The impact of childhood maltreatment: A review of neurobiological and genetic factors

Frontiers in Psychiatry

Volumn 2, Issue JUL, 2011, Pages

  McCrory, Eamon ^a,b   De Brito, Stephane A ^a,b   Viding, Essi ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ANNA FREUD CENTRE   (United Kingdom)

Author keywords

Child abuse; Genetics; HPA; Maltreatment; MRI; Neuroscience; Psychopathology; Resilience

Indexed keywords

AMYGDALOID NUCLEUS; ANTERIOR CINGULATE; BRAIN REGION; CHILD ABUSE; CHILD BEHAVIOR; COPING BEHAVIOR; CORPUS CALLOSUM; EPIGENETICS; EVENT RELATED POTENTIAL; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC DIFFERENCE; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HIPPOCAMPUS; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LATERAL BRAIN VENTRICLE; NEUROIMAGING; NONHUMAN; ORBITAL CORTEX; PHYSICAL ABUSE; POSTTRAUMATIC STRESS DISORDER; REVIEW; RISK FACTOR;

EID: 84860298178     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2011.00048     Document Type: Review

References (127)

1. Ahnert, L., Gunnar, M. R., Lamb, M. E., and Barthel, M. (2004). Transition to child care: associations with infant-mother attachment, infant negative emotion, and cortisol elevations. Child Dev. 75, 639-650.
2. Albers, E. M., Marianne Riksen-Walraven, J., Sweep, F. C. G. J., and Weerth, C. D. (2008). Maternal behavior predicts infant cortisol recovery from a mild everyday stres-sor. J. Child. Psychol. Psychiatry 49, 97-103.
3. Amodio, D. M., and Frith, C. D. (2006). Meeting of minds: the medial frontal cortex and social cognition. Nat. Rev. Neurosci. 7, 268-277.
4. Andersen, S. L., Tomada, A., Vincow, E. S., Valente, E., Polcari, A., and Teicher, M. H. (2008). Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development. J. Neu-ropsychiatry Clin. Neurosci. 20, 292-301.
5. Arborelius, L., Owens, M. J., Plotsky, P. M., and Nemeroff, C. B. (1999). The role of corticotropin-releasing factor in depression and anxiety disorders. J. Endocrinol. 160, 1-12.
6. Bakermans-Kranenburg, M. J., Van Ijzendoorn, M. H., Pijlman, F. T. A., Mesman, J., and Juffer, F. (2008). Experimental evidence for differential susceptibility: dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers' externalizing behavior in a randomized controlled trial. Dev. Psychol. 44, 293-300.
7. Beach, S. R., Brody, G. H., Todorov, A. A., Gunter, T. D., and Philibert, R. A. (2011). Methylation at 5HTT mediates the impact of child sex abuse on women's antisocial behavior: an examination of the Iowa adoptee sample. Psychosom. Med. 73, 83-87.
8. Bremner, J. D., Randall, P., Vermetten, E., Staib, L., Bronen, R. A., Mazure, C., Capelli, S., Mccarthy, G., Innis, R. B., and Charney, D. S. (1997). Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhoo d physical and sexual abuse -a preliminary report. Biol. Psychiatry 41, 23-32.
9. Carrion, V. G., Garrett, A., Menon, V., Weems, C. F., and Reiss, A. L. (2008). Posttraumatic stress symptoms and brain function during a response-inhibition task: an fMRI study in youth. Depress. Anxiety 25, 514-526.
10. Carrion, V. G., Haas, B. W., Garrett, A., Song, S., and Reiss, A. L. (2010). Reduced hippocampal activity in youth with posttraumatic stress symptoms: an fMRI study. J. Pediatr. Psychol. 35, 559-569.
11. Carrion, V. G., Weems, C. F., Eliez, S., Patwardhan, A., Brown, W., Ray, R. D., and Reiss, A. L. (2001). Attenuation of frontal asymmetry in pedi-atric posttraumatic stress disorder. Biol. Psychiatry 50, 943-951.
12. Carrion, V. G., Weems, C. F., Ray, R. D., Glaser, B., Hessl, D., and Reiss, A. L. (2002). Diurnal salivary cortisol in pediatric posttraumatic stress disorder. Biol. Psychiatry 51, 575-582.
13. Carrion, V. G., Weems, C. F., and Reiss, A. L. (2007). Stress predicts brain changes in children: a pilot longitudinal study on youth stress, posttraumatic stress disorder, and the hippocampus. Pediatrics 119, 509-516.
14. Carrion, V. G., Weems, C. F., Watson, C., Eliez, S., Menon, V., and Reiss, A. L. (2009). Converging evidence for abnormalities of the prefrontal cortex and evaluation of midsagit-tal structures in pediatric posttraumatic stress disorder: an MRI study. Psychiatry Res. 172, 226-234.
15. Caspi, A., Mcclay, J., Moffitt, T., Mill, J., Martin, J., Craig, I. W., Taylor, A., and Poulton, R. (2002). Role of genotype in the cycle of violence in maltreated children. Science 297, 851-854.
16. Caspi, A., and Moffitt, T. E. (2006). Gene-environment interactions in psychiatry: joining forces with neu-roscience. Nat. Rev. Neurosci. 7, 583-590.
17. Choi, J., Jeong, B., Rohan, M. L., Polcari, A. M., and Teicher, M. H. (2009). Preliminary evidence for white matter tract abnormalities in young adults exposed to parental verbal abuse. Biol. Psychiatry 65, 227-234.
18. Cicchetti, D., and Curtis, W J. (2005). An event-related potential study of the processing of affective facial expressions in young children who experienced maltreatment during the first year of life. Dev. Psy-chopathol. 17, 641-677.
19. Cicchetti, D., and Gunnar, M. R. (2008). Integrating biological measures into the design and evaluation of preventive interventions. Dev. Psychopathol. 20, 737-743.
20. Cicchetti, D., and Rogosch, F. A. (2001). The impact of child maltreatment and psychopathology on neuroendocrine functioning. Dev. Psychopathol. 13, 783-804.
21. Cicchetti, D., Rogosch, E A., and Cox Kearns, S. (2001). Diverse patterns of neuroendocrine activity in maltreated children. Dev. Psychopathol. 13, 677-693.
22. Cicchetti, D., Rogosch, F. A., and Sturge-Apple, M. L. (2007). Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: depressive symptomatology among adolescents from lowsocioeconomic status backgrounds. Dev. Psychopathol. 19, 1161-1180.
23. Craig, I. W (2007). The importance of stress and genetic variation in human aggression. Bioessays 29, 227-236.
24. Croy, I., Schellong, J., Gerber, J., Joraschky, P., Iannilli, E., and Hummel, T. (2010). Women with a history of childhood maltreatment exhibit more activation in association areas following non-traumatic olfactory stimuli: a fMRI study. PLoS ONE 5, e9362. doi: 10.1371/jour-nal.pone.0009362
25. Currie, J., and Widom, C. S. (2010). Long-term consequences of child abuse and neglect on adult economic well-being. Child Maltreat. 15, 111-120.
26. Davidson, R. J., Putnam, K. M., and Larson, C. L. (2000). Dysfunction in the neural circuitry of emotion regulation-a possible prelude to violence. Science 289, 591-594.
27. De Bellis, M. D., Baum, A. S., Birma-her, B., Keshavan, M. S., Eccard, C. H., Boring, A. M., Jenkins, F. J., and Ryan, N. D. (1999a). Developmental traumatology part I: biological stress systems. Biol. Psychiatry 45, 1259-1270.
28. De Bellis, M. D., Keshavan, M. S., Clark, D. B., Casey, B. J., Giedd, J. N., Boring, A. M., Frustaci, K., and Ryan, N. D. (1999b). Developmental traumatology part II: brain development. Biol. Psychiatry 45, 1271-1284.
29. De Bellis, M. D., Chrousos, G. P., Dorn, L. D., Burke, L., Helmers, K., Kling, M. A., Trickett, P. K., and Putnam, F. W. (1994). Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls. J. Clin. Endocrinol. Metab. 78, 249-255.
30. De Bellis, M. D., and Keshavan, M. S. (2003). Sex differences in brain maturation in maltreatment-related pediatric posttraumatic stress disorder. Neurosci. Biobehav. Rev. 27, 103-117.
31. De Bellis, M. D., Keshavan, M. S., Shifflett, H., Iyengar, S., Beers, S. R., Hall, J., and Moritz, G. (2002). Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographi-cally matched study. Biol. Psychiatry 52, 1066-1078.
32. Dillon, D. G., Holmes, A. J., Birk, J. L., Brooks, N., Lyons-Ruth, K., and Pizzagalli, D. A. (2009). Childhood adversity is associated with left basal ganglia dysfunction during reward anticipation in adulthood. Biol. Psychiatry 66, 206-213.
33. Dozier, M., Manni, M., Gordon, M. K., Peloso, E., Gunnar, M. R., Stovall-Mcclough, K. C., Eldreth, D., and Levine, S. (2006a). Foster children's diurnal production of cortisol: an exploratory study. Child Maltreat. 11, 189-197.
34. Dozier, M., Peloso, E., Lindhiem, O., Gordon, M. K., Manni, M., Sepul-veda, S., Ackerman, J., Bernier, A., and Levine, S. (2006b). Developing evidence-based interventions for foster children: an example of a randomized clinical trial with infants and toddlers. J. Soc. Issues 62, 767-785.
35. Dozier, M., Peloso, E., Lewis, E., Laurenceau, J. P., and Levine, S. (2008). Effects of an attachment-based intervention on the cortisol production of infants and toddlers in foster care. Dev. Psychopathol. 20, 845-869.
36. Eluvathingal, T. J., Chugani, H. T., Behen, M. E., Juhãsz, C., Muzik, O., Maqbool, M., Chugani, D. C., and Makki, M. (2006). Abnormal brain connectivity in children after early severe socioemotional deprivation: a diffusion tensor imaging study. Pediatrics 117, 2093-2100.
37. Feder, A., Nestler, E. J., and Charney, D. S. (2009). Psychobiology and molecular genetics of resilience. Nat. Rev. Neurosci. 10, 446-457.
38. Fries, E., Hesse, J., Hellhammer, J., and Hellhammer, D. H. (2005). A new view on hypocortisolism. Psychoneuroendocrinology 30, 1010-1016.
39. Fuster, J. M. (1997). The Prefrontal Cortex: Anatomy, Physiology, and Neu-rophysiology of the Frontal Lobe. Philadelphia: Lippincott-Raven.
40. Giedd, J. N., Rumsey, J. M., Castellanos, F. X., Rajapakse, J. C., Kaysen, D., Vaituzis, A. C., Vauss, Y. C., Hamburger, S. D., and Rapoport, J. L. (1996). A quantitative MRI study of the corpus callosum in children and adolescents. Brain Res. Dev. Brain Res. 91, 274-280.
41. Gilbert, R., Kemp, A., Thoburn, J., Side-botham, P., Radford, L., Glaser, D., andMacmillan, H. L. (2009). Recognising and responding to child maltreatment. Lancet 373, 167-180.
42. Gilbertson, M. W., Shenton, M. E., Ciszewski, A., Kasai, K., Lasko, N. B., Orr, S. P., and Pitman, R. K. (2002). Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat. Neurosci. 5, 1242-1247.
43. Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent III, T. F., Herman, D. H., Clasen, L. S., Toga, A. W., Rapoport, J. L., and Thompson, P. M. (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proc. Natl. Acad. Sci. U.S.A. 101, 8174-8179.
44. Goodyer, I. M., Herbert, J., and Altham, P. M. E. (1998). Adrenal steroid secretion and major depression in 8- to 16-year-olds, III. Influence of cortisol/DHEA ratio at presentation on subsequent rates of disappointing life events and persistent major depression. Psychol Med. 28, 265-273.
45. Govindan, R. M., Behen, M. E., Helder, E., Makki, M. I., and Chugani, H. T. (2010). Altered water diffu-sivity in cortical association tracts in children with early deprivation identified with tract-based spatial statistics (TBSS). Cereb. Cortex 20, 561-569.
46. Grant, M. M., Cannistraci, C., Hollon, S. D., Gore, J., and Shelton, R. (2011). Childhood trauma history differentiates amygdala response to sad faces within MDD. J. Psychiatr. Res. 45, 886-895.
47. Gunnar, M. R., and Cheatham, C. L. (2003). Brain and behavior interface: stress and the developing brain. InfantMent. HealthJ. 24, 195-211.
48. Gunnar, M. R., and Donzella, B. (2002). Social regulation of the cortisol levels in early human development. Psychoneuroendocrinology 27, 199-220.
49. Gunnar, M. R., Fisher, P. A., Dozier, M., Fox, N., Levine, S., Neal, C., Pollak, S., Plotsky, P., Sanchez, M., and Vazquez, D. (2006). Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Dev. Psychopathol. 18, 651-677.
50. Hanson, J. L., Chung, M. K., Avants, B. B., Shirtcliff, E. A., Gee, J. C., Davidson, R. J., and Pollak, S. D. (2010). Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphome-try investigation of brain structure and behavioral risk. J. Neurosci 30, 7466-7472.
51. Hart, J., Gunnar, M., and Cicchetti, D. (1995). Salivary cortisol in maltreated children: evidence of relations between neuroendocrine activity and social competence. Dev. Psychopathol. 7, 11-26.
52. Hart, J., Gunnar, M., and Cicchetti, D. (1996). Altered neuroendocrine activity in maltreated children related to symptoms of depression. Dev. Psychopathol. 8, 201-214.
53. Heim, C., Mletzko, T., Purselle, D., Musselman, D. L., and Nemeroff, C. B. (2008). The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma. Biol. Psychiatry 63, 398-405.
54. Heim, C., Newport, D. J., Wagner, D., Wilcox, M. M., Miller, A. H., and Nemeroff, C. B. (2002). The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress. Anxiety 15, 117-125.
55. Herrenkohl, R. C., and Herrenkohl, T. I. (2009). Assessing a child's experience of multiple maltreatment types: some unfinished business. J. Fam. Violence 24, 485-496.
56. Izard, C.E., and Harris, P. (1995)."Emotional development and developmental psychopathology, " in Developmental Psychopathology: Vol. I: Theories and Methods, eds D. Cicchetti and J. Cohen (New York: John Wiley), 467-503.
57. Jackowski, A. P., De Araújo, C. M., De Lacerda, A. L. T., De Jesus Mari, J., and Kaufman, J. (2009).Neurostruc-tural imaging findings in children with post-traumatic stress disorder: brief review. Psychiatry Clin. Neurosci. 63, 1-8.
58. Jackowski, A. P., Douglas-Palumberi, H., Jackowski, M., Win, L., Schultz, R. T., Staib, L. W., Krystal, J. H., and Kaufman, J. (2008). Corpus callosum in maltreated children with posttraumatic stress disorder: a diffusion tensor imaging study. Psychiatry Res. 162, 256-261.
59. Kaufman, J. (1991). Depressive disorders in maltreated children. J. Am. Acad. Child Adolesc. Psychiatry 30, 257-265.
60. Kaufman, J., Birmaher, B., Perel, J., Dahl, R. E., Moreci, P., Nelson, B., Wells, W., and Ryan, N. D. (1997). The corticotropin-releasing hormone challenge in depressed abused, depressed nonabused, and normal control children. Biol. Psychiatry 42, 669-679.
61. Kaufman, J., Yang, B. Z., Douglas-Palumberi, H., Grasso, D., Lip-schitz, D., Houshyar, S., Krystal, J. H., and Gelernter, J. (2006). Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol. Psychiatry 59, 673-680.
62. Kitayama, N., Brummer, M., Hertz, L., Quinn, S., Kim, Y., and Bremner, J. D. (2007). Morphologic alterations in the corpus callosum in abuse-related posttraumatic stress disorder: a preliminary study. J. Nerv. Ment. Dis. 195, 1027-1029.
63. Kitterle, F. (1995). Hemispheric Communication: Mechanisms and Models. Hillsdale, NJ: Laurence Erlbaum Associates, Inc.
64. Koenen, K. C., Nugent, N. R., and Amstadter, A. B. (2008). Gene-environment interaction in posttraumatic stress disorder: review, strategy and new directions for future research. Eur. Arch. Psychiatry Clin. Neurosci. 258, 82-96.
65. Lansford, J. E., Dodge, K. A., Pettit, G. S., Bates, J. E., Crozier, J., and Kaplow, J. (2002). A 12-year prospective study of the long-term effects of early child physical maltreatment on psychological, behavioral, and academic problems in adolescence. Arch. Pediatr. Adolesc. Med. 156, 824-830.
66. Lenroot, R. K., and Giedd, J. N. (2011). Annual research review: developmental considerations of gene by environment interactions. J. Child Psychol. Psychiatry 52, 429-441.
67. Litrownik, A. J., Lau, A., English, D. J., Briggs, E., Newton, R. R., Romney, S., and Dubowitz, H. (2005). Measuring the severity of child maltreatment. Child Abuse Negl. 29, 553-573.
68. Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., and Meaney, M. J. (1997). Maternal care, hippocampal glucocorti-coid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 277, 1659-1662.
69. Lotfipour, S., Ferguson, E., Leonard, G., Perron, M., Pike, B., Richer, L., Seguin, J. R., Toro, R., Veillette, S., Pausova, Z., and Paus, T. (2009). Orbitofrontal cortex and drug use during adolescence: role of prenatal exposure to maternal smoking and BDNF genotype. Arch. Gen. Psychiatry 66, 1244-1252.
70. Lupien, S. J., De Leon, M., De Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., Mcewen, B. S., Hauger, R. L., and Meaney, M. J. (1998). Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat. Neurosci. 1, 69-73.
71. Lupien, S. J., Mcewen, B. S., Gunnar, M. R., and Heim, C. (2009). Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat. Rev. Neurosci. 10, 434-445.
72. Maheu, F. S., Dozier, M., Guyer, A. E., Mandell, D., Peloso, E., Poeth, K., Jenness, J., Lau, J. Y., Ackerman, J. P., Pine, D. S., and Ernst, M. (2010). A preliminary study of medial temporal lobe function in youths with a history of caregiver deprivation and emotional neglect. Cogn. Affect. Behav. Neurosci. 10, 34-49.
73. McCrory, E., De Brito, S. A., and Viding, E. (2010). Research review: the neu-robiology and genetics of maltreatment and adversity. J. Child. Psychol. Psychiatry 51, 1079-1095.
74. McEwen, B. S. (1999). Stress and hippocampal plasticity. Annu. Rev. Neurosci. 22, 105-122.
75. McEwen, B. S., and Gianaros, P. J. (2010). Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease. Ann. N Y. Acad. Sci. 1186, 190-222.
76. McGowan, P. O., Sasaki, A., D'alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., and Meaney, M. J. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 12, 342-348.
77. Meewisse, M. L., Reitsma, J. B., De Vries, G. J., Gersons, B. P. R., and Olff, M. (2007). Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis. Br. I Psychiatry 191, 387-392.
78. Mehta, M. A., Golembo, N. I., Nosarti, C., Colvert, E., Mota, A., Williams, S. C. R., Rutter, M., and Sonuga-Barke, E. J. S. (2009). Amygdala, hippocampal and corpus callosum size following severe early institutional deprivation: the English and Romanian Adoptees Study Pilot. J. Child. Psychol. Psychiatry 50, 943-951.
79. Meyer-Lindenberg, A., Buckholtz, J. W., Kolachana, B., Hariri, A. R., Pezawas, L., Blasi, G., Wabnitz, A., Honea, R., Verchinski, B., Callicott, J. H., Egan, M., Mattay, V., and Weinberger, D. R. (2006). Neural mechanisms of genetic risk for impulsivity and violence in humans. Proc. Natl. Acad. Sci. U.S.A. 103, 6269-6274.
80. Mill, J. (2011). Toward an integrated genetic and epigenetic approach to Alzheimer's disease. Neurobiol. Aging 32, 1188-1191.
81. Miller, E. K., and Cohen, J. D. (2001). An integrative theory of prefrontal cortex function. Annu. Rev. Neurosci. 24, 167-202.
82. Miller, G. E., Chen, E., and Zhou, E. S. (2007). If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol. Bull. 133, 25-45.
83. Mizomuri, S. J. Y., Smith, D. M., and Puryear, C. B. (2007). "Mnemonic contributions of hippocampal place cells, " in Neurobiology of Learning and Memory, eds J. Martinez and R. Kesner (Burlington, MA: Elsevier), 155-190.
84. Moffitt, T. E., Caspi, A., and Rutter, M. (2005). Strategy for investigating interactions between measured genes and measured environments. Arch. Gen. Psychiatry 62, 473-481.
85. Mueller, S. C., Maheu, F. S., Dozier, M., Peloso, E., Mandell, D., Leiben-luft, E., Pine, D. S., and Ernst, M. (2010). Early-life stress is associated with impairment in cognitive control in adolescence: an fMRI study. Neuropsychologia 48, 3037-3044.
86. Nachmias, M., Gunnar, M., Mangels-dorf, S., Parritz, R. H., and Buss, K. (1996). Behavioral inhibition and stress reactivity: the moderating role of attachment security. Child Dev. 67, 508-522.
87. Neigh, G. N., Gillespie, C. F., and Nemeroff, C. B. (2009). The neurobiological toll of child abuse and neglect. Trauma Violence Abuse 10, 389-410.
88. Newport, D. J., Heim, C., Bonsall, R., Miller, A. H., and Nemeroff, C. B. (2004). Pituitary-adrenal responses to standard and low-dose dexam-ethasone suppression tests in adult survivors of child abuse. Biol. Psychiatry 55, 10-20.
89. Parker, S. W., and Nelson, C. A. (2005). The impact of early institutional rearing on the ability to discriminate facial expressions of emotion: an event-related potential study. Child Dev. 76, 54-72.
90. Parker, S. W., Nelson, C. A., Zeanah, C. H., Smyke, A. T., Koga, S. F., Fox, N. A., Marshall, P. J., and Woodward, H. R. (2005). An event-related potential study of the impact of institutional rearing on face recognition. Dev. Psychopathol. 17, 621-639.
91. Pears, K. C., Kim, H. K., and Fisher, P. A. (2008). Psychosocial and cognitive functioning of children with specific profiles of maltreatment. Child Abuse Negl. 32, 958-971.
92. Pederson, C. L., Maurer, S. H., Kamin-ski, P. L., Zander, K. A., Peters, C. M., Stokes-Crowe, L. A., and Osborn, R. E. (2004). Hippocampal volume and memory performance in a community-based sample of women with posttraumatic stress disorder secondary to child abuse. J. Trauma Stress 17, 37-40.
93. Phelps, E. A., and LeDoux, J. E. (2005). Contributions of the amygdala to emotion processing: from animal models to human behavior. Neuron 48, 175-187.
94. Plomin, R., Owen, M. J., and Mcguffin, P. (1994). The genetic basis of complex human behaviors. Science 264, 1733-1739.
95. Pollak, S. D. (2008). Mechanisms linking early experience and the emergence of emotions: illustrations from the study of maltreated children. Curr. Dir. Psychol. Sci. 17, 370-375.
96. Pollak, S. D., Cicchetti, D., Klorman, R., and Brumaghim, J. T. (1997). Cognitive brain event-related potentials and emotion processing in maltreated children. Child Dev. 68, 773-787.
97. Pollak, S. D., Klorman, R., Thatcher, J. E., and Cicchetti, D. (2001). P3b reflects maltreated children's reactions to facial displays of emotion. Psychophysiology 38, 267-274.
98. Pollak, S. D., and Tolley-Schell, S. A. (2003). Selective attention to facial emotion in physically abused children. J. Abnorm. Psychol. 112, 323-338.
99. Rhee, S. H., and Waldman, I. D. (2002). Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studies. Psychol. Bull. 128, 490-529.
100. Richert, K. A., Carrion, V. G., Karchem-skiy, A., and Reiss, A. L. (2006). Regional differences of the prefrontal cortex in pediatric PTSD: an MRI study. Depress. Anxiety 23, 17-25.
101. Roth, T. L., Lubin, F. D., Funk, A. J., and Sweatt, J. D. (2009). Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol. Psychiatry 65, 760-769.
102. Sapolsky, R. M., Uno, H., Rebert, C. S., and Finch, C. E. (1990). Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J. Neurosci. 10, 2897-2902.
103. Shackman, J. E., Shackman, A. J., and Pollak, S. D. (2007). Physical abuse amplifies attention to threat and increases anxiety in children. Emotion 7, 838-852.
104. Shea, M. T., Yen, S., Pagano, M. E., Morey, L. C., Mcglashan, T. H., Grilo, C. M., Sanislow, C. A., Stout, R. L., Skodol, A. E., Gunderson, J. G., Bender, D. S., and Zanarini, M. C. (2004). Associations in the course of personality disorders and axis i disorders over time. J. Abnorm. Psychol. 113, 499-508.
105. Shirtcliff, E. A., Coe, C. L., and Pollak, S. D. (2009). Early childhood stress is associated with elevated antibody levels to herpes simplex virus type 1. Proc. Natl. Acad. Sci. U.S.A. 106, 2963-2967.
106. Sullivan, P. F., Neale, M. C., and Kendler, K. S. (2000). Genetic epidemiology of major depression: review and meta-analysis. Am. J. Psychiatry 157, 1552-1562.
107. Tarullo, A.R., andGunnar, M.R. (2006). Child maltreatment and the developing HPA axis. Horm. Behav. 50, 632-639.
108. Taylor, A., and Kim-Cohen, J. (2007). Meta-analysis of gene-environment interactions in developmental psy-chopathology. Dev. Psychopathol. 19, 1029-1037.
109. Teicher, M. H., Andersen, S. L., Polcari, A., Anderson, C. M., Navalta, C. P., and Kim, D. M. (2003). The neurobiological consequences of early stress and childhood maltreatment. Neurosci. Biobehav. Rev. 27, 33-44.
110. Teicher, M. H., Dumont, N. L., Ito, Y., Vaituzis, C., Giedd, J. N., and Andersen, S. L. (2004). Childhood neglect is associated with reduced corpus callosum area. Biol. Psychiatry 56, 80-85.
111. Tomoda, A., Suzuki, H., Rabi, K., Sheu, Y.-S., Polcari, A., and Teicher, M. H. (2009). Reduced prefrontal cortical gray matter volume in young adults exposed to harsh corporal punishment. Neuroimage 47, T66-T71.
112. Tottenham, N., Hare, T. A., Mill-ner, A., Gilhooly, T., Zevin, J. D., and Casey, B. J. (2011). Elevated amygdala response to faces following early deprivation. Dev. Sci. 14, 190-204.
113. Tottenham, N., Hare, T. A., Quinn, B. T., Mccarry, T. W., Nurse, M., Gilhooly, T., Millner, A., Galvan, A., Davidson, M. C., Eigsti, I. M., Thomas, K. M., Freed, P. J., Booma, E. S., Gunnar, M. R., Altemus, M., Aron-son, J., and Casey, B. J. (2010). Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation. Dev. Sci. 13, 46-61.
114. Tottenham, N., and Sheridan, M. A. (2010). A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing. Front. Hum. Neurosci. 3:68. doi: 10.3389/neuro.09.068.2009
115. Treadway, M. T., Grant, M. M., Ding, Z., Hollon, S. D., Gore, J. C., and Shelton, R. C. (2009). Early adverse events, HPA activity and rostral anterior cingulate volume in MDD. PLoS ONE 4, e4887. doi: 10.1371/journal.pone.0004887
116. Tsankova, N., Renthal, W., Kumar, A., and Nestler, E. J. (2007). Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci. 8, 355-367.
117. U.S. Department of Health and Human Services, Administration on Children, Youth, and Families. (2007). Child Maltreatment 2005. Washington, DC: U.S. Government Printing Office.
118. van Goozen, S. H. M., and Fairchild, G. (2008). How can the study of biological processes help design new interventions for children with severe antisocial behavior? Dev. Psy-chopathol. 20, 941-973.
119. van Harmelen, A.-L., Van Tol, M.-J., Van Der Wee, N. J. A., Veltman, D. J., Aleman, A., Spinhoven, P., Van Buchem, M. A., Zitman, F. G., Pen-ninx, B. W J. H., and Elzinga, B. M. (2010). Reduced medial prefrontal cortex volume in adults reporting childhood emotional maltreatment. Biol. Psychiatry 68, 832-838.
120. Vermetten, E., Schmahl, C., Lindner, S., Loewenstein, R. J., and Bremner, J. D. (2006). Hippocampal and amyg-dalar volumes in dissociative identity disorder. Am. J. Psychiatry 163, 630-636.
121. Viding, E., and Frith, U. (2006). Genes for susceptibility to violence lurk in the brain. Proc. Natl. Acad. Sci. U.S.A. 103, 6085-6086.
122. Viding, E., Williamson, D. E., and Hariri, A. R. (2006). Developmental imaging genetics: challenges and promises for translational research. Dev. Psychopathol. 18, 877-892.
123. Vyas, A., Bernal, S., and Chattarji, S. (2003). Effects of chronic stress on dendritic arborization in the central and extended amygdala. Brain Res. 965, 290-294.
124. Vythilingam, M., Heim, C., Newport, J., Miller, A. H., Anderson, E., Bronen, R., Brummer, M., Staib, L., Vermetten, E., Charney, D. S., Nemeroff, C. B., and Douglas Bremner, J. (2002). Childhood trauma associated with smaller hippocampal volume in women with major depression. Am. J. Psychiatry 159, 2072-2080.
125. Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., and Meaney, M. J. (2004). Epigenetic programming by maternal behavior. Nat. Neurosci. 7, 847-854.
126. Weder, N., Yang, B. Z., Douglas-Palumberi, H., Massey, J., Krystal, J. H., Gelernter, J., and Kaufman, J. (2009). MAOA genotype, maltreatment, and aggressive behavior: the changing impact of genotype at varying levels of trauma. Biol. Psychiatry 65, 417-424.
127. Woon, F. L., and Hedges, D. W. (2008). Hippocampal and amygdala volumes in children and adults with childhood maltreatment-related posttraumatic stress disorder: a meta-analysis. Hippocampus 18, 729-736.