Synthesis and activity on rat aorta rings and rat pancreatic β-cells of ring-opened analogues of benzopyran-type potassium channel activators

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 11, 2008, Pages 6124-6130

  Khelili, Smail ^a   Florence, Xavier ^b   Bouhadja, Mourad ^a   Abdelaziz, Samia ^a   Mechouch, Nadia ^a   Mohamed, Yekhlef ^a   de Tullio, Pascal ^b   Lebrun, Philippe ^c   Pirotte, Bernard ^b  

^a UNIVERSITY OF JIJEL   (Algeria)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Inhibition of insulin secretion; Potassium channel opener; Ring opened cromakalim analogues; Vasorelaxant effect

Indexed keywords

1 (2 ETHOXYBENZYL) 3 (3 CHLOROPHENYL)UREA; 1 (2 ETHOXYBENZYL) 3 (4 CHLOROPHENYL)SULFONYLUREA; 1 (2 ETHOXYBENZYL) 3 (4 CHLOROPHENYL)UREA; 1 (2 ETHOXYBENZYL) 3 ETHYLUREA; 1 (2 METHOXYBENZYL) 3 (3 CHLOROPHENYL)UREA; 1 (2 METHOXYBENZYL) 3 (4 CHLOROPHENYL)SULFONYLUREA; 1 (2 METHOXYBENZYL) 3 (4 CHLOROPHENYL)UREA; 1 (2 METHOXYBENZYL) 3 ETHYLUREA; 4 (3 CHLOROPHENYLAMINOCARBONYLAMINO) 3,4 DIHYDRO 2,2 DIMETHYL 2H 1 BENZOPYRAN; 4 (4 CHLOROPHENYLAMINOCARBONYLAMINO) 3,4 DIHYDRO 2,2 DIMETHYL 2H 1 BENZOPYRAN; CROMAKALIM; N (2 ETHOXYBENZYL) 4 NITROBENZAMIDE; N (2 ETHOXYBENZYL)THIOPHENE 2 CARBOXAMIDE; N (2 METHOXYBENZYL) 4 NITROBENZAMIDE; N (2 METHOXYBENZYL)THIOPHENE 2 CARBOXAMIDE; PINACIDIL; POTASSIUM CHANNEL STIMULATING AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG SYNTHESIS; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; RING OPENING; STRUCTURE ACTIVITY RELATION; VASODILATATION;

ANIMALS; AORTA; BENZOPYRANS; CHROMANS; CROMAKALIM; INSULIN; INSULIN ANTAGONISTS; INSULIN-SECRETING CELLS; MUSCLE RELAXATION; POTASSIUM CHANNELS; RATS; RATS, WISTAR;

RATTUS;

EID: 44449092065     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.043     Document Type: Article

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