Nasal absorption kinetics of human growth hormone enhanced by acylcarnitines in rats

International Journal of Pharmaceutics

Volumn 169, Issue 2, 1998, Pages 245-253

  Kagatani, Seiya ^a   Inaba, Noriko ^a   Fukui, Muneo ^a   Sonobe, Takashi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Acylcarnitines; Human growth hormone; Lauroylcarnitine; Nasal absorption enhancer; Pharmacokinetic analysis; Single dose toxicity

Indexed keywords

ACYLCARNITINE; HUMAN GROWTH HORMONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SAFETY; IMMUNORADIOMETRIC ASSAY; INTRANASAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032528453     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00132-X     Document Type: Article

References (24)

1. Agerholm C., Bastholm L., Johansen P.B., Nielson M.H., Wiling F. Epithelial transport and bioavailability of intranasally administered human growth hormone formulated with absorption erhancers didecanoyl L-alpha-phosphatidylcholine and alpha-cyclodextrin in rabbits. J. Pharm. Sci. 83:1994;1706-1711.
2. Albertsson W.K., Hedin L., Jansson P., Rosberg S., Wikstrom C. Intranasal delivery of human growth hormone: optimization of formulation. Drug Dev. Res. 34:1995;353-360.
3. Baldwin P.A., Klingbeil C.K., Grimm C.J., Longenecker J.P. The effect of sodium tauro-24,25-dihydrofusidate on the nasal absorption of human growth hormone in three animal models. Pharm. Res. 7:1990;547-552.
4. Clark R.G., Carlsson L.M., Robinson I.C. Growth hormone (GH) secretion in the conscious rat: negative feedback of GH on its own release. J. Endocrinol. 119:1988;201-209.
5. Clark R.G., Jansson J.O., Isaksson O., Robinson I.C. Intravenous growth hormone: growth responses to patterned infusions in hypophysectomized rats. J. Endocrinol. 104:1985;53-61.
6. Daugherty A.L., Liggitt H.D., McCabe J.G., Moore J.A., Patton J.S. Absorption of recombinant methionyl-human growth hormone (Met-HGH) from rat nasal mucosa. Int. J. Pharm. 45:1988;197-206.
7. Ennis R.D., Borden L., Lee W.W. The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study. Pharm. Res. 7:1990;468-475.
8. Fisher A.N., Farraj N.F., O'Hagan D.T., Gill I.J., Johansen B.R., Davis S.S., Illum L. Effect of L-alpha-lysophosphatidylcholine on the nasal absorption of human growth hormone in three animal species. Int. J. Pharm. 74:1991;147-156.
9. Fix J.A., Engle K., Porter P.A., Leppert P.S., Selk S.J., Gardner C.R., Alexander J. Acylcarnitines: drug absorption-enhancing agents in the gastrointestinal tract. Am. J. Physiol. 251:1986;G332-G340.
10. Gizurarson S., Marriott C., Martin G.P., Bechgaard E. The influence of insulin and some excipients used in nasal insulin preparations on mucociliary clearance. Int. J. Pharm. 65:1990;243-247.
11. Hedin L., Olsson B., Diczfalusy M., Flyg C., Petersson A.S., Rosberg S., Albertsson W.K. Intranasal administration of human growth hormone (HGH) in combination with a membrane permeation enhancer in patients with GH deficiency: a pharmacokinetic study. J. Clin. Endocrinol. Metab. 76:1993;962-967.
12. Hermens W.A., Hooymans P.M., Verhoef J.C., Merkus F.W. Effects of absorption enhancers on human nasal tissue ciliary movement in vitro. Pharm. Res. 7:1990;144-146.
13. Hochman J.H., Fix J.A., LeCluyse E.L. In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine. J. Pharmacol. Exp. Ther. 269:1994;813-822.
14. Illum L., Farraj N.F., Davis S.S., Johansen B.R., O'Hagan D.T. Investigation of the nasal absorption of biosynthetic human growth hormone in sheep - use of a bioadhesive microsphere delivery system. Int. J. Pharm. 63:1990;207-211.
15. Kagatani S., Shinoda T., Fukui M., Ohmura T., Hasumi S., Sonobe T. Enhancement of nasal salmon calcitonin absorption by lauroylcarnitine chloride in rats. Pharm. Res. 13:1996;739-743.
16. LeCluyse E.L., Sutton S.C., Fix J.A. In vitro effects of long-chain acylcarnitines on the permeability, transepithelial electrical resistance morphology of rat colonic mucosa. J. Pharmacol. Exp. Ther. 265:1993;955-962.
17. Lee W.A., Lu H.F., Maffuid P.W., Botet M.T., Baldwin P.A., Benkert T.A. The synthesis, characterization and biological testing of a novel class of mucosal permeation enhancers. J. Control. Release. 22:1992;223-237.
18. Lin Y.J., Shen W.C. Effects of deoxycholate on the transepithelial transport of sucrose and horseradish peroxidase in filter-grown Madin-Darby canine kidney (MDCK) cells. Pharm. Res. 8:1991;498-501.
19. Marttin E., Verhoef J.C., Rorneign S.G., Merkus F.W. Effects of absorption enhancers on rat nasal epithelium in vivo: release of marker compounds in the nasal cavity. Pharm. Res. 12:1995;1151-1157.
20. Metzler, C.M., Weiner, D.L., 1984. NONLIN84 (version 2), Statistical Consultants, Lexington, KY.
21. O'Hagan D.T., Critchley H., Farraj N.F., Fisher A.N., Johansen B.R., Davis S.S., Illum L. Nasal absorption enhancers for biosynthetic human growth hormone in rats. Pharm. Res. 7:1990;772-776.
22. Raeissi S.D., Borchardt R.T. Cultured human colon carcinoma cells (Caco-2) as a model to study the mechanism by which palmitoyl-DL-carnitine enhances intestinal permeability of drugs. Stp Pharma Sci. 3:1993;56-62.
23. Robinson I.C. Chronopharmacology of growth hormone and related peptides. Adv. Drug Deliv. Rev. 6:1991;57-82.
24. SAS/STAT® User's Guide, 1988. Release 6.03 Edition. SAS Institute Inc., Cary, NC.