CriticalSorb™: A novel efficient nasal delivery system for human growth hormone based on Solutol HS15

Journal of Controlled Release

Volumn 162, Issue 1, 2012, Pages 194-200

  Illum, Lisbeth ^a   Jordan, Faron ^a   Lewis, Andrew L ^a  

^a Critical Pharmaceuticals Ltd   (United Kingdom)

Author keywords

Absorption enhancer; Bioadhesive formulations; hGH; Nasal delivery; Solutol HS15

Indexed keywords

12-HYDROXYSTEARIC ACID; ABSORPTION-ENHANCERS; BIOADHESIVES; HGH; HUMAN GROWTH HORMONE; NASAL ABSORPTION; NASAL ADMINISTRATION; NASAL DELIVERY; POLYGLYCOLS; RAT MODEL; TOXIC EFFECT;

BIOCHEMISTRY; POLYETHYLENE GLYCOLS;

RATS;

12 HYDROXYSTEARIC ACID; HUMAN GROWTH HORMONE; MACROGOL; SOLUTOL HS 15; STEARIC ACID DERIVATIVE; UNCLASSIFIED DRUG; DRUG VEHICLE; MACROGOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; HISTOPATHOLOGY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXICITY TESTING; ANIMAL; BIOAVAILABILITY; HUMAN; INTRANASAL DRUG ADMINISTRATION; METABOLISM; SPRAGUE DAWLEY RAT;

ADMINISTRATION, INTRANASAL; ANIMALS; BIOLOGICAL AVAILABILITY; HUMAN GROWTH HORMONE; HUMANS; MALE; NASAL MUCOSA; PHARMACEUTICAL VEHICLES; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; STEARIC ACIDS;

EID: 84864722272     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.06.014     Document Type: Article

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