Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosis

EMBO Reports

Volumn 3, Issue 8, 2002, Pages 780-784

  Pelizon, Cristina ^a   d'Adda di Fagagna, Fabrizio ^a   Farrace, Lorena ^a   Laskey, Ronald A ^a  

^a HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 3; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 6; DNA; MINICHROMOSOME MAINTENANCE PROTEIN; UNCLASSIFIED DRUG; CASP3 PROTEIN, HUMAN; CDC6 PROTEIN, HUMAN; DNA FRAGMENT; NUCLEAR PROTEIN;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DEATH; CELL DIVISION; CELL LINE; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; DNA REPLICATION; DNA REPLICATION ORIGIN; EUKARYOTE; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; STIMULUS RESPONSE; CELL NUCLEUS; CELL STRAIN HL 60; HELA CELL; LEUKEMIA CELL LINE; METABOLISM; MUTATION; PLASMID; TIME; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL CYCLE PROTEINS; CELL DEATH; CELL LINE; CELL NUCLEUS; CHROMATIN; DNA FRAGMENTATION; HELA CELLS; HL-60 CELLS; HUMAN; JURKAT CELLS; MUTATION; NUCLEAR PROTEINS; PLASMIDS; PROTEIN BINDING; TIME FACTORS; CASPASE 3; HUMANS;

EUKARYOTA;

EID: 0036668639     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvf161     Document Type: Article

References (12)

1. Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast
2. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
3. Survival and proliferation of cells expressing caspase-uncleavable Poly(ADP-ribose) polymerase in response to death-inducing DNA damage by an alkylating agent
4. Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation
5. Regulation of chromosome replication
6. Structure and function of Cdc6/Cdc18: Implications for origin recognition and checkpoint control
7. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis
8. Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle
9. Lamin proteolysis facilitates nuclear events during apoptosis
10. Selective proteolysis of the nuclear replication factor MCM3 in apoptosis
11. Executioner caspase-3,-6, and-7 perform distinct, non-redundant roles during the demolition phase of apoptosis
12. Cdc6 protein causes premature entry into S phase in a mammalian cell-free system