Development and evaluation as vaccines in mice of Brucella melitensis Rev.1 single and double deletion mutants of the bp26 and omp31 genes coding for antigens of diagnostic significance in ovine brucellosis

Vaccine

Volumn 22, Issue 21-22, 2004, Pages 2827-2835

  Cloeckaert, Axel ^a   Jacques, Isabelle ^a,b   Grilló, Maria Jesus ^c   Marín, Clara M ^c   Grayon, Maggy ^a   Blasco, Jose Maria ^c   Verger, Jean Michel ^a  

^a CEMAGREF   (France)

^b Institut Universitaire de Technologie   (France)

^c Instituto Agroalimentario de Aragón IA2   (Spain)

Author keywords

Mice; Mutants; Vaccination

Indexed keywords

BACTERIAL PROTEIN; BP26 PROTEIN; OMP31 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY REACTION; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BRUCELLOSIS; CONTROLLED STUDY; DELETION MUTANT; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; DRUG SCREENING; DRUG SYNTHESIS; GENE DELETION; GENETIC CODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEROLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BRUCELLA MELITENSIS; BRUCELLA VACCINE; BRUCELLOSIS; CATTLE; CATTLE DISEASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MUTATION; SEQUENCE DELETION;

EID: 3142540891     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2004.01.001     Document Type: Article

References (53)

1. Blasco JM. Brucella ovis. In: Nielsen K, Duncan JR, editors. Animal brucellosis. Boca Raton, FL: CRC Press; 1990. p. 351-78.
2. Blasco J.M. A review of the use of B. melitensis Rev.1 vaccine in adult sheep and goats. Prev. Vet. Med. 31:1997;275-283
3. Garin-Bastuji B., Blasco J.M., Grayon M., Verger J.M. Brucella melitensis infection in sheep: present and future. Vet. Res. 29:1998;255-274
4. Jimenez de Bagues M.P., Marin C.M., Blasco J.M., Moriyon I., Gamazo C. An ELISA with Brucella lipopolysaccharide antigen for the diagnosis of B. melitensis infection in sheep and for the evaluation of serological responses following subcutaneous or conjunctival B. melitensis strain Rev.1 vaccination. Vet. Microbiol. 30:1992;233-241
5. Salih-Alj Debbarh H., Cloeckaert A., Bezard G., Dubray G., Zygmunt M.S. Enzyme-linked immunosorbent assay with partially purified cytosoluble 28-kDa protein for serological differentiation between Brucella melitensis-infected and B. melitensis Rev.1-vaccinated sheep. Clin. Diagn. Lab. Immunol. 3:1996;305-308
6. Zygmunt M.S., Debbarh H.S., Cloeckaert A., Dubray G. Antibody response to Brucella melitensis outer membrane antigens in naturally infected and Rev.1 vaccinated sheep. Vet. Microbiol. 39:1994;33-46
7. Marin C.M., Moreno E., Moriyon I., Diaz R., Blasco J.M. Performance of competitive and indirect enzyme-linked immunosorbent assays, gel immunoprecipitation with native hapten polysaccharide, and standard serological tests in diagnosis of sheep brucellosis. Clin. Diagn. Lab. Immunol. 6:1999;269-272
8. Cloeckaert A., Baucheron S., Vizcaino N., Zygmunt M.S. Use of recombinant BP26 protein in serological diagnosis of Brucella melitensis infection in sheep. Clin. Diagn. Lab. Immunol. 8:2001;772-775
9. Cloeckaert A., Debbarh H.S., Zygmunt M.S., Dubray G. Production and characterisation of monoclonal antibodies to Brucella melitensis cytosoluble proteins that are able to differentiate antibody responses of infected sheep from Rev.1 vaccinated sheep. J. Med. Microbiol. 45:1996;206-213
10. Cloeckaert A., Debbarh H.S., Vizcaino N., Saman E., Dubray G., Zygmunt M.S. Cloning, nucleotide sequence, and expression of the Brucella melitensis bp26 gene coding for a protein immunogenic in infected sheep. FEMS Microbiol. Lett. 140:1996;139-144
11. Debbarh H.S., Cloeckaert A., Zygmunt M.S., Dubray G. Identification of sero-reactive Brucella melitensis cytosoluble proteins which discriminate between antibodies elicited by infection and Rev.1 vaccination in sheep. Vet. Microbiol. 44:1995;37-48
12. Lindler L.E., Hadfield T.L., Tall B.D., Snellings N.J., Rubin F.A., Van De Verg L.L., et al. Cloning of a Brucella melitensis group 3 antigen gene encoding Omp28, a protein recognized by the humoral immune response during human brucellosis. Infect. Immun. 64:1996;2490-2499
13. Rossetti O.L., Arese A.I., Boschiroli M.L., Cravero S.L. Cloning of Brucella abortus gene and characterization of expressed 26-kDa periplasmic protein: potential use for diagnosis. J. Clin. Microbiol. 34:1996;165-169
14. Debbarh H.S., Zygmunt M.S., Dubray G., Cloeckaert A. Competitive enzyme-linked immunosorbent assay using monoclonal antibodies to the Brucella melitensis BP26 protein to evaluate antibody responses in infected and B. melitensis Rev.1 vaccinated sheep. Vet. Microbiol. 53:1996;325-337
15. Boschiroli M.L., Cravero S.L., Arese A.I., Campos E., Rossetti O.L. Protection against infection in mice vaccinated with a Brucella abortus mutant. Infect. Immun. 65:1997;798-800
16. Marin C.M., Jimenez de Bagues M.P., Blasco J.M., Gamazo C., Moriyon I., Diaz R. Comparison of three serological tests for Brucella ovis infection of rams using different antigenic extracts. Vet. Rec. 125:1989;504-508
17. Vigliocco A.M., Silva Paulo P.S., Mestre J., Briones G.C., Draghi G., Tossi M., et al. Development and validation of an indirect enzyme immunoassay for detection of ovine antibody to Brucella ovis. Vet. Microbiol. 54:1997;357-368
18. Gamazo C., Winter A.J., Moriyon I., Riezu-Boj J.I., Blasco J.M., Diaz R. Comparative analyses of proteins extracted by hot saline or released spontaneously into outer membrane blebs from field strains of Brucella ovis and Brucella melitensis. Infect. Immun. 57:1989;1419-1426
19. Riezu-Boj J.I., Moriyon I., Blasco J.M., Gamazo C., Diaz R. Antibody response to Brucella ovis outer membrane proteins in ovine brucellosis. Infect. Immun. 58:1990;489-494
20. Riezu-Boj J.I., Moriyon I., Blasco J.M., Marin C.M., Diaz R. Comparison of lipopolysaccharide and outer membrane protein-lipopolysaccharide extracts in an enzyme-linked immunosorbent assay for the diagnosis of Brucella ovis infection. J. Clin. Microbiol. 23:1986;938-942
21. Vizcaino N., Cloeckaert A., Zygmunt M.S., Dubray G. Cloning, nucleotide sequence, and expression of the Brucella melitensis omp31 gene coding for an immunogenic major outer membrane protein. Infect. Immun. 64:1996;3744-3751
22. Kittelberger R., Diack D.S., Vizcaino N., Zygmunt M.S., Cloeckaert A. Characterization of an immuno-dominant antigen in Brucella ovis and evaluation of its use in an enzyme-linked immunosorbent assay. Vet. Microbiol. 59:1998;213-227
23. Kittelberger R., Hilbink F., Hansen M.F., Ross G.P., de Lisle G.W., Cloeckaert A., et al. Identification and characterization of immunodominant antigens during the course of infection with Brucella ovis. J. Vet. Diagn. Invest. 7:1995;210-218
24. Chin J.C., Pang-Turner B. Profiles of serological reactivity against cytosoluble antigens of Brucella ovis in experimentally infected rams. J. Clin. Microbiol. 28:1990;2647-2652
25. Teixeira-Gomes A.P., Cloeckaert A., Bezard G., Bowden R.A., Dubray G., Zygmunt M.S. Identification and characterization of Brucella ovis immunogenic proteins using two-dimensional electrophoresis and immunoblotting. Electrophoresis. 18:1997;1491-1497
26. Zygmunt M.S., Baucheron S., Vizcaino N., Bowden R.A., Cloeckaert A. Single-step purification and evaluation of recombinant BP26 protein for serological diagnosis of Brucella ovis infection in rams. Vet. Microbiol. 87:2002;213-220
27. Alton GG, Jones LM, Angus RD, Verger JM. Techniques for the brucellosis laboratory. Paris, France: Institut National de la Recherche Agronomique; 1988.
28. Vizcaino N., Cloeckaert A., Zygmunt M.S., Fernandez-Lago L. Molecular characterization of a Brucella species large DNA fragment deleted in Brucella abortus strains: evidence for a locus involved in the synthesis of a polysaccharide. Infect. Immun. 67:1999;2700-2712
29. Robertson G.T., Kovach M.E., Allen C.A., Ficht T.A., Roop R.M. II The Brucella abortus Lon functions as a generalized stress response protease and is required for wild-type virulence in BALB/c mice. Mol. Microbiol. 35:2000;577-588
30. Cloeckaert A., Grayon M., Grepinet O. An IS711 element downstream of the bp26 gene is a specific marker of Brucella spp. isolated from marine mammals. Clin. Diagn. Lab. Immunol. 7:2000;835-839
31. Vizcaino N., Verger J.M., Grayon M., Zygmunt M.S., Cloeckaert A. DNA polymorphism at the omp-31 locus of Brucella spp.: evidence for a large deletion in Brucella abortus, and other species-specific markers. Microbiology. 143:1997;2913-2921
32. Bowden R.A., Cloeckaert A., Zygmunt M.S., Bernard S., Dubray G. Surface exposure of outer membrane protein and lipopolysaccharide epitopes in Brucella species studied by enzyme-linked immunosorbent assay and flow cytometry. Infect. Immun. 63:1995;3945-3952
33. Cloeckaert A., de Wergifosse P., Dubray G., Limet J.N. Identification of seven surface-exposed Brucella outer membrane proteins by use of monoclonal antibodies: immunogold labeling for electron microscopy and enzyme-linked immunosorbent assay. Infect. Immun. 58:1990;3980-3987
34. Cloeckaert A., Weynants V., Godfroid J., Verger J.M., Grayon M., Zygmunt M.S. O-Polysaccharide epitopic heterogeneity at the surface of Brucella spp. studied by enzyme-linked immunosorbent assay and flow cytometry. Clin. Diagn. Lab. Immunol. 5:1998;862-870
35. Bosseray N. Brucella melitensis Rev.1 living attenuated vaccine: stability of markers, residual virulence and immunogenicity in mice. Biologicals. 19:1991;355-363
36. Grillo M.J., Bosseray N., Blasco J.M. In vitro markers and biological activity in mice of seed lot strains and commercial Brucella melitensis Rev.1 and Brucella abortus B19 vaccines. Biologicals. 28:2000;119-127
37. Bosseray N., Plommet M. Brucella suis S2 Brucella melitensis Rev.1 and Brucella abortus S19 living vaccines: residual virulence and immunity induced against three Brucella species challenge strains in mice. Vaccine. 8:1990;462-468
38. Bonet-Maury P., Jude A., Servat P. La mesure statistique de la virulence et de l'immunité Revue d'Immunol. 1:1954;21-50
39. Bosseray N., Plommet M. Transformation normalisant la distribution du nombre de Brucella dans la rate de souris inoculées par voie intrapéritoneale. J. Biol. Stand. 4:1976;341-351
40. Bowden R.A., Cloeckaert A., Zygmunt M.S., Dubray G. Outer-membrane protein- and rough lipopolysaccharide-specific monoclonal antibodies protect mice against Brucella ovis. J. Med. Microbiol. 43:1995;344-347
41. Bowden R.A., Estein S.M., Zygmunt M.S., Dubray G., Cloeckaert A. Identification of protective outer membrane antigens of Brucella ovis by passive immunization of mice with monoclonal antibodies. Microbes Infect. 2:2000;481-488
42. Estein S.M., Cassataro J., Vizcaino N., Zygmunt M.S., Cloeckaert A., Bowden R.A. The recombinant Omp31 from Brucella melitensis alone or associated with rough lipopolysaccharide induces protection against Brucella ovis infection in BALB/c mice. Microbes Infect. 5:2003;85-93
43. Cloeckaert A., Jacques I., de Wergifosse P., Dubray G., Limet J.N. Protection against Brucella melitensis or Brucella abortus in mice with immunoglobulin G (IgG), IgA, and IgM monoclonal antibodies specific for a common epitope shared by the Brucella A and M smooth lipopolysaccharides. Infect. Immun. 60:1992;312-315
44. Jacques I., Olivier-Bernardin V., Dubray G. Induction of antibody and protective responses in mice by Brucella O-polysaccharide-BSA conjugate. Vaccine. 9:1991;896-900
45. Phillips M., Deyoe B.L., Canning P.C. Protection of mice against Brucella abortus infection by inoculation with monoclonal antibodies recognizing Brucella O-antigen. Am. J. Vet. Res. 50:1989;2158-2161
46. Montaraz J.A., Winter A.J., Hunter D.M., Sowa B.A., Wu A.M., Adams L.G. Protection against Brucella abortus in mice with O-polysaccharide specific monoclonal antibodies. Infect. Immun. 51:1986;961-963
47. Winter A.J., Rowe G.E., Duncan J.R., Eis M.J., Widom J., Ganem B., et al. Effectiveness of natural and synthetic complexes of porin and O polysaccharide as vaccines against Brucella abortus in mice. Infect. Immun. 56:1988;2808-2817
48. Cloeckaert A., Zygmunt M.S., Guilloteau L.A. Brucella abortus vaccine strain RB51 produces low levels of M-like O-antigen. Vaccine. 20:2002;1820-1822
49. Schurig G.G., Roop R.M. II, Bagchi T., Boyle S., Buhrman D., Sriranganathan N. Biological properties of RB51; a stable rough strain of Brucella abortus. Vet. Microbiol. 28:1991;171-188
50. Stevens M.G., Hennager S.G., Olsen S.C., Cheville N.F. Serologic responses in diagnostic tests for brucellosis in cattle vaccinated with Brucella abortus 19 or RB51. J. Clin. Microbiol. 32:1994;1065-1066
51. Stevens M.G., Olsen S.C. Antibody responses to Brucella abortus 2308 in cattle vaccinated with B. abortus RB51. Infect. Immun. 64:1996;1030-1034
52. el Idrissi A.H., Benkirane A., el Maadoudi M., Bouslikhane M., Berrada J., Zerouali A. Comparison of the efficacy of Brucella abortus strain RB51 and Brucella melitensis Rev.1 live vaccines against experimental infection with Brucella melitensis in pregnant ewes. Rev. Sci. Tech. 20:2001;741-747
53. Jimenez de Bagues M.P., Barberan M., Marin C.M., Blasco J.M. The Brucella abortus RB51 vaccine does not confer protection against Brucella ovis in rams. Vaccine. 13:1995;301-304