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Angewandte Chemie - International Edition

Volumn 51, Issue 32, 2012, Pages 8110-8113

A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity

(10) Demmer, Oliver a,b Frank, Andreas O a,b Hagn, Franz a,b Schottelius, Margret c Marinelli, Luciana d Cosconati, Sandro e Brack Werner, Ruth f Kremb, Stephan f Wester, Hans Jürgen c Kessler, Horst a,b

a TECHNICAL UNIVERSITY OF MUNICH (Germany)

b KING ABDULAZIZ UNIVERSITY (Saudi Arabia)

c Lehrstuhl für Pharmazeutische Radiochemie (Germany)

d UNIVERSITY OF NAPLES FEDERICO II (Italy)

e SECOND UNIVERSITY OF NAPLES (Italy)

f INSTITUTE OF EPIDEMIOLOGY (Germany)

Author keywords

biological activity; drug design; medicinal chemistry; peptides; peptidomimetics

Indexed keywords

ANTI-HIV ACTIVITY; BINDING AFFINITIES; CHEMOKINE RECEPTOR CXCR4; CONFORMATIONAL FREEDOM; DRUG DESIGN; HIV-1 INFECTIONS; ITS EFFICIENCIES; MEDICINAL CHEMISTRY; NITROGEN ATOM; PEPTIDOMIMETICS; SIDE-CHAINS;

BINDING ENERGY; BIOACTIVITY; PEPTIDES;

AMINO ACIDS;

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE RECEPTOR CXCR4; CXCR4 PROTEIN, HUMAN; LIGAND; PEPTOID;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECT; DRUG POTENTIATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; HIV-1; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTOIDS; RECEPTORS, CXCR4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864753795 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201202090 Document Type: Article

Times cited : (49)

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