn P., Göllner C., Pfeffer M., Huber B., Busse H.J., and Nöckler K. Brucella microti sp. nov., isolated from the common vole Microtus arvalis. International Journal of Systematic and Evolutionary Microbiology 58 (2008) 375-382
140. Schurig G.G., Roop R.M., Bagchi T., Boyle S., Buhrman D., and Sriranganathan N. Biological properties of RB51: a stable rough strain of Brucella abortus. Veterinary Microbiology 28 (1991) 171-188
141. Sieira R., Comerci D.J., Sanchez D.O., and Ugalde R.A. A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication. Journal of Bacteriology 182 (2000) 849-855
142. Sohn A.H., Probert W.S., Glaser C.A., Gupta N., Bollen A.W., Wong J.D., Grace E.M., and McDonald W.C. Human neurobrucellosis with intracerebral granuloma caused by a marine mammal Brucella spp. Emerging Infectious Diseases 9 (2003) 485-488
143. Sola-Landa A., Pizarro-Cerdá J., Griló M.J., Moreno E., Moriyón I., Blasco J.M., Gorvel J.P., and López-Goñi I. A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence. Molecular Microbiology 29 (1998) 125-138
144. Stevens M.G., Pugh Jr. G.W., and Tabatabai L.B. Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice. Infection and Immunity 60 (1992) 4407-4409
145. Sun Y.H., Den Hartigh A.B., Santos R.L., Adams L.G., and Tsolis R.M. Vir-B mediated survival of Brucella abortus in mice and macrophages is independent of a functional inducible nitric oxide synthase or macrophage NADPH oxidase in macrophages. Infection and Immunity 70 (2002) 4826-4832
146. Takeda K., and Akira S. Toll-like receptors in innate immunity. International Immunology 17 (2005) 1-14
147. Trichard C.J., Herr S., Bastianello S.S., and Roux D. Unilateral orchitis in a bull caused by Brucella abortus biotype 1. Journal of South African Veterinary Association 53 (1982) 60-62
148. Trujillo I.Z., Zavala A.N., Caceres J.G., and Miranda C.Q. Brucellosis infection. Infectious Disease Clinics of North America 8 (1994) 225-241
149. Tsolis R.M. Comparative genome analysis of the α-proteobacteria: relationships between plant and animal pathogens and host specificity. Proceedings of the National Academy of Science of the United States of America 99 (2002) 12503-12505
150. Verger J.M., Grimont F., Grimont P.A.D., and Grayon M. Brucella, a monospecific genus as shown by deoxyribonucleic acid hybridization. International Journal of Systematic Bacteriology 35 (1985) 292-295
151. Verger J., Grimont F., Grimont P.A.D., and Grayon M. Taxonomy of the genus Brucella. Annual Institute Pasteur Microbiology 138 (1987) 235-238
152. Wang M., Qureshi N., Soeurt N., and Splitter G. High levels of nitric oxide production decrease early but increase late survival of Brucella abortus in macrophages. Microbial Pathology 31 (2001) 221-230
153. Watarai M., Makino S., Michikawa M., Yanagisawa K., Murakami S., and Shirahata T. Macrophage plasma membrane cholesterol contributes to Brucella abortus infection of mice. Infection and Immunity 70 (2002) 4818-4825
154. Waterman-Storer C.M., Worthylake R.A., Liu B.P., Burridge K., and Salmon E.D. Microtubule growth activates Rac 1 to promote lamelliopodial protrusion in fibroblasts. Nature Cell Biology 1 (1999) 45-50
155. Weiss D.S., Takeda K., Akira S., Zychlinsky A., and Moreno E. MyD88, but not Toll like receptors 4 and 2, is required for efficient clearance of Brucella abortus. Infection and Immunity 73 (2005) 5137-5143
156. Wilesmith J.W. The persistence of Brucella abortus in calves: a retrospective study of heavily infected herds. Veterinary Record 103 (1978) 149-153
157. Wyckoff III J.H. Bovine T lymphocyte responses to Brucella abortus. Veterinary Microbiology 90 (2002) 395-415
158. Xavier, M.N., Paixão, T.A., Poester, F.P., Lage, A.P., Santos, R.L., in press. Pathology, immunohistochemistry, and bacteriology of tissues and milk of cows and fetuses experimentally infected with Brucella abortus. Journal of Comparative Pathology. doi:10.1016/j.jcpa.2008.10.004.
159. Young E.J. Human brucellosis. Reviews of Infectious Diseases 5 (1983) 821-842
160. Zhan Y.F., Stanley E.R., and Cheers C. Prophylaxis or treatment of experimental brucellosis with interleukin-1. Infection and Immunity 59 (1991) 1790-1794
161. Zhan Y., Yang J.L., and Cheers C. Cytokine response of T-cell subsets from Brucella abortus-infected mice to soluble Brucella proteins. Infection and Immunity 61 (1993) 2841-2847
162. Zhan Y., Liu Z., and Cheers C. Tumor necrosis factor alpha and interleukin 12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms. Infection and Immunity 64 (1996) 2782-2786