3-alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: Design, synthesis, and pharmacological evaluation

Journal of Medicinal Chemistry

Volumn 43, Issue 8, 2000, Pages 1456-1466

  Pirotte, Bernard ^a   Ouedraogo, Raogo ^b   De Tullio, Pascal ^a   Khelili, Small ^a   Somers, Fabian ^a   Boverie, Stéphane ^a   Dupont, Léon ^c   Fontaine, Jeanine ^b   Damas, Jacques ^c   Lebrun, Philippe ^b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DIAZOXIDE; PINACIDIL; POTASSIUM CHANNEL; THIADIAZINE DERIVATIVE;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MUSCLE RELAXATION; MYOMETRIUM; NONHUMAN; RAT; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; AORTA; CYCLIC S-OXIDES; DIAZOXIDE; DRUG DESIGN; FEMALE; GUINEA PIGS; ILEUM; INSULIN; ISLETS OF LANGERHANS; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PINACIDIL; POTASSIUM CHANNELS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZINES; UTERINE CONTRACTION; VASODILATOR AGENTS;

EID: 18144437525     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991069o     Document Type: Article

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