A humanized anti-osteopontin antibody protects from Concanavalin A induced-liver injury in mice

European Journal of Pharmacology

Volumn 657, Issue 1-3, 2011, Pages 144-151

  Fan, Kexing ^a,c   Zhang, Bo ^a,b   Yang, Haiou ^a   Wang, Huajing ^a   Tan, Min ^a,b,c   Hou, Sheng ^a,b,c   Qian, Weizhu ^a,b,c   Li, Bohua ^a,b,c   Wang, Hao ^a,b,c   Dai, Jianxin ^a,b,c   Guo, Yajun ^a,b,c  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b National Engineering Research Center for Antibody Medicine   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Concanavalin A induced liver injury; Humanization; Monoclonal antibody; Osteopontin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CONCANAVALIN A; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HU23C3; OSTEOPONTIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; HEPATITIS; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LIVER INJURY; LIVER PROTECTION; MALE; MONOCYTE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CELL MOVEMENT; CONCANAVALIN A; DRUG-INDUCED LIVER INJURY; HEPATITIS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; INTERFERON-GAMMA; LYMPHOCYTES; MALE; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MONOCYTES; NF-KAPPA B; OSTEOPONTIN; PROTEIN CONFORMATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79952485703     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.01.041     Document Type: Article

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