Indole based cyclooxygenase inhibitors: Synthesis, biological evaluation, docking and NMR screening

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 823-833

  Estevão, Mónica S ^a   Carvalho, Luísa C R ^a   Freitas, Marisa ^b   Gomes, Ana ^b   Viegas, Aldino ^a   Manso, João ^a   Erhardt, Stefan ^a   Fernandes, Eduarda ^b   Cabrita, Eurico J ^a   Marques, M Manuel B ^a  

^a DEPARTAMENTO DE QUÍMICA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Anti inflammatory activity; Cyclooxygenase 2 inhibitors; Indole based library; NMR screening

Indexed keywords

2,3 BIS (4 BROMOBENZYL) 5 (METHYLSULFONYL) 1H INDOLE; 2,3 BIS (4 CHLOROBENZYL) 5 (METHYLSULFONYL) 1H INDOLE; 2,3 BIS (4 FLUOROBENZYL) 5 (METHYLSULFONYL) 1H INDOLE; 3 (4 BROMOBENZYL) 1H INDOLE 5 SULFONAMIDE; 3 (4 BROMOBENZYL) 5 (METHYLSULFONYL) 1H INDOLE; 3 (4 CHLOROBENZYL) 1H INDOLE 5 SULFONAMIDE; 3 (4 CHLOROBENZYL) 5 (METHYLSULFONYL) 1H INDOLE; 3 (4 FLUOROBENZYL) 1H INDOLE 5 SULFONAMIDE; 3 (4 FLUOROBENZYL) 5 (METHYLSULFONYL) 1H INDOLE; 4 ((5 BROMO 1H INDOL 3 YL)METHYL)BENZENESULFONAMIDE; 4 [5 (4 BROMOPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 5 (METHYLSULFONYL) 1H INDOLE; ALKYL GROUP; BENZOPYRAN DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; DIMETHYL SULFONE; ETORICOXIB; FUNCTIONAL GROUP; IBUPROFEN; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; INDOMETACIN; PYRROLE DERIVATIVE; ROFECOXIB; SULFONAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALDECOXIB;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE;

ANIMALS; CHEMISTRY TECHNIQUES, SYNTHETIC; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; HUMANS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION;

EID: 84864416220     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.06.040     Document Type: Article

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