One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 813-822

  Zhao, Pei Liang ^a   Ma, Wei Feng ^a   Duan, An Na ^a   Zou, Min ^a   Yan, Yi Chen ^a   You, Wen Wei ^a   Wu, Shu Guang ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

1,2,4 Triazole; Antifungal; Antitumor activity; Isoindoline 1,3 dione; One pot synthesis

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 2 [3 (2 CHLOROBENZYLTHIO) 5 (3,4,5 TRIMETHOXYPHENYL) 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 (2 CHLOROBENZYLTHIO) 5 METHYL 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 (2 CHLOROBENZYLTHIO) 5 PROPYL 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 (2 OXO 2 4 TOLYLETHYLTHIO) 5 PROPYL 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 (2 OXO 2 PHENYLETHYLTHIO) 5 PROPYL 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 (ALLYLTHIO) 5 (3,4,5 TRIMETHOXYPHENYL) 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 (ALLYLTHIO) 5 ETHYL 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 (ALLYLTHIO) 5 PROPYL 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 (BENZYLTHIO) 5 ETHYL 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 (BENZYLTHIO) 5 METHYL 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 (METHYLTHIO) 5 PROPYL 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 [2 (4 CHLOROPHENYL) 2 OXOETHYLTHIO] 5 ETHYL 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 [2 (4 CHLOROPHENYL) 2 OXOETHYLTHIO] 5 METHYL 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 [2 (4 CHLOROPHENYL) 2 OXOETHYLTHIO] 5 PROPYL 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 ETHYL 5 (2 OXO 2 4 TOLYLETHYLTHIO) 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 ETHYL 5 (2 OXO 2 PHENYLETHYLTHIO) 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 ETHYL 5 (METHYLTHIO) 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 ETHYL 5 (PROP 2 YNYLTHIO) 4H 1,2,4 TRIAZOL 4 YL)ISOINDOLINE 1,3 DIONE; 2 [3 METHYL 5 (2 OXO 2 4 TOLYLETHYLTHIO) 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 METHYL 5 (2 OXO 2 PHENYLETHYLTHIO) 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 METHYL 5 (METHYLTHIO) 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; 2 [3 METHYL 5 (PROP 2 YNYLTHIO) 4H 1,2,4 TRIAZOL 4 YL]ISOINDOLINE 1,3 DIONE; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; ETHYL 2 [4 (1,3 DIOXOISOINDOLIN 2 YL) 5 ETHYL 4H 1,2,4 TRIAZOL 3 YLTHIO]ACETATE; ETHYL 2 [4 (1,3 DIOXOISOINDOLIN 2 YL) 5 METHYL 4H 1,2,4 TRIAZOL 3 YLTHIO)ACETATE; ISOINDOLINE 1,3 DIONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; ASCOMYCETES; BOTRYODIPLODIA THEOBROMAE; CANCER CELL; CELL PROLIFERATION; CELL STRAIN HEPG2; COLLETOTRICHUM; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; FUSARIUM OXYSPORUM; HUMAN; HUMAN CELL; IC 50; NONHUMAN; ONE POT SYNTHESIS; PHYRICULARIA ORYZAE; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; FUNGI; HUMANS; ISOINDOLES; TRIAZOLES;

EID: 84864407684     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.06.041     Document Type: Article

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