Assessment of I-FIAU imaging of herpes simplex viral gene expression in the treatment of glioma

Nuclear Medicine Communications

Volumn 27, Issue 8, 2006, Pages 611-617

  Dempsey, Mary F ^a   Wyper, David ^b   Owens, Jonathan ^b   Pimlott, Sally ^a   Papanastassiou, Vakis ^a   Patterson, James ^a   Hadley, Donald M ^a   Nicol, Alice ^c   Rampling, Roy ^c   Brown, S M ^d  

^a Division of Neurology   (United Kingdom)

^b West of Scotland Radionuclide Dispensary   (United Kingdom)

^c BEATSON WEST OF SCOTLAND CANCER CENTRE   (United Kingdom)

^d S Moira Brown Crusade Laboratories Glasgow   (United Kingdom)

Author keywords

FIAU; Glioma; Herpes simplex virus; Molecular imaging

Indexed keywords

DIAGNOSTIC AGENT; DRUG DERIVATIVE; FIALURIDINE; RADIOACTIVE IODINE; RADIOPHARMACEUTICAL AGENT; THYMIDINE KINASE; THYMIDINE KINASE, CANID HERPESVIRUS 1; URACIL ARABINOSIDE; VIRUS PROTEIN; ANTINEOPLASTIC AGENT; FIALURIDINE I 123; HSV 1716; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL TRIAL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE THERAPY; GLIOMA; HERPES SIMPLEX VIRUS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; VIROLOGY; VIRUS REPLICATION; BLOOD SAMPLING; CANCER GRADING; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG UPTAKE; GLIOBLASTOMA; HERPES SIMPLEX VIRUS 1; IMAGE ANALYSIS; ISOTOPE LABELING; NON INVASIVE PROCEDURE; REPORTER GENE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STEREOTAXIC SURGERY;

ARABINOFURANOSYLURACIL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE THERAPY; GLIOMA; HUMANS; IODINE RADIOISOTOPES; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SIMPLEXVIRUS; THYMIDINE KINASE; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 33748110630     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/00006231-200608000-00003     Document Type: Article

References (23)

1. Brown SM, Harland J, MacLean AR, Podlech J, Clements JB. Cell type and cell state determine differential in vitro growth of non-neurovirulent ICP34.5-negative herpes simplex virus types 1 and 2. J Gen Virol 1994; 75:2367-2377.
2. McKie EA, MacLean AR, Lewis AD, Cruickshank G, Rampling R, Barnett SC, et al. Selective in vitro replication of herpes simplex virus type 1 (HSV-1) ICP34.5 null mutants in primary human CNS tumours - evaluation of a potentially effective clinical therapy. Br J Cancer 1996; 74:745-752.
3. Tjuvajev JG, Stockhammer G, Desai R, Uehara H, Watanabe K, Gansbacher B, et al. Imaging the expression of transfected genes in vivo. Cancer Res 1995; 55:6126-6132.
4. Tjuvajev JG, Finn R, Watanabe K, Joshi R, Oku T, Kennedy J, et al. Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res 1996; 56:4087-4095.
5. Tjuvajev JG, Avril N, Oku T, Sasajima T, Miyagawa T, Joshi R, et al. Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res 1998; 58:4333-4341.
6. Penuelas I, Mazzolini G, Boan JF, Sangro B, Marti-Clement J, Ruiz M, et al. Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients. Gastroenterology 2005; 128:1787-1795.
7. Tjuvajev JG, Doubrovin M, Akhurst T, Cai S, Balatoni J, Alauddin MM, et al. Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. J Nucl Med 2002; 43:1072-1083.
8. 124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression. Eur J Nucl Med 2001; 28:721-729.
9. Deng WP, Yang WK, Lai WF, Liu RS, Hwang JJ, Yang DM, et al. Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir. Eur J Nucl Med Mol Imaging 2004; 31:99-109.
10. Haubner R, Avril N, Hantzopoulos PA, Gansbacher B, Schwaiger M. In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU. Eur J Nucl Med 2000; 27:283-291.
11. Blasberg RG, Tjuvajev JG. Herpes simplex virus thymidine kinase as a marker/reporter gene for PET imaging of gene therapy. Q J Nucl Med 1999; 43:163-169.
12. 124I]FIAU in cat and man. J Nucl Med 2001; 42:467-475.
13. Jacobs A, Tjuvajev JG, Dubrovin M, Akhurst T, Balatoni J, Beattie B, et al. Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. Cancer Res 2001; 61:2983-2995.
14. Bennett JJ, Tjuvajev J, Johnson P, Doubrovin M, Akhurst T, Malholtra S, et al. Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer. Nat Med 2001; 7:859-863.
15. Papanastassiou V, Rampling R, Fraser M, Petty R, Hadley D, Nicoll J, et al. The potential for efficacy of the modified (ICP 34.5(−)) herpes simplex virus HSV1716 following intratumoural injection into human malignant glioma: a proof of principle study. Gene Ther 2002; 9:398-406.
16. Rampling R, Cruickshank G, Papanastassiou V, Nicoll J, Hadley D, Brennan D, et al. Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma. Gene Ther 2000; 7:859-866.
17. 211At]astato-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil by a halodestannylation reaction. Nucl Med Biol 1998; 25:487-496.
18. Yaghoubi S, Barrio JR, Dahlbom M, Iyer M, Namavari M, Satyamurthy N, et al. Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med 2001; 42:1225-1234.
19. Morin KW, Duan W, Xu L, Zhou A, Moharram S, Knaus EE, et al. Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells. Nucl Med Biol 2004; 31:623-630.
20. Kang KW, Min JJ, Chen X, Gambhir SS. Comparison of [(14)C]FMAU, [(3)H]FEAU, [(14)C]FIAU, and [(3)H]PCV for monitoring reporter gene expression of wild type and mutant herpes simplex virus type 1 thymidine kinase in cell culture. Mol Imaging Biol 2005; 7:296-303.
21. Temsamani J, Rousselle C, Rees AR, Scherrmann JM. Vector-mediated drug delivery to the brain. Expert Opin Biol Ther 2001; 1:773-782.
22. Rapoport SI. Advances in osmotic opening of the blood-brain barrier to enhance CNS chemotherapy. Expert Opin Investig Drugs 2001; 10:1809-1818.
23. 18F-FEAU as a radiotracer for herpes simplex virus thymidine kinase gene expression: in-vitro comparison with other PET tracers. Nucl Med Commun 2006; 27:25-30.