Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 39, Issue 1, 2012, Pages 182-191

  Stoltenberg, Scott F ^a   Christ, Christa C ^a   Highland, Krista B ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

5 HTTLPR; HTR1B (rs6296); HTR2A (rs6313); MAOA uVNTR; TPH2 (rs1386483)

Indexed keywords

5 HTTLPR GENE; ADULT; ARTICLE; BARRATT IMPULSIVENESS SCALE; EARLY LIFE STRESS; FEMALE; GENE; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC EPISTASIS; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HTR1B GENE; HTR2A GENE; HUMAN; IMPULSIVENESS; MALE; MAOA GENE; PSYCHOLOGIC ASSESSMENT; PSYCHOLOGICAL RATING SCALE; PSYCHOTRAUMA; SCORING SYSTEM; SEROTONINERGIC SYSTEM; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TPH2 GENE; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; ADULT SURVIVORS OF CHILD ABUSE; CROSS-SECTIONAL STUDIES; EPISTASIS, GENETIC; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; IMPULSIVE BEHAVIOR; LIFE CHANGE EVENTS; MALE; MONOAMINE OXIDASE; POLYMORPHISM, GENETIC; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT1B; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX CHARACTERISTICS; TRYPTOPHAN HYDROXYLASE;

EID: 84864504045     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2012.06.012     Document Type: Article

References (82)

1. Barratt E.S., Felthous A.R. Impulsive versus premeditated aggression: implications for mens rea decisions. Behav Sci Law 2003, 21:619-630.
2. Barry D., Clarke M., Petry N.M. Obesity and its relationship to addictions: is overeating a form of addictive behavior?. Am J Addict 2009, 18:439-451.
3. Benjamini Y., Hochberg Y. Controlling the False Discovery Rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995, 57:289-300.
4. Benko A., Lazary J., Molnar E., Gonda X., Tothfalusi L., Pap D., et al. Significant association between the C(-1019)G functional polymorphism of the HTR1A gene and impulsivity. Am J Med Genet B Neuropsychiatr Genet 2010, 153B:592-599.
5. Beste C., Domschke K., Falkenstein M., Konrad C. Differential modulations of response control processes by 5-HT1A gene variation. Neuroimage 2010, 50:764-771.
6. Beste C., Domschke K., Radenz B., Falkenstein M., Konrad C. The functional 5-HT1A receptor polymorphism affects response inhibition processes in a context-dependent manner. Neuropsychologia 2011, 49:2664-2672.
7. Bezdjian S., Baker L.A., Tuvblad C. Genetic and environmental influences on impulsivity: a meta-analysis of twin, family and adoption studies. Clin Psychol Rev 2011, 31:1209-1223.
8. Biver F., Lotstra F., Monclus M., Wikler D., Damhaut P., Mendlewicz J., et al. Sex difference in 5HT2 receptor in the living human brain. Neurosci Lett 1996, 204:25-28.
9. Bjork J.M., Moeller F.G., Dougherty D.M., Swann A.C., Machado M.A., Hanis C.L. Serotonin 2a receptor T102C polymorphism and impaired impulse control. Am J Med Genet 2002, 114:336-339.
10. Blonigen D.M., Timko C., Moos B.S., Moos R.H. Impulsivity is an independent predictor of 15-year mortality risk among individuals seeking help for alcohol-related problems. Alcohol Clin Exp Res 2011, 35:2082-2092.
11. Carver C.S., Johnson S.L., Joormann J. Serotonergic function, two-mode models of self-regulation, and vulnerability to depression: what depression has in common with impulsive aggression. Psychol Bull 2008, 134:912-943.
12. Carver C.S., Johnson S.L., Joormann J., Kim Y., Nam J.Y. Serotonin transporter polymorphism interacts with childhood adversity to predict aspects of impulsivity. Psychol Sci 2011, 22:589-595.
13. Caspi A., Hariri A.R., Holmes A., Uher R., Moffitt T.E. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 2010, 167:509-527.
14. Conner T.S., Jensen K.P., Tennen H., Furneaux H.M., Kranzler H.R., Covault J. Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men. Am J Med Genet B Neuropsychiatr Genet 2010, 153B:67-78.
15. Derringer J., Krueger R.F., Dick D.M., Saccone S., Grucza R.A., Agrawal A., et al. Predicting sensation seeking from dopamine genes. A candidate-system approach. Psychol Sci 2010, 21:1282-1290.
16. Dick D.M., Smith G., Olausson P., Mitchell S.H., Leeman R.F., O'Malley S.S., et al. Understanding the construct of impulsivity and its relationship to alcohol use disorders. Addict Biol 2010, 15:217-226.
17. DiLillo D., Hayes-Skelton S.A., Fortier M.A., Perry A.R., Evans S.E., Messman Moore T.L., et al. Development and initial psychometric properties of the Computer Assisted Maltreatment Inventory (CAMI): a comprehensive self-report measure of child maltreatment history. Child Abuse Negl 2010, 34:305-317.
18. Evenden J.L. Varieties of impulsivity. Psychopharmacology (Berl) 1999, 146:348-361.
19. Fineberg N.A., Potenza M.N., Chamberlain S.R., Berlin H.A., Menzies L., Bechara A., et al. Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review. Neuropsychopharmacology 2010, 35:591-604.
20. Giegling I., Olgiati P., Hartmann A.M., Calati R., Moller H.J., Rujescu D., et al. Personality and attempted suicide. Analysis of anger, aggression and impulsivity. J Psychiatr Res 2009, 43:1262-1271.
21. Hamilton K.R., Potenza M.N. Relations among delay discounting, addictions, and money mismanagement: implications and future directions. Am J Drug Alcohol Abuse 2012, 36:434-449.
22. Hu X., Oroszi G., Chun J., Smith T.L., Goldman D., Schuckit M.A. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res 2005, 29:8-16.
23. Huang Y.Y., Cate S.P., Battistuzzi C., Oquendo M.A., Brent D., Mann J.J. An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology 2004, 29:1498-1505.
24. Ioannidis J.P., Ntzani E.E., Trikalinos T.A. 'Racial' differences in genetic effects for complex diseases. Nat Genet 2004, 36:1312-1318.
25. Jabbi M., Korf J., Kema I.P., Hartman C., van der Pompe G., Minderaa R.B., et al. Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA. Mol Psychiatry 2007, 12:483-490.
26. Jakubczyk A., Wrzosek M., Lukaszkiewicz J., Sadowska-Mazuryk J., Matsumoto H., Sliwerska E., et al. The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients. J Psychiatr Res 2012, 46:44-49.
27. Juhasz G., Downey D., Hinvest N., Thomas E., Chase D., Toth Z.G., et al. Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders. Neuropsychopharmacology 2010, 35:1109-1119.
28. Kuntsi J., McLoughlin G., Asherson P. Attention deficit hyperactivity disorder. Neuromolecular Med 2006, 8:461-484.
29. Lemonde S., Turecki G., Bakish D., Du L., Hrdina P.D., Bown C.D., et al. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 2003, 23:8788-8799.
30. Liu L., Guan L.L., Chen Y., Ji N., Li H.M., Li Z.H., et al. Association analyses of MAOA in Chinese Han subjects with attention-deficit/hyperactivity disorder: family-based association test, case-control study, and quantitative traits of impulsivity. Am J Med Genet B Neuropsychiatr Genet 2011, 156B:737-748.
31. Lopez de Lara C., Brezo J., Rouleau G., Lesage A., Dumont M., Alda M., et al. Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression. Biol Psychiatry 2007, 62:72-80.
32. Lung F.W., Tzeng D.S., Huang M.F., Lee M.B. Association of the MAOA promoter uVNTR polymorphism with suicide attempts in patients with major depressive disorder. BMC Med Genet 2011, 12:74.
33. Mackay T.F., Stone E.A., Ayroles J.F. The genetics of quantitative traits: challenges and prospects. Nat Rev Genet 2009, 10:565-577.
34. Manchia M., Zai C.C., Squassina A., Vincent J.B., De Luca V., Kennedy J.L. Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes. Eur Neuropsychopharmacol 2010, 20:663-670.
35. McCrory E., De Brito S.A., Viding E. The impact of childhood maltreatment: a review of neurobiological and genetic factors. Front Psychiatry 2011, 2:48.
36. Murphy D.L., Moya P.R. Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional GxG and GxE differences in health and disease. Curr Opin Pharmacol 2011, 11:3-10.
37. Nakamura M., Ueno S., Sano A., Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry 2000, 5:32-38.
38. New A.S., Gelernter J., Goodman M., Mitropoulou V., Koenigsberg H., Silverman J., et al. Suicide, impulsive aggression, and HTR1B genotype. Biol Psychiatry 2001, 50:62-65.
39. Nishizawa S., Benkelfat C., Young S.N., Leyton M., Mzengeza S., de Montigny C., et al. Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci U S A 1997, 94:5308-5313.
40. Niv S., Tuvblad C., Raine A., Wang P., Baker L.A. Heritability and longitudinal stability of impulsivity in adolescence. Behav Genet 2012, 42:378-392.
41. Nugent N.R., Tyrka A.R., Carpenter L.L., Price L.H. Gene-environment interactions: early life stress and risk for depressive and anxiety disorders. Psychopharmacology (Berl) 2011, 214:175-196.
42. Oades R.D., Lasky-Su J., Christiansen H., Faraone S.V., Sonuga-Barke E.J., Banaschewski T., et al. The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): findings from a family-based association test (FBAT) analysis. Behav Brain Funct 2008, 4:48.
43. Paaver M., Nordquist N., Parik J., Harro M., Oreland L., Harro J. Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing. Psychopharmacology (Berl) 2007, 194:545-554.
44. Paaver M., Kurrikoff T., Nordquist N., Oreland L., Harro J. The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations in girls. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32:1263-1268.
45. Parsons M.J., D'Souza U.M., Arranz M.J., Kerwin R.W., Makoff A.J. The -1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity. Biol Psychiatry 2004, 56:406-410.
46. Pattij T., Vanderschuren L.J. The neuropharmacology of impulsive behaviour. Trends Pharmacol Sci 2008, 29:192-199.
47. Patton J.H., Stanford M.S., Barratt E.S. Factor structure of the Barratt impulsiveness scale. J Clin Psychol 1995, 51:768-774.
48. Perez-Rodriguez M.M., Weinstein S., New A.S., Bevilacqua L., Yuan Q., Zhou Z., et al. Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls. J Psychiatr Res 2010, 44:1075-1081.
49. Peterson R.E., Maes H.H., Holmans P., Sanders A.R., Levinson D.F., Shi J., et al. Genetic risk sum score comprised of common polygenic variation is associated with body mass index. Hum Genet 2011, 129:221-230.
50. Reuter M., Ott U., Vaitl D., Hennig J. Impaired executive control is associated with a variation in the promoter region of the tryptophan hydroxylase 2 gene. J Cogn Neurosci 2007, 19:401-408.
51. Robbins T.W., Gillan C.M., Smith D.G., de Wit S., Ersche K.D. Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry. Trends Cogn Sci 2012, 16:81-91.
52. Rujescu D., Giegling I., Sato T., Moller H.J. Lack of association between serotonin 5-HT1B receptor gene polymorphism and suicidal behavior. Am J Med Genet B Neuropsychiatr Genet 2003, 116B:69-71.
53. Sabol S.Z., Hu S., Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 1998, 103:273-279.
54. Saiz P.A., Garcia-Portilla M.P., Florez G., Arango C., Corcoran P., Morales B., et al. Differential role of serotonergic polymorphisms in alcohol and heroin dependence. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:695-700.
55. Saiz P.A., Garcia-Portilla M.P., Herrero R., Arango C., Corcoran P., Morales B., et al. Interactions between functional serotonergic polymorphisms and demographic factors influence personality traits in healthy Spanish Caucasians. Psychiatr Genet 2010, 20:171-178.
56. Saleptsi E., Bichescu D., Rockstroh B., Neuner F., Schauer M., Studer K., et al. Negative and positive childhood experiences across developmental periods in psychiatric patients with different diagnoses - an explorative study. BMC Psychiatry 2004, 4:40.
57. Salo J., Pulkki-Raback L., Hintsanen M., Lehtimaki T., Keltikangas-Jarvinen L. The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness. Psychiatr Genet 2010, 20:273-281.
58. Sato H., Skelin I., Diksic M. Chronic buspirone treatment decreases 5-HT1B receptor densities and the serotonin transporter but increases the density of 5-HT2A receptors in the bulbectomized rat model of depression: an autoradiographic study. Brain Res 2010, 1345:28-44.
59. Shenassa E.D., Paradis A.D., Dolan S.L., Wilhelm C.S., Buka S.L. Childhood impulsive behavior and problem gambling by adulthood: a 30-year prospective community-based study. Addiction 2012, 107:160-168.
60. Shiffman D., Rowland C.M., Sninsky J.J., Devlin J.J. Polymorphisms associated with coronary heart disease: better by the score. Curr Opin Mol Ther 2006, 8:493-499.
61. Soloff P.H., Price J.C., Mason N.S., Becker C., Meltzer C.C. Gender, personality, and serotonin-2A receptor binding in healthy subjects. Psychiatry Res 2010, 181:77-84.
62. Stoltenberg S.F. Epistasis among presynaptic serotonergic system components. Behav Genet 2005, 35:199-209.
63. Stoltenberg S.F., Nag P. Description and validation of a dynamical systems model of presynaptic serotonin function: genetic variation, brain activation and impulsivity. Behav Genet 2010, 40:262-279.
64. Stoltenberg S.F., Glass J.M., Chermack S.T., Flynn H.A., Li S., Weston M.E., et al. Possible association between response inhibition and a variant in the brain-expressed tryptophan hydroxylase-2 gene. Psychiatr Genet 2006, 16:35-38.
65. Stoltenberg S.F., Lehmann M.K., Anderson C., Nag P., Anagnopoulos C. Serotonin transporter (5-HTTLPR) genotype and childhood trauma are associated with individual differences in decision making. Front Genet 2011, 2.
66. Stoltenberg S.F., Lehmann M.K., Christ C.C., Hersrud S.L., Davies G.E. Associations among types of impulsivity, substance use problems and neurexin-3 polymorphisms. Drug Alcohol Depend 2011, 119:e31-e38.
67. Stoltenberg S.F., Anderson C., Nag P., Anagopoulos C. Association between the serotonin transporter triallelic genotype and eating problems is moderated by the experience of childhood trauma in women. Int J Eat Disord 2012, 45:492-500.
68. Swann A.C. Mechanisms of impulsivity in bipolar disorder and related illness. Epidemiol Psichiatr Soc 2010, 19:120-130.
69. Templeton A.R. Epistasis and complex traits. Epistasis and the evolutionary process 2000, 41-57. Oxford University Press, New York. J.B. Wolf, E.D. Brodie, M.J. Wade (Eds.).
70. Tikkanen R., Ducci F., Goldman D., Holi M., Lindberg N., Tiihonen J., et al. MAOA alters the effects of heavy drinking and childhood physical abuse on risk for severe impulsive acts of violence among alcoholic violent offenders. Alcohol Clin Exp Res 2010, 34:853-860.
71. Tops M., Russo S., Boksem M.A., Tucker D.M. Serotonin: modulator of a drive to withdraw. Brain Cogn 2009, 71:427-436.
72. Uher R., Caspi A., Houts R., Sugden K., Williams B., Poulton R., et al. Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results. J Affect Disord 2011, 135:56-65.
73. Varga G., Szekely A., Antal P., Sarkozy P., Nemoda Z., Demetrovics Z., et al. Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity. Am J Med Genet B Neuropsychiatr Genet 2012, 159B:281-288.
74. Viikki M., Huuhka K., Leinonen E., Illi A., Setala-Soikkeli E., Huuhka M., et al. Interaction between two HTR2A polymorphisms and gender is associated with treatment response in MDD. Neurosci Lett 2011, 501:20-24.
75. Villafuerte S.M., Vallabhaneni K., Sliwerska E., McMahon F.J., Young E.A., Burmeister M. SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A. Psychiatr Genet 2009, 19:281-291.
76. Wagner S., Baskaya O., Lieb K., Dahmen N., Tadic A. The 5-HTTLPR polymorphism modulates the association of serious life events (SLE) and impulsivity in patients with Borderline Personality Disorder. J Psychiatr Res 2009, 43:1067-1072.
77. Waxman S.E. A systematic review of impulsivity in eating disorders. Eur Eat Disord Rev 2009, 17:408-425.
78. Wendland J.R., Martin B.J., Kruse M.R., Lesch K.P., Murphy D.L. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 2006, 11:224-226.
79. Williams R.B., Marchuk D.A., Gadde K.M., Barefoot J.C., Grichnik K., Helms M.J., et al. Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology 2003, 28:533-541.
80. Winstanley C.A. The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders. Br J Pharmacol 2011, 164:1301-1321.
81. Wrzosek M., Lukaszkiewicz J., Serafin P., Jakubczyk A., Klimkiewicz A., Matsumoto H., et al. Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report. Psychiatry Res 2011, 190:149-151.
82. Zupanc T., Pregelj P., Tomori M., Komel R., Paska A.V. TPH2 polymorphisms and alcohol-related suicide. Neurosci Lett 2011, 490:78-81.