An NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of tanshinone IIA against non-small cell lung cancer

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Liu, Fang ^a   Yu, Guo ^a   Wang, Guangji ^a   Liu, Huiying ^a   Wu, Xiaolan ^a   Wang, Qiong ^a   Liu, Miao ^a   Liao, Ke ^a   Wu, Mengqiu ^a   Cheng, Xuefang ^a   Hao, Haiping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYTOCHROME C; DICOUMAROL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAX; PROTEIN BCL XL; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TANSHINONE IIA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CONTROLLED STUDY; DNA DAMAGE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN SECRETION; TISSUE DISTRIBUTION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL TRANSPORT; CARCINOMA, NON-SMALL-CELL LUNG; CASPASES; CELL LINE, TUMOR; DITERPENES, ABIETANE; DNA DAMAGE; HUMANS; LUNG NEOPLASMS; MICE; MITOCHONDRIA; NAD(P)H DEHYDROGENASE (QUINONE); REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS MUSCULUS;

EID: 84864416923     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042138     Document Type: Article

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