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Volumn , Issue , 2010, Pages 227-238

Gene therapy and imaging of transgene expression in living subjects

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; GENE THERAPY; HISTOLOGY; PATIENT TREATMENT; TISSUE;

EID: 84864530380     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511730405.010     Document Type: Chapter
Times cited : (3)

References (61)
  • 1
    • 34247855110 scopus 로고    scopus 로고
    • Nonviral gene delivery: What we know and what is next
    • Gao, X., Kim, K., Liu, D. (2007). Nonviral gene delivery: What we know and what is next. AAPS Journal 9(1): E92–E104.
    • (2007) AAPS Journal , vol.9 , Issue.1
    • Gao, X.1    Kim, K.2    Liu, D.3
  • 2
  • 3
    • 0742289464 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Noninvasive imaging of gene therapy in living subjects
    • Min, J. J., Gambhir, S. S. (2004).Gene therapy progress and prospects: noninvasive imaging of gene therapy in living subjects. Gene Therapy 11: 115–125.
    • (2004) Gene Therapy , vol.11 , pp. 115-125
    • Min, J.J.1    Gambhir, S.S.2
  • 4
    • 38949192176 scopus 로고    scopus 로고
    • Bret-based method for detection of specific rna species
    • Walls, Z., Gambhir, S. S. (2007). BRET-based method for detection of specific RNA species. Bioconjug Chem 19(1): 178–184.
    • (2007) Bioconjug Chem , vol.19 , Issue.1 , pp. 178-184
    • Walls, Z.1    Gambhir, S.S.2
  • 5
    • 46749148868 scopus 로고    scopus 로고
    • A generalizable strategy for imaging pre-mrna levels in living subjects using spliceosomemediated rna trans-splicing
    • Walls, Z. et al. (2008). A generalizable strategy for imaging pre-mRNA levels in living subjects using spliceosomemediated RNA trans-splicing. J Nucl Med 49(7): 1146–1154.
    • (2008) J Nucl Med , vol.49 , Issue.7 , pp. 1146-1154
    • Walls, Z.1
  • 6
    • 84882854046 scopus 로고    scopus 로고
    • Imaging and cancer
    • Mendelsohn, J. Et al. (Eds.), Saunders Elsevier: Philadelphia
    • Yaghoubi, S. S., Gambhir, S. S. (2008). Imaging and cancer. In: Mendelsohn, J. et al. (Eds.), The Molecular Basis of Cancer. Saunders Elsevier: Philadelphia: 309–323.
    • (2008) The Molecular Basis of Cancer , pp. 309-323
    • Yaghoubi, S.S.1    Gambhir, S.S.2
  • 7
    • 33845788246 scopus 로고    scopus 로고
    • Fetal gene transfer using lentiviral vectors: In vivo detection of gene expression by micropet and optical imaging in fetal and infantmonkeys
    • Tarantal, A. F. et al. (2006). Fetal gene transfer using lentiviral vectors: In vivo detection of gene expression by microPET and optical imaging in fetal and infantmonkeys. Hum Gene Ther 17: 1254–1261.
    • (2006) Hum Gene Ther , vol.17 , pp. 1254-1261
    • Tarantal, A.F.1
  • 8
    • 0034759663 scopus 로고    scopus 로고
    • A noninvasive reporter systemto image adenoviral-mediated gene transfer to ovarian cancer xenografts
    • Chaudhuri, T. R. et al. (2001). A noninvasive reporter systemto image adenoviral-mediated gene transfer to ovarian cancer xenografts. Gynecol Oncol 83: 432–438.
    • (2001) Gynecol Oncol , vol.83 , pp. 432-438
    • Chaudhuri, T.R.1
  • 9
    • 33746781077 scopus 로고    scopus 로고
    • Imaging chemically modified adenovirus for targeting tumors expressing integrin avb3 in living mice withmutant herpes simplex virus type 1 thymidine kinase pet reporter gene
    • Xiong, Z. et al. (2006). Imaging chemically modified adenovirus for targeting tumors expressing integrin avb3 in living mice withmutant herpes simplex virus type 1 thymidine kinase PET reporter gene. J Nucl Med 47(1): 130–139.
    • (2006) J Nucl Med , vol.47 , Issue.1 , pp. 130-139
    • Xiong, Z.1
  • 10
    • 0037047039 scopus 로고    scopus 로고
    • Positron emission tomography imaging of cardiac reporter gene expression in living rats
    • Wu, J. C. et al. (2002). Positron emission tomography imaging of cardiac reporter gene expression in living rats. Circulation 106: 180–183.
    • (2002) Circulation , vol.106 , pp. 180-183
    • Wu, J.C.1
  • 11
    • 0344897661 scopus 로고    scopus 로고
    • Imaging the spatial distribution of transgene expression in the lungswith positron emission tomography
    • Richard, J.-C. et al. (2003). Imaging the spatial distribution of transgene expression in the lungswith positron emission tomography. Gene Therapy 10: 2074–2080.
    • (2003) Gene Therapy , vol.10 , pp. 2074-2080
    • Richard, J.-C.1
  • 12
    • 33746883603 scopus 로고    scopus 로고
    • Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging
    • Deroose, C. M. et al. (2006). Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging. Mol Ther 14(3): 423–431.
    • (2006) Mol Ther , vol.14 , Issue.3 , pp. 423-431
    • Deroose, C.M.1
  • 13
    • 34247240603 scopus 로고    scopus 로고
    • Enhanced expression of adenovirusmediated sodium iodide symporter gene in mcf-7 breast cancer cells with retinoic acid treatment
    • Lim, S. J. et al. (2007). Enhanced expression of adenovirusmediated sodium iodide symporter gene in MCF-7 breast cancer cells with retinoic acid treatment. J Nucl Med 48(3): 398–404.
    • (2007) J Nucl Med , vol.48 , Issue.3 , pp. 398-404
    • Lim, S.J.1
  • 14
    • 34248136542 scopus 로고    scopus 로고
    • Positron emission tomography of herpes simplex virus 1 oncolysis
    • Kuruppu, D. et al. (2007). Positron emission tomography of herpes simplex virus 1 oncolysis. Cancer Research 67(7): 3295–3300.
    • (2007) Cancer Research , vol.67 , Issue.7 , pp. 3295-3300
    • Kuruppu, D.1
  • 15
    • 20844440770 scopus 로고    scopus 로고
    • Noninvasive imaging of ex vivo intracoronarily delivered nonviral therapeutic transgene expression in heart
    • Sen, L. et al. (2005). Noninvasive imaging of ex vivo intracoronarily delivered nonviral therapeutic transgene expression in heart. Mol Ther 12(1): 49–57.
    • (2005) Mol Ther , vol.12 , Issue.1 , pp. 49-57
    • Sen, L.1
  • 16
    • 0038103733 scopus 로고    scopus 로고
    • Optical imaging of transferrin targeted pei/dna complex in living subjects
    • Hildebrandt, I. J. et al. (2003). Optical imaging of transferrin targeted PEI/DNA complex in living subjects. Gene Therapy 10: 758–764.
    • (2003) Gene Therapy , vol.10 , pp. 758-764
    • Hildebrandt, I.J.1
  • 17
    • 0038529610 scopus 로고    scopus 로고
    • Noninvasive imaging of lentiviral-mediated reporter gene expression in living mice
    • De, A., Lewis, X. Z., Gambhir, S. S. (2003). Noninvasive imaging of lentiviral-mediated reporter gene expression in living mice. Mol Ther 7(5): 681–691.
    • (2003) Mol Ther , vol.7 , Issue.5 , pp. 681-691
    • De, A.1    Lewis, X.Z.2    Gambhir, S.S.3
  • 18
    • 0035300468 scopus 로고    scopus 로고
    • Positron emission tomographybased imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo
    • Jacobs, A. et al. (2001). Positron emission tomographybased imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. Cancer Research 61: 2983–2995.
    • (2001) Cancer Research , vol.61 , pp. 2983-2995
    • Jacobs, A.1
  • 19
    • 0034924079 scopus 로고    scopus 로고
    • Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer
    • Bennett, J. J. et al. (2001). Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer. Nat Med 7(7): 859–863.
    • (2001) Nat Med , vol.7 , Issue.7 , pp. 859-863
    • Bennett, J.J.1
  • 20
    • 14644408765 scopus 로고    scopus 로고
    • Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography
    • Yaghoubi, S. S. et al. (2005). Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography. Cancer Gene Therapy 12: 329–339.
    • (2005) Cancer Gene Therapy , vol.12 , pp. 329-339
    • Yaghoubi, S.S.1
  • 21
    • 0036717714 scopus 로고    scopus 로고
    • Cl1-sr39:Anoninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomography
    • Pantuck, A. J. et al. (2002).CL1-SR39:Anoninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomography. J Urol 168: 1193–1198.
    • (2002) J Urol , vol.168 , pp. 1193-1198
    • Pantuck, A.J.1
  • 22
    • 0036252491 scopus 로고    scopus 로고
    • Optimizing prostate cancer suicide gene therapy using herpes simplex virus thymidine kinase active site variants
    • Pantuck, A. J. et al. (2002). Optimizing prostate cancer suicide gene therapy using herpes simplex virus thymidine kinase active site variants. HumGene Ther 13: 777–789.
    • (2002) Humgene Ther , vol.13 , pp. 777-789
    • Pantuck, A.J.1
  • 23
    • 49149086250 scopus 로고    scopus 로고
    • Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer
    • Burton, J. B. et al. (2008). Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer. Nat Med 14(8): 882–888.
    • (2008) Nat Med , vol.14 , Issue.8 , pp. 882-888
    • Burton, J.B.1
  • 24
    • 1642512319 scopus 로고    scopus 로고
    • Non-invasive in vivo imaging with radiolabelled fiau for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir
    • Deng, W. et al. (2004). Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir. Eur J Nucl Med Mol Imaging 31(1): 99–109.
    • (2004) Eur J Nucl Med Mol Imaging , vol.31 , Issue.1 , pp. 99-109
    • Deng, W.1
  • 25
    • 33747125144 scopus 로고    scopus 로고
    • Molecular imaging with 123i-fiau, 18f-fudr, 18f-fet, and 18f-fdg for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer
    • Wang, H. et al (2006).Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET, and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and Ganciclovir prodrug activation gene therapy of cancer. J Nucl Med 47: 1161–1171.
    • (2006) J Nucl Med , vol.47 , pp. 1161-1171
    • Wang, H.1
  • 26
    • 33745552227 scopus 로고    scopus 로고
    • Serial in vivo imaging of lung metastases model and gene therapy using hsv1-tk and ganciclovir
    • Deng, W. et al (2006). Serial in vivo imaging of lung metastases model and gene therapy using HSV1-tk and Ganciclovir. J Nucl Med 47: 877–884.
    • (2006) J Nucl Med , vol.47 , pp. 877-884
    • Deng, W.1
  • 27
    • 29144475795 scopus 로고    scopus 로고
    • Gene therapy imaging in patients for oncological applications
    • Penuelas, I. et al. (2005). Gene therapy imaging in patients for oncological applications. Eur J Nucl Med Mol Imaging 32(14): S384–S403.
    • (2005) Eur J Nucl Med Mol Imaging , vol.32 , Issue.14 , pp. S384-S403
    • Penuelas, I.1
  • 28
    • 0034898675 scopus 로고    scopus 로고
    • Human pharmacokinetic and dosimetry studies of [18f]fhbg: A reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression
    • Yaghoubi, S. S. et al. (2001). Human pharmacokinetic and dosimetry studies of [18F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med 42: 1225–1234.
    • (2001) J Nucl Med , vol.42 , pp. 1225-1234
    • Yaghoubi, S.S.1
  • 29
    • 33745080072 scopus 로고    scopus 로고
    • Preclinical safety evaluation of 18f-fhbg: A pet reporter probe for imaging herpes simplex virus type 1 thymidine kinase (hsv1-tk) ormutant hsv1-sr39tk's expression
    • Yaghoubi, S. S. et al. (2006). Preclinical safety evaluation of 18F-FHBG: A PET reporter probe for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) ormutant HSV1-sr39tk's expression. J Nucl Med 47(4): 706–715.
    • (2006) J Nucl Med , vol.47 , Issue.4 , pp. 706-715
    • Yaghoubi, S.S.1
  • 30
    • 20444466384 scopus 로고    scopus 로고
    • Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients
    • Penuelas, I. et al. (2005). Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients. Gastroenterology 128(7): 1787–1795.
    • (2005) Gastroenterology , vol.128 , Issue.7 , pp. 1787-1795
    • Penuelas, I.1
  • 31
    • 0035448565 scopus 로고    scopus 로고
    • Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas
    • Jacobs, A. et al. (2001). Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas. Lancet 358: 727–729.
    • (2001) Lancet , vol.358 , pp. 727-729
    • Jacobs, A.1
  • 32
    • 33748110630 scopus 로고    scopus 로고
    • Assessment of 123i-fiau imaging of herpes simplex viral gene expression in the treatment of glioma
    • Dempsey, M. F. et al. (2006). Assessment of 123I-FIAU imaging of herpes simplex viral gene expression in the treatment of glioma. Nucl Med Commun 27: 611–617.
    • (2006) Nucl Med Commun , vol.27 , pp. 611-617
    • Dempsey, M.F.1
  • 33
    • 73949092897 scopus 로고    scopus 로고
    • Noninvasive detection of therapeutic cytolytic t cells with 18f-fhbg in a patient with glioma
    • Yaghoubi, S. S. et al. Noninvasive detection of therapeutic cytolytic T cells with 18F-FHBG in a patient with glioma. Nat Clin Pract Oncol 6: 53–58.
    • Nat Clin Pract Oncol , vol.6 , pp. 53-58
    • Yaghoubi, S.S.1
  • 34
    • 39549086787 scopus 로고    scopus 로고
    • Semiautomated radiosynthesis and biological evaluation of [18f]feau: A novel pet imaging agent for hsv1-tk/sr39tk reporter gene expression
    • Chin, F. T. et al. (2008). Semiautomated radiosynthesis and biological evaluation of [18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression. Mol Imaging Biol 10(2): 82–91.
    • (2008) Mol Imaging Biol , vol.10 , Issue.2 , pp. 82-91
    • Chin, F.T.1
  • 35
    • 18244428952 scopus 로고    scopus 로고
    • Synthesis and preliminary evaluation of 9-(4-[18f]-fluoro-3- hydroxymethylbutyl)guanine ([18f]fhbg): Anewpotential imaging agent for viral infection and gene therapy using pet
    • Alauddin, M. M., Conti, P. S. (1998). Synthesis and preliminary evaluation of 9-(4-[18F]-Fluoro-3- Hydroxymethylbutyl)Guanine ([18F]FHBG): anewpotential imaging agent for viral infection and gene therapy using PET. Nucl Med Biol 25: 175–180.
    • (1998) Nucl Med Biol , vol.25 , pp. 175-180
    • Alauddin, M.M.1    Conti, P.S.2
  • 36
    • 0035209394 scopus 로고    scopus 로고
    • Preclinical evaluation of the penciclovir analog 9-(4-[18f]fluoro-3-hydroxymethylbutyl) guanine for in vivo measurement of suicide gene expression with pet
    • Alauddin, M. A. et al. (2001). Preclinical evaluation of the penciclovir analog 9-(4-[18F]fluoro-3-hydroxymethylbutyl) guanine for in vivo measurement of suicide gene expression with PET. J Nucl Med 42(11): 1682–1690.
    • (2001) J Nucl Med , vol.42 , Issue.11 , pp. 1682-1690
    • Alauddin, M.A.1
  • 37
    • 0034753231 scopus 로고    scopus 로고
    • Monitoring gene therapy with reporter gene imaging
    • Ray, P. et al. (2001).Monitoring gene therapy with reporter gene imaging. Semin Nucl Med 31(4): 312–320.
    • (2001) Semin Nucl Med , vol.31 , Issue.4 , pp. 312-320
    • Ray, P.1
  • 38
    • 29444443670 scopus 로고    scopus 로고
    • Applications ofmolecular imaging in cancer gene therapy
    • Iyer, M. et al (2005). Applications ofmolecular imaging in cancer gene therapy. Curr Gene Ther 5: 607–618.
    • (2005) Curr Gene Ther , vol.5 , pp. 607-618
    • Iyer, M.1
  • 39
    • 0034048929 scopus 로고    scopus 로고
    • Imaging transgene expression with radionuclide imaging technologies
    • Gambhir, S. S. et al. (2000). Imaging transgene expression with radionuclide imaging technologies. Neoplasia 2(1–2): 118–138.
    • (2000) Neoplasia , vol.2 , Issue.1-2 , pp. 118-138
    • Gambhir, S.S.1
  • 40
    • 0013109414 scopus 로고    scopus 로고
    • Monitoring gene therapy by positron emission tomography
    • Curiel, D. T., and Douglas, J. T. (Eds.), Wiley-Liss: New York
    • Herschman, H. R. et al. (2002). Monitoring gene therapy by positron emission tomography. In: Curiel, D. T., and Douglas, J. T. (Eds.), Vector Targeting for Therapeutic Gene Delivery 661–685.Wiley-Liss: New York.
    • (2002) Vector Targeting for Therapeutic Gene Delivery 661–685
    • Herschman, H.R.1
  • 41
    • 0034785946 scopus 로고    scopus 로고
    • Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors
    • Yaghoubi, S. S. et al. (2001). Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors. Gene Therapy 8: 1072–1080.
    • (2001) Gene Therapy , vol.8 , pp. 1072-1080
    • Yaghoubi, S.S.1
  • 42
    • 0033827201 scopus 로고    scopus 로고
    • Quantification of target gene expression by imaging reporter gene expression in living animals
    • Yu, Y. et al. (2000).Quantification of target gene expression by imaging reporter gene expression in living animals. Nat Med 6(8): 933–937.
    • (2000) Nat Med , vol.6 , Issue.8 , pp. 933-937
    • Yu, Y.1
  • 43
    • 0036665466 scopus 로고    scopus 로고
    • Noninvasive, repetitive, quantitative measurement of gene expression froma bicistronic message by positron emission tomography, following gene transfer with adenovirus
    • Liang, Q. et al. (2002).Noninvasive, repetitive, quantitative measurement of gene expression froma bicistronic message by positron emission tomography, following gene transfer with adenovirus. Mol Ther 6(1): 73–82.
    • (2002) Mol Ther , vol.6 , Issue.1 , pp. 73-82
    • Liang, Q.1
  • 44
    • 19644398835 scopus 로고    scopus 로고
    • Noninvasive monitoring of target gene expression by imaging reporter gene expression in living animals using improved bicistronic vectors
    • Wang, Y. et al. (2005). Noninvasive monitoring of target gene expression by imaging reporter gene expression in living animals using improved bicistronic vectors. J Nucl Med 46: 667–674.
    • (2005) J Nucl Med , vol.46 , pp. 667-674
    • Wang, Y.1
  • 45
    • 1642329864 scopus 로고    scopus 로고
    • Micro–positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery
    • Chen, I. Y. et al. (2004). Micro–positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery. Circulation 109: 1415–1420.
    • (2004) Circulation , vol.109 , pp. 1415-1420
    • Chen, I.Y.1
  • 46
    • 0033205584 scopus 로고    scopus 로고
    • A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase
    • Tjuvajev, J. G. et al. (1999). A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase. Neoplasia 1: 315–320.
    • (1999) Neoplasia , vol.1 , pp. 315-320
    • Tjuvajev, J.G.1
  • 47
    • 0034652214 scopus 로고    scopus 로고
    • A 9- nt segment of a cellular mrna can function as an internal ribosome entry site (ires) and when present in linked multiple copies greatly enhances ires activity
    • Chappell, S. A., Edelman, G. M., Mauro, V. P. (2000). A 9- nt segment of a cellular mRNA can function as an Internal Ribosome Entry Site (IRES) and when present in linked multiple copies greatly enhances IRES activity. PNAS 97(4): 1536–1541.
    • (2000) PNAS , vol.97 , Issue.4 , pp. 1536-1541
    • Chappell, S.A.1    Edelman, G.M.2    Mauro, V.P.3
  • 48
    • 11144307071 scopus 로고    scopus 로고
    • Coexpression of herpesviral thymidine kinase reporter gene and vegf gene for noninvasive monitoring of therapeutic gene transfer: An in vitro evaluation
    • Anton, M. et al. (2004). Coexpression of herpesviral thymidine kinase reporter gene and VEGF gene for noninvasive monitoring of therapeutic gene transfer: an in vitro evaluation. J Nucl Med 45(10): 1743–1746.
    • (2004) J Nucl Med , vol.45 , Issue.10 , pp. 1743-1746
    • Anton, M.1
  • 49
    • 84864537600 scopus 로고    scopus 로고
    • Monitoring p53 therapeutic transgene expression in mice by imaging the expression of a linked hsv1-sr39tk pet reporter transgene
    • Yaghoubi, S. S., Gambhir, S. S. (2003). Monitoring p53 therapeutic transgene expression in mice by imaging the expression of a linked HSV1-sr39tk PET reporter transgene. J Nucl Med 44(5): 30P [Abstract#95].
    • (2003) J Nucl Med , vol.44 , Issue.5
    • Yaghoubi, S.S.1    Gambhir, S.S.2
  • 50
    • 0035172469 scopus 로고    scopus 로고
    • Quantitative imaging of gene induction in living animals
    • Sun, X. et al. (2001). Quantitative imaging of gene induction in living animals. Gene Therapy 8: 1572–1579.
    • (2001) Gene Therapy , vol.8 , pp. 1572-1579
    • Sun, X.1
  • 51
    • 3142770344 scopus 로고    scopus 로고
    • Novel bidirectional vector strategy for amplification of therapeutic and reporter gene expression
    • Ray, S. et al. (2004). Novel bidirectional vector strategy for amplification of therapeutic and reporter gene expression. Hum Gene Ther 15: 681–690.
    • (2004) Hum Gene Ther , vol.15 , pp. 681-690
    • Ray, S.1
  • 52
    • 1242338786 scopus 로고    scopus 로고
    • Imaging tri-fusion multimodality reporter gene expression in living subjects
    • Ray, P. et al. (2004). Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Research 64: 1323–1330.
    • (2004) Cancer Research , vol.64 , pp. 1323-1330
    • Ray, P.1
  • 53
    • 34248169598 scopus 로고    scopus 로고
    • Construction and validation of improved triple fusion reporter gene vectors for molecular imaging of living subjects
    • Ray, P., Tsien, R., Gambhir, S. S. (2007). Construction and validation of improved triple fusion reporter gene vectors for molecular imaging of living subjects. Cancer Research 67(7): 3085–3093.
    • (2007) Cancer Research , vol.67 , Issue.7 , pp. 3085-3093
    • Ray, P.1    Tsien, R.2    Gambhir, S.S.3
  • 54
    • 0037444158 scopus 로고    scopus 로고
    • Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice
    • Ray, P., Wu, A. M., Gambhir, S. S. (2003). Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice. Cancer Research 63: 1160–1165.
    • (2003) Cancer Research , vol.63 , pp. 1160-1165
    • Ray, P.1    Wu, A.M.2    Gambhir, S.S.3
  • 55
    • 0042475156 scopus 로고    scopus 로고
    • Development of a new reporter gene system-dsred/xanthine phosphoribosyltransferase- xanthine for molecular imaging of processes behind the intact blood–brain barrier
    • Doubrovin, M. et al Development of a new reporter gene system-dsRed/Xanthine Phosphoribosyltransferase- Xanthine for molecular imaging of processes behind the intact blood–brain barrier. Mol Imaging 2(2): 93–112.
    • Mol Imaging , vol.2 , Issue.2 , pp. 93-112
    • Doubrovin, M.1
  • 56
    • 2442562277 scopus 로고    scopus 로고
    • A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging
    • Ponomarev, V. et al. (2004). A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. Eur JNuclMedMol Imaging 31: 740–751.
    • (2004) Eur Jnuclmedmol Imaging , vol.31 , pp. 740-751
    • Ponomarev, V.1
  • 57
    • 0033139768 scopus 로고    scopus 로고
    • Functional coexpression of hsv-thymidine kinase and green fluorescent protein: Implications for noninvasive imaging of transgene expression
    • Jacobs, A. et al. (1999). Functional coexpression of HSV-thymidine kinase and green fluorescent protein: implications for noninvasive imaging of transgene expression. Neoplasia 1(2): 154–161.
    • (1999) Neoplasia , vol.1 , Issue.2 , pp. 154-161
    • Jacobs, A.1
  • 58
    • 34248531774 scopus 로고    scopus 로고
    • Development of a dual membrane protein reporter system using sodium iodide symporter and mutant dopamine d2 receptor transgenes
    • Hwang, D. W. et al. Development of a dual membrane protein reporter system using sodium iodide symporter and mutant dopamine D2 receptor transgenes. J Nucl Med 48(4): 588–595.
    • J Nucl Med , vol.48 , Issue.4 , pp. 588-595
    • Hwang, D.W.1
  • 59
    • 0035979208 scopus 로고    scopus 로고
    • Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo
    • Doubrovin, M. et al. (2001). Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo. PNAS 98(16): 9300–9305.
    • (2001) PNAS , vol.98 , Issue.16 , pp. 9300-9305
    • Doubrovin, M.1
  • 60
    • 0036211595 scopus 로고    scopus 로고
    • Indirect monitoring of endogenous gene expression by positron emission tomography (pet) imaging of reporter gene expression in transgenic mice
    • Green, L. A. et al. (2002). Indirect monitoring of endogenous gene expression by positron emission tomography (PET) imaging of reporter gene expression in transgenic mice. Mol Imaging Biol 4(1): 71–81.
    • (2002) Mol Imaging Biol , vol.4 , Issue.1 , pp. 71-81
    • Green, L.A.1
  • 61
    • 6944256513 scopus 로고    scopus 로고
    • A tracer kinetic model for 18ffhbg for quantitating herpes simplex virus type 1 thymidine kinase reporter gene expression in living animals using pet
    • Green, L. A. et al. (2004). A tracer kinetic model for 18FFHBG for quantitating herpes simplex virus type 1 thymidine kinase reporter gene expression in living animals using PET. J Nucl Med 45(9): 1560–1570.
    • (2004) J Nucl Med , vol.45 , Issue.9 , pp. 1560-1570
    • Green, L.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.