Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45

Molecular Cell

Volumn 9, Issue 2, 2002, Pages 233-240

  Wohlschlegel, James A ^a   Dhar, Suman K ^a   Prokhorova, Tatyana A ^b   Dutta, Anindya ^a   Walter, Johannes C ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; M PROTEIN;

ARTICLE; BINDING ASSAY; CELL CYCLE; CHROMATIN; DNA REPLICATION; KINETICS; MODEL; MOLECULAR CLONING; NONHUMAN; PLASMID; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; XENOPUS;

EID: 0036190356     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00456-2     Document Type: Article

References (35)

1. Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication
2. Control of chromosomal DNA replication in the early Xenopus embryo
3. Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs
4. Replication origins in Xenopus egg extract are 5-15 kilobases apart and are activated in clusters that fire at different times
5. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage
6. Two steps in the assembly of complexes at yeast replication origins in vivo
7. Initiation of DNA replication in eukaryotic cells
8. Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins
9. Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos
10. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase
11. Cell cycle-dependent proteolysis and phosphorylation of human Mcm10
12. Xenopus Cdc7 function is dependent on licensing but not on XORC, XCdc6 or CDK activity and is required for XCdc45 loading
13. Interactions between Mcm10p and other replication factors are required for proper initiation and elongation of chromosomal DNA replication in Saccharomyces cerevisiae
14. Regulation of chromosome replication
15. Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?
16. Identification of the Xenopus laevis homolog of Saccharomyces cerevisiae DNA2 and its role in DNA replication
17. DNA replication initiates at multiple sites on plasmid DNA in Xenopus egg extracts
18. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
19. A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae
20. Nuclear reconstitution in vitro: Stages of assembly around protein-free DNA
21. The Cdt1 protein is required to license DNA for replication in fission yeast
22. Interaction between the origin recognition complex and the replication licensing system in Xenopus
23. Cdc7p-Dbf4p becomes famous in the cell cycle
24. Genetic and molecular analysis of DNA43 and DNA52: Two new cell-cycle genes in Saccharomyces cerevisiae
25. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
26. Eukaryotic DNA replication: From pre-replication complex to initiation complex
27. Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases
28. DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p
29. Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts
30. Regulation of replicon size in Xenopus egg extracts
31. Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha
32. Regulated chromosomal DNA replication in the absence of a nucleus
33. Inhibition of eukaryotic DNA replication by geminin binding to cdt1
34. Mutational analysis of the Cy motif from p21 reveals sequence degeneracy and specificity for different cyclin-dependent kinases
35. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase