메뉴 건너뛰기




Volumn 7, Issue 8, 2012, Pages

SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+FoxP3+ T regulatory cells by production of IFN-γ

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; SA 4 1BBL RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 84864749497     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042459     Document Type: Article
Times cited : (34)

References (39)
  • 1
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • Zou W, (2006) Regulatory T cells, tumour immunity and immunotherapy. Nature reviews Immunology 6: 295-307.
    • (2006) Nature Reviews Immunology , vol.6 , pp. 295-307
    • Zou, W.1
  • 2
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, et al. (2004) Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature medicine 10: 942-949.
    • (2004) Nature Medicine , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5
  • 3
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, Lei KJ, Li L, et al. (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. The Journal of experimental medicine 198: 1875-1886.
    • (2003) The Journal of Experimental Medicine , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5
  • 4
    • 33646239606 scopus 로고    scopus 로고
    • Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25- lymphocytes is thymus and proliferation independent
    • Valzasina B, Piconese S, Guiducci C, Colombo MP, (2006) Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25- lymphocytes is thymus and proliferation independent. Cancer research 66: 4488-4495.
    • (2006) Cancer Research , vol.66 , pp. 4488-4495
    • Valzasina, B.1    Piconese, S.2    Guiducci, C.3    Colombo, M.P.4
  • 5
    • 78049276260 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma
    • Klages K, Mayer CT, Lahl K, Loddenkemper C, Teng MW, et al. (2010) Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer research 70: 7788-7799.
    • (2010) Cancer Research , vol.70 , pp. 7788-7799
    • Klages, K.1    Mayer, C.T.2    Lahl, K.3    Loddenkemper, C.4    Teng, M.W.5
  • 6
    • 78049243425 scopus 로고    scopus 로고
    • Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth
    • Teng MW, Ngiow SF, von Scheidt B, McLaughlin N, Sparwasser T, et al. (2010) Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth. Cancer research 70: 7800-7809.
    • (2010) Cancer Research , vol.70 , pp. 7800-7809
    • Teng, M.W.1    Ngiow, S.F.2    von Scheidt, B.3    McLaughlin, N.4    Sparwasser, T.5
  • 7
    • 0036721629 scopus 로고    scopus 로고
    • Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
    • Liyanage UK, Moore TT, Joo HG, Tanaka Y, Herrmann V, et al. (2002) Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. Journal of immunology 169: 2756-2761.
    • (2002) Journal of Immunology , vol.169 , pp. 2756-2761
    • Liyanage, U.K.1    Moore, T.T.2    Joo, H.G.3    Tanaka, Y.4    Herrmann, V.5
  • 9
    • 40749114476 scopus 로고    scopus 로고
    • Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo
    • Powell DJ Jr, Felipe-Silva A, Merino MJ, Ahmadzadeh M, Allen T, et al. (2007) Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo. Journal of immunology 179: 4919-4928.
    • (2007) Journal of Immunology , vol.179 , pp. 4919-4928
    • Powell Jr., D.J.1    Felipe-Silva, A.2    Merino, M.J.3    Ahmadzadeh, M.4    Allen, T.5
  • 10
    • 0030845586 scopus 로고    scopus 로고
    • 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
    • Shuford WW, Klussman K, Tritchler DD, Loo DT, Chalupny J, et al. (1997) 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. The Journal of experimental medicine 186: 47-55.
    • (1997) The Journal of Experimental Medicine , vol.186 , pp. 47-55
    • Shuford, W.W.1    Klussman, K.2    Tritchler, D.D.3    Loo, D.T.4    Chalupny, J.5
  • 11
    • 63149163677 scopus 로고    scopus 로고
    • The role of TNF superfamily members in T-cell function and diseases
    • Croft M, (2009) The role of TNF superfamily members in T-cell function and diseases. Nature reviews Immunology 9: 271-285.
    • (2009) Nature Reviews Immunology , vol.9 , pp. 271-285
    • Croft, M.1
  • 12
    • 77952845427 scopus 로고    scopus 로고
    • 4-1BB ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines
    • Sharma RK, Schabowsky RH, Srivastava AK, Elpek KG, Madireddi S, et al. (2010) 4-1BB ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines. Cancer research 70: 3945-3954.
    • (2010) Cancer Research , vol.70 , pp. 3945-3954
    • Sharma, R.K.1    Schabowsky, R.H.2    Srivastava, A.K.3    Elpek, K.G.4    Madireddi, S.5
  • 13
    • 66249141668 scopus 로고    scopus 로고
    • Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumors
    • Sharma RK, Elpek KG, Yolcu ES, Schabowsky RH, Zhao H, et al. (2009) Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumors. Cancer research 69: 4319-4326.
    • (2009) Cancer Research , vol.69 , pp. 4319-4326
    • Sharma, R.K.1    Elpek, K.G.2    Yolcu, E.S.3    Schabowsky, R.H.4    Zhao, H.5
  • 14
    • 17644389199 scopus 로고    scopus 로고
    • TNF/TNFR family members in costimulation of T cell responses
    • Watts TH, (2005) TNF/TNFR family members in costimulation of T cell responses. Annual review of immunology 23: 23-68.
    • (2005) Annual Review of Immunology , vol.23 , pp. 23-68
    • Watts, T.H.1
  • 16
    • 70649103798 scopus 로고    scopus 로고
    • A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity
    • Schabowsky RH, Elpek KG, Madireddi S, Sharma RK, Yolcu ES, et al. (2009) A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity. Vaccine 28: 512-522.
    • (2009) Vaccine , vol.28 , pp. 512-522
    • Schabowsky, R.H.1    Elpek, K.G.2    Madireddi, S.3    Sharma, R.K.4    Yolcu, E.S.5
  • 17
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    • Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR, et al. (2004) Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. Journal of immunology 172: 5149-5153.
    • (2004) Journal of Immunology , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3    Pallone, F.4    Galle, P.R.5
  • 18
    • 33847337912 scopus 로고    scopus 로고
    • Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-beta
    • Liu VC, Wong LY, Jang T, Shah AH, Park I, et al. (2007) Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-beta. Journal of immunology 178: 2883-2892.
    • (2007) Journal of Immunology , vol.178 , pp. 2883-2892
    • Liu, V.C.1    Wong, L.Y.2    Jang, T.3    Shah, A.H.4    Park, I.5
  • 19
    • 51549089858 scopus 로고    scopus 로고
    • OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo
    • Xiao X, Kroemer A, Gao W, Ishii N, Demirci G, et al. (2008) OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo. Journal of immunology 181: 3193-3201.
    • (2008) Journal of Immunology , vol.181 , pp. 3193-3201
    • Xiao, X.1    Kroemer, A.2    Gao, W.3    Ishii, N.4    Demirci, G.5
  • 20
    • 15444377017 scopus 로고    scopus 로고
    • Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors
    • Yu P, Lee Y, Liu W, Krausz T, Chong A, et al. (2005) Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. The Journal of experimental medicine 201: 779-791.
    • (2005) The Journal of Experimental Medicine , vol.201 , pp. 779-791
    • Yu, P.1    Lee, Y.2    Liu, W.3    Krausz, T.4    Chong, A.5
  • 23
    • 34548590892 scopus 로고    scopus 로고
    • Agonistic anti-4-1BB antibody promotes the expansion of natural regulatory T cells while maintaining Foxp3 expression
    • Zhang P, Gao F, Wang Q, Wang X, Zhu F, et al. (2007) Agonistic anti-4-1BB antibody promotes the expansion of natural regulatory T cells while maintaining Foxp3 expression. Scandinavian journal of immunology 66: 435-440.
    • (2007) Scandinavian Journal of Immunology , vol.66 , pp. 435-440
    • Zhang, P.1    Gao, F.2    Wang, Q.3    Wang, X.4    Zhu, F.5
  • 24
    • 4043089873 scopus 로고    scopus 로고
    • The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells
    • Zheng G, Wang B, Chen A, (2004) The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. Journal of immunology 173: 2428-2434.
    • (2004) Journal of Immunology , vol.173 , pp. 2428-2434
    • Zheng, G.1    Wang, B.2    Chen, A.3
  • 25
    • 38849108168 scopus 로고    scopus 로고
    • Ex vivo expansion of CD4+CD25+FoxP3+ T regulatory cells based on synergy between IL-2 and 4-1BB signaling
    • Elpek KG, Yolcu ES, Franke DD, Lacelle C, Schabowsky RH, et al. (2007) Ex vivo expansion of CD4+CD25+FoxP3+ T regulatory cells based on synergy between IL-2 and 4-1BB signaling. Journal of immunology 179: 7295-7304.
    • (2007) Journal of Immunology , vol.179 , pp. 7295-7304
    • Elpek, K.G.1    Yolcu, E.S.2    Franke, D.D.3    Lacelle, C.4    Schabowsky, R.H.5
  • 27
    • 55549084247 scopus 로고    scopus 로고
    • Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells
    • Hill JA, Hall JA, Sun CM, Cai Q, Ghyselinck N, et al. (2008) Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity 29: 758-770.
    • (2008) Immunity , vol.29 , pp. 758-770
    • Hill, J.A.1    Hall, J.A.2    Sun, C.M.3    Cai, Q.4    Ghyselinck, N.5
  • 28
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    • Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S, (2002) Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nature immunology 3: 135-142.
    • (2002) Nature Immunology , vol.3 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 29
    • 6344279933 scopus 로고    scopus 로고
    • Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells
    • Stephens GL, McHugh RS, Whitters MJ, Young DA, Luxenberg D, et al. (2004) Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. Journal of immunology 173: 5008-5020.
    • (2004) Journal of Immunology , vol.173 , pp. 5008-5020
    • Stephens, G.L.1    McHugh, R.S.2    Whitters, M.J.3    Young, D.A.4    Luxenberg, D.5
  • 30
    • 42249097689 scopus 로고    scopus 로고
    • OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
    • Piconese S, Valzasina B, Colombo MP, (2008) OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. The Journal of experimental medicine 205: 825-839.
    • (2008) The Journal of Experimental Medicine , vol.205 , pp. 825-839
    • Piconese, S.1    Valzasina, B.2    Colombo, M.P.3
  • 31
    • 14744285671 scopus 로고    scopus 로고
    • Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR
    • Valzasina B, Guiducci C, Dislich H, Killeen N, Weinberg AD, et al. (2005) Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood 105: 2845-2851.
    • (2005) Blood , vol.105 , pp. 2845-2851
    • Valzasina, B.1    Guiducci, C.2    Dislich, H.3    Killeen, N.4    Weinberg, A.D.5
  • 32
    • 34948883517 scopus 로고    scopus 로고
    • OX40 costimulation turns off Foxp3+ Tregs
    • Vu MD, Xiao X, Gao W, Degauque N, Chen M, et al. (2007) OX40 costimulation turns off Foxp3+ Tregs. Blood 110: 2501-2510.
    • (2007) Blood , vol.110 , pp. 2501-2510
    • Vu, M.D.1    Xiao, X.2    Gao, W.3    Degauque, N.4    Chen, M.5
  • 33
    • 58849143012 scopus 로고    scopus 로고
    • Antagonism of airway tolerance by endotoxin/lipopolysaccharide through promoting OX40L and suppressing antigen-specific Foxp3+ T regulatory cells
    • Duan W, So T, Croft M, (2008) Antagonism of airway tolerance by endotoxin/lipopolysaccharide through promoting OX40L and suppressing antigen-specific Foxp3+ T regulatory cells. Journal of immunology 181: 8650-8659.
    • (2008) Journal of Immunology , vol.181 , pp. 8650-8659
    • Duan, W.1    So, T.2    Croft, M.3
  • 34
    • 8444234229 scopus 로고    scopus 로고
    • 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses
    • Dawicki W, Bertram EM, Sharpe AH, Watts TH, (2004) 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses. Journal of immunology 173: 5944-5951.
    • (2004) Journal of Immunology , vol.173 , pp. 5944-5951
    • Dawicki, W.1    Bertram, E.M.2    Sharpe, A.H.3    Watts, T.H.4
  • 35
    • 77955560503 scopus 로고    scopus 로고
    • SA-4-1BBL as the immunomodulatory component of a HPV-16 E7 protein based vaccine shows robust therapeutic efficacy in a mouse cervical cancer model
    • Sharma RK, Srivastava AK, Yolcu ES, MacLeod KJ, Schabowsky RH, et al. (2010) SA-4-1BBL as the immunomodulatory component of a HPV-16 E7 protein based vaccine shows robust therapeutic efficacy in a mouse cervical cancer model. Vaccine 28: 5794-5802.
    • (2010) Vaccine , vol.28 , pp. 5794-5802
    • Sharma, R.K.1    Srivastava, A.K.2    Yolcu, E.S.3    MacLeod, K.J.4    Schabowsky, R.H.5
  • 36
    • 33947696816 scopus 로고    scopus 로고
    • Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice
    • Niu L, Strahotin S, Hewes B, Zhang B, Zhang Y, et al. (2007) Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice. Journal of immunology 178: 4194-4213.
    • (2007) Journal of Immunology , vol.178 , pp. 4194-4213
    • Niu, L.1    Strahotin, S.2    Hewes, B.3    Zhang, B.4    Zhang, Y.5
  • 37
  • 38
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, et al. (1997) Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nature medicine 3: 682-685.
    • (1997) Nature Medicine , vol.3 , pp. 682-685
    • Melero, I.1    Shuford, W.W.2    Newby, S.A.3    Aruffo, A.4    Ledbetter, J.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.