Small molecules that protect against β-amyloid-induced cytotoxicity by inhibiting aggregation of β-amyloid

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 16, 2012, Pages 4921-4935

  Lee, Yun Suk ^a,b   Kim, Hye Yun ^a   Kim, Youngsoo ^a   Seo, Jae Hong ^c   Roh, Eun Joo ^a   Han, Hogyu ^b   Shin, Kye Jung ^c  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

^c The Catholic University of Korea   (South Korea)

Author keywords

Amyloid; Aggregation inhibitor; Alzheimer disease; Bis styryl aromatic compound

Indexed keywords

2 METHOXY 4,6 BIS(3' HYDROXY 4' METHOXYSTYRYL)PYRIMIDINE; 2 METHOXY 4,6 BIS(3' HYDROXY 4' N,N DIMETHYLAMINOSTYRYL)PYRIMIDINE; 2 METHOXY 4,6 BIS(3' HYDROXYSTYRYL)PYRIMIDINE; 2 METHOXY 4,6 BIS(4' HYDROXY 3' METHOXYSTYRYL)PYRIMIDINE; 2 METHOXY 4,6 BIS(4' HYDROXY 3' N,N DIMETHYLAMINOSTYRYL)PYRIMIDINE; 2 METHOXY 4,6 BIS(4' HYDROXYSTYRYL)PYRIMIDINE; 2 METHYLTHIO 4,6 BIS(3' HYDROXY 4' METHOXYSTYRYL)PYRIMIDINE; 2 METHYLTHIO 4,6 BIS(3' HYDROXY 4' N,N DIMETHYLAMINOSTYRYL)PYRIMIDINE; 2 METHYLTHIO 4,6 BIS(3' HYDROXYSTYRYL)PYRIMIDINE; 2 METHYLTHIO 4,6 BIS(4' HYDROXY 3' METHOXYSTYRYL)PYRIMIDINE; 2 METHYLTHIO 4,6 BIS(4' HYDROXY 3' N,N DIMETHYLAMINOSTYRYL)PYRIMIDINE; 2 METHYLTHIO 4,6 BIS(4' HYDROXYSTYRYL)PYRIMIDINE; 3,5 BIS(3' HYDROXY 4' METHOXYSTYRYL)BENZENE; 3,5 BIS(3' HYDROXY 4' N,N DIMETHYLAMINOSTYRYL)BENZENE; 3,5 BIS(3' HYDROXYSTYRYL)BENZENE; 3,5 BIS(3' HYDROXYSTYRYL)PHENOL; 3,5 BIS(4' HYDROXY 3' METHOXYSTYRYL)BENZENE; 3,5 BIS(4' HYDROXY 3' N,N DIMETHYLAMINOSTYRYL)BENZENE; 3,5 BIS(4' HYDROXYSTYRYL)BENZENE; 3,5 BIS(4' HYDROXYSTYRYL)PHENOL; 4,6 BIS(3' HYDROXY 4' METHOXYSTYRYL)PYRIMIDINE; 4,6 BIS(3' HYDROXY 4' N,N DIMETHYLAMINOSTYRYL)PYRIMIDINE; 4,6 BIS(3' HYDROXYSTYRYL)PYRIMIDINE; 4,6 BIS(4' HYDROXY 3' METHOXYSTYRYL)PYRIMIDINE; 4,6 BIS(4' HYDROXY 3' N,N DIMETHYLAMINOSTYRYL)PYRIMIDINE; 4,6 BIS(4' HYDROXYSTYRYL)PYRIMIDINE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; KMS 4005; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; LEARNING DISORDER; MALE; MAZE TEST; MEMORY DISORDER; MOUSE; NEUROPROTECTION; NONHUMAN; PASSIVE AVOIDANCE; PROTEIN AGGREGATION;

AMYLOID BETA-PEPTIDES; ANIMALS; BENZENE DERIVATIVES; CELLS, CULTURED; COUMARIC ACIDS; CURCUMIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; MICE, INBRED ICR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PEPTIDE FRAGMENTS; STILBENES; THIAZOLES;

MUS;

EID: 84864426034     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.06.045     Document Type: Article

References (40)

1. W.L. Klein, G.A. Krafft, and C.E. Finch Trends Neurosci. 24 4 2001 219
2. M.P. Lambert, A.K. Barlow, B.A. Chromy, C. Edwards, R. Freed, M. Liosatos, T.E. Morgan, I. Rozovsky, B. Trommer, K.L. Viola, P. Wals, C. Zhang, C.E. Finch, G.A. Krafft, and W.L. Klein Proc. Natl. Acad. Sci. U.S.A. 95 11 1998 6448
3. R. Kayed, E. Head, J.L. Thompson, T.M. McIntire, S.C. Milton, C.W. Cotman, and C.G. Glabe Science 300 5618 2003 486
4. M.A. Smith, K. Hirai, K. Hsiao, M.A. Pappolla, P.L.R. Harris, S.L. Siedlak, M. Tabaton, and G. Perry J. Neurochem. 70 5 1998 2212
5. I. Hussain, D. Powell, D.R. Howlett, D.G. Tew, T.D. Meek, C. Chapman, I.S. Gloger, K.E. Murphy, C.D. Southan, D.M. Ryan, T.S. Smith, D.L. Simmons, F.S. Walsh, C. Dingwall, and G. Christie Mol. Cell. Neurosci. 14 6 1999 419
6. W.P. Esler, and M.S. Wolfe Science 293 5534 2001 1449
7. J. Hardy, and D.J. Selkoe Science 297 5580 2002 353
8. M. Ohno, E.A. Sametsky, L.H. Younkin, H. Oakley, S.G. Younkin, M. Citron, R. Vassar, and J.F. Disterhoft Neuron 41 1 2004 27
9. H.F. Dovey, V. John, J.P. Anderson, L.Z. Chen, P.D. Andrieu, L.Y. Fang, S.B. Freedman, B. Folmer, E. Goldbach, E.J. Holsztynska, K.L. Hu, K.L. Johnson-Wood, S.L. Kennedy, D. Kholedenko, J.E. Knops, L.H. Latimer, M. Lee, Z. Liao, I.M. Lieberburg, R.N. Motter, L.C. Mutter, J. Nietz, K.P. Quinn, K.L. Sacchi, P.A. Seubert, G.M. Shopp, E.D. Thorsett, J.S. Tung, J. Wu, S. Yang, C.T. Yin, D.B. Schenk, P.C. May, L.D. Altstiel, M.H. Bender, L.N. Boggs, T.C. Britton, J.C. Clemens, D.L. Czilli, D.K. Dieckman-McGinty, J.J. Droste, K.S. Fuson, B.D. Gitter, P.A. Hyslop, E.M. Johnstone, W.Y. Li, S.P. Little, T.E. Mabry, F.D. Miller, B. Ni, J.S. Nissen, W.J. Porter, B.D. Potts, J.K. Reel, D. Stephenson, Y. Su, L.A. Shipley, C.A. Whitesitt, T. Yin, and J.E. Audia J. Neurochem. 76 1 2001 173
10. D. Schenk, R. Barbour, W. Dunn, G. Gordon, H. Grajeda, T. Guido, K. Hu, J.P. Huang, K. Johnson-Wood, K. Khan, D. Kholodenko, M. Lee, Z.M. Liao, I. Lieberburg, R. Motter, L. Mutter, F. Soriano, G. Shopp, N. Vasquez, C. Vandevert, S. Walker, M. Wogulis, T. Yednock, D. Games, and P. Seubert Nature 400 6740 1999 173
11. B. Permanne, C. Adessi, G.P. Saborio, S. Fraga, M.J. Frossard, J. Van Dorpe, I. Dewachter, W.A. Banks, F. Van Leuven, and C. Soto FASEB J. 16 6 2002 860
12. D.M. Walsh, M. Townsend, M.B. Podlisny, G.M. Shankar, J.V. Fadeeva, O. El Agnaf, D.M. Hartley, and D.J. Selkoe J. Neurosci. 25 10 2005 2455
13. N. Kokkoni, K. Stott, H. Amijee, J.M. Mason, and A.J. Doig Biochemistry 45 32 2006 9906
14. V.M.Y. Lee Neurobiol. Aging 23 6 2002 1039
15. K. Ono, M. Hirohata, and M. Yamada Biochem. Biophys. Res. Commun. 336 2 2005 444
16. R. Sultana, A. Ravagna, H. Mohmmad-Abdul, V. Calabrese, and D.A. Butterfield J. Neurochem. 92 4 2005 749
17. J.J. Yan, J.Y. Cho, H.S. Kim, K.L. Kim, J.S. Jung, S.O. Huh, H.W. Suh, Y.H. Kim, and D.K. Song Br. J. Pharmacol. 133 1 2001 89
18. C.A. Riceevans, N.J. Miller, G.P. Bolwell, P.M. Bramley, and J.B. Pridham Free Radic. Res. 22 4 1995 375
19. G.J. Soleas, L. Grass, P.D. Josephy, D.M. Goldberg, and E.P. Diamandis Clin. Biochem. 35 2 2002 119
20. J.H. Jang, and Y.J. Surh Free Radic. Biol. Med. 34 8 2003 1100
21. F.S. Yang, G.P. Lim, A.N. Begum, O.J. Ubeda, M.R. Simmons, S.S. Ambegaokar, P.P. Chen, R. Kayed, C.G. Glabe, S.A. Frautschy, and G.M. Cole J. Biol. Chem. 280 7 2005 5892
22. D.M. Walsh, I. Klyubin, J.V. Fadeeva, W.K. Cullen, R. Anwyl, M.S. Wolfe, M.J. Rowan, and D.J. Selkoe Nature 416 6880 2002 535
23. K.H. Lee, B.H. Shin, K.J. Shin, D.J. Kim, and J. Yu Biochem. Biophys. Res. Commun. 328 4 2005 816
24. R.A. Sharma, S.A. Euden, S.L. Platton, D.N. Cooke, A. Shafayat, H.R. Hewitt, T.H. Marczylo, B. Morgan, D. Hemingway, S.M. Plummer, M. Pirmohamed, A.J. Gescher, and W.P. Steward Clin. Cancer Res. 10 20 2004 6847
25. P. Anand, A.B. Kunnumakkara, R.A. Newman, and B.B. Aggarwal Mol. Pharmacol. 4 6 2007 807
26. H. Levine Protein Sci. 2 3 1993 404
27. H.F. Kung, C.W. Lee, Z.P. Zhuang, M.P. Kung, C. Hou, and K. Plossl J. Am. Chem. Soc. 123 50 2001 12740
28. S. Varadarajan, J. Kanski, M. Aksenova, C. Lauderback, and D.A. Butterfield J. Am. Chem. Soc. 123 24 2001 5625
29. A. Nitta, A. Itoh, T. Hasegawa, and T. Nabeshima Neurosci. Lett. 170 1-2 1994 63
30. K. Yamada, T. Tanaka, K. Senzaki, T. Kameyama, and T. Nabeshima Eur. J. Pharmacol. 349 1 1998 15
31. A. Ennaceur, and J. Delacour Behav. Brain Res 31 1 1988 47
32. D.K. Song, M.H. Won, J.S. Jung, J.C. Lee, T.C. Kang, H.W. Suh, S.O. Huh, S.H. Paek, Y.H. Kim, S.H. Kim, and Y.H. Suh J. Neurochem. 71 2 1998 875
33. R. Morris J. Neurosci. Methods 11 1 1984 47
34. S.A. Frautschy, W. Hu, P. Kim, S.A. Miller, T. Chu, M.E. Harris-White, and G.M. Cole Neurobiol. Aging 22 6 2001 993
35. M. Bucciantini, E. Giannoni, F. Chiti, F. Baroni, L. Formigli, J. Zurdo, N. Taddei, G. Ramponi, C.M. Dobson, and M. Stefani Nature 416 6880 2002 507
36. T. Cohen, A. Frydman-Marom, M. Rechter, and E. Gazit Biochemistry 45 15 2006 4727
37. J.W. Kwak, H.K. Kim, and C.B. Chae J. Med. Chem. 49 16 2006 4813
38. B.M. Austen, K.E. Paleologou, S.A.E. Ali, M.M. Qureshi, D. Allsop, and O.M.A. El-Agnaf Biochemistry 47 7 2008 1984
39. P. Hammarstrom, R.L. Wiseman, E.T. Powers, and J.W. Kelly Science 299 5607 2003 713
40. S.E. Laursen, and J.K. Belknap J. Pharmacol. Methods 16 4 1986 355