Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination

Nature Cell Biology

Volumn 6, Issue 3, 2004, Pages 260-267

  Li, Anatoliy ^a   Blow, Julian ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CYCLIN DEPENDENT KINASE; DNA; GEMININ; MINICHROMOSOME MAINTENANCE PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA REPLICATION; EGG; GENE INACTIVATION; GENE REPLICATION; METAPHASE; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FUNCTION; UBIQUITINATION; XENOPUS LAEVIS;

ANIMALIA; XENOPUS LAEVIS;

EID: 1542714427     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1100     Document Type: Article

References (30)

1. Blow, J. J. & Hodgson, B. Replication licensing - defining the proliferative state? Trends Cell Biol. 12, 72-78 (2002).
2. Nishitani, H. & Lygerou, Z. Control of DNA replication licensing in a cell cycle. Genes Cells 7, 523-534 (2002).
3. Tada, S., Li, A., Maiorano, D., Mechali, M. & Blow, J. J. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nature Cell Biol. 3, 107-113 (2001).
4. Hodgson, B., Li, A., Tada, S. & Blow, J. J. Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import. Current Biol. 12, 678-683 (2002).
5. McGarry, T. J. & Kirschner, M. W. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93, 1043-1053 (1998).
6. Wohlschlegel, J. A. et al. Inhibition of eukaryotic replication by geminin binding to Cdt1. Science 290, 2309-2312 (2000).
7. Chong, J. P., Mahbubani, H. M., Khoo, C. Y. & Blow, J. J. Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375, 418-421 (1995).
8. Kubota, Y., Mimura, S., Nishimoto, S., Takisawa, H. & Nojima, H. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. Cell 81, 601-609 (1995).
9. Madine, M. A., Khoo, C.-Y., Mills, A. D. & Laskey, R. A. MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature 375, 421-424 (1995).
10. Blow, J. J. & Laskey, R. A. A role for the nuclear envelope in controlling DNA replication within the cell cycle. Nature 332, 546-548 (1988).
11. Blow, J. J. Preventing re-replication of DNA in a single cell cycle: Evidence for a replication licensing factor. J. Cell Biol. 122, 993-1002 (1993).
12. Kubota, Y. & Takisawa, H. Determination of initiation of DNA replication before and after nuclear formation in Xenopus egg cell free extracts. J. Cell Biol. 123, 1321-1331 (1993).
13. Gillespie, P. J. & Blow, J. J. Nucleoplasmin-mediated chromatin remodelling is required for Xenopus sperm nuclei to become licensed for DNA replication. Nucleic Acids Res. 28, 472-480 (2000).
14. Gillespie, P. J., Li, A. & Blow, J. J. Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins. BioMed Central Biochem. 2, 15 (2001).
15. Mahbubani, H. M., Chong, J. P., Chevalier, S., Thömmes, P. & Blow, J. J. Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor. J. Cell Biol. 136, 125-135 (1997).
16. Meijer, L. et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur. J. Biochem. 243, 527-536 (1997).
17. Blow, J. J. & Nurse, P. A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts. Cell 62, 855-862 (1990).
18. Zachariae, W. & Nasmyth, K. Whose end is destruction: Cell division and the anaphase-promoting complex. Genes Dev. 13, 2039-2058 (1999).
19. Peters, J. M. The anaphase-promoting complex: Proteolysis in mitosis and beyond. Mol. Cell 9, 931-943 (2002).
20. Luca, F. C. & Ruderman, J. V. Control of programmed cyclin destruction in a cell-free system. J. Cell Biol. 109, 1895-1909 (1989).
21. Peter, M. et al. The APC is dispensable for first meiotic anaphase in Xenopus oocytes. Nature Cell Biol. 3, 83-87 (2001).
22. Nishiyama, A. et al. A non-proteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M phase. Genes Dev. 14, 2344-2357 (2000).
23. Mahaffey, D., Yoo, Y. & Rechsteiner, M. Ubiquitin metabolism in cycling Xenopus egg extracts. J. Biol. Chem. 268, 21205-21211 (1993).
24. Bach, I. & Ostendorff, H. P. Orchestrating nuclear functions: ubiquitin sets the rhythm. Trends Biochem. Sci. 28, 189-195 (2003).
25. Schnell, J. D. & Hicke, L. Non-traditional functions of ubiquitin and ubiquitin-binding proteins. J. Biol. Chem. 278, 35857-35860 (2003).
26. Su, T. T. & O'Farrell, P. H. Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles. J. Cell Biol. 140, 451-460 (1998).
27. Coverley, D., Laman, H. & Laskey, R. A. Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nature Cell Biol. 4, 523-528 (2002).
28. Chong, J. P., Thömmes, P., Rowles, A., Mahbubani, H. M. & Blow, J. J. Characterization of the Xenopus replication licensing system. Methods Enzymol. 283, 549-564 (1997).
29. Strausfeld, U. P. et al. Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts. J. Cell Sci. 109, 1555-1563 (1996).
30. Maiorano, D., Moreau, J. & Mechali, M. XCDT1 is required for the assembly of prereplicative complexes in Xenopus laevis. Nature 404, 622-625 (2000).