The dual role of osteopontin in acetaminophen hepatotoxicity

Acta Pharmacologica Sinica

Volumn 33, Issue 8, 2012, Pages 1004-1012

  He, Chun Yan ^a,b   Liang, Bei Bei ^a,b   Fan, Xiao Yu ^b   Cao, Lei ^a,b   Chen, Rui ^b   Guo, Ya Jun ^a,b,c   Zhao, Jian ^b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

acetaminophen; cytokine; hepatocyte; hepatotoxicity; liver; macrophage; osteopontin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; GLUTATHIONE; INTERLEUKIN 1ALPHA; NEUTRALIZING ANTIBODY; OSTEOPONTIN; PARACETAMOL; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; SPP1 PROTEIN, MOUSE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG METABOLISM; HISTOPATHOLOGY; INFLAMMATORY CELL; LIPID PEROXIDATION; LIVER TOXICITY; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; KNOCKOUT MOUSE; LIVER CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; TOXIC HEPATITIS;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANIMALS; CELLS, CULTURED; DRUG-INDUCED LIVER INJURY; HEPATOCYTES; INFLAMMATION MEDIATORS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOPONTIN;

EID: 84864681542     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.47     Document Type: Article

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