Dynamic association of orca with prereplicative complex components regulates dna replication initiation

Molecular and Cellular Biology

Volumn 32, Issue 15, 2012, Pages 3107-3120

  Shen, Zhen ^a   Chakraborty, Arindam ^a   Jain, Ankur ^b   Giri, Sumanprava ^a   Ha, Taekjip ^b,c   Prasanth, Kannanganattu V ^a   Prasanth, Supriya G ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c University of Illinois at Urbana Champaign   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GEMININ; ORIGIN RECOGNITION COMPLEX; ORIGIN RECOGNITION COMPLEX ASSOCIATED; REPLICATION LICENSING FACTOR CDT1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CHROMATIN; DNA REPLICATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOSIS; MOLECULE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; CHROMATIN; DNA REPLICATION; DNA-BINDING PROTEINS; G1 PHASE CELL CYCLE CHECKPOINTS; HELA CELLS; HUMANS; MITOSIS; ORIGIN RECOGNITION COMPLEX; PROTEIN BINDING;

EUKARYOTA; ORCINUS ORCA;

EID: 84864580820     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00362-12     Document Type: Article

References (65)

1. Aparicio OM, Weinstein DM, Bell SP. 1997. Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 91:59-69.
2. Arias EE, Walter JC. 2007. Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev. 21:497-518.
3. Ballabeni A, et al. 2004. Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J. 23:3122- 3132.
4. Bartke T, et al. 2010. Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 143:470-484.
5. Bastians H, Topper LM, Gorbsky GL, Ruderman JV. 1999. Cell cycleregulated proteolysis of mitotic target proteins. Mol. Biol. Cell 10:3927- 3941.
6. Bell SP, Dutta A. 2002. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71:333-374.
7. Blow JJ, Dutta A. 2005. Preventing re-replication of chromosomal DNA. Nat. Rev. Mol. Cell Biol. 6:476-486.
8. Cook JG. 2009. Replication licensing and the DNA damage checkpoint. Front. Biosci. 14:5013-5030.
9. De Marco V, et al. 2009. Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing. Proc. Natl. Acad. Sci. U. S. A. 106:19807-19812.
10. Dhar SK, Delmolino L, Dutta A. 2001. Architecture of the human origin recognition complex. J. Biol. Chem. 276:29067-29071.
11. Diffley JF. 2010. The many faces of redundancy in DNA replication control. Cold Spring Harbot Symp. Quant. Biol. 75:135-142.
12. Drury LS, Perkins G, Diffley JF. 1997. The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J. 16:5966 -5976.
13. Evrin C, et al. 2009. A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication. Proc. Natl. Acad. Sci. U. S. A. 106:20240 -20245.
14. Ferenbach A, Li A, Brito-Martins M, Blow JJ. 2005. Functional domains of the Xenopus replication licensing factor Cdt1. Nucleic Acids Res. 33: 316-324.
15. Fujita M. 2006. Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells. Cell Div. 1:22.
16. Gambus A, et al. 2006. GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat. Cell Biol. 8:358 -366.
17. Gopalakrishnan V, et al. 2001. Redundant control of rereplication in fission yeast. Proc. Natl. Acad. Sci. U. S. A. 98:13114 -13119.
18. Heller RC, et al. 2011. Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases. Cell 146: 80-91.
19. Hu J, Xiong Y. 2006. An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage. J. Biol. Chem. 281:3753-3756.
20. Jain A, et al. 2011. Probing cellular protein complexes using singlemolecule pull-down. Nature 473:484-488.
21. Jallepalli P, Bogyo M. 1997. A degrading business: the biology of proteolysis. Trends Cell Biol. 7:333-335.
22. Jallepalli PV, Brown GW, Muzi-Falconi M, Tien D, Kelly TJ. 1997. Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev. 11:2767-2779.
23. Jee J, et al. 2010. Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues forbinding to replicative helicase Mcm proteins. J. Biol. Chem. 285:15931- 15940.
24. Khayrutdinov BI, et al. 2009. Structure of the Cdt1 C-terminal domain: conservation of the winged helix fold in replication licensing factors. Protein Sci. 18:2252-2264.
25. Kim J, Kipreos ET. 2008. Control of the Cdc6 replication licensing factor in metazoa: the role of nuclear export and the CUL4 ubiquitin ligase. Cell Cycle 7:146 -150.
26. Lee C, et al. 2004. Structural basis for inhibition of the replication licensing factor Cdt1 by geminin. Nature 430:913-917.
27. Li A, Blow JJ. 2005. Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. EMBO J. 24:395- 404.
28. Li A, Blow JJ. 2004. Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination. Nat. Cell Biol. 6:260 -267.
29. Liu C, et al. 2012. Structural insights into the Cdt1-mediated MCM2-7 chromatin loading. Nucleic Acids Res. 40:3208 -3217.
30. Lutzmann M, Maiorano D, Mechali M. 2006. A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus. EMBO J. 25:5764 -5774.
31. Lutzmann M, Mechali M. 2009. How to load a replicative helicase onto chromatin: a more and more complex matter during evolution. Cell Cycle 8:1309 -1313.
32. Lutzmann M, Mechali M. 2008. MCM9 binds Cdt1 and is required for the assembly of prereplication complexes. Mol. Cell 31:190 -200.
33. Maiorano D, Rul W, Mechali M. 2004. Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis. Exp. Cell Res. 295:138 -149.
34. McGarry TJ, Kirschner MW. 1998. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93:1043-1053.
35. Means CK, et al. 2011. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc. Natl. Acad. Sci. U. S. A. 108:E1227-E1235.
36. Mimura S, Seki T, Tanaka S, Diffley JF. 2004. Phosphorylationdependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature 431:1118 -1123.
37. Moyer SE, Lewis PW, Botchan MR. 2006. Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc. Natl. Acad. Sci. U. S. A. 103:10236 -10241.
38. Nishitani H, Lygerou Z, Nishimoto T, Nurse P. 2000. The Cdt1 protein is required to licenseDNAfor replication in fission yeast. Nature 404:625- 628.
39. Nishitani H, Taraviras S, Lygerou Z, Nishimoto T. 2001. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J. Biol. Chem. 276:44905- 44911.
40. Pacek M, Walter JC. 2004. A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication. EMBO J. 23:3667-3676.
41. Pelizon C, d'Adda di Fagagna F, Farrace L, Laskey RA. 2002. Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosis. EMBO Rep. 3:780 -784.
42. Prasanth SG, Prasanth KV, Siddiqui K, Spector DL, Stillman B. 2004. Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. EMBO J. 23:2651-2663.
43. Ralph E, Boye E, Kearsey SE. 2006. DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1. EMBO Rep. 7:1134 -1139.
44. Remus D, et al. 2009. Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell 139:719 -730.
45. Saxena S, Dutta A. 2005. Geminin-Cdt1 balance is critical for genetic stability. Mutat. Res. 569:111-121.
46. Saxena S, et al. 2004. A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. Mol. Cell 15:245-258.
47. Shen Z, et al. 2010. A WD-repeat protein stabilizes ORC binding to chromatin. Mol. Cell 40:99 -111.
48. Siddiqui K, Stillman B. 2007. ATP-dependent assembly of the human origin recognition complex. J. Biol. Chem. 282:32370 -32383.
49. Sugimoto N, Yugawa T, Iizuka M, Kiyono T, Fujita M. 2011. Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 proteindependent transcript 1 (Cdt1) and promotes pre-replication complex formation. J. Biol. Chem. 286:39200 -39210.
50. Tada S, Li A, Maiorano D, Mechali M, Blow JJ. 2001. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat. Cell Biol. 3:107-113.
51. Takara TJ, Bell SP. 2011. Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases. EMBO J. 30:4885- 4896.
52. Tanaka S, Araki H. 2010. Regulation of the initiation step of DNA replication by cyclin-dependent kinases. Chromosoma 119:565-574.
53. Teer JK, Dutta A. 2008. Human Cdt1 lacking the evolutionarily conserved region that interacts with MCM2-7 is capable of inducing rereplication. J. Biol. Chem. 283:6817- 6825.
54. Thommes P, Blow JJ. 1997. The DNA replication licensing system. Cancer Surv. 29:75-90.
55. Truong LN, Wu X. 2011. Prevention of DNA re-replication in eukaryotic cells. J. Mol. Cell. Biol. 3:13-22.
56. Ulbrich MH, Isacoff EY. 2007. Subunit counting in membrane-bound proteins. Nat. Methods 4:319 -321.
57. Vashee S, Simancek P, Challberg MD, Kelly TJ. 2001. Assembly of the human origin recognition complex. J. Biol. Chem. 276:26666 -26673.
58. Vermeulen M, et al. 2010. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell 142:967-980.
59. Wilmes GM, et al. 2004. Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an originlocalized replication control switch. Genes Dev. 18:981-991.
60. Wohlschlegel JA, Dhar SK, Prokhorova TA, Dutta A, Walter JC. 2002. Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. Mol. Cell 9:233-240.
61. Wohlschlegel JA, et al. 2000. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 290:2309 -2312.
62. Xouri G, et al. 2007. Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin. EMBO J. 26:1303- 1314.
63. Yanagi K, Mizuno T, You Z, Hanaoka F. 2002. Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. J. Biol. Chem. 277:40871- 40880.
64. Zhang J, et al. 2010. The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells. Cell Cycle 9:4848-4857.
65. Zhong W, Feng H, Santiago FE, Kipreos ET. 2003. CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature 423:885- 889.