Investigation of the effect of anaesthesia on nasal absorption of insulin in rats

International Journal of Pharmaceutics

Volumn 149, Issue 1, 1997, Pages 123-129

  Mayor, Susan H ^a   Illum, Lisbeth ^a,b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Danbiosyst UK Ltd   (United Kingdom)

Author keywords

Anaesthetics; Insulin; Mucociliary clearance; Nasal delivery; Rats

Indexed keywords

ANESTHETIC AGENT; DEOXYCHOLATE SODIUM; HALOTHANE; HYPNORM; INSULIN; PENTOBARBITAL;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; GLUCOSE BLOOD LEVEL; INHALATIONAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; INTRANASAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MUCOCILIARY CLEARANCE; NONHUMAN; NOSE CAVITY; PRIORITY JOURNAL; RAT;

EID: 0031001332     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04858-2     Document Type: Article

References (23)

1. Auger, C., van Bommel, T., Phadana-anek, S., Reich, A., Butler, J., Stahl, H. and Deimer, T., Behaviour of relative humidity and temperature in the inspiratory part of a Drager circle system and their influence on the functioning of the ciliary epithelieum. Anasth. Intensivther. Notfallmed., 25 (1990) 107-111.
2. Aungst, B.J. and Rogers, N.J., Comparison of the effects of various transmucosal absorption promoters on the effect of buccal insulin delivery. Int. J. Pharm., 53 (1989) 227-235.
3. Baldwin, P.A., Corine, K.K, Grimm, C.J. and Longenecker, J.P., The effect of sodium tauro 24,25-dihydrofusidate on the nasal absorption of human growth factor in three animal models. Pharm. Res., 1 (1990) 547-552.
4. Batts, A.H., Martin, G.P. and Bond, S.W., The effect of some preservatives used in nasal preparations on mucociliary clearance. J. Pharm. Pharmacol., 41 (1989) 156-159.
5. Daugherty, A.L., Liggit, H.D., MCCaobe, J.G., Moore, J.A. and Patton, J.S., Absorption of recombinant-methionyl-human growth hormone from rat nasal mucosa. Int. J. Pharm., 45 (1988) 197-206.
6. Duerbo, M.J., Hermens, W.A.J.J., Romeyn, S.G., Verhoef, J.C. and Merkus, F.W.H.M., Absorption enhancement of intranasally administered insulin by sodium taurodihydrofusidate (STDHF) in rabbits and rats. Pharm. Res., 6 (1989) 854-856.
7. Fisher, A.N., Illum, L, Davis, S.S. and Schacht, E.H., Diiodotyrosine labelled dextrans as molecular size markers of nasal absorption in the rat. J. Pharm. Pharmacol., 44 (1992) 550-554.
8. Fix, J.A., Engle, K., Porter, P.A., Leppet, P.S., Selk, S.J., Gardner, C.R. and Alexander, J., Acylcarnitines: drug absorption enhancing agents in the gastrointestinal tract. Am. J. Physiol., 251 (1986) G332-G340.
9. Hirai, S., Yashiki, T., Matsuzawa, T. and Mima, H., Absorption of drugs from the nasal mucosa of rat. Int. J. Pharm., 7 (1981) 317-326.
10. Illum, L., Nasal delivery. The use of animal models to predict performance in man. J. Drug Target., 3 (1996) 427-442.
11. Illum, L., Farraj, N.F., Critchley, H., Johansen, B.R. and Davis, S.S., Enhanced absorption of insulin in rats using lysophosphatidylcholine. Int. J. Pharm., 57 (1989) 49-54.
12. Illum, L., Farraj, N.F., Davis, S.S., Johansen, B.R. and O'Hagan, D.T., Investigation of the nasal absorption of biosynthetic human growth hormone in sheep: use of a bioadhesive microsphere delivery system. Int. J. Pharm., 63 (1990) 207-211.
13. Irie, T., Wakamatsu, K., Arima, H., Aritomi, H. and Uekama, K., Enhancing effects of cyclodextrins on nasal absorption of insulin in rats. Int. J. Pharm., 84 (1992) 129-139.
14. Merkus, F.W.H.M., Verhoef, J.C., Romeijn, S.G. and Schipper, N.G.M., Interspecies differences in the nasal absorption of insulin (letter). Pharm. Res., 8 (1991) 1343.
15. Middleton, P.G., Geddes, D.M. and Alton, E.W.E.W., Effect of amiloride and saline on nasal mucociliary clearance and potential difference in cystic fibrosis and normal subjects. Thorax, 48 (1993) 812-816.
16. O'Hagan, D.T., Critchley, H., Farraj, N.F., Fisher, A.N., Johansen, B.R., Davis, S.S. and Illum, L., Nasal absorption enhancers for the biosynthetic human growth hormone in rats. Pharm. Res., 7 (1990) 112-716.
17. Olanoff, L.S., Titus, C.R., Shea, M.S., Gibson, R.E. and Brooks, C.D., Effect of intranasal histamine on nasal blood flow and the antidiuretic activity of desmopressin. J. Clin. Invest., 80 (1987) 890-895.
18. Rang, H.P. and Dale, M.M., Pharmacology, Churchill Livingstone, London, 1987, pp. 471-485.
19. Schipper, N.G.M., Hermens, W.A.J., Romeyn, S.G., Verhoef, J. and Merkus, E.W.H.M., Nasal absorption of 17-betaestradiol and progesterone from a dimethyl-cyclodextrin inclusion formulation in rats. Int. J. Pharm., 64 (1990) 61-66.
20. Tacheuchi, T., Suzumura, E., Majima, Y. and Sakakura, Y., Effect of atropine on nasal mucociliary clearance. Acta Otolaryngol, 110 (1990) 120-123.
21. Vickers, M.D., Morgan, M. and Spencer, P.S.J., Drugs in anaesthetic practice. Butterworth and Heineman, London, 1991.
22. Visor, G.C., Bajka, E. and Benjamin, E., Intranasal delivery of nicardipine in the rat. J. Pharm. Sci., 75 (1986) 44-46.
23. Wolff, R.K., Allen, D.L., Hughes, B.L., Osier, M. and Dorato, M.A., Nasal clearance in rhesus monkeys. J. Aerosol Med., 6 (1993) 111-119.