Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 15, 2005, Pages 5535-5540

  Tsvetkov, Peter ^a   Asher, Gad ^a   Reiss, Veronica ^a   Shaul, Yosef ^a   Sachs, Leo ^a   Lotem, Joseph ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Cancer hot spot p53 mutant; Disruption of NQO1 p53 binding; NQO1 dependent pathway; p53 induced apoptosis

Indexed keywords

CURCUMIN; DICOUMAROL; OXIDOREDUCTASE; PROTEIN P53; QUINONE NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE 1; SMALL INTERFERING RNA; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CURCUMA LONGA; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; MOUSE; MYELOID LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INDUCTION; SPICE; THYMOCYTE; WILD TYPE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELLS, CULTURED; CURCUMIN; HUMANS; MICE; MUTATION, MISSENSE; NAD(P)H DEHYDROGENASE (QUINONE); NEOPLASMS; THYMUS GLAND; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN;

CURCUMA LONGA;

EID: 17244378011     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0501828102     Document Type: Article

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