Design, syntheses, biological evaluation, and docking studies of 2-substituted 5-methylsulfonyl-1-phenyl-1H-indoles: Potent and selective in vitro cyclooxygenase-2 inhibitors

ChemMedChem

Volumn 2, Issue 1, 2007, Pages 88-100

  Cruz López, Olga ^a   Díaz Mochón, Juan José ^a   Campos, Joaquín M ^a   Entrena, Antonio ^a   Núñez, María T ^b   Labeaga, Luis ^b   Orjales, Aurelio ^b   Gallo, Miguel A ^a   Espinosa, Antonio ^a  

^a Facultad de Farmacia   (Spain)

^b Departamanto de Investigacion   (Spain)

Author keywords

COX 2 selectivity; Cyclooxygenase inhibitors; Docking studies; Heterocycles; Ketones

Indexed keywords

ANALGESIC AGENT; CYCLOOXYGENASE 2 INHIBITOR; ESTER; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; KETONE; NONSTEROID ANTIINFLAMMATORY AGENT;

ALGORITHM; ANIMAL; ARTICLE; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; DRUG DESIGN; EVALUATION; HUMAN; HYDROPHOBICITY; IC 50; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALGORITHMS; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING SITES; CYCLOOXYGENASE 2 INHIBITORS; DRUG DESIGN; ESTERS; HETEROCYCLIC COMPOUNDS; HUMANS; HYDROPHOBICITY; INDOLES; INHIBITORY CONCENTRATION 50; KETONES; MODELS, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47049112486     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200600179     Document Type: Article

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