메뉴 건너뛰기




Volumn 10, Issue , 2012, Pages

Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker

Author keywords

Adult onset still's disease; GCK like kinase (GLK, MAP4K3); Mitogen activated protein kinases (mapks); Pathogenesis; Th17 related cytokines

Indexed keywords

GERMINAL CENTER KINASE LIKE KINASE; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; INTERLEUKIN DERIVATIVE; MAP4K3 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

EID: 84864498623     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-10-84     Document Type: Article
Times cited : (28)

References (44)
  • 1
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signaling cascades
    • 10.1038/35065000, 11242034
    • Chang L, Karin M. Mammalian MAP kinase signaling cascades. Nature 2001, 410:37-40. 10.1038/35065000, 11242034.
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 2
    • 34248597065 scopus 로고    scopus 로고
    • Differential regulation and properties of MAPKs
    • 10.1038/sj.onc.1210392, 17496909
    • Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 2007, 26:3100-3112. 10.1038/sj.onc.1210392, 17496909.
    • (2007) Oncogene , vol.26 , pp. 3100-3112
    • Raman, M.1    Chen, W.2    Cobb, M.H.3
  • 3
    • 35648969120 scopus 로고    scopus 로고
    • Primer: signal transduction in rheumatic disease - a clinician's guide
    • 10.1038/ncprheum0631, 17968336
    • Sweeney SE, Firestein GS. Primer: signal transduction in rheumatic disease - a clinician's guide. Nat Clin Pract Rheumatol 2007, 3:651-660. 10.1038/ncprheum0631, 17968336.
    • (2007) Nat Clin Pract Rheumatol , vol.3 , pp. 651-660
    • Sweeney, S.E.1    Firestein, G.S.2
  • 4
    • 34548485028 scopus 로고    scopus 로고
    • Intracellular JNK, p38 MAPK and NF-kappaB regulate IL-25 induced release of cytokines and chemokines from costimulated T helper lymphocytes
    • 10.1016/j.imlet.2007.07.002, 17719653
    • Wong CK, Li PW, Lam CW. Intracellular JNK, p38 MAPK and NF-kappaB regulate IL-25 induced release of cytokines and chemokines from costimulated T helper lymphocytes. Immunol Lett 2007, 112:82-91. 10.1016/j.imlet.2007.07.002, 17719653.
    • (2007) Immunol Lett , vol.112 , pp. 82-91
    • Wong, C.K.1    Li, P.W.2    Lam, C.W.3
  • 5
    • 72849109689 scopus 로고    scopus 로고
    • Activation profile of intracellular mitogen-activated protein kinases in peripheral lymphocytes of patients with systemic lupus erythematosus
    • 10.1007/s10875-009-9318-4, 19756990
    • Wong CK, Wong PTY, Tam LS, Li EK, Chen DP, Lam CWK. Activation profile of intracellular mitogen-activated protein kinases in peripheral lymphocytes of patients with systemic lupus erythematosus. J Clin Immunol 2009, 29:738-746. 10.1007/s10875-009-9318-4, 19756990.
    • (2009) J Clin Immunol , vol.29 , pp. 738-746
    • Wong, C.K.1    Wong, P.T.Y.2    Tam, L.S.3    Li, E.K.4    Chen, D.P.5    Lam, C.W.K.6
  • 7
    • 12644257580 scopus 로고    scopus 로고
    • Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase
    • 10.1073/pnas.94.18.9687, 23251, 9275185
    • Diener K, Wang XS, Chen C, Meyer CF, Keesler G, Zukowski M, Tan TH, Yao Z. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc Natl Acad Sci USA 1997, 94:9687-9692. 10.1073/pnas.94.18.9687, 23251, 9275185.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9687-9692
    • Diener, K.1    Wang, X.S.2    Chen, C.3    Meyer, C.F.4    Keesler, G.5    Zukowski, M.6    Tan, T.H.7    Yao, Z.8
  • 8
    • 34147141941 scopus 로고    scopus 로고
    • A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signaling
    • 10.1042/BJ20061881, 1828895, 17253963
    • Findlay GM, Yan L, Procter J, Mieulet V, Lamb RF. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signaling. Biochem J 2007, 403:13-20. 10.1042/BJ20061881, 1828895, 17253963.
    • (2007) Biochem J , vol.403 , pp. 13-20
    • Findlay, G.M.1    Yan, L.2    Procter, J.3    Mieulet, V.4    Lamb, R.F.5
  • 9
    • 67749133996 scopus 로고    scopus 로고
    • MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins
    • 10.1073/pnas.0900608106, 2707271, 19587239
    • Lam D, Dickens D, Reid EB, Loh SH, Moisoi N, Martins LM. MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins. Proc Natl Acad Sci USA 2009, 106:11978-11983. 10.1073/pnas.0900608106, 2707271, 19587239.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 11978-11983
    • Lam, D.1    Dickens, D.2    Reid, E.B.3    Loh, S.H.4    Moisoi, N.5    Martins, L.M.6
  • 10
    • 1842334483 scopus 로고    scopus 로고
    • In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune disease
    • 10.1002/art.1780400216, 9041943
    • Lorenz HM, Grunke M, Hieronymus T, Herrmann M, Kuhnel A, Manger B, Kalden JR. In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune disease. Arthritis Rheum 1997, 40:306-317. 10.1002/art.1780400216, 9041943.
    • (1997) Arthritis Rheum , vol.40 , pp. 306-317
    • Lorenz, H.M.1    Grunke, M.2    Hieronymus, T.3    Herrmann, M.4    Kuhnel, A.5    Manger, B.6    Kalden, J.R.7
  • 11
    • 37349015936 scopus 로고    scopus 로고
    • Increased apoptosis of peripheral blood lymphocytes and its association with interleukin-18 in patients with active untreated adult-onset Still's disease
    • 10.1002/art.23088, 18050226
    • Chen DY, Hsieh TY, Hsieh CW, Lin FJ, Lan JL. Increased apoptosis of peripheral blood lymphocytes and its association with interleukin-18 in patients with active untreated adult-onset Still's disease. Arthritis Rheum 2007, 57:1530-1538. 10.1002/art.23088, 18050226.
    • (2007) Arthritis Rheum , vol.57 , pp. 1530-1538
    • Chen, D.Y.1    Hsieh, T.Y.2    Hsieh, C.W.3    Lin, F.J.4    Lan, J.L.5
  • 14
    • 0015030792 scopus 로고
    • Still's disease in the adults
    • 10.1136/ard.30.2.121, 1005739, 5315135
    • Bywaters EGL. Still's disease in the adults. Ann Rheum Dis 1971, 30:121-133. 10.1136/ard.30.2.121, 1005739, 5315135.
    • (1971) Ann Rheum Dis , vol.30 , pp. 121-133
    • Bywaters, E.G.L.1
  • 15
  • 16
    • 0035080102 scopus 로고    scopus 로고
    • Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease
    • 10.1002/1529-0131(200103)44:3<550::AID-ANR103>3.0.CO;2-5, 11263769
    • Kawashima M, Yamamura M, Taniai M, Yamauchi H, Tanimoto T, Kurimoto M, Miyawaki S, Amano T, Takeuchi T, Makino H. Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease. Arthritis Rheum 2001, 44:550-560. 10.1002/1529-0131(200103)44:3<550::AID-ANR103>3.0.CO;2-5, 11263769.
    • (2001) Arthritis Rheum , vol.44 , pp. 550-560
    • Kawashima, M.1    Yamamura, M.2    Taniai, M.3    Yamauchi, H.4    Tanimoto, T.5    Kurimoto, M.6    Miyawaki, S.7    Amano, T.8    Takeuchi, T.9    Makino, H.10
  • 17
    • 7544248841 scopus 로고    scopus 로고
    • Proinflammatory cytokine profiles in the sera and in the pathological tissues of patients with active untreated adult onset Still's disease
    • Chen DY, Lan JL, Lin FJ, Hsieh TY. Proinflammatory cytokine profiles in the sera and in the pathological tissues of patients with active untreated adult onset Still's disease. J Rheumatol 2004, 31:2189-2198.
    • (2004) J Rheumatol , vol.31 , pp. 2189-2198
    • Chen, D.Y.1    Lan, J.L.2    Lin, F.J.3    Hsieh, T.Y.4
  • 19
    • 4644253851 scopus 로고    scopus 로고
    • A predominance of Th1 cytokine in peripheral blood and pathological tissues of patients with active untreated adult-onset Still's disease
    • 10.1136/ard.2003.013680, 1754751, 15361391
    • Chen DY, Lan JL, Lin FJ, Hsieh TY, Wen MC. A predominance of Th1 cytokine in peripheral blood and pathological tissues of patients with active untreated adult-onset Still's disease. Ann Rheum Dis 2004, 63:1300-1306. 10.1136/ard.2003.013680, 1754751, 15361391.
    • (2004) Ann Rheum Dis , vol.63 , pp. 1300-1306
    • Chen, D.Y.1    Lan, J.L.2    Lin, F.J.3    Hsieh, T.Y.4    Wen, M.C.5
  • 23
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987, 162:156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 24
    • 1642463417 scopus 로고    scopus 로고
    • Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications
    • 10.1016/j.clim.2003.11.009, 15047199
    • Krutzik PO, Irish JM, Nolan JP, Perez OD. Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications. Clin Immunol 2004, 110:206-221. 10.1016/j.clim.2003.11.009, 15047199.
    • (2004) Clin Immunol , vol.110 , pp. 206-221
    • Krutzik, P.O.1    Irish, J.M.2    Nolan, J.P.3    Perez, O.D.4
  • 25
    • 0032146063 scopus 로고    scopus 로고
    • TNF receptor-associated factor-2 signaling mediates activation of p38 and Jun N-terminal kinase, cytokine secretion, and Ig production following ligation of CD40 on human B cells
    • Grammer AC, Swantek JL, McFarland RD, Miura Y, Geppert T, Lipsky PE. TNF receptor-associated factor-2 signaling mediates activation of p38 and Jun N-terminal kinase, cytokine secretion, and Ig production following ligation of CD40 on human B cells. J Immunol 1998, 161:1183-1193.
    • (1998) J Immunol , vol.161 , pp. 1183-1193
    • Grammer, A.C.1    Swantek, J.L.2    McFarland, R.D.3    Miura, Y.4    Geppert, T.5    Lipsky, P.E.6
  • 26
    • 1342308590 scopus 로고    scopus 로고
    • Flow cytometric assessment of the signaling status of human B lymphocytes from normal and autoimmune individuals
    • 400425, 14979930
    • Grammer AC, Fischer R, Lee O, Zhang X, Lipsky PE. Flow cytometric assessment of the signaling status of human B lymphocytes from normal and autoimmune individuals. Arthritis Res Ther 2004, 6:28-39. 400425, 14979930.
    • (2004) Arthritis Res Ther , vol.6 , pp. 28-39
    • Grammer, A.C.1    Fischer, R.2    Lee, O.3    Zhang, X.4    Lipsky, P.E.5
  • 27
    • 66049151440 scopus 로고    scopus 로고
    • Th17 and natural Treg cell population dynamics in systemic lupus erythematosus
    • 10.1002/art.24499, 19404966
    • Yang J, Chu Y, Yang X, Gao D, Zhu L, Yang X, Wan L, Li M. Th17 and natural Treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum 2009, 60:1472-1483. 10.1002/art.24499, 19404966.
    • (2009) Arthritis Rheum , vol.60 , pp. 1472-1483
    • Yang, J.1    Chu, Y.2    Yang, X.3    Gao, D.4    Zhu, L.5    Yang, X.6    Wan, L.7    Li, M.8
  • 28
    • 55249119291 scopus 로고    scopus 로고
    • IL-17 and the Th17 lineage in systemic lupus erythematosus
    • 10.1097/BOR.0b013e328304b6b5, 18698171
    • Garrett-Sinha LA, John S, Gaffen SL. IL-17 and the Th17 lineage in systemic lupus erythematosus. Curr Opin Rheumatol 2008, 20:519-525. 10.1097/BOR.0b013e328304b6b5, 18698171.
    • (2008) Curr Opin Rheumatol , vol.20 , pp. 519-525
    • Garrett-Sinha, L.A.1    John, S.2    Gaffen, S.L.3
  • 29
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • 10.1038/ni1488, 17581537
    • Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007, 8:967-974. 10.1038/ni1488, 17581537.
    • (2007) Nat Immunol , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5    Egawa, T.6    Levy, D.E.7    Leonard, W.J.8    Littman, D.R.9
  • 30
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • 10.1038/ni1261, 1618871, 16200068
    • Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005, 6:1133-1141. 10.1038/ni1261, 1618871, 16200068.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3    Chang, S.H.4    Nurieva, R.5    Wang, Y.H.6    Wang, Y.7    Hood, L.8    Zhu, Z.9    Tian, Q.10    Dong, C.11
  • 33
    • 77649278937 scopus 로고    scopus 로고
    • Bordetella pertussis commits human dendritic cells to promote a Th1/Th17 response through the activity of adenylate cyclase toxin and MAPK-pathways
    • 10.1371/journal.pone.0008734, 2806909, 20090944
    • Fedele G, Spensieri F, Palazzo R, Nasso M, Cheung GY, Coote JG, Ausiello CM. Bordetella pertussis commits human dendritic cells to promote a Th1/Th17 response through the activity of adenylate cyclase toxin and MAPK-pathways. PLoS One 2010, 5:e8734. 10.1371/journal.pone.0008734, 2806909, 20090944.
    • (2010) PLoS One , vol.5
    • Fedele, G.1    Spensieri, F.2    Palazzo, R.3    Nasso, M.4    Cheung, G.Y.5    Coote, J.G.6    Ausiello, C.M.7
  • 34
    • 77952758245 scopus 로고    scopus 로고
    • IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation
    • 10.4049/jimmunol.0903162, 20228195
    • Roussel L, Houle F, Chan C, Yao Y, Bérubé J, Olivenstein R, Martin JG, Huot J, Hamid Q, Ferri L, Rousseau S. IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation. J Immunol 2010, 184:4531-4537. 10.4049/jimmunol.0903162, 20228195.
    • (2010) J Immunol , vol.184 , pp. 4531-4537
    • Roussel, L.1    Houle, F.2    Chan, C.3    Yao, Y.4    Bérubé, J.5    Olivenstein, R.6    Martin, J.G.7    Huot, J.8    Hamid, Q.9    Ferri, L.10    Rousseau, S.11
  • 36
    • 68149169760 scopus 로고    scopus 로고
    • Inhibition of ERK MAPK suppresses IL-23 and IL-1-driven IL-17 production and attenuates autoimmune disease
    • 10.4049/jimmunol.0803851, 19570828
    • Brereton CF, Sutton CE, Lalor SJ, Lavelle EC, Mills KHG. Inhibition of ERK MAPK suppresses IL-23 and IL-1-driven IL-17 production and attenuates autoimmune disease. J Immunol 2009, 183:1715-1723. 10.4049/jimmunol.0803851, 19570828.
    • (2009) J Immunol , vol.183 , pp. 1715-1723
    • Brereton, C.F.1    Sutton, C.E.2    Lalor, S.J.3    Lavelle, E.C.4    Mills, K.H.G.5
  • 37
    • 75749092187 scopus 로고    scopus 로고
    • 'Go upstream, young man': lessons learnt from the p38 saga
    • Hammaker D, Firestein GS. 'Go upstream, young man': lessons learnt from the p38 saga. Ann Rheum Dis 2010, 69(Suppl.1):77-82.
    • (2010) Ann Rheum Dis , vol.69 , Issue.SUPPL.1 , pp. 77-82
    • Hammaker, D.1    Firestein, G.S.2
  • 38
    • 34347392053 scopus 로고    scopus 로고
    • Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes
    • 10.1186/ar2215, 2206340, 17559674
    • Hammaker DR, Boyle DL, Inoue T, Firestein GS. Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. Arthritis Res Ther 2007, 9:R57. 10.1186/ar2215, 2206340, 17559674.
    • (2007) Arthritis Res Ther , vol.9
    • Hammaker, D.R.1    Boyle, D.L.2    Inoue, T.3    Firestein, G.S.4
  • 39
    • 70249087377 scopus 로고    scopus 로고
    • Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression
    • 10.4049/jimmunol.0900483, 2744479, 19561096
    • Yoshizawa T, Hammaker D, Boyle DL, Corr M, Flavell R, Davis R, Schett G, Firestein GS. Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression. J Immunol 2009, 183:1360-1367. 10.4049/jimmunol.0900483, 2744479, 19561096.
    • (2009) J Immunol , vol.183 , pp. 1360-1367
    • Yoshizawa, T.1    Hammaker, D.2    Boyle, D.L.3    Corr, M.4    Flavell, R.5    Davis, R.6    Schett, G.7    Firestein, G.S.8
  • 40
    • 35348907987 scopus 로고    scopus 로고
    • Protein kinases as small molecule inhibitor targets in inflammation
    • 10.2174/092986707781696636, 17896971
    • Gaestel M, Mengel A, Bothe U, Asadullah K. Protein kinases as small molecule inhibitor targets in inflammation. Curr Med Chem 2007, 14:2214-2234. 10.2174/092986707781696636, 17896971.
    • (2007) Curr Med Chem , vol.14 , pp. 2214-2234
    • Gaestel, M.1    Mengel, A.2    Bothe, U.3    Asadullah, K.4
  • 41
    • 67650093218 scopus 로고    scopus 로고
    • The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo
    • 10.1002/art.24567, 19565475
    • Kremer JM, Bloom BJ, Breedveld FC, Coombs JH, Fletcher MP, Gruben D, Krishnaswami S, Burgos-Vargas R, Wilkinson B, Zerbini CA, Zwillich SH. The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo. Arthritis Rheum 2009, 60:1895-1905. 10.1002/art.24567, 19565475.
    • (2009) Arthritis Rheum , vol.60 , pp. 1895-1905
    • Kremer, J.M.1    Bloom, B.J.2    Breedveld, F.C.3    Coombs, J.H.4    Fletcher, M.P.5    Gruben, D.6    Krishnaswami, S.7    Burgos-Vargas, R.8    Wilkinson, B.9    Zerbini, C.A.10    Zwillich, S.H.11
  • 42
    • 78650294662 scopus 로고    scopus 로고
    • An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents
    • 10.1002/art.30114, 21279990
    • Genovese MC, Kavanaugh A, Weinblatt ME, Peterfy C, DiCarlo J, White ML, O'Brien M, Grossbard EB, Magilavy DB. An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents. Arthritis Rheum 2011, 63:337-345. 10.1002/art.30114, 21279990.
    • (2011) Arthritis Rheum , vol.63 , pp. 337-345
    • Genovese, M.C.1    Kavanaugh, A.2    Weinblatt, M.E.3    Peterfy, C.4    DiCarlo, J.5    White, M.L.6    O'Brien, M.7    Grossbard, E.B.8    Magilavy, D.B.9
  • 43
    • 34547878809 scopus 로고    scopus 로고
    • Anakinra in patients with treatment-resistant adult-onset Still's disease: four case reports with serial cytokine measurements and a review of the literature
    • 10.1016/j.semarthrit.2007.04.002, 17583775
    • Kötter I, Wacker A, Koch S, Henes J, Richter C, Engel A, Günaydin I, Kanz L. Anakinra in patients with treatment-resistant adult-onset Still's disease: four case reports with serial cytokine measurements and a review of the literature. Semin Arthritis Rheum 2007, 37:189-197. 10.1016/j.semarthrit.2007.04.002, 17583775.
    • (2007) Semin Arthritis Rheum , vol.37 , pp. 189-197
    • Kötter, I.1    Wacker, A.2    Koch, S.3    Henes, J.4    Richter, C.5    Engel, A.6    Günaydin, I.7    Kanz, L.8
  • 44
    • 2642559875 scopus 로고    scopus 로고
    • Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention
    • 10.1038/nrd1342, 15060528
    • Braddock M, Quinn A. Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention. Nat Rev Drug Discov 2004, 3:330-339. 10.1038/nrd1342, 15060528.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 330-339
    • Braddock, M.1    Quinn, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.