The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients

Journal of Psychiatric Research

Volumn 46, Issue 1, 2012, Pages 44-49

  Jakubczyk, Andrzej ^a   Wrzosek, Malgorzata ^a   Lukaszkiewicz, Jacek ^a   Sadowska Mazuryk, Joanna ^a   Matsumoto, Halina ^a   Śliwerska, Elzbieta ^c   Glass, Jennifer ^b   Burmeister, Margit ^b,c   Brower, Kirk J ^b   Wojnar, Marcin ^a,b  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Alcohol dependence; Genetic polymorphism; HTR2A; Impulsivity; Serotonin

Indexed keywords

ALCOHOL; SEROTONIN;

ADULT; ARTICLE; BEHAVIOR GENETICS; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; GENETIC MARKER; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SELF REPORT; SEROTONIN TYPE 2A RECEPTOR GENE;

EID: 81855206494     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2011.09.001     Document Type: Article

References (41)

1. Arce E., Santisteban C. Impulsivity: a review. Psicothema 2006, 18:213-220.
2. Audenaert K., Goethals I., Van Laere K., Lahorte P., Brans B., Versijpt J., et al. SPECT neuropsychological activation procedure with the Verbal Fluency Test in attempted suicide patients. Nuclear Medicine Communications 2002, 23:907-916.
3. Band G.P., van der Molen M.W., Logan G.D. Horse-race model simulations of the stop-signal procedure. Acta Psychologica 2003, 112:105-142.
4. Bjork J.M., Moeller F.G., Dougherty D.M., Swann A.C., Machado M.A., Hanis C.L. Serotonin 2a receptor T102C polymorphism and impaired impulse control. American Journal of Medical Genetics 2002, 114:336-339.
5. Bondy B., Kuznik J., Baghai T., Schule C., Zwanzger P., Minov C., et al. Lack of association of serotonin-2A receptor gene polymorphism (T102C) with suicidal ideation and suicide. American Journal of Medical Genetics 2000, 96:831-835.
6. Congdon E., Canli T. A neurogenetic approach to impulsivity. Journal of Personality 2008, 76:1447-1484.
7. de Wit H. Impulsivity as a determinant and consequence of drug use: a review of underlying processes. Addiction Biology 2009, 14:22-31.
8. do Prado-Lima P.A., Chatkin J.M., Taufer M., Oliveira G., Silveira E., Neto C.A., et al. Polymorphism of 5HT2A serotonin receptor gene is implicated in smoking addiction. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 2004, 128B:90-93.
9. Du L., Bakish D., Lapierre Y.D., Ravindran A.V., Hrdina P.D. Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. American Journal of Medical Genetics 2000, 96:56-60.
10. Erdmann J., Shimron-Abarbanell D., Rietschel M., Albus M., Maier W., Korner J., et al. Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. Human Genetics 1996, 97:614-619.
11. Evenden J.L. Varieties of impulsivity. Psychopharmacology (Berlin) 1999, 146:348-361.
12. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 1975, 12:189-198.
13. Harrison A.A., Everitt B.J., Robbins T.W. Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms. Psychopharmacology (Berlin) 1997, 133:329-342.
14. Higgins G.A., Enderlin M., Haman M., Fletcher P.J. The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism. Psychopharmacology (Berlin) 2003, 170:309-319.
15. Hwu H.G., Chen C.H. Association of 5HT2A receptor gene polymorphism and alcohol abuse with behavior problems. American Journal of Medical Genetics 2000, 96:797-800.
16. Le A.D., Funk D., Harding S., Juzytsch W., Li Z., Fletcher P.J. Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and reward. Psychopharmacology (Berlin) 2008, 195:605-615.
17. Lejuez C.W., Magidson J.F., Mitchell S.H., Sinha R., Stevens M.C., de Wit H. Behavioral and biological indicators of impulsivity in the development of alcohol use, problems, and disorders. Alcoholism: Clinical and Experimental Research 2010, 34:1334-1345.
18. Li C.S., Luo X., Yan P., Bergquist K., Sinha R. Altered impulse control in alcohol dependence: neural measures of stop signal performance. Alcoholism: Clinical and Experimental Research 2009, 33:740-750.
19. Linnoila M., Virkkunen M., George T., Higley D. Impulse control disorders. International Clinical Psychopharmacology 1993, 8(Suppl 1):53-56.
20. Logan G.D., Cowan W.B., Davis K.A. On the ability to inhibit simple and choice reaction time responses: a model and a method. Journal of Experimental Psychology. Human Perception and Performance 1984, 10:276-291.
21. Lykouras L., Moussas G., Botsis A. Examination of type I/type II alcoholism typology in a Greek hospital treatment population. European Psychiatry 2004, 19:214-218.
22. Moeller F.G., Barratt E.S., Dougherty D.M., Schmitz J.M., Swann A.C. Psychiatric aspects of impulsivity. American Journal of Psychiatry 2001, 158:1783-1793.
23. Patton J.H., Stanford M.S., Barratt E.S. Factor structure of the Barratt impulsiveness scale. Journal of Clinical Psychology 1995, 51:768-774.
24. Petry N.M. Delay discounting of money and alcohol in actively using alcoholics, currently abstinent alcoholics, and controls. Psychopharmacology (Berlin) 2001, 154:243-250.
25. Polesskaya O.O., Aston C., Sokolov B.P. Allele C-specific methylation of the 5-HT2A receptor gene: evidence for correlation with its expression and expression of DNA methylase DNMT1. Journal of Neuroscience Research 2006, 83:362-373.
26. Polesskaya O.O., Sokolov B.P. Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. Journal of Neuroscience Research 2002, 67:812-822.
27. Preuss U.W., Koller G., Bahlmann M., Soyka M., Bondy B. No association between suicidal behavior and 5-HT2A-T102C polymorphism in alcohol dependents. American Journal of Medical Genetics 2000, 96:877-878.
28. Preuss U.W., Koller G., Bondy B., Bahlmann M., Soyka M. Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disorders. Neuropsychobiology 2001, 43:186-191.
29. Preuss U.W., Koller G., Soyka M., Bondy B. Association between suicide attempts and 5-HTTLPR-S-allele in alcohol-dependent and control subjects: further evidence from a German alcohol-dependent inpatient sample. Biological Psychiatry 2001, 50:636-639.
30. Rubio G., Jimenez M., Rodriguez-Jimenez R., Martinez I., Avila C., Ferre F., et al. The role of behavioral impulsivity in the development of alcohol dependence: a 4-year follow-up study. Alcoholism: Clinical and Experimental Research 2008, 32:1681-1687.
31. Samochowiec J., Lesch K.P., Rottmann M., Smolka M., Syagailo Y.V., Okladnova O., et al. Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism. Psychiatry Research 1999, 86:67-72.
32. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., et al. The Mini-International Neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of clinical Psychiatry 1998, 59(Suppl. 20):22-33.
33. Smith G.E., Ross R.L., Rost K.M. Psychiatric outcomes module: substance abuse outcomes module (SAOM). Outcome assessment in clinical practice 1996, 85-88. Williams and Wilkins, Baltimore, MD. L.I. Sederer, B. Dickey (Eds.).
34. Sole X., Guino E., Valls J., Iniesta R., Moreno V. SNPStats: a web tool for the analysis of association studies. Bioinformatics 2006, 22:1928-1929.
35. Stoltenberg S.F., Glass J.M., Chermack S.T., Flynn H.A., Li S., Weston M.E., et al. Possible association between response inhibition and a variant in the brain-expressed tryptophan hydroxylase-2 gene. Psychiatric Genetics 2006, 16:35-38.
36. Thakkar K.N., Schall J.D., Boucher L., Logan G.D., Park S. Response inhibition and response monitoring in a saccadic countermanding task in schizophrenia. Biological Psychiatry 2011, 69:55-62.
37. Wilhelm C.J., Reeves J.M., Phillips T.J., Mitchell S.H. Mouse lines selected for alcohol consumption differ on certain measures of impulsivity. Alcoholism: Clinical and Experimental Research 2007, 31:1839-1845.
38. Winstanley C.A., Theobald D.E., Dalley J.W., Robbins T.W. Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders. Neuropsychopharmacology 2005, 30:669-682.
39. Wojnar M., Ilgen M.A., Jakubczyk A., Wnorowska A., Klimkiewicz A., Brower K.J. Impulsive suicide attempts predict post-treatment relapse in alcohol dependent patients. Drug and Alcohol Dependence 2008, 97:268-275.
40. Wojnar M., Brower K.J., Strobbe S., Ilgen M.A., Matsumoto H., Nowosad I., et al. Association between Val66Met brain-derived Neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence. Alcoholism: Clinical and Experimental Research 2009, 33:693-702.
41. Wong M.M., Brower K.J., Nigg J.T., Zucker R.A. Childhood sleep problems, response inhibition, and alcohol and drug outcomes in adolescence and young adulthood. Alcoholism: Clinical and Experimental Research 2010, 34:1033-1044.