Insulin efficiently stores triglycerides in adipocytes by inhibiting lipolysis and repressing PGC-1α induction

Kobe Journal of Medical Sciences

Volumn 53, Issue 3, 2007, Pages 99-106

  Nishino, Naonobu ^a   Tamori, Yoshikazu ^a   Kasuga, Masato ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adipocytes; Insulin; Lipolysis; PGC ; PKA

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; HORMONE SENSITIVE LIPASE; INSULIN; PERILIPIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BIOGENESIS; CONTROLLED STUDY; ENERGY EXPENDITURE; HORMONE ACTION; LIPID STORAGE; LIPOLYSIS; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION;

3T3 CELLS; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ADIPOCYTES; ADRENERGIC BETA-AGONISTS; ANIMALS; BLOTTING, WESTERN; ENERGY METABOLISM; GENE EXPRESSION; INSULIN; LIPOLYSIS; MICE; PHOSPHOPROTEINS; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROL ESTERASE; TRANS-ACTIVATORS; TRIGLYCERIDES;

EID: 34548420614     PISSN: 00232513     EISSN: 18830498     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Flier, J.S. 2004. Obesity wars: molecular progress confronts an expanding epidemic. Cell 116:337-350.
2. Frost, S.C., and Lane, M.D. 1985. Evidence for the involvement of vicinal sulfhydryl groups in insulin-activated hexose transport by 3T3-L1 adipocytes. J. Biol. Chem. 260:2646-2652.
3. Greenberg, A.S., Egan, J.J., Wek, S.A., Garty, N.B., Blanchette-Mackie, E.J., and Londos, C. 1991. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem. 266:11341-11346.
4. Guan, H.P., Li, Y., Jensen, M.V., Newgard, C.B., Steppan, C.M., and Lazar, M.A. 2002. A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat. Med. 8:1122-1128.
5. Hagiwara, M., Brindle, P., Harootunian, A., Armstrong, R., Rivier, J., Vale, W., Tsien, R., and Montminy, M.R. 1993. Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol. Cell. Biol. 13: 4852-4859.
6. Holm, C., Osterlund, T., Laurell, H., and Contreras, J.A. 2000. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Annu. Rev. Nutr. 20:365-393
7. Holman, G.D., and Sandoval, I.V. 2001. Moving the insulin-regulated glucose transporter GLUT4 into and out of storage. Trends. Cell Biol. 11:173-179.
8. Kitamura, T., Kitamura, Y., Kuroda, S., Hino, Y., Ando, M., Kotani, K., Konishi, H., Matsuzaki, H., Kikkawa, U., Ogawa, W., and Kasuga, M. 1999. Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt. Mol. Cell. Biol. 19: 6286-6296.
9. Lafontan, M. and Berlan, M. 1993. Fat cell adrenergic receptors and the control of white and brown fat cell function. J. Lipid Res. 34:1057-1091.
10. Matsuzawa, Y. 2006. The metabolic syndrome and adipocytokines. FEBS Lett. 580:2917-2921.
11. Mayr, B., and Montminy, M. 2001. Transcriptional regulation by the phosphorylation-dependent factor CREB. 2: 599-609.
12. McKnight, G.S. 1991. Cyclic AMP second messenger systems. Curr. Opin. Cell Biol. .3:213-217.
13. Puigserver, P. and Spiegelman, B.M. 2003. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr. Rev. 24:78-90.
14. Puigserver, P., Wu, Z., Park, C.W., Graves, R., Wright, M., and Spiegelman, B.M. 1998. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839.
15. Schulman, G.I. 2000. Cellular mechanisms of insulin resistance. J. Clin. Invest. 106:171-176.
16. Tamori, Y., Masugi, J., Nishino, N., and Kasuga, M. 2002. Role of Peroxisome Proliferator-Activated Receptor- in Maintenance of the Characteristics of Mature 3T3-L1 Adipocytes. Diabetes 51:2045-2055.
17. Zhang, J., Hupfeld, C.J., Taylor, S.S., Olefsky, J.M., and Tsien, R.Y. 2005. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature 437:569-573.