Exploration of physicochemical properties and molecular modelling studies of 2-sulfonyl-phenyl-3-phenyl-indole analogs as cyclooxygenase-2 inhibitors

European Journal of Medicinal Chemistry

Volumn 43, Issue 6, 2008, Pages 1297-1303

  Gupta, Arun Kumar ^a   Gupta, Revathi A ^a   Soni, Love Kumar ^a   Kaskhedikar, S G ^a  

^a CADD Laboratory   (India)

Author keywords

2 Sulfonyl phenyl 3 phenyl indole analogs; COX 2 inhibitor; Docking; QSAR; SEQ MLR

Indexed keywords

ARGININE DERIVATIVE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GLYCINE DERIVATIVE; INDOLE DERIVATIVE; LEUCINE; METHIONINE DERIVATIVE; PHENYLALANINE DERIVATIVE; SERINE DERIVATIVE; SULFONAMIDE; TRYPTOPHAN DERIVATIVE; VALINE;

AMINO ACID SEQUENCE; ARTICLE; CORRELATION COEFFICIENT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HYDROPHOBICITY; MOLECULAR MODEL; MULTIPLE LINEAR REGRESSION ANALYSIS; ORTHOGONAL ROTATION; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SEQUENTIAL ANALYSIS; STRUCTURE ANALYSIS;

CYCLOOXYGENASE INHIBITORS; INDOLES; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44449111719     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.06.022     Document Type: Article

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