Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1- benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 873-878

  Khelili, Smail ^a   Kihal, Nadjib ^a   Yekhlef, Mohamed ^a   De Tullio, Pascal ^c   Lebrun, Philippe ^b   Pirotte, Bernard ^c  

^a UNIVERSITY OF JIJEL   (Algeria)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Benzopyranes; Benzothiadiazine dioxides; Hybrid compounds; Insulin secretion; Myorelaxant activity; Tissue selectivity

Indexed keywords

7 CHLORO N ( 2,2 DIMETHYL 6 NITRO 3,4 DIHYDRO 2H 1 BENZOPYRAN 4 YL) 4H 1,2,4 BENZOTHIADIAZINE 3 CARBOXAMIDE 1,1 DIOXIDE; BENZOPYRAN DERIVATIVE; BENZOTHIADIAZINE DERIVATIVE; BROMINE; CHROMAN; CROMAKALIM; DIAZOXIDE; INSULIN; MUSCLE RELAXANT AGENT; N ( 2,2 DIMETHYL 6 FLUORO 3,4 DIHYDRO 2H 1 BENZOPYRAN 4 YL) 4H 1,2,4 BENZOTHIADIAZINE 3 CARBOXAMIDE 1,1 DIOXIDE; N ( 2,2 DIMETHYL 6 FLUORO 3,4 DIHYDRO 2H 1 BENZOPYRAN 4 YL) 7 METHYL 4H 1,2,4 BENZOTHIADIAZINE 3 CARBOXAMIDE 1,1 DIOXIDE; N ( 2,2 DIMETHYL 6 NITRO 3,4 DIHYDRO 2H 1 BENZOPYRAN 4 YL) 4H 1,2,4 BENZOTHIADIAZINE 3 CARBOXAMIDE 1,1 DIOXIDE; N ( 2,2 DIMETHYL 6 NITRO 3,4 DIHYDRO 2H 1 BENZOPYRAN 4 YL) 7 METHYL 4H 1,2,4 BENZOTHIADIAZINE 3 CARBOXAMIDE 1,1 DIOXIDE; N ( 6 BROMO 2,2 DIMETHYL 3,4 DIHYDRO 2H 1 BENZOPYRAN 4 YL) 7 METHYL 4H 1,2,4 BENZOTHIADIAZINE 3 CARBOXAMIDE 1,1 DIOXIDE; N ( 6 BROMO 2,2, DIMETHYL 3,4 DIHYDRO 2H 1 BENZOPYRAN 4 YL) 4H 1,2,4 BENZOTHIADIAZINE 3 CARBOXAMIDE 1,1 DIOXIDE; OXYTOCIN; PINACIDIL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AORTA; ARTICLE; ATOM; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG SYNTHESIS; HYBRID; INSULIN RELEASE; MUSCLE DEVELOPMENT; MUSCLE RELAXATION; MYOMETRIUM; NONHUMAN; PANCREAS ISLET BETA CELL; PHARMACODYNAMICS; RAT; RING OPENING; UTERUS; UTERUS RELAXATION; VASODILATATION;

ANIMALS; AORTA; BENZOTHIADIAZINES; CHEMISTRY TECHNIQUES, SYNTHETIC; FEMALE; INSULIN; INSULIN-SECRETING CELLS; MUSCLE RELAXATION; MUSCLE, SMOOTH; RATS; UTERUS;

EID: 84864416307     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.05.011     Document Type: Article

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