Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N′-(2,2-dimethyl-2H-1-benzopyran-4-yl)urea s structurally related to cromakalim

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 10, 2006, Pages 3530-3534

  Khelili, Smail ^a   Lebrun, Philippe ^b   de Tullio, Pascal ^c   Pirotte, Bernard ^c  

^a UNIVERSITY OF JIJEL   (Algeria)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Contractile activity; Cromakalim derivatives; Insulin secretion; Potassium channel openers

Indexed keywords

CROMAKALIM; DIAZOXIDE; INSULIN; N (4 CHLOROBENZENESULFONYL) N METHYL N (2,2 DIMETHYL 6 FLUORO 2H 1 BENZOPYRAN 4 YL)UREA; N (4 CHLOROBENZENESULFONYL) N METHYL N' (6 BROMO 2,2 DIMETHYL 2H 1 BENZOPYRAN 4 YL)UREA; N (4 METHYLBENZENESULFONYL) N METHYL N' (2,2 DIMETHYL 6 FLUORO 2H 1 BENZOPYRAN 4 YL)UREA; N (4 METHYLBENZENESULFONYL) N METHYL N' (6 BROMO 2,2 DIMETHYL 2H 1 BENZOPYRAN 4 YL)UREA; N BENZENESULFONYL N METHYL N' (2,2 DIMETHYL 6 FLUORO 2H 1 BENZOPYRAN 4 YL)UREA; N BENZENESULFONYL N METHYL N' (6 BROMO 2,2 DIMETHYL 2H 1 BENZOPYRAN 4 YL)UREA; PINACIDIL; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HORMONE INHIBITION; INSULIN RELEASE; MUSCLE RELAXATION; MYOMETRIUM; NONHUMAN; PANCREAS ISLET; RAT; STRUCTURE ACTIVITY RELATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; BENZOPYRANS; CROMAKALIM; DRUG EVALUATION, PRECLINICAL; FEMALE; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; UTERINE CONTRACTION; VASODILATION; VASODILATOR AGENTS;

EID: 33646488916     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.009     Document Type: Article

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