Comparative evaluation of traditional prescriptions from Cichorium intybus L. for wound healing: Stepwise isolation of an active component by in vivo bioassay and its mode of activity

Journal of Ethnopharmacology

Volumn 143, Issue 1, 2012, Pages 299-309

  Süntar, Ipek ^a   Küpeli Akkol, Esra ^a   Keles, Hikmet ^b   Yesilada, Erdem ^c   Sarker, Satyajit D ^d   Baykal, Turhan ^a  

^a GAZI UNIVERSITY   (Turkey)

^b AFYON KOCATEPE UNIVERSITY   (Turkey)

^c YEDITEPE UNIVERSITY   (Turkey)

^d UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

Author keywords

Anti inflammatory; Cichorium; Collagenase; Elastase; Hyaluronidase; Wound healing

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ACETIC ACID; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CICHORIUM INTYBUS EXTRACT; COLLAGENASE; ELASTASE; HYALURONIDASE; HYDROXYPROLINE; METHANOL; PHENOL; PLANT EXTRACT; SITOSTEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CAPILLARY PERMEABILITY; CARBON NUCLEAR MAGNETIC RESONANCE; CHICORY; CONTROLLED STUDY; DRUG ISOLATION; ENZYME INHIBITION; IN VIVO STUDY; MALE; MASS SPECTROMETRY; NONHUMAN; PLANT LEAF; PLANT ROOT; PRESCRIPTION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TRADITIONAL MEDICINE; ULTRAVIOLET SPECTROSCOPY; WOUND HEALING;

ANIMALS; CHICORY; MALE; MEDICINE, TRADITIONAL; MICE; MICE, INBRED STRAINS; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT PREPARATIONS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; SITOSTEROLS; TURKEY; WOUND HEALING; WOUNDS AND INJURIES;

CICHORIUM; CICHORIUM INTYBUS; RATTUS;

EID: 84864696675     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.06.036     Document Type: Article

References (58)

1. E. Barrantes, and M. Guinea Inhibition of collagenase and metalloproteinases by aloins and aloe gel Life Science 72 2003 843 850
2. A.T. Bischoff, C.J. Kelley, Y. Karchesy, M. Laurantos, P. Nguyen-Dinh, and A.G. Arefi Antimalarial activity of Lactucin and Lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L Journal of Ethnopharmacology 95 2004 455 457
3. M. Blumenthal The Complete German Commission E Monographs 1st ed. 1998 Integrative Medicine Communications Boston
4. C. Cavin, M. Delannoy, A. Malnoe, E. Debefve, A. Touche, D. Courtois, and B. Schilter Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract Biochemical and Biophysical Research Communications 327 2005 742 749
5. F. Conforti, G. Ioele, G.A. Statti, M. Marrelli, G. Ragno, and F. Menichini Antiproliferative activity against human tumor cell lines and toxicity test on Mediterranean dietary plants Food and Chemical Toxicology 46 2008 3325 3332
6. Z. Degim, N. Çelebi, H. Sayan, A. Babül, D. Erdogan, and G. Take An investigation on skin wound healing in mice with a taurine-chitosan gel formulation Amino Acids 22 2002 187 198
7. J.V. Edwards, F. Howley, and I.K. Cohen In vitro inhibition of human neutrophil elastase by oleic acid albumin formulations from derivatized cotton wound dressings International Journal of Pharmaceutics 284 2004 1 12
8. T. Fleming PDR for Herbal Medicines 3rd ed. 2000 Medical Economics Company Montvale
9. J.C. Foster, K.A. Cassida, and K.E. Turner In vitro analysis of the anthelmintic activity of forage chicory (Cichorium intybus L.) sesquiterpene lactones against a predominantly Haemonchus contortus egg population Veterinary Parasitology 180 3-4 2011 298 306
10. J. Francisco, M. Hidalgo, M. León, and R. Zamora Effect of β-sitosterol in the antioxidative activity of oxidized lipid-amine reaction products Food Research International 42 2009 1215 1222
11. C. Gadgoli, and S.H. Mishra Antihepatotoxic activity of Cichorium intybus Journal of Ethnopharmacology 58 1997 131 134
12. G. Gazzani, M. Daglia, A. Papetti, and C. Gregotti In vitro and ex vivo anti- and prooxidant components of Cichorium intybus Journal of Pharmaceutical and Biomedical Analysis 23 223 2000 127 133
13. M. Getie, Gebre, T. Mariam, R. Reitz, and RH. Neubert Evaluation of the release profiles of flavonoids from topical formulations of the crude extract of the leaves of Dodonea viscosa (Sapindaceae) Pharmazie 57 2002 320 322
14. P. Gupta, S. Balwani, S. Kumar, N. Aggarwal, M. Rossi, S. Paumier, F. Caruso, P. Bovicelli, L. Saso, A.L. DePass, A.K. Prasad, V.S. Parmar, and B. Ghosh β-sitosterol among other secondary metabolites of Piper galeatum shows inhibition of TNFα-induced cell adhesion molecule expression on human endothelial cells Biochimie 92 2010 1213 1221
15. I. Gürbüz, O. Üstün, E. Yesilada, E. Sezik, and N. Akyürek In vivo gastroprotective effects of five Turkish folk remedies against ethanol-induced lesions Journal of Ethnopharmacology 83 2002 241 244
16. B. Hazra, R. Sarkar, S. Bhattacharyya, and P. Roy Tumour inhibitory activity of chicory root extract against Ehrlich ascites carcinoma in mice Fitoterapia 73 2002 730 733
17. P.I. Jewo, I.O. Fadeyibi, O.S. Babalola, L.C. Saalu, A.S. Benebo, M.C. Izegbu, and O.A.A. Ashiru Comparative study of the wound healing properties of moist exposed burn ointment (Mebo) and silver sulphadiazine Annals of Burns and Fire Disasters 22 2 2009 79 82
18. A. Kamboj, and A. Saluja Isolaton of Stigmasterol and β-sitosterol from Petroleum Ether Extract of Aerial Parts of Ageratum conyzoides (Asteraceae) International Journal of Pharmacy and Pharmaceutical Sciences 3 1 2011 94 96
19. W. Kisiel, and K. Michalska A new coumarin glucoside ester from Cichorium intybus Fitoterapia 73 2002 544 546
20. W. Kisiel, K. Michalska, and E. Szneler Norisoprenoids from aerial parts of Cichorium pumilum Biochemical Systematics and Ecology 32 2004 343 346
21. W. Kisiel, and K. Michalska Sesquiterpenoids and phenolics from roots of Cichorium endivia var. crispum Fitoterapia 77 2006 354 357
22. D. Kmiecik, J. Korczak, M. Rudzinska, J. Kobus-Cisowska, A. Gramza-Michałowska, and M. Hes β-Sitosterol and campesterol stabilisation by natural and synthetic antioxidants during heating Food Chemistry 128 2011 937 942
23. E.O. Krebsky, J.M.C. Geuns, and M. De Proft Polyamines and sterols in Cichorium heads Phytochemistry 50 1999 549 553
24. Y. Kumarasamy, L. Nahar, P.J. Cox, M. Jaspars, and S.D. Sarker Bioactivity of secoiridoid glycosides from Centaurium erythraea Phytomedicine 10 2003 344 347
25. S. Lodhi, R.S. Pawar, A.P. Jain, and A.K. Singhai Wound healing potential of Tephrosia purpurea (Linn.) Pers. in rats Journal of Ethnopharmacology 108 2006 204 210
26. S. Loizou, I. Lekakis, G.P. Chrousos, and P. Moutsatsou Beta-sitosterol exhibits anti-inflammatory activity in human aortic endothelial cells Molecular Nutrition & Food Research 54 4 2010 551 558
27. A. Lante, T. Nardi, F. Zocca, A. Giacomini, and V. Corich Evaluation of Red Chicory extract as a natural antioxidant by pure lipid oxidation and yeast oxidative stress response as model systems Journal of Agricultural and Food Chemistry 59 2011 5318 5324
28. K.K. Lee, and J.D. Choi The effects of Areca catechu L. extracts on anti ageing International Journal of Cosmetic Sciences 21 1999 285 294
29. J. Manikandan, B.K.H. Tan, C.H. Tan, P.N. Pushparaj, and H.K. Low Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats Journal of Ethnopharmacology 111 2007 430 434
30. M.F. Melzig, B. Löser, and S. Ciesielski Inhibition of neutrophil elastase activity by phenolic compounds from plants Pharmazie 56 2001 967 970
31. K. Michalska, and W. Kisiel Further sesquiterpene lactones and phenolics from Cichorium spinosum Biochemical Systematics and Ecology 35 2007 714 716
32. E.J. Moon, Y.M. Lee, O.H. Lee, M.J. Lee, S.K. Lee, M.H. Chung, Y.I. Park, C.K. Sung, J.S. Choi, and K.W. Kim A novel angiogenic factor derived from Aloe vera gel: beta-sitosterol, a plant sterol Angiogenesis 3 1999 117 123
33. N. Mulinacci, M. Innocenti, S. Gallori, A. Romani, G. La Marca, and F.F. Vincieri Optimization of the chromatographic determination of polyphenols in the aerial parts of Cichorium intybus L Chromatographia 54 2001 455 461
34. S. Nandagopal, and B.D. Ranjitha Kumari Phytochemical and antibacterial studies of Chicory (Cichorium intybus L.) - a multipurpose medicinal plant Advances in Biological Research 1 1-2 2007 17 21
35. R. Norbaek, K. Nielsen, and T. Kondo Anthocyanins from flowers of Cichorium intybus Phytochemistry 60 2002 357 359
36. A. Papetti, M. Daglia, and G. Gazzani Anti- and pro-oxidant activity of water soluble compounds in Cichorium intybus var. silvestre (Treviso red chicory) Journal of Pharmaceutical and Biomedical Analysis 30 2002 939 945
37. A. Papetti, M. Daglia, P. Grisoli, C. Dacarro, C. Gregotti, and G. Gazzani Anti- and pro-oxidant activity of Cichorium genus vegetables and effect of thermal treatment in biological systems Food Chemistry 97 2006 157 165
38. A. Papetti, M. Daglia, C. Aceti, B. Sordelli, V. Spini, C. Carazzone, and G. Gazzani Hydroxycinnamic acid derivatives occurring in Cichorium endivia vegetables Journal of Pharmaceutical and Biomedical Analysis 48 2008 472 476
39. J. Petrovic, A. Stanojkovic, L.J. Comic, and S. Curcic Antibacterial 264 activity of Cichorium intybus Fitoterapia 75 2004 737 739
40. P.N. Pushparaj, H.K. Low, J. Manikandan, B.K.H. Tan, and C.H. Tan Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats Journal of Ethnopharmacology 111 2007 430 434
41. A. Sahasrabudhe, and M. Deodhar Anti-hyaluronidase, anti-elastase activity of Garcinia indica International Journal of Botany 6 3 2010 299 303
42. E. Sezik, M. Tabata, E. Yesilada, G. Honda, K. Goto, and Y. Ikeshiro Traditional medicine in Turkey I. Folk medicine in Northeast Anatolia Journal of Ethnopharmacology 35 1991 191 196
43. E. Sezik, E. Yesilada, G. Honda, Y. Takaishi, Y. Takeda, and T. Tanaka Traditional medicine in Turkey X. Folk medicine in Central Anatolia Journal of Ethnopharmacology 75 2001 95 115
44. S.R.U. Shah, G. Hassan, A. Rehman, and I. Ahmed Ethnobotanical study of wild flora of District Musakhel and Barkhan in Balochistan Pakistan Journal of Weed Science Research 12 2006 199 211
45. S. Shetty, S. Udupa, and L. Udupa Evaluation of antioxidant and wound healing effects of alcoholic and aqueous extract of Ocimum sanctum Linn in rats Evidence Based Complementary and Alternative Medicine 5 2008 95 101
46. G.A. Spanos, and R.E. Wrolstad Influence of processing and storage on the phenolic composition of Thompson seedless grape juice Journal of Agricultural Food and Chemistry 38 1990 1565 1571
47. L. Suguna, S. Singh, P. Sivakumar, P. Sampath, and G. Chandrakasan Influence of Terminalia chebula on dermal wound healing in rats Phytotherapy Research 16 2002 227 231
48. X. Sun, I.G. Andrew, K.N. Joblin, P.J. Harris, A. McDonald, and S.O. Hoskin Polysaccharide compositions of leaf cell walls of forage chicory (Cichorium intybus L.) Plant Science 170 2006 18 27
49. I. Süntar, A. Baldemir, M. Coşkun, H. Keleş, and E. Küpeli Akkol Wound healing acceleration effect of endemic Ononis species growing in Turkey Journal of Ethnopharmacology 135 2011 63 70
50. N.A. Syed, T.N. Hasan, and S.M.M. Aalam Evaluation of Wound Healing Potential of Cichorium intybus. L (Asteraceae) in rats Iranian Journal of Pharmacology and Therapeutics 7 2008 181 184
51. V.A. Tramontina, M.A. Machado, R. Nogueira Filho Gda, S.H. Kim, M.R. Vizzioli, and S. Toledo Effect of bismuth subgallate (local hemostatic agent) on wound healing in rats. Histological and histometric findings Brazilian Dental Journal 13 2002 11 16
52. E. Tuzlac, D.P. Alparslan Işbilen, and G. Bulut Turkish folk medicinal plants. VIII: Lalapaşa (Edirne) Marmara Pharmaceutical Journal 14 2010 47 52
53. M. Valerio, and A.B. Awad β-Sitosterol down-regulates some pro-inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase SHP-1 in J774A.1 murine macrophages International Immunopharmacology 11 2011 1012 1017
54. A. Wesolowska, A. Nikiforuk, K. Michalska, W. Kisiel, and E. Chojnacka-Wojcik Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice Journal of Ethnopharmacology 107 2006 254 258
55. B.A. Whittle The use of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesics British Journal of Pharmacology and Chemotherapy 22 1964 246 253
56. H. Wu, Z. Su, Y. Yang, H. Ba, and H.A. Aisa Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography Journal of Chromatography A 1176 2007 217 222
57. E. Yesilada, E. Sezik, G. Honda, Y. Takaishi, Y. Takeda, and T. Tanaka Traditional medicine in Turkey IX. Folk medicine in north-west Anatolia Journal of Ethnopharmacology 64 1999 195 210
58. E. Yesilada, and E. Küpeli Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects Journal of Ethnopharmacology 110 2007 504 515