Human monoclonal antibodies specific to hepatitis B virus generated in a human/mouse radiation chimera: The Trimera system

Immunology

Volumn 93, Issue 2, 1998, Pages 154-161

  Eren, R ^a   Lubin, I ^a   Terkieltaub, D ^a   Ben Moshe, O ^a   Zauberman, A ^a   Uhlmann, R ^a   Tzahor, T ^a   Moss, S ^a   Ilan, E ^a   Shouval, D ^b   Galun, E ^b   Daudi, N ^b   Marcus, H ^c   Reisner, Y ^c   Dagan, S ^a  

^a XTL Biopharmaceuticals Ltd Israel   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; CHIMERA; COMBINED IMMUNODEFICIENCY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HYBRIDOMA; MOUSE; MYELOMA; NONHUMAN; PRIORITY JOURNAL; RADIATION PROTECTION; TRANSGENIC ANIMAL; WHOLE BODY RADIATION;

EID: 6844258881     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1998.00426.x     Document Type: Article

References (43)

1. BORREBAECK C.A.K. & LARRICK J.W. (1990) Therapeutic Monoclonal Antibodies. Stockton Press, Now York.
2. KHAZAELI M.B., CONRY R.M. & LOBUGLIO F.A. (1994) Human immune response to monoclonal antibodies. J Immunother 15, 42.
3. THOMPSON K., BAKDEN G., SUTHERLAND J., BELDEN I. & MELAMED M. (1990) Human monoclonal antibodies to C, c, E, e, and G antigens of the Rh system. Immunology 71, 323.
4. RANDEN L, THOMPSON K.M., THORPE S.J., FORRE O. & NATVIG J.B. (1993) Human monoclonal IgG rheumatoid factors from the synovial tissue of patients with rheumatoid arthritis. Scand J Immunol 37, 668.
5. OI V.T. & MORRISON S.L. (1986) Chimeric antibodies. Biotechniques 4, 214.
6. QUEEN C., SCHNEIDER W.P., SELICK H.E. et al. (1989) A humanized antibody that binds to the interleukin 2 receptor. Proc Natl Acad Sci USA 86, 10 029.
7. MCCAFFERTY J., GRIFFTTHS A.D., WINTER G. & CHISWELL D.J. (1990) Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348, 552.
8. BARBAS C.F. 3RD, KANG A.S., LERNER R.A. & BENKOVIC S.J. (1991) Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc Natl Acad Sci USA 88, 7978.
9. BRUGGEMANN M. & NEUBERGER M.S. (1996) Strategies for expressing human antibody repertoires in transgenic mice. Immunol Today 17, 391.
10. MENDEZ M.J., GREEN L.L., CORVALAN J.R.F. et al. (1997) Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nature Genet 15, 146.
11. LONBERG N., TAYLOR L.D., HARDING F.A. et al (1994) Antigen-specific human antibodies from mice comprising four distinct genetic modifications. Nature 368, 856.
12. LUBIN I., FAKTOROWICH Y., LAPIDOT T. et al. (1991) Engraftment and development of human T and B cells in mice after bone marrow transplantation. Science 252, 427.
13. LUBIN L, SEGAN H., MARCUS H. et al. (1994) Engraftment of human peripheral blood lymphocytes in normal strains of mice. Blood 83, 2368.
14. LUBIN L, SEGALL H., ERLICH P. et al. (1995) Conversion of normal rats into SCID-like animals by means of bone marrow transplantation from SCID donors allows engraftment of human peripheral blood mononuclear cells. Transplantation 60, 740.
15. SEGALL H., LUBIN I., MARCUS H., CANAAN A. & REISNER Y. (1996) Generation of primary antigen-specific human cytotoxic T lymphocytes in human mouse radiation chimera. Blood 88, 721.
16. MARCUS H., DAVID M., CANAAN A. et al. (1995) Human mouse radiation chimera are capable of mounting a human primary humoral response. Blood 86, 398.
17. DEINHART F. & ZUCKERMAN A.J. (1985) Immunization against hepatitis B: report on a WHO meeting on viral hepatitis in Europe. J Med Virol 17, 209.
18. LEVTTE M., MESHORER A. & REISNER Y. (1991) A rapid method for obtaining murine bone marrow cells in high yield. Bone Marrow Transplant 8, 225.
19. SHOUVAI D., ILAN Y., ADLER R. et al. (1994) Improved immunogenicity in mice of a mammalian cell-derived recombinant hepatitis B vaccine containing pre-S1 and pre-S2 antigens as compared with the conventional yeast-derived vaccines. Vaccine 12, 1453.
20. POSNER M.R., ELBOIM H. & SANTOS D. (1987) The construction and use of a human mouse myeloma analogue suitable for the routine production of hybridomas secreting human monoclonal antibodies. Hybridoma 6, 611.
21. LANE R.D., CRISSMANN R.S. & GINN S. (1986) High efficiency fusion procedure for producing monoclonal antibodies against weak immunogens. Methods Enzymol 121, 183.
22. FRIGUET B., CHAFFOTTE A.F., DJAVADI-OHANIANCE L. & GOLDBERG M.E. (1985) Measurements of the true affinity constant in solution of antigen antibody complexes by enzyme-linked immunosorbent assay. J Immunol Methods 77, 305.
23. KABAT E.A., WU T.T., PERRY H.M., GOTTESMAN K.S. & FOELLER C. (1991) Sequences of proteins of immunological interest, edn 5. US Department of Health & Human Services. National Institutes of Health, Bethesda, MD.
24. MOSIER D.E. (1991) Adoptive transfer of human lymphoid cells to severely immunodeficient mice: models for normal human immune function, autoimmunity, lymphomagenesis and AIDS. Adv Immunol 50, 303.
25. CARLSSON R., MARTENSSON C., KALLIOMAKI S., OHLIN M. & BORREBAECK C.A. (1992) Human peripheral blood lymphocytes transplanted into SCID mice constitute an in vivo culture system exhibiting several parameters found in a normal humoral immune response and are a source of immunocyles for the production of human monoclonal antibodies. J Immunol 148, 1065.
26. TARY-LEHMAN M. & SAXON A. (1992) Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J Exp Med 175, 503.
27. SAXON A., MACY E., DENIS K., TARY-LEHMAN M., WITTE O. & BRAUN J. (1991) Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans. J Clin Invest 87, 658.
28. GARCIA S., DADAGLIO G. & GOUGEON M.-L. (1997) Limits of the human-PBL-SCID mice model: severe restriction of the Vβ T-cell repertoire of engrafted human T cells. Blood 89, 329.
29. SANDHU J., SHPITZ B., GALLINGER S. & HOZUMI N. (1994) Human primary immune response in SCID mice engrafted with human peripheral blood lymphocytes. J Immunol 152, 3806.
30. IFVERSEN P. & BORREBAECK C.A.K. (1996) SCID-hu-PBL: a model for making human antibodies? Semin Immunol 8, 243.
31. BURAKOVA T., MARCUS H., DAVID M. et al. (1997) Engrafted human T and B lymphocytes form mixed follicles in lymphoid organs of human mouse and human rat radiation chimera. Transplantation 63, 1166.
32. GLASSY M.C. & DILLMAN R.O. (1988) Molecular biotherapy with human mAbs. Mol Biother 1, 7.
33. STEINITZ M., KLEIN G., KOSKIMIES S. & MAKEL O. (1977) EB virus-induced B lymphocytes cell lines producing specific antibody. Nature 269, 420.
34. MILSTFIN C. (1990) Antibodies: a paradigm tor the biology of molecular recognition. Proc Roy Soc Lond Biol 239, 1.
35. WINTER G. & MILSTEIN C. (1991) Man-made antibodies. Nature 349, 293.
36. ZANETTI A.R., TANZI E., ROMANO L. & COCCHIONI M. (1991) The control of hepatitis B by vaccination. In: Progress in Hepatitis Research (ed. O. Crivelli). p. 79. Sorin Biomedica, Saluggia, Italy.
37. MULLER R., LAUCHART W., FARLE M., KLEIN H., NIEHOFF G. & PICHLMAYR R. (1988) Simultaneous passive-active immunization for preventing hepatitis B virus reinfection in hepatitis B surface antigen-positive liver transplant recipients. In: Viral Hepatitis and Liver Disease (ed. A. J. Zuckermann), p. 810. Alan R. Liss., Inc. New York.
38. FLOWER A.J.E. & TANNER M.S. (1988) Use of hepatitis B vaccine in babies of hepatitis B surface antigen-positive carrier mothers. In: Viral Hepatitis and Liver Disease. (ed. A. J. Zuckermann). p. 980. Alan R. Liss, Inc. New York.
39. HARADA K., ICHIMORI Y., SASANO K. et al. (1989) Human human hybridomas secreting hepatitis B virus-neutralizing antibodies. Biotechnology 7, 374.
40. EHRLICH P.H., MOUSTAFA Z.A., JUSTICE J.C., HARFELDT K.E., KELLY R.L. & OSTBERG L. (1992) Characterization of human monoclonal antibodies directed against hepatitis B surface antigen. Hum Antibodies Hybrid 3, 2.
41. SAWADA H., IWASA S., NISHIMURA O. & KITANO K. (1995) Efficient production of anti (hepatitis B virus) antibodies and their neutralizing activity in chimpanzees. Appl Microbiol Biotechnol 43, 445.
42. MCMAHON G., EHRLICH P.H., MOUSTAFA Z.A. et al. (1992) Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibody-treated liver transplant patients. Hepatology 15, 757.
43. ICHIMORI Y., SASANO K., ITOH H. et al. (1985) Establishment of hybridomas secreting human monoclonal antibodies against tetanus toxin and hepatitis B virus surface antigen. Biochem Biophys Res Comm 129, 26.