A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition

Molecular Cell

Volumn 15, Issue 2, 2004, Pages 245-258

  Saxena, Sandeep ^a   Yuan, Ping ^b   Dhar, Suman Kumar ^f   Senga, Takeshi ^a   Takeda, David ^a   Robinson, Howard ^c   Kornbluth, Sally ^d   Swaminathan, Kunchithapadam ^b,e   Dutta, Anindya ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

GEMININ; GLUTAMIC ACID DERIVATIVE; PROTEIN DERIVATIVE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DIMERIZATION; DNA MICROARRAY; GENE DISRUPTION; GENE REPLICATION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; PROTEIN DOMAIN; PROTEIN TARGETING; SURFACE PROPERTY;

AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; CRYSTALLIZATION; DIMERIZATION; DNA REPLICATION; DNA-BINDING PROTEINS; GLUTAMIC ACID; HOMEODOMAIN PROTEINS; HUMANS; INTERPHASE; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; S PHASE; SELENOMETHIONINE; XENOPUS LAEVIS;

EID: 3242739398     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2004.06.045     Document Type: Article

References (25)

1. Akey D., Malashkevich V., Kim P. Buried polar residues in coiled-coil interfaces. Biochemistry. 40:2001;6352-6360
2. Bell S.P., Dutta A. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71:2002;333-374
3. Burkhard P., Stetefeld J., Strelkov S.V. Coiled coils. a highly versatile protein folding motif Trends Cell Biol. 11:2001;82-88
4. Chaudhuri B., Xu H., Todorov I., Dutta A., Yates J.L. Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus. Proc. Natl. Acad. Sci. USA. 98:2001;10085-10089
5. Del Bene F., Tessmar-Raible K., Wittbrodt J. Direct interaction of geminin and Six3 in eye development. Nature. 427:2004;745-749
6. Dhar S.K., Yoshida K., Machida Y., Khaira P., Chaudhuri B., Wohlschlegel J.A., Leffak M., Yates J., Dutta A. Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin. Cell. 106:2001;287-296
7. Gerbi S.A., Strezoska Z., Waggener J.M. Initiation of DNA replication in multicellular eukaryotes. J. Struct. Biol. 140:2002;17-30
8. Gillespie P.J., Li A., Blow J.J. Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins. BMC Biochem. 2:2001;15
9. Jackson P.K., Chevalier S., Philippe M., Kirschner M.W. Early events in DNA replication require cyclin E and are blocked by p21CIP1. J. Cell Biol. 130:1995;755-769
10. Kelly T.J., Brown G.W. Regulation of chromosome replication. Annu. Rev. Biochem. 69:2000;829-880
11. Luo L., Yang X., Takihara Y., Knoetgen H., Kessel M. The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature. 427:2004;749-753
12. McGarry T.J., Kirschner M.W. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell. 93:1998;1043-1053
13. Mihaylov I.S., Kondo T., Jones L., Ryzhikov S., Tanaka J., Zheng J., Higa L.A., Minamino N., Cooley L., Zhang H. Control of DNA replication and chromosome ploidy by geminin and cyclin A. Mol. Cell. Biol. 22:2002;1868-1880
14. Nicholls A., Sharp K.A., Honig B. Protein folding and association. insights from the interfacial and thermodynamic properties of hydrocarbons Proteins. 11:1991;281-296
15. O'Shea E.K., Klemm J.D., Kim P.S., Alber T. X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. Science. 254:1991;539-544
16. Otwinowski Z., Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276:1997;307-326
17. Schepers A., Ritzi M., Bousset K., Kremmer E., Yates J.L., Harwood J., Diffley J.F., Hammerschmidt W. Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus. EMBO J. 20:2001;4588-4602
18. Siegel L.M., Monty K.J. Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. Biochim. Biophys. Acta. 112:1966;346-362
19. Smythe C., Newport J.W. Systems for the study of nuclear assembly, DNA replication, and nuclear breakdown in Xenopus laevis egg extracts. Methods Cell Biol. 35:1991;449-468
20. Tada S., Li A., Maiorano D., Mechali M., Blow J.J. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat. Cell Biol. 3:2001;107-113
21. Terwilliger T.C.B.J. Automated MAD and MIR structure solution. Acta Crystallogr. D. 55:1999;849-861
22. Thepaut M., Hoh F., Dumas C., Calas B., Strub M.P., Padilla A. Crystallization and preliminary X-ray crystallographic analysis of human Geminin coiled-coil domain. Biochim. Biophys. Acta. 1599:2002;149-151
23. Vaziri C., Saxena S., Jeon Y., Lee C., Murata K., Machida Y., Wagle N., Hwang D.S., Dutta A. A p53-dependent checkpoint pathway prevents rereplication. Mol. Cell. 11:2003;1415
24. Wohlschlegel J.A., Dwyer B.T., Dhar S.K., Cvetic C., Walter J.C., Dutta A. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science. 290:2000;2309-2312
25. Yanagi K., Mizuno T., You Z., Hanaoka F. Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. J. Biol. Chem. 277:2002;40871-40880